Method of diagnosing bladder cancer

ABSTRACT

The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated.

FIELD OF THE INVENTION

The present invention is in the field of bladder cancer diagnosis, and in particular the methods for predicting the progression of bladder cancer tumors. The invention provides diagnostic methods and diagnostic compositions for use in such methods. The invention further provides therapeutic targets for treating specific forms of bladder cancers.

BACKGROUND OF THE INVENTION

Bladder cancer is the fifth most common cancer in the western world with an incidence of 20 new cases per year per 100,000 people in the U.S. Unfortunately, these statistics do not include superficial pTa bladder cancer, which represents the most common type of bladder cancer. In the Netherlands, the incidence of both superficial and invasive bladder cancer is estimated as about 30 new cases per year per 100,000 people. This is in accordance with data from global cancer statistics for the western world. Superficial bladder tumors are removed by transurethral resection. However, up to 70% of these patients will develop one or more recurrences, and it has been estimated that 1 in 1,450 people is under surveillance for bladder cancer in the United Kingdom. Cystoscopy is an uncomfortable, invasive, and expensive procedure, but currently remains the gold standard for detection of recurrences. Because patients have to be monitored perpetually and have a long-term survival, bladder cancer is the most expensive cancer when calculated on a per patient basis.

Hence there exists a need for an inexpensive, noninvasive, and simple procedure for the detection of bladder cancer. Cytology done on voided urine is a noninvasive procedure with up to 100% specificity. Unfortunately, this method is limited by its sensitivity, which is especially poor for low-grade tumors. Because of this limited sensitivity, alternative methods need to be developed for the detection of tumor cells in voided urine.

SUMMARY OF THE INVENTION

The present inventors have found that the methylation of a number of specific CpG islands (CGIs) in the DNA of cells shaded in the urine of a subject is indicative of the present of a tumor, in particular a bladder tumor. Thus, aberrant methylation of these CpG islands in the DNA of a subject may be used as diagnostic and/or prognostic marker as well as a therapeutic target.

The present finding has been found to be particularly advantageous in the case of bladder cancer diagnostics (including disease prognosis and prediction of disease recurrence and progression), since the detection of methylation may occur in DNA (of cells) in a sample of urine obtained from the subject to be diagnosed. In particular urothelial cells present in said urine sample are used for this purpose. The skilled person will understand that diagnostic methods as indicated herein may make use of any body sample in which DNA comprising the aberrant methylations as defined herein can be detected, including biopsies of cancerous tissue, or tissue suspected of being malignant.

The present inventors have demonstrated the suitability of using methylation of specified CpG islands as diagnostic markers in bladder cancer diagnostics, such as for:

-   -   detection of recurrent cancer in DNA isolated from patient         urine, and     -   detection of primary cancer in DNA isolated from patient urine.

Thus, in a first aspect, the present invention provides a method for diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated. The presence of a hypermethylated CpG island might indicate that the subject is at risk of, or suffering from, a cancer.

Preferably said CpG island is selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12.

In a preferred embodiment of methods of the invention, said cancer is bladder cancer.

In another preferred embodiment of methods of the invention, said method comprises detection of recurrent forms of cancer in DNA isolated from patient urine and wherein said at least one CpG islands methylation associated with cancer selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12.

In yet another preferred embodiment of methods of the invention, said method comprises detection of primary forms of cancer in DNA isolated from patient urine and wherein said at least one CpG islands methylation associated with cancer selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12.

In still a further preferred embodiment of methods of the invention, said DNA is obtained from a urine sample of said subject.

In another preferred embodiment of methods of the invention, said bladder cancer is non muscle-invasive bladder cancer. Alternatively, said bladder cancer is muscle-invasive bladder cancer. In a further preferred embodiment, said method provides detection of differential methylation of one or more of the genes provided in Table 7. Differential methylation of one or more of the genes provided in Table 7 is used to discriminate between subgroups of bladder cancer, such as between NMI-wt and MI and NMI-mt groups.

In a preferred embodiment of methods of the inveniton, general inflammatory cells in urine, preferably lymphocytes, are detected by methylation of at least one of the CGIs listed in Table 9. Table 9 indicates a number of CGIs methylated in blood but not in bladder cancer. The differential methylation of these CGIs, which can be detected in DNA (of cells) in a sample of urine obtained from the subject to be diagnosed, and in particular in urothelial cells present in said urine sample, are useful for the detection of lymphocytes in urine, or in general inflammatory cells in urine, which is indicative of cystitis. Positive detection of the presence of inflammatory cells in the urine can be used to diagnose infection or non-infective inflammation of the urinary tract and kidney.

In a preferred embodiment, said method comprises detection of recurrent cancer in DNA isolated from patient urine. This method entails the detection of specific CpG island methylations associated with recurrent forms of the cancer.

In another preferred embodiment, said method comprises detection of primary cancer in DNA isolated from patient urine. This method entails the detection of specific CpG island methylations associated with primary forms of the cancer.

The present inventors have further demonstrated the suitability of using methylation of specified CpG islands as prognostic markers in bladder cancer diagnostics, such as for:

-   -   prediction of disease course based on analysis of tumor-derived         or urine derived DNA, including:         -   prediction of invasive potential of non-muscle invasive             urothelial carcinomas;         -   prediction of urothelial carcinoma-specific survival, and         -   prediction of presence/absence of lymph node and distant             metastases caused by urothelial carcinomas

Thus, in a second aspect, the present invention provides a method for the prediction of the recurrence, progression or prognosis of cancer, in particular bladder cancer, comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated. The presence of a hypermethylated CpG island might indicate that the subject is at risk of cancer recurrence, progression of a cancer, and/or poor prognosis. A preferred method for the prognosis of a risk of cancer recurrence, progression of a cancer, and/or poor prognosis comprises detection of one or more methylated CpGs in CGIs of the genes listed in Table 12B, whereby the CGIs are preferably chosen from GPR103, DBC1 and/or GATA2 genes. Said cancer is preferably bladder cancer.

In a preferred embodiment of said method for the prediction of the recurrence, progression or prognosis of cancer, said CpG island is selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12, preferably from Table 5 and Table 10.

In aspects of the present invention the methylation of dinucleotide in or methylation level of a CpG island may be determined by any method available to the skilled person. Preferably said method comprises methylation-specific PCR (MSP). Alternatively, or additionally, use may be made of a multiplex ligation-dependent probe amplification (MLPA).

The present inventors have further demonstrated the suitability of using methylation of specified CpG islands as markers in bladder cancer diagnostics for prediction of therapeutic response, such as for prediction of failure or success of (neo)-adjuvant therapies.

The present inventors now envision as part of their invention the use of demethylating agents capable of specifically demethylating the CpG islands associated with tumor, in particular bladder cancer, as defined herein. They may also be of use as priming therapy for chemotherapeutic regimes.

Hence, the present invention provides a method for the treatment or prevention of cancer, in particular bladder cancer, comprising administering to a subject in need of such treatment a therapeutically effective amount of a demethylating agent capable of selectively demethylating at least one of the CpG islands methylations associated with cancer as described herein.

Clinical outcome of demethylating agents may depend on specific methylation profiles.

The present invention further provides pharmaceutical compositions comprising demethylating agents capable of selectively demethylating at least one of the CpG islands methylations associated with cancer as described herein.

The present invention further provides diagnostic compositions comprising PCR primirs and reagent or probes capable of selectively hybridising under stringent conditions to hypermethylated CpG islands as defined herein.

DETAILED DESCRIPTION OF THE INVENTION

As used herein the term “CpG island” refers to genomic regions that contain a high frequency of CG nucleotides. In mammalian genomes, CpG islands are typically 300-3,000 base pairs in length. They are in and near approximately 40% of promoters of mammalian genes (about 70% in human promoters). The “p” in CpG notation refers to the phosphodiester bond between the cytosine and the guanine. CpG islands are characterized by CpG dinucleotide content of at least 60% of that which would be statistically expected (˜4-6%), whereas the rest of the genome has much lower CpG frequency (˜1%), a phenomenon called CG suppression. Unlike CpG sites in the coding region of a gene, in most instances, the CpG sites in the CpG islands of promoters are unmethylated if genes are expressed.

As used herein the term “CpG island methylation” refers to a methylation of at least one CG dinucleotide in a CpG region as defined herein. Hence, the methods of the present invention include the detection of at least a single CG dinucleotide being methylated in a CpG island as defined herein.

As used herein the term “hypermethylated CpG islands” refers to a CpG island exhibiting an elevation in the level of methylation, relative to the level of methylation in the same CpG island of a control subject. Again, the level of methylation includes the presence of a single methylated CG dinucleotide in the CpG island as compared to the control situation, in which the same CpG island is unmethylated. Also, methods of the invention include embodiments wherein the methylation of a single CG dinucleotide in a CpG island as defined herein is detected among other methylated sites.

As used herein, “cancer” shall be taken to mean any one or more of a wide range of benign or malignant tumors, including those that are capable of invasive growth and metastasis through a human or animal body or a part thereof, such as, for example, via the lymphatic system and/or the blood stream. As used herein, the term “tumor” includes both benign and malignant tumors or solid growths, notwithstanding that the present invention is particularly directed to the diagnosis or detection of malignant tumors and solid cancers. Typical cancers include but are not limited to carcinomas, lymphomas, or sarcomas, such as, for example, ovarian cancer, colon cancer, breast cancer, pancreatic cancer, lung cancer, prostate cancer, urinary tract cancer, uterine cancer, acute lymphatic leukemia, Hodgkin's disease, small cell carcinoma of the lung, melanoma, neuroblastoma, glioma, and soft tissue sarcoma of humans; and lymphoma, melanoma, sarcoma, and adenocarcinoma of animals.

The term “bladder cancer” as used herein refers in general to urothelial cell carcinoma, i.e. carcinomas of the urinary bladder, ureter, renal pelvis and urethra. The term includes reference to the non muscle-invasive (NMI) or superficial forms, as well as to the more dangerous muscle invasive (MI) types. Also included in the term is reference to the primary forms as well as to recurrent forms of the cancer.

The NMI types may further be subdivided into FGFR3⁺ and FGFR3⁻. Mutations in the fibroblast growth factor receptor 3 (FGFR3, indicated herein as FGFR3⁺) occur in 50% of primary bladder tumors. It is known (e.g. Van Oers et al. 2005 Clin. Cancer Res; 11(21), pp. 7743-7748) that an FGFR3 mutation is associated with good prognosis, illustrated by a significantly lower percentage of patients with progression and disease-specific mortality. FGFR3 mutations are especially prevalent in low grade/stage tumors, with pTa tumors harboring mutations in 85% of the cases. These tumors recur in 70% of patients. Efficient FGFR3 mutation detection for prognostic purposes and for detection of recurrences in urine is an important clinical issue. Thus, in preferred embodiments of the present invention the method of diagnosis includes further the step of detecting an FGRF3 gene mutation. This additional step may be performed prior to, during or after the step of detecting the hypermethylated CpG island as indicated herein. The detection of the FGFR3 gene mutation as indicated in Van Oers et al (this reference is expressly referred to and incorporated herein by reference in its entirety for the methods and mutations to be detected as described therein) indicates the cancer is very likely of the non invasive type.

“Subject” as used herein includes, but is not limited to, mammals, including, e.g., a human, a non-human primate, a mouse, a pig, a cow, a goat, a cat, a rabbit, a rat, a guinea pig, a hamster, a degu, a horse, a monkey, a sheep, or other non-human mammal; and non-mammal animals, including, e.g., a non-mammalian vertebrate, such as a bird (e.g., a chicken or duck) or a fish, and an invertebrate.

A method of the invention can be performed on any suitable body fluid, such as for instance on abdominal fluid, pleural fluid, bronchial fluid, pericardial fluid, blood, serum, milk, plasma, sweat, tears, urine, peritoneal fluid, lymph, vaginal secretion, semen, spinal fluid, cerebrospinal fluid, ascitic fluid, saliva, stool, sputum, mucus or breast exudate. Preferably, a method of the invention is performed on blood, serum, plasma or ascitic fluid, more preferably serum. Depending on the methods employed, the skilled person will be capable of establishing the amount of sample required to perform the various steps of the method of the present invention. Generally, such amounts will comprise a volume ranging from 0.01 μl to 100 ml or more. Preferred samples are urine samples.

In even more preferred embodiments of aspects of the invention the cell fraction of urine, preferably tumor cell fraction, is used. Urine cell fractions may be obtained by filtration or centrifugation. The cellular DNA may subsequently be analyzed, for instance upon extraction of the DNA from the cells, although in situ methods performed on whole cells are also envisioned.

The skilled physician or biologist will be familiar with the various ways of providing a sample of a body fluid from a subject, in particular an urine sample. Urine collection and preparation of the sample for CpG island methylation analysis suitably comprises for instance the collection of a urine sample were collected into a 50 ml centrifuge tube. The sample may optionally be used for additional tests, such as dip stick tests for leucocytes, erythrocytes and nitrite as routinely performed in the art. The cells in the urine are suitably spun down for 10 min @ 3000 rpm; 4° C. An amount of supernatant is suitably stored at −80° C. for later use. The cell pellet may then be washed, for instance by adding a suitable amount of PBS (phosphate-buffered saline), such as 10 ml, to the cell pellet. After mixing and centrifugation (e.g. 10 min @ 3000 rpm; 4° C.), the PBS may be discarded. The cell pellet may then be resuspended in PBS (e.g. 1 ml) and transferred to a microcentrifuge tube. The suspension is then suitably centrifuged (e.g. 5 min @ 6000 rpm; 4° C.). The supernatant can then be carefully removed and the cell pellet may be stored in a −80° C. freezer until DNA extraction.

Commercial systems for DNA isolation from blood, urine and tissue are available form various suppliers of molecular biological reagents. Special reference is made to the DNeasy® Blood & Tissue Kit and DNeasy® 96 Blood & Tissue Kit available from QIAGEN GmbH, Hilden, Germany.

The term “therapeutically effective amount” as used herein refers to an amount of a therapeutic agent to treat, ameliorate, or prevent a desired disease or condition, or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers or antigen levels. Therapeutic effects also include reduction in physical symptoms. The precise effective amount for a subject will depend upon the subject's size and health, the nature and extent of the condition, and the therapeutics or combination of therapeutics selected for administration. Thus, it is not useful to specify an exact effective amount in advance. However, the effective amount for a given situation can be determined by routine experimentation and is within the judgment of the clinician.

For purposes of the present invention, an effective dose will be from about 0.01 mg/kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the polynucleotide or polypeptide compositions in the individual to which it is administered.

The present invention also pertains to pharmaceutical compositions comprising demethylating agents as defined herein.

A pharmaceutical composition can also contain a pharmaceutically acceptable carrier. The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent, such as a polypeptide, polynucleotide, and other therapeutic agents. The term refers to any pharmaceutical carrier that does not itself induce the production of antibodies harmful to the individual receiving the composition, and which may be administered without undue toxicity. Suitable carriers may be large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, and inactive virus particles. Such carriers are well known to those of ordinary skill in the art.

Pharmaceutically acceptable salts can be used therein, for example, mineral acid salts such as hydrochlorides, hydrobromides, phosphates, sulfates, and the like; and the salts of organic acids such as acetates, propionates, malonates, benzoates, and the like. A thorough discussion of pharmaceutically acceptable excipients is available in Remington's Pharmaceutical Sciences (Mack Pub. Co., N.J. 1991).

Pharmaceutically acceptable carriers in therapeutic compositions may contain liquids such as water, saline, glycerol and ethanol. Additionally, auxiliary substances, such as wetting or emulsifying agents, pH buffering substances, and the like, may be present in such vehicles. Typically, the therapeutic compositions are prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. Liposomes are included within the definition of a pharmaceutically acceptable carrier.

Once formulated, the pharmaceutical compositions of the invention can be (1) administered directly to the subject; (2) delivered ex vivo, to cells derived from the subject; or (3) delivered in vitro for expression of recombinant proteins.

Direct delivery of the compositions will generally be accomplished by injection, either subcutaneously, intraperitoneally, intravenously or intramuscularly, or delivered to the interstitial space of a tissue. The compositions can also be administered into the nervous system. Other modes of administration include topical, oral, suppositories, and transdermal applications, needles, and particle guns or hyposprays. Dosage treatment may be a single dose schedule or a multiple dose schedule.

Specific aspects of the present invention relate to the CpG islands indicative of certain forms of cancer emerging for instance from the following comparisons:

A) CpG islands hypermethylated in non muscle-invasive (NMI) bladder cancer (BC) that are FGFR3 wild type, herein referred to as NMI-BC wt, vs. muscle-invasive (MI) bladder cancer herein referred to as MI-BC (n=31)

B) CpG islands hypermethylated in MI-BC vs. NMI-BC wt (n=11)

C) CpG islands hypermethylated in all bladder cancers (n=62)

D) CpG islands hypermethylated in NMI-BC-FGFR3 wild type vs. NMI-BC-FGFR3 mutant (n=31), and

E) Hypermethylated CpG islands predicting progression of disease or death of disease (resp. n=3 and n=11)).

The methods of the invention comprise the detection of hypermethylated CpG islands in the DNA of a subject. As indicated, hypermethylation is a relative term indicating that the methylation level of the respective CpG island is higher than or elevated with respect to the methylation level of the corresponding CpG island in a healthy control subject.

The methods of the invention comprise the detection of at least one hypermethylated CpG island in the DNA of a subject. Since there are many CpG island indicated herein whose hypermethylation is indicative of cancer, in particular bladder cancer, the method preferably entails the detection of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28, 29, 30, or more, such as 35, 40, 45, 50, 55, 60, 65 or more hypermethylations in the DNA of a subject. In such instances, it is possible to speak of a CpG island methylation profile. In such a profile, the percentage of positively dectected CpG islands is preferably at least 50%, more preferably at least 70%, more preferably at least 90%.

The CpG island methylation profiles may comprise of between 2-25 CpG islands for diagnostic purpose, such as determining whether a bladder cancer is present, and/or whether it is an NMI or MI type.

The CpG island methylation profiles preferably comprise of between 2-25, more preferably more, such as between 50 and 150, for instance about 100 CpG islands for diagnostic purpose, such as determining the prognosis of an NMI to develop into a more aggressive MI type of tumor. Thus, the present invention provides for a prognostic method for determining whether an NMI type bladder cancer can develop into an MI type.

It is also possible to use a method of the present invention to distinguish between a primary or recurrent form of the tumor.

The skilled person is well aware of the various methods that have been developed to analyze DNA methylation. Amongst these methods are restriction enzyme- and sodium bisulfite based approaches, as well as multiplex ligation-dependent probe amplification (MLPA) approches.

Restriction-enzyme based methods are based on the inability of methylation sensitive restriction enzymes to cleave methylated cytosines in their recognition site. The identification of the methylation status relies on Southern hybridization techniques or PCR and is based on the length of the digested DNA fragment. The inability to digest methylated sequences results in longer fragments, indicating a methylated CpG dinucleotide. Restriction-enzyme based methods are simple, rapid and highly sensitive and are suitable for genome-wide methylation analyses as well as marker discovery techniques.

Preferred methods for application in aspects of the present invention is sodium bisulfite (NaHSO₃) based detection of DNA methylation. Such methods are essentially based on the fact that treatment of single-stranded DNA with sodium bisulfite results in sequence differences due to deamination of unmethylated cytosines to uracil under conditions whereby methylated cytosines remain unchanged. The difference in methylation status marked by bisulfite reactivity can accurately be determined and quantified by PCR-based technology. Bisulfite sequencing techniques (such as described in Frommer et al. Proc. Natl. Acad. Sci. USA 89 (1992), 1827-1831) provide qualitative data on the methylation status of 5-methylcytosines in the amplicon between the sequence primers and thus requires primers specific for bisulfite converted, but not specific for unmethylated or methylated DNA. This approach provides detailed information on the methylation status of all CpG-sites.

A methylation-specific PCR (MSP) assay for determining the methylation status of CpG islands may be used. Such methods are for instance described in Herman et al. 1996 (Proc. Natl. Acad. Sci. USA 93 (1996), 9821-9826) and Herman and Baylin (Current Protocols in Human Genetics 10 (1998), 10.16.11-10.16.10). The MSP assay is based on the use of two distinct methylation-specific primer sets for the sequence of interest. The unmethylated (U) primer only amplifies sodium bisulfite converted DNA in unmethylated condition, while the methylated (M) primer is specific for sodium bisulfite converted methylated DNA. Using MSP, 1 methylated allele may be detected in a background of 1000 unmethylated alleles. MSP is very suitable for analyzing the methylation status of CpG dinucleotides in a CpG-island. The method may also be applied for high-throughput analysis of clinical samples. The most critical parameters determining the success and specificity of MSP, i.e. bisulfite conversion, primer design and PCR as well as several post PCR validation approaches are discussed in Derks et al. 2004 (Cellular Oncology 26 (2004) 291-299). Methylation Specific PCR (MSP) is described in great detail in U.S. Pat. No. 5,786,146, U.S. Pat. No. 6,017,704, U.S. Pat. No. 6,200,756 and U.S. Pat. No. 6,265,171 and International Patent WO 97/46705.

Commercial systems for DNA methylation analysis using MSP are available form various suppliers of molecular biological reagents. Special reference is made to the EZ DNA Methylation-Startup™ Kit and EZ DNA Methylation-Direct™ Kit available from Zymo Research Corp. Orange, Calif., U.S.A.

Use can also be made, alone, or in combination with any of the above, of the MLPA technique. The MLPA technique is for instance described in great detail in Schouten et al., 2002 (Nucleic Acids Research 3(12) e57, 13 pp.).

Also, use can be made of a microarray chip to which DNA of a subject is hybridized. Such arrays for CpG islands are for instance commercially available from Agilent Technologies Inc., Santa Clara, USA.

Herein below are provided the following Tables:

Table 1. Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006). These CpG islands are aspect of the present invention as hypermethylation of these regions is associated with cancer, preferably bladder cancer and/or certain forms of said cancer.

Table 2. CpG islands differentially methylated in NMI-BC wt vs. invasive BC. These 42 CpG islands are aspect of the present invention as hypermethylation of these regions is associated with either NMI or more aggressive MI forms of the cancer. Hence, these regions are particularly indicated for use in diagnostic methods wherein typing of the cancer is relevant. The table provides data on CpG islands hypermethylated in non muscle-invasive (NMI) bladder cancer (BC) that are FGFR3 wild type, herein referred to as NMI-BC wt, vs. muscle-invasive (MI) bladder cancer herein referred to as MI-BC (n=31) as well as CpG islands hypermethylated in MI-BC vs. NMI-BC wt (n=11).

Table 3. CpG islands hypermethylated in (bladder) cancer. These 62 CpG islands are aspect of the present invention as hypermethylation of these CpG islands is associated with (bladder) cancer.

Table 4. CpG islands hypermethylated in NMI-BC FGFR3 wt vs NMI-BC FGFR3 mut. These 31 CpG islands are aspect of the present invention diagnostic markers for typing of (bladder) cancers and in particular indicate the relevance of FGFR3 mutations in bladder cancer. These 31 CpG islands may be used for diagnosis of FGFR3 wt primary and recurrent tumors in for instance urine. These 31 CpG islands may also be used for detection of FGFR3 wt tumors in patients with a FGFR3 ml (mutant) primary tumor. Alternatively, these 31 CpG islands may be used for the identification of recurrences that progressed to muscle-invasive disease or to stage pT1 or to high grade (WHO 2004 grading system) or G3(WHO grading system 1973). These 31 CpG islands may also be used to present specific targets for therapy in NMI-BC tumors that are FGFR3 wt.

Table 5. CpG islands potentially involved in progression and death of disease. These 14 CpG islands are aspect of the present invention as hypermethylation of these regions is associated with prediction of the recurrence, progression or prognosis of cancer of cancer, in particular bladder cancer.

Table 7 (including Tables 7A and 7B) indicates differentially labeled CGIs between subgroups of bladder cancer and/or between subgroups of bladder cancer and a reference sample (i.e. blood).

Table 9 indicates a number of CGIs methylated in blood but not in bladder cancer. The differential methylation of these CGIs, which can be detected in DNA (of cells) in a sample of urine obtained from the subject to be diagnosed, and in particular in urothelial cells present in said urine sample, are—apart from the purpose indicated herein for diagnosing bladder cancer—also useful for the detection of lymphocytes in urine, or in general inflammatory cells in urine, which is indicative of cystitis. Positive detection of the presence of inflammatory cells in the urine can be used to diagnose infection or non-infective inflammation of the urinary tract and kidney.

Table 10 provides a list of hypermethylated CGIs that show 3 or more CpG dinucleotides highly methylated in a specific CGI. This list comprises 82 CGIs representing 71 genes and 11 CGIs not directly associated with a gene. A preferred gene from Table 10 is MEIS1, showing the highest degree of methylation with a fold change of 4.8 and an average fold change of 2.2 across the 10 probes that were present on the array for this CGI.

Table 12 (including Tables 12A and 12B) provides a list of CGIs that are differentially methylated between tumors and urine from non-bladder cancer control. These genes represent potential biomarkers for urine tests.

LEGEND TO THE FIGURES

FIG. 1. Methylation pattern and expression of selected genes. (a) MEIS1, (b) NR4A2 and (c) HOXA9. (d), (e), (f) are Box plots representing the expression profiles which were taken from oncomine

FIG. 2. Comparison of differential methylation between subgroups. (a) Unsupervised analysis performed on all probes present on the 244K array without selection: PCA showing the distinct bladder tumor groups cluster separately (Red-MI, Blue-NMI-mt and Green NMI-wt), (b) Venn diagram showing the number of CGIs that are differentially methylated

FIG. 3. Semi-supervised analyses between bladder tumor subgroups involving hierarchical clustering and PCA. (a) Clustering and PCA of NMI-mt and NMI-wt tumors, (b) Clustering and PCA of MI and NMI-wt tumors, (c) Clustering and PCA of NMI-mt and MI tumors.

FIG. 4. Most methylated gene-associated CGIs are targets of polycomb complexes. (a) Overrepresentation of PcG genes in BC methylated CGIs. (b), Venn diagram showing the overlap in PcG target genes between bladder cancer subgroups.

FIG. 5. A. Hierarchical clustering of GGMA data of all the investigated samples. B. Heat map showing the probes which are methylated in all tumor subgroups vs. blood and urine; C) Methylation of two CpGs in the MEIS1 CGI (black peaks: methylated CpG, red: not methylated. IM, in vitro methylated DNA; RT112, T24, J82: bladder cancer cell lines; PU: patient urine; NU: normal urine; NB: blood), D) KM curve for progression to muscle-invasive disease based on a combination of methylation of GRP103, DBC1 and GATA2.

TABLE 1 Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006) chr1: 119333484-119333719 chr1: 149638545-149639227 chr1: 160220156-160220709 chr1: 178464743-178471598 chr1: 2072175-2072389 chr1: 2106293-2106715 chr1: 232106869-232108183 chr1: 33385564-33385979 chr1: 41122328-41122880 chr1: 47672249-47672972 chr1: 68288825-68289104 chr1: 71284766-71286392 chr10: 21828640-21829645 chr10: 22804715-22807056 chr10: 73437163-73438385 chr10: 7449476-7449790 chr10: 7489383-7495345 chr12: 113657930-113659205 chr12: 118612357-118612674 chr12: 94776044-94776377 chr13: 113930978-113931584 chr13: 34950488-34951119 chr13: 49595986-49600287 chr13: 94152191-94153185 chr14: 36205192-36206099 chr14: 37746906-37747538 chr14: 53488428-53488700 chr15: 94688798-94689131 chr15: 94696311-94696840 chr15: 94705727-94706054 chr15: 94712480-94712812 chr16: 52873104-52882105 chr16: 52873104-52882105 chr16: 85098883-85102729 chr16: 86294154-86294408 chr16: 87372445-87372729 chr17: 24303411-24303889 chr17: 34157398-34159854 chr17: 44074280-44075233 chr17: 56827843-56838048 chr17: 58865328-58865618 chr17: 73932992-73933361 chr17: 75377960-75381951 chr17: 75531280-75531546 chr18: 5186244-5187389 chr18: 68359955-68362770 chr19: 4059891-4060207 chr19: 42586165-42586705 chr19: 63420090-63420541 chr19: 63784504-63785085 chr2: 104835284-104839920 chr2: 105864220-105865009 chr2: 111591678-111597436 chr2: 115635091-115637285 chr2: 124498611-124499725 chr2: 156892636-156892878 chr2: 156893736-156894685 chr2: 171384729-171385226 chr2: 176737610-176738187 chr2: 19424445-19425131 chr2: 43251514-43251780 chr2: 45249374-45251726 chr2: 63134470-63134933 chr2: 66525936-66527222 chr2: 70984709-70985764 chr2: 72224630-72228512 chr20: 22505518-22507240 chr20: 22510737-22514165 chr20: 22514762-22515148 chr20: 35582018-35583550 chr20: 54012011-54014085 chr20: 60061693-60062033 chr21: 33316999-33322115 chr21: 36990008-36995832 chr21: 37857725-37858416 chr21: 43350621-43351134 chr3: 129688131-129694023 chr3: 148591199-148594390 chr3: 62330280-62330608 chr3: 62331767-62332398 chr4: 111780013-111780343 chr4: 122520930-122521740 chr4: 155881084-155881434 chr4: 177159356-177159814 chr4: 40134579-40135662 chr4: 9756136-9756429 chr5: 115810975-115811393 chr5: 122461778-122463450 chr5: 134390896-134393045 chr5: 135442969-135443206 chr5: 140724146-140724826 chr5: 174091287-174092335 chr6: 101023927-101024343 chr6: 1549606-1560865 chr6: 21704622-21705099 chr6: 26312699-26313302 chr7: 121727243-121727884 chr7: 1481682-1482268 chr7: 155266364-155266696 chr7: 155288454-155292175 chr7: 156895132-156895886 chr7: 2082782-2083345 chr7: 27164708-27165039 chr7: 27219187-27220360 chr7: 2724511-2724848 chr7: 27251165-27252762 chr7: 32768010-32768497 chr7: 55040457-55041024 chr7: 8449587-8450236 chr7: 96488158-96489591 chr8: 132985505-132986242 chr8: 142288380-142288718 chr8: 57520625-57522095 chr8: 65661156-65662687 chr8: 9798161-9799053 chr9: 121170908-121172141 chrX: 39749470-39754050 chrX: 50040955-50041296

TABLE 2 CpG islands differentially methylated in NMI-BC wt vs invasive BC. Provided for each are: ID; Comparision; Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006); Chromosome; GeneName; Location relative to gene Sequence. 7; I vs SW; chr1: 41122328-41122880; 1; chr1: 041122606-041122650; Unknown CGGATGTGCGTGGACTCTGCGGGCGGGGCGCCCGTAGTCTCCCTCCTTCGCACCCCGGGCGCCTGGGAAC CTCCTCGCGCGTTTGGCCACTCGCTGCTCCTGGCAGTAGGGGCTTCGGGCCCCGCCGTGTCCCCACCCAG GTATGGGGATGCGGAGTTGATGGGTGCGGGGCGCTGGGAGGGGGCAGATGAAAGGGGCAGTCGAAAGG GGGCCATGCGCGCCGAGCGCAGCCGGGTCATTAGCCGCGGGTGTGAGCGGCGGGGCAGGCTTATCGCCC ATCCAGGCCTGGCGGGCGGGCGGTCCCCGACGCGGCTGCCGCCGCCGCCCGCGGCAGAGGGCACGGCGG TTCCCACGCTCGGGCCCTGGTTCGGGGGCGTTCTCGGGACGGCGTGGCCGCGCTCACCACCACCGCGGA GGCCGGGCTGTAATTAGGATAATTGCGCTGCTCCCAGCCTGGGGCAGCTCAGGACCCGGCTGCACCGCGC TGGCCCGGGACGGGCGGGGGCAGGGGGTGGCGGGGCCCGAGCGATACAGCCCCTGGCGCAGTCCG 61; I vs SW; chr10: 73437163-73438385; 10; CHST3; INSIDE CGCCCAGACCGGCCGTGGCGGGGCCCCGGCGCCACGTGCTGCTCATGGCCACCACGCGCACCGGCTCCT CGTTCGTGGGCGAGTTCTTCAACCAGCAGGGCAACATCTTCTACCTCTTCGAGCCGCTTGGCACATCGAGC GCACAGTGTCCTTCGAGCCGGGGGGCGCCAACGCCGCGGGCTCGGCCCTGGTGTACCGCGACGTGCTCA AGCAGCTCTTCCTGTGCGACCTGTACGTGCTGGAGCACTTCATCACGCCGCTGCCCGAGGACCACCTGAC TCAGTTCATGTTCCGCCGGGCTCCAGCCGCTCCCTGTGCGAGGACCCCGTCTGTACGCCCTTCGTCAAGA AGGTCTTCGAGAAGTACCACTGCAAGAACCGCCGCTGCGGCCCCCTCAACGTGACGCTGGCCGCAGAGGC CTGCCGCCGCAAGGAGCACATGGCCCTCAAGGCGGTGCGCATCCGGCAGCTGAGTTCCTGCAGCCGCTGG CCGAGGACCCCCGCCTGGACCTGCGCGTCATCCAGCTGGTGCGCGACCCCCGGGCCGTGCTGGCCTCGC GCATGGTGGCCTTCGCCGGCAAGTATAAGACCTGGAAGAAGTGGCTGGACGACGAGGGCCAGGACGGCC TGAGGGAAGAGGAGGTCAGCGGCTGCGGGGCAACTGCGAGAGCATCCGCCTGTCCGCGGAGCTGGGGCT GCGGCAGCCCGCCTGGCTGCGGGGCCGCTACATGCTGGTGCGCTACGAGGACGTGGCACGCGGGCCGCT GCAGAAGGCCCGCGAGATGTACCGCTTCGCCGGCATCCCCCTGACCCCGCGGTGGAAGACTGGATCCAAA AGAACACGCAGGCGGCCCACGACGGCAGCGGCATCTACTCCACGCAGAAGAACTCCTCGGAGCAGTTCGA GAAGTGGCGCTTCAGCATGCCCTTCAAGCTGGCCCAGGTGGTGCAGGCCGCCTGCGGCCCTGCCATGCGC CTCTTCGGCTACAACTGGCGCGGGACGCCGCCGCCCTCACCAACCGCTCAGTCAGCCTGCTGGAGGAGAG GGGCACCTTCTGGGTCACGTAGGGGGGCCGGGGCCCCGTATGCCCCTCCTCGTGAAAGGCCTGCCCCGTC TTTCTGCCGCAGCCCTCGCAGAGGGCGGGTGCACAGCGCCATGACGGGCAGCGCCTCCTGTAGCAGTAGG GCCCCCAGCCAGCGCTCCAGCCAA 97; I vs SW; chr12: 118612357-118612674; 12; CIT; INSIDE CGGGGTCCTCACGGCTCCCGCAGGCAGCCGGCCCCTGCTGCTGTCTTCAAACAGCCTCCCGGGGGACCGC TCTCTCCGCGTGCTGAGCATCCGGCCGGGGGACTTCTCTCGCTCCAGGGGGCGGCCAGAGACTTGTCCCT GCGCAGCTCGGTCCGCCCCTCGCGGTAGCGGTGGGGTGTGCTTGGCTCTCGCGGGTGGCTGGGGCCTTC GGGCGGCGCTGGGCTGGAGGCCACGCGCTTGGTGATGTGCTCGTTGTACGTGGGTGGGCCTCGCTTGTTG GGGCTGCTGGCGACACAAGAGAACGTAGGGAGCTGCG 162; I vs SW; chr17: 34157398-34159854; 17; PCGF2-PSMB3; DIVERGENT_PROMOTER CGAGAGGACCCGGACCCCGGCGGGGAAGGGCGCCCTCCCCCGGCCTCGCGGCCGCCCCAAAGCACATCC CCTTCTGCCGGCCCCAAGTCCCCGCGCGTCCACGGCGCCCCTGTGCCCACGGGAGAGCACCCCCGCCCAG ATGGAAAAGGGGGTAGACCGGGCAGAGCGAGAGGCGGCTTTGGCTCGTGGGGAGCGGCGACCCAACCCA GCGCGCATCCCGCAAGCCCTCCCGGCTGCCCCGGACCTTCCCCCTCGCTACCTCGGAACAGGGTCTGCCC GGGGGCTGCTGCACAAAGAGGGGTGGTCGAGGGAGACGCCAAATCGTTAAGACGGGGAGCCCGTTTCGG CCATCTTGGAAGAGAGGAAAGGGAAAAAGGGACAGAAAAAAGGGAGAAAGAAAGGCGGACGGGGCAAGC TGGGCTAGGGACTGACGGGGCGCGGGGGGTGCGAAGGCAGGATCGGCTCAGAGCCCCCCCTCCCATCGG GGCTTGCGAAGAACGGCCGGCCCCCATCCCAATCCCCAGAGGGTTACAGGCCAGGAGAGGGAAAGGCAG GGGGAGTCCGCTCCGCTTACCTGGGTTCGGGGTCCGGTGGGTCTCGGGGAGGGGGGGATGGGAGGGAGG GAGGGAAGGGAGGGGAGGGGGCCGCAGCCGTGTCGCTCGCCCGGGCGGCGGGAGGGGAGAAACCTACG GTAAGAAAGGAGTTTGTGAAAGCGGCTTGGGGTGGGAGGGAGAGGGGAGGGGAGGGGACCGAGGGGGG AGGGGAGGGACCGGAGTGTGGGGGGGAGACAAAATGGCTTTTTTCCTCCAGACAAGGTAGGTCCCGCCC ACCACTCACCCACGTGACCTCATTCCTTCAGGATGCTGGCAGAGACGGGAAGAGGAGGGGGAGGCTGGC GCGGCCGCTCCCCGCCACCGGCTGCCGGGTCCCTAGCCAGGACGAGACCCCTCCCTTCCCATGCGGCCGC CCCGACCCCGGAGGATGGATCTCTTATGTTACCTTCCGCAGTTAGCCCCCCTCCCTTCAAAATATGGGTTC CCCCCACTGACACTGTGATGCCCATCCCTAACTGGGGCGCCTGGAAAATGGTGAAATGGGGACTGGGCTG AAAGGTGGCTCGTGGTCCTCCACGCCCCGGCCTAGACCAAAGGGCGCGGGGTCCGGCGGGGGACGCGAC GCCTTCAGCCAGGCGTCCGAGCGATTTTCATT 169; I vs SW; chr17: 56827843-56838048; 17; TBX2; INSIDE CGGAGGCGGCACAGCTGGAGCCCGGATTGTGGCACGCCGTCACCGTGCTGCTCCGGGGAATCCCGACCC GCTCCCTGCGAAAGCGTTTCCGAACGCGAACCCAGAGCCTGTGAACGCGCCGGCAAGCCCCCACTCCCCC ACCGCCGCCCGTCGCAGGTGGGCCCGTCCTAGGGGTCCTTCCTGCGCTCTACCCCGTCTCTCAAGTCACT CAGTCGATCGCCCCGTTCACGCTCCCGTGATCCCAGACATCCATAACCACGATCTCGCCTCCATGCACATC CAACGCACGACGGTGCACAACGTGCACCTGACTTCTGCGGACCAGGTGTCTCAAGCGTACAGCGGCCACC CGCGGAACCGCGGCCCGGGGCCAGTGAGTCGTCTGCAGCTCCCCGGGTTAGGGGATTCCCCAGAACTCC GGGAAAGTCACCCGAAGTCCATCCGGGATGCGGCCTTGGTTCTCGGCCGCGTATCTCGCCCTTAGGTGCA GAACGACGCCCTTCCAGGGCCCACAGCTGCCAGGCTGGGCCTTGCCCTCGCATCCCCCGGGAAGACCAGG GACGGGGCCACACAGGCCGTGGCTGCGGAGACGCTTCCCCGGGCCACCCCGCGACCAGGAGGGAGTCGA GCCGCCCGCTCTCCCGCGTCCCCCGCCCCATCCCAGCCAGTTGGCCCCACCCTGCGCGGGATAATTGGGA CGGGAGGGAGGCGACGGGAGGGCGGCGGCTCCAGAGAGACTGCGCGCCTGTCAGCGGCAATTTGTTTAA GTGGACGGGACGGGCCGGGCCGCTGCGGGCTGGGGTCACCGAGGCCGCGCCCCCACCCCAACCAGACCT GGGACCGCGGGGGAGCCCGGTCCGGCCGCTAAACCGGGCTGGCTGGCGCCAGGGCTCCGGGAGGTGCG GTCCGGCGGGGAAGCCGTGATGGGAAGCGACTCTGTCCAGGGAGTGTCCTTCACCACCACACTCCTCACG TCCAGGCAGTGATGACGGCCTGGCGGCACCCTCACAGCGGGCCCATAGCACGGGGCCACACACGTCCCCT GAGCTTAGCCTGGGCACATTCGTCTGCCACCGAGGGCTTAAGCCAGTCTGCAGCCCGCGCCCCGTCACTC GGACGCAAGTCCGTCGTCCGCTCTGCCACGCGGCCGCACAGCCCGGCTTCCTGCTGCCCACTGCCCGCGG GGTCACGCAACCCCGGCCCTGCACA 270; I vs SW; chr21: 37857725-37858416; 21; chr21: 037857850-037857894; Unknown CGATTTCCGCAGATTTCCTGCTGGAACGTTCTCTCGGGCCTCAAGTTTTCCTGAGAGGACGACGTGGAGA GTGGAGACAAAGATGCTCAAAAGCCAGGAAATCGCAGGCTCGGAAGCCCCCACGCATCCTCTGAACGCAG CGCCATCTCGGGGCTGCGGCGGGACCAAGCGGGACGCTTGCAGGCTGTCGGCGGCGGGGGCCGCGAGCC GCCGGCGTAGGCCGCTCCAGCTGGAAGACCCCACCGCTAGGGTTCCAGGGGGCTGCGGACGCTTCCGAG GGGCCCAAGGCGAAAGAACGCGCCCGCTTGTCGGCCACGTGACCGTCCCCGTCCGCGTCCGCAGCGACC ACGTGACTGTGCGTCCGCGGCGTCGATTGACTGGGAGCTCCCTGGCCACGCCCTAAGCGCCAGCCCCGGG CTTCGGGGGGCGGTGCTGCTGCGGTTGCCATGGCGTCTTCCGAGCGCGCAGGCGGGGCCCAGAGTAGCT TTTCGGGTATTTGCTACCGGCTCTCGGTAGGGCTGGTCACCTTTGCTTGCTGAGCTTCGCGCCCTGCGTCC TTTGGTCCCCAGCAACTTGCAGGGCAGCCGTCCCTCATGAGGCCCTCCAGCGAATGCCCTAAAGCTCCGA AGTTGCTCCGGAGGAAACAGGCTTGCTCCGAGGGTGCACGTCCTTACTGCCCGTGACGTCG 271; I vs SW; chr21: 43350621-43351134; 21; CBS; INSIDE CTGCTGCACTTGTAAAGTGGGTGCTTCTCAGCTTCATGGTTTGAGGGGTGCAGCCAGCTTCGGCCTAAGT GGTGTTGAGGGTCGAGGACCCAGCACCCCCACACGGGAAGCGCGGTGTCCCGCCTTCAGGCTGGAGTACT CTGGCACCCTCTGGGGTCCCGAAGTGCCTGAGTACCTGTTTGAGCCGCGTGTAGGTGACTGCGCACCTGT TTGAACTGCGTGTAGGTGACCGCGCACCTGTTTGAGCTGCCTGTAGCTGACCGGGCACCTGTTTGAGCTG CCTGTAGGTGACCGCGCACTGTTTGAGCTGCCTGTAGGTGACTGGGCACCCGTTTGAGCTGCCTGTAGGT GACCGCGCACCCGTTTGAGCTGCCTGTAGGTGACCGGGCACCCGTTTGAGCTGCCTGTAGGTGACCGGGC ACCCGTTTGAGCTGCCTGTAGGTGACTGGGCACCCGTTTGAGCTGCCTGTAGTGACCGCGCACCCGCTTG AGCTGCCTGTAGCTGACCGCG 283; I vs SW; chr4: 40134579-40135662; 4; FLJ20273; INSIDE CGCGTTGTAGGGGTAGCCGTAGTAGGCCAGTGTGTAGGGGTCGCAGGAGTACACGTAGCTGGGCTGCTG CGCTGCCTCAGCCGCGCCGCCGCCCCTGGCTGCCTTCTGGTAGCGCGAGTACTGCTCCTGTCCACGGGCT TGGCCAGCGTGACCTCCAGGCACGAGCCCTCCAGCTCAGTGCCGTTGAGGTTGTTCATGGCATGCACGGC ATCCTCGCGGCTGGTGAAGTGCACGAAGGCGTAGTCGCGGATCTTCTTGACGCGCTCCACGCAGCCGGGG TTGAACTGGCCGAAGCTCTTTTGATGGTGTCCTCGGTGGTCTCGATCATGAGGTTGCGCACGTAGAGGAT CTTCACGGTCTCCATCACGTCCTCGTCCACGTCGATCTCAGGTTCGGCCCAGTCCACGGCGATCTGGTGGC CCCACAGCTGGATGCGGCCAGGCATGAGCTTGCGGCGAGCCATGGCAGCCGGCGGTGGCTCTCGTACTCC ACGAAGGCGAAGCCGCGGTTCTTCATCTTGTCGGCCGCGCTGGCGTAGACGATCACGTCCAGCACGCCCT CGGTGACCTTGGCAATCTCCTCCAGGATTTCCTCGCGCTTCTTCATCTTGGGGATCCCGCCGATGAAGAGG CGGCAGTTGTCCCGCTGCAGCACACGCCGAGCAGGCGGCCCGGGCGGATCTCGTAGTTGTTGAGCTCACG CACTGCGCGCTTGGCCTCGTGCTTGTGGCAGTACATGACGAAGGCGTAGCCGCGGTTCTTGCCGTCAAAG TCCATCATGAGGCGCAGCTCGTAGATGCGGCCCACGGCCTCGAAACGGGCACCAGCTCGTCCTCGTACAC GTCGCGCGGGATCTTGCCCACGAAGACCTCGCAGCCACGCTGCGGGTGCGGGCCCTCCCAGCCGGGCGG TGGGCCGCCGTACTTGCGCTGCCCGTTCTCTTGCACCATGCTGTAGCCCGTGCGCTCCATCAGCGCCAGC AGTGCTGCTCGTTGGGCGCGCCCGCCACGCCCTCGGGCACCTTGGCGGAGGACCCGGCGGCCGAGTCAC TGCTCATGGCTGCGGTGGAATCCTCTGCG 357; I vs SW; chr7: 27219187-27220360; 7; chr7: 027219187-027219246; Unknown AAGTCTGGAGATAATTATGTCGTACAGTCGCAAACATTATTCCGTTCTTACTGTAAACGGCCCCGGCCACC TTTACGAGAAACCAGGAAACTTCTGAGAGTTACTAGCAGCGTTTACGCGGGCAAACGAGTTCTTTTTCTTT CTCTCCCGGATTGTTCGAAGTATCTATCGGGCGGCTTCGATGCCAGGTTCAGAGGCGCGCCAGGGAGAGG GCGCCCCGCAGAGGAGCGCAGCGGAGAGGCCTACGCAGGTCCCCGGTGCCCGCGGCCCTCGGAGGCCGG GCCCTGCGTCTTGGCCAGCACTGGGTGGCAGCTGAGGCTGGTGGCCCGGAGCCCTCGCGGCCGCGGGCA GGCCCCTTCTTGGGCAGGGTCGGGCACTCCCGCTGTCCAGGGCTCTTCGGCACCCTCCTTCCAATCAGGT CGCTCTCCCCTGCTCCCCAGACTCAACTCCTCCGAAGCTGCTCCAGGTTGAATGTGACCGCTAGGCCGACT CCCTGGGCCCGCGAGCAGTTCTCGAAAGGTGCGGACTGAGCCCTTTCTGGGGTGGGGTGCGGGTTGGTTC TCGCAAGTGTGACCCAGGGTGAACTTGCTATTTCGGGTCCCGGGTGCTGCAGGGCCAGGAGAACAGCTGG GATGGGGGACCCCGCCTCCACCCTCGGGCCGGCACGTCCGCGCCCTGTCAGGTCCCCCTCCCTCCTCTAT GATGGCCAAGGCGTGCGCCAGGGCTATCCGGGAACCTTGTAAGGCCTCGTGCTGGCACCTAACCCCACTC GCGGCACACTTCCTCTATGTAGTCTGCGGCCCCGCCTGCCAAATAGAGTGACCAGTGCAGGGACAGAATG CCAGGCTGGTGGCCGACCGCCTGAGGGACAAAGGCGAGCATTCACAAGCCAACAGCAGACCCCTGCCCCC CATATTTCCATTTCGCTCAGGCTTTTAGGACAAAATCAACAAGGCCGCAGAGTGGTGCAGGCGCTCACCCC GGGTGCAGCCTGGGGAGCCACTGGTTCCGCGACCCTGGGCATGAAACTCCTCAAGGGCGGCCCTCGAGA CGCAGGGGAGAGGATGCTGCCGGCGCCTGCCCGAGGGCTTCTCTGCGGGAAGCGGGCAGGCACCCCACC GGAGTCATTGCCGGGACCCTCAGCGCAACGCGGGCCTGTTCCTCTCG 373; I vs SW; chr7: 156895132-156895886; 7; DNAJB6; INSIDE CGGAGATGGCGCGTCTGGATTCAGGGAGATCGTGCGGCCAGCTTCCCTCCCTCTGCTCTGGATGGGGGCC GGCCGCCGCCGCTCACTCACGGCTCTCTCTCTCCCGCTGTGCCTGCAGGTGTGGCCGCGACGATGCCCTC GCTGAGGAGCGCATGCGGAGAGGCCAGAACGCCCTGCCAGCCCAGCCTGCCGGCCTCCGCCCGCCGAAG CCGCCCCGGCCTGCCTCGCTGCTGAGACACGCGCCTCACTGTCTCTCTGAGGAGGAGGGCGAGCAGGACC GACCTCGGGCACCCGGGCCCGGGACCCCCTCGCGTCCGCAGCAGGTGTGCAAAGGGAGGCAGCCGTGGA GCAGGCGCAGAGTGAGACTTCTCTGGGTGCCAGAGGACAGCGAGGACACAAACCGCGCCTGGGCTGCTG TGTTCTGACCTGAGCGGGCGTGGGCGGTCGGGCGGGGCGGGAGGAGGTAGCCTCCTCTGCTCCTCTCCC GCTCGCGGCGCCCCACGCCACGGTGGCTCCGGGCCCCCCACCGTTAAAACGGGGTCCGCGTGTCCTGTAC GCAGCGTGTTGCTCCGCAAAGGATGACAGAGCTGCCACGGCAGTGCGAGGTGCTGCTTTTACCGTAGACG TGCCTTTTCGTAGCTTTAGCGTAGAGCTTGAGGCCTGTGGCTTAGGCCGGGTGGTCTCGTGCTGGTGGGG TCTGCGTTTGCCCCTGCCCCTCCGTCAGCTTCACCTTCTCGTGCCTTCTTCTGCG 389; I vs SW; chr8: 132985505-132986242; 8; chr8: 132985506-132985550; Unknown CGTAACGGGCGTGGGTCGTCCGTCGCGCCGCCCGGCGAGGAGTGGGCTGGCGGCGGTAGCTGTCGCCCG CTTGGTTGCGTGACCGCGGGGTCCGCGTCCGCTCCCTCCACCCTTCGCCCTTCGCCCTCGCCTCGTTCCG GCCTCCGCGGCCCAGCAACGGCCGTCATGGTGCCGTCGGCGCTCCCTGCGCGGCCCCGCTGAGCCTCGGT GCGGCGGCGAGCGCGGTCGAGATCGCCATGCCTACCCGTGAGTGGCCGGCCGAGGGCCGGGGGCGTTGG GAGGCGACTGCCTGCGCGACGGCTTGGGCCGGGTACTCCTCCCGGGCGGCTGGGGAGGCTGGGCCGCGC TGAGCAGAGCCAGGAAGTGTCTGCGAGCGGCGGAGTTAGTTTCGTTTCGGCTTAGCCTTCCGGAGATGGC GTGAGCCCGTTGCACGGATCGGGAAACTGAGGCCCGAACGTTAAGGGAACTGCGGGACGCGCTGTTAGG AGGCGGCAGAGCTGGTGGTAACCTGACCCGTGGGATTTCAAAGTTAAAGCCCTTTTCCCACGGCCACACG GCTTCGTGGGACTTTATGGAAATATTGAAAATAACTGCGGTACCATTGTCAGTCCCTTCTCACCTCGGGCC GGACGTCGCTAGTGGAGCGCCGGCCCCGAGTCCCTTCCCGCGGCCGCCAGACAGACCCCCGACAGCCTAA CTCGGCGTCCGTATCGCCGTCGGGGCGGCTGAAGTCG 12; SW vs I; chr1: 68288825-68289104; 1; DIRAS3; INSIDE CGGAGGCACGAACCAAGCAGCCTAGAAGACAAATGCGCTGCTCGGAGAGACTGCCGCGGCAACCAACTG GACACCCCAAGAGCTCACTCCTCCGCGGTTTTATATTCCGACTTGCGCACAGGAGCGGGTGCGGGGGCGC AGGGAGTGTGGGTAACAGGCATAGATTCCGCTTGCGCAATACGTGGTAAGAAACCAGCTGTGAGGGGCTG GCCCAACGCAGAGCGGCGCGAGGTCCGCTTGGCATCTACAACAATCGAGGGGCTAGTCCAGAAGTTCAAG 15; SW vs I; chr1: 71284766-71286392; 1; PTGER3; INSIDE GCTCAGCTAGTAAGTGAGGAGCTCAGCTCTGAAGCTGTAACCAAGACCGCGCGGGCAGGAGGAAAGGAC ACTTCAGCGCTCTGCGGTTGCAAACACACCCCTGCGGGTGCTGCCACTTAGCAAAGTCTAGGTTCCCGCTT ACTCGCACACGCATCCTGACTTCCCCCAACCCTGGAACTACCTACCAGGAGCGGAGACCAGCAGACCGAC AGCACGCACATGATCCCCATAAGCTGAATGGCCGTCTCGGTCGTGATGCGGCCCCACTGGGCACTGGACT GAGATGCCGTGGCCTTGGCCGGCAGCGGGACACCAGGGCCTTAATGGTGGCCAGGTTGCAGGAAAAGGT GACTGTCAGCGCCAAGAGCCCCAGGAAGGCAAAGGCAGAGGCGAAGAAAAGGTTGCCCCAGTTATGCGA AGAGCTAGTCCCGTTGCCCCCTCGCCCGGTGCTGATGAAGCACCACGTCCCGGCCACTGGACGGTGTACT GGCCCACGCCCAGCACCGGCAGCAGGGCGAAGGCGAGCACGGCCAGCCACACGCCGAGCAGCACAGCGC GGGTGGCACGCGTCTTCATGTGGCTCGCATACCAGTGCGGCGCCCTGATGGCCAGCGCCCGCTCGACGGC CATGGCGCTGGCGATGACAACGAGGAGAGCCCGAAAACAGTCATGGTCAGCCCGAAAAAGGTGCAGAGC CGCCCCGACGGGTCGATGTGCTCCCAACGCTGCTTGGACAGGTACACGACGATGACGACCGGGGTGGTGA GAAGCTGCCCGACCAGGTCGGTGAGCGCCAGCCAGCCGATGCACAGCAGAAGGACTTCTTGCGCTTGCTC TCCCGGCGCCGGTAGCTGCGCGACACGAGCAGCATGGCCAGTGCGTTGCCCACGAAACCAGTGAGCAGC ATGGTGATCGGGAAGGCCACGGACACCGATCCGCAATCCTCGCCAGACCCTGGAGGGCGCGTGAGGTTG CCCCGCGCCTCGGGGAACGCTCGGGCGCCCACATGCCTGTGTAGGAGTGGTTGAGGCGGGTGCAGAAGG GGGCATCCCCTCCGTAGCCCCGGGTCTCCTTCATGTTGGCTTCGAGGTGAGGAGGGGATGGCGTCCAGAG AGCCGCAGCGGGAGGGGGCAGACGCGGCGCGGGCGGCGGCGGAGGTGGCGTTTACCGCGGCTGGGGCT GGGCTGCCCCCCATGGTGCGGGGCGCAG 21; SW vs I; chr1: 119333484-119333719; 1; TBX15; INSIDE ATTCTTAATTCCCACACCTCTTCCCAAGTTACGCCACCGGTCGAGGACGGCAGGAGACCCCCGAGTGCAG AGAAAGCTCAAACCGGCAGCGAAGTCGGTCCTAGCCAAGCTGAAAAAACGTCTCGGATTCGCGGACAGCG GCCTAGACACAGCCCGATCTTCCAGTCCTAGTGCCCTGGTCGAGACGGTTCTATCCTTTTGCAAAGAAGCC GGAAAGAGCTGGGTCCCGGGGGCG 26; SW vs I; chr1: 178464743-178471598; 1; LHX4; INSIDE CGGGGTGGGCTTCCCGCGCCTGCAGCCCGGAGGCGTCGAGCGCCTGATGGAGCGTCAGAGGAGACCTCG TCCCAGCGTTGGGCCTTCTGTTGTATTTCTGCCAGAAACTCGCGTTGAGGAGAATTTGTTTAAGCGTTTCT CTACCTGTCCATGCATCTCGTAAATACAGTAAGCATGGCAAGCCCTTTCGCTGGTTAACCCCGGCGTCCGT GTGCTCACTGCCGCCCTGCACGCACGAGGTCGCGGATGGTTCAAAGCACCCGCGGTGGCAGCCGGAGAG GCAGAGCGGGCTCTAGGGACTAAGACAGGGCCGAGCTGGACGACTGGTGGCAGGGCGGCCGGGGAGGCC CCGCCGCGGGGAGGTTTGGGCCCCCTACCCTGCGGAACTGGAGGCAAGTGCGGACTCCGGCTGCAGGCC GCGGTCTGCGGGGACGCGCGCGGGGGGCCTGCGTCCCGCCACCTCCGCGCACACCCCTGGTCCCCTTCC CCAGCCCGGGCCGGCGCCGCCCGCCGCGTGACTCGCGCGTTCCGGGCCGAGTACGGGCTGTCCCTTGGC CCAGCCTCAGCCAGACGCGGGGGAGAGAGAGCAGGGGCTGGGAAGTGCCGGCAGGAAAGGAATTGGCCA GGGGAAAGAGGAGGAGGAGATAGATGGAGTCATCGGTTACGGAGCGCGCTCCGTCCGGCGGAGCGAAGC CGGGGACCGAGAGCGCGCAAGGCGAAGACACAGCGACGCAGCCCCGTCCCCGGCCTCCGGACCGCCTGC CCCGCTCGGCCCCGGCTCGGCTCCGCCCCGCCCCTGGGTCCGAACGGAGGAGGAGGAGGACACGAGCCG CGCGGGCTTGGAACCCACGAAGACCCGCAAACCCAGGGCGCCGCCGTCTCCGACCACCTGCTGCCGCGG CAGGCCATCAGCAGAATTTATACCCAGGGCGCGAGCCCGCCACGGCTGGGCGGAGGCGGAGGCGGAGGC GGGGAGGGGGGGGGGGTCCGGCTTGCGAGGCCCCGCCCCGCTCCCTGCCGCCCCGCCCCCCTCCGCCCC GCCGGCCTCACTCGGGGCGCCGGGACCCCCACTCCCTCCGGGGTCGGCTGCCCGCCGCCGGGTTGGGGG ATGTGCCGAAGGGCGGGCCTCCCTGCGGAAAGCGACGTCACGGCCGCTCCTCAGTGTGAATGAATCAAAA CGCCCGGGTGACCGCGGCCTCCCGGGCGGCC 40; SW vs I; chr10: 7449476-7449790; 10; SFMBT2; INSIDE AAACCACTCTGAAAGAACTGTGAGACCTTTGCACTAAGACCATTAGGGATTCTACGCAAGGTTCTCTCTGC TCCTTGCAAAATTACAGGCGTCATGAAGGATGGCGGCTCGTAAATCGAAGCCTTTGAACAGGGGCTCACC GTCCGGCGGCATCAACACCTTGTTGTTCTGTGTGCACCACCCCACGGGGTGCAAATCCGCGATGACTACG TCACACCAGAAGTCGGCCCTGCGGTCCTCCCCGTAACCGCAGTAGCGCAGAAGCAGCAGCTGCCCGCACG TGGTAATGATCGTGGCCACCAGTACGTGTCCG 41; SW vs I; chr10: 7489383-7495345; 10; SFMBT2; INSIDE CGGCAACCGAGCCAGATCCAAGAGGGGTCGGCCTCGTCTAAATTGGTTTCCCACCAATGGCCTCGGATCA GCCGCGGCTGTGCTGCGGGAGCCCTCAGGACGCGGCTGGGGTTGGTGCGCGGGGCCCGGAACCCCAAAC CCGGCTCGGTTCGGCAAGGTTCAGGGAGACAAGGTAGAGAAGGCTGGGGTGAGCGAGAAGTCGGGCGGC CGATCGTCAGGGCCACGAGCCTCGCCTTGCCTTCTTGGAATCCCACCCAACTTTAAAGGCCCAAAGATCCT GAAAATTCCGAAAGCGAAACGCGAGCTGGTCTCCAGAAGTTTGAGAACGGTCTCCCAGGCTTTCCAGCGT CGTCCCGGGATTCTCGGACACCACAAACGCCATCAACCACGAGCACCGGTGTCCGTGGCTATTGCCCCGA ATGGTCCCCATCCGCGTCCCCGGGAACTCCCTCGGCTTTTCGCGCATCCAGGCCCCAGCCCCAGCTACTG GTGCGCCCCGAGCCCCTAGGTGCCAGAGCGGTGGTCGGCCGGGCTCCTGCCCAGTCTCGGCTCCTCCCTC CTCCCCACCAGAAGGAAAAACTTGGGCCCTTCGAGAACCCTGTGGAATGTTCTTTGTAATCAACTGTACAT CCGCTTCCACGGCCGGCCTCGTGCAAAATCGCGGGTTTCGGGGCCTTGGAGCAAATTGCGCTTGTCAGCG GCGACGTCAGGAGGACAAGGGGAGGGGTTCGCGGCTGAAACTGCAGCTTCGCAGCACAGAGCCATTTTA GGCTGCTCCCCACCTCGCGGGGCCCATGGGAAAGCCGGCCCCGGGAGGCGCGCCCAAACGCAGGCTGGA GGAGCCACGGACGCGTCCTGGCCGGCGTGTCGCCATCGTTCAGCCTCGCTGCCCAGGTGGGAGGGGTCA CCTGCCGCGGGGTCTCCAAGCCAGTGCCGCTTGCTCCCGGCCCCCACCCACTGACAGCACGGCGTCCGAG TGACCCTGTCAGCCTCGTTCTGCGCTCCTGCAAACCACGTTGCTGCGCTAACTACAAACCTGGCCAACATG TCTTTGTAACCCTATCATTTAAAAACGCTTCCAGGCACCTGGCCGCTGCCAGATCAGGTTCGCGGGCCCGG AGGAGGTCCTCCCACCTGCCCCCGCCAGCCCCGGGGACCGGCGCGGCCTCCGTGTGGCCCCCGCCCACG AGGTCCCTCGGGCAGGAACCG 112; SW vs I; chr14: 37746906-37747538; 14; SSTR1; INSIDE CGGAAAAACTCGAATGTCGCCCTGCCGTTCCTGGGGTTGGTGACAGGTCTGGTCATCGCACGGCGGCAGC TCCTCACCTGGATTTAGAAGAGCTGGCGTCCCCGCCCGCCCAAGCCTTTAAACTCTCTCTGCCAGAACCCG CCAACTCTCCAGGGTACAAAGTACAGCAGGGACGCGGGTGGAGCCCTTCCAAGCGGCGCAGCCTTATCTT TCCCGAGTGAACACCTAGGTGGATTCCCAACACCGCGCCTGGCACGTTTCTGGAGGGAGTCTCAAGCTCC TCCAGAGCTCCCAGCTGCCGTCCTCGTTTCTGCAGTCGATATTCCTGTGGGAGACACGGGGGGCTCTGAG CGCTACGAGCTTTATTAAGAGATTTGCGAATGGTTCACTCAGGTCCCTGAACACTCCCAATAGCCTAAGCT GCCTGCTGTGTTATAGCGCAGAAGCCCCTAACGCACGGTGGTTGTCCTTCTTCTCATAACGCTCGCAGCTT AGGGCCAGTTTCCGCGATTCTAAGAGTAATTGCGTGGGCACCTGTGCTGGGGCCAGGCGCAAAGAAGGGA GTTGGTCTGCGCGAAGATCGTCAACCTGCTAACAGACCGCACATGCACTTTGCACCGACCATCTACG 118; SW vs I; chr14: 53488428-53488700; 14; BMP4; INSIDE CGGTAAAGATCCCGCATGTAGTCCGGAATGACGGCACTCTTGCTAGGCTGCGGGCGGCGGCGCAGCCCAA ACATCTGCAGAAGTGTCGCCTCGAAGTCCCGCAGGAGCTCATGGCTCTGCCCTGAGCGCGTCCTCCCGCG TGGCCCTGAATCTCGGCGACTTTTTTCTTCCCCGTCTCAGGTATCAAACTAGCATGGCTCGCGCCTCCTAG CAGGACTTGGCATAATAAAACGACCATCAGCATTCGGTTACCAGGAATCATGGTGTCTCTG 147; SW vs I; chr16: 52873104-52882105; 16; IRX3; PROMOTER CGCGAGGATGGGCGGGCTCCACGTCTGGGGGCGCTGTGAGCAGGGCCAGAGCGAAACCTCAGTCTGAGT TTACGAACTGGGAAGGAGCCTGAACCCCAGAAACACCGTTAACAAAGAGGGCGAACGCAGGGAGCCGAG GAGACGTCTCCTTGGCCTCTGGGGAAGGGGCTGGAGGAGCGAGCCAGCTGAGAAGCGGCTTTGCCGGGT GTCCACTAGCGGTTCGCCAGCCCTCTGTGCGCCCGCAGAGTGACGCAGAGGCCGACACAGTCCCCTCCCC ACTCGCCCCTGGGGCGCCGCCGACCTTGATCACCCCCTTCGCGGAGGGAACTCCCAAGGCGCGGCGCTGG CCGCTGGGTCCGCATGGCCCAGTCCTGTCGGGCTCCGCTCTGCTGCCGCCGAGCTTCGAAGGTGTGCAGT GTTGAGCCGTGTCTTGTTCCGTGGCTTCGAGGGGTGTGCGCGCTTCCTATACCTCCCGGAACGCGCGAGA TAGTCACACGCGCCACTTTGAGGGTCAAACACCCCGCATCTGGCCACACTGTACCTTTACTAACGTGGGGA GGGGGCAAAAAAATGTGTCTCTCCTTCTTACCCCGAGGTGTCACTCGCCCAAACACTCCCTACAACTTCTT CAAGTCAAACTTGGCAAGGTTGGCTGGCTGACTGCGAGAGGAAAAAGAGGGCGCGGAGGGGGCGCGGCG CGCGGCCGGGTGTAGAGGCCACGGAGGCGAGGCGCCGAGCGTCCCCTTTGTCCTGTAGAGGGAGCTCCA GCCCCAAATTTCCCTGCTGCCTCCCCCGGCCCGCCCACCCCAGGCCCGCTGGAGCCGGAATCCCGGCTGG AAAGGTGCGGCGGTCTGACACCCCCGCAACCCCCGCGCCGGGGCCTTAGCAGGATGCCTCTTCTAGGGCA CGTGGGAAAACCCACCAGGGTGCCAAGACGCACAGATGCTCCCAGGACCCGGGCTCCCCAACTCTCAACT AGAGCTGGGCGTCACACATCATCTAGAGGATTATGTACCCCTAGGCGACCCTCTTCTCCATATCCGCCTCC ACCGTCACCCCACACCCTGGCATCTATAAAGAGGGAAGGGGGGCAACCGGGTTGGAAGGAGGATGGAAT CTGGGCTTGCACAGCCTCTTATAGGTAACAGTGAGAAAGCCTAACTGTGTCGATCAAAGAATGGGGACGA AGGGAGTGATGAGAACACGACC 151; SW vs I; chr16: 85098883-85102729; 16; FOXF1; PROMOTER CACACACACACACACAAAAGTTGGGAGAGAATGTGAGAATGCTTGTGTTCGTGGACGCGTGCGCACGTAT GGAGCGGCGGTACCTATGATTATTTGCGCGTGGCGCCTGGCTATGCGTGGGCGAACGGCAGTGGAGAACA TGTGGGCGTGCATGAAGTGTGCACTTAAACCAAAGTGTGCCCTCCCCGTTGGGCAGGCCTGTGTGTTGGT CCAAGGGTTGGGAGCGCCTGAGCTGTGTGAGGGTCGCTGGGAAGGGTGTTTGAGGCCGTGGGCGGTGCG GAGCGTGTCTGTGTGCGCGGGGCTGAGCTGGTTGTGTGAAGTGGTAGCGGGTCTGCCAGAGAGCGTTTAC CTGCGTGAATGCACAACCACACACTACGGGTCACGTCCCACACTCATTCTTTCCCTAGGCGGGCCAGGCT GTCTGCACGCGGAGACCCAGAGAGGCCAGCGGAAGGGCAGCGCGGGAAGGCGCTCTCTTCTCCCGCGAG CGCAGATCTGGCGGAGGAGGCGGCGACTGCCCGGCAGGCTGCGCCGGCGAGCCCCCCAGCTCCTCTCAC CGACGTGCCAGGCGCCCCGAAGGCGACAGGCGTCTCCCGCCGAAAATGAAGGCGTCCGAGCCAGGAAGG TGGGGGCGGGTAGTTAGGGGAGACAAGGAGTCCGGAGAAAACCGAGAGGCGGGTAGGCTTTGAACGCGC CGCGCCGCGGGCCGTGCTGCGAGCCCGGCACACGCCTCTCGCCCCAGCTCGCGCTGGGGCTTGGCCTCTA GGCTCTTCGCGATGACCCGCGAAAACACCCCTCGCCCCCCTCTTCTCAACCGGAACCCTGGAGGGAGAGG CCGCGCCCGGCCAGCAGTCGCTGCGAGAGCAGCACTCACCTGGGTCTGTGCGCGCCGCGATGCGCCGGG GCTCCTGCGCTGTCCTGCGCTCCGCTCTCGGCACCACCTTTCGTGGCTCCACCGCCCCCAGCCCGCACCC GAGCGCTGAGGTGCAAGGGCAGGTCTGCGTGCGAGCCCCCTGCGGGCTGGCAGCCAGGTGCGCGAGGGC CGCCCTTGCCGGCGCTCCCAGCCCGCGCTGTCTGCTCTCAGGAACCTGGCCTGGCGCGCAGTGTCAGAGG CCCCGCGGCGGCGGCAGGCCGAGCCCACAGGGGCATTAGGCCAACTCCCCCTCCCGCCCTGCGCACGCG GAATTCTCTATTATTATTATTAAAGAA 180; SW vs I; chr17: 75377960-75381951; 17; CBX8; DOWNSTREAM CGAGCAGGAGCAGGCGCGGCCCCGGATGTGGAGCCAGGCTTTCGGGAGAGCCCATTTCTACAGGGATTC GGCCCGACGGGTGCCGGGCCGAGCTCGCTCGGCCTTTGTTAGTTTCGGCGCCGCTGATTGATCGCCTAAT CCAGTGGACCCTGAGAAGAACAGACTGGGCTGCCAATGGCCCGACCCCACGCCGCCGCGACCTGCCCGA GGGCACCGGGAGCGATGGGTGCGGAGGGGCTGGGAGGACGGTCATCCGGGCGGCTGGACCTCTCCTTCC TCCCCTCCGCCTTCGTGGCTCGGCGCCGGGCCTCAGGGAGGACGCAGAGGGGGCGCCCGTGGCGGTGGG CGCCCAGCGGTACCTTTGGGTCGGGGGGAGGTAAGGCTTTCTCAGCTCGGGTTCGGAACCAGAAAGCCAC CGGCCCCCCGGGGGTAAGGGGTGGGCGCCGGCGACCCGGGCCGACGCCGCCACCTCAGAGGGCGCGCG CGTCCCACCAAGGTCGGCCGCCGGCCCTTCGGACGGACGAGGGAAAAGCCAGCCGCGGCTCCAGGGTGC CCGAGACTCAATCGCACCACCTGCACCCCGGCCACCTCCGCCTCCGAAGTCTCAGGAGGAAAGCCCCGAC CCAGCCCGCAGCCTCTCTCGCGCGTTCAGGACCCGAGGCTGCGGGCAGCCGCCTTCCACGACGGACAGCA CGGAGTCCCGCCGGGCCCCGAGCCACGCCAGTCTCGGACTTCAGCTGGGTCCGAGGCTCCTCTGGGCCTG GAGGGCTTTTAGAGGAGAAGAGGAAACCAGCACAGGAGCCCCAGAGGGCCGGACAGGTCTGTGCGCCAG CGGCCCGGGCGCATGGCACAGTGCCTGGATCAGGATTGGTGCGAAGCCAGCATCAAACGGACAGAAAAT GAATCCGATCCGACACTCTAGGAAGAGCATGAACCTTCCAATCCAACCAATGTTTGTGCGAGGCCAGGTTC CCCGCCGCGGTGGCCCACAAGCCAGCCCTGTCCTCGGGACGCAAGGTAACCAGTCCGGCTGGAGGCCGC CACGCACGCCTGGTCTCTGCAGTTGTGGCGGATTCCCAGGGACTCTGCCCAGGAAATGGAAACCCGTGAG GGCGCTCCTCAAAGCCGAGGGTGGTGATGGCCAGCGAACCCGAAAAAGGGCAGGGTGGGCGCCCTCCCA TCCGCTTAAGCAGTAGCCCATTCCACTGC 187; SW vs I; chr18: 68359955-68362770; 18; CBLN2; INSIDE CGCGCGCGCAGGTCCCCGCCCCTCTCCCCGGGCTGGGGGCGGGGTGGGCAGGCCGACGGCTGACCTGGT CGAAATAGATGGTCATGGTGCGGTTGCTCATCTCGGACGGCTCGTGGTTGGTGCTCCGGTGGCGGAGAAG GCCACCTTGGCGCTGCCGGAGCGCACGGAGATGCCTAGGGAGGAGGTGACGGCGCCGTCCGCCGACGGG CTGGAGTCGCACACCACCAGGCACTTGCCCTCCAGCACGATGGGCTCCGTGTCGTTCTGCGCCCGCACGG GGCAGCAGGCGGGCAGTAGCACAACAGCAGGGCCAGCGCCACCCCCAGGCAGGATCCGCAGCCGCCCGG CTCGCGCAGCGCCCCCCGGCGCCCGGGCATCATCAGCCGCAGCCCGAGTGGCCCCCGGCCGGGCGCCTG CATCGGGACTGGTGGGAGGCGGCGCGCGGGGGTGGAGGCCGGCGCCGGCGCGAGCGCGCGGAAGGGCG CGAAGGAACGCGCGGAGCTCGCAGCAGCCTCCGGGGGCCTTCGTCCCCGGCTCTGACGTTCAAGGCCAG GGTCGTTCTCAGAAGAAAGGCGCCTGTGAACCTGTCAGGGCACAGAACCCAAAGCCTTACACCGGGAGGT GGAGCCACCGGGAAGAAGGGGACTGGGAGCAGGTGCCTGCGGCTCGGGGGTTCTCCCCGAAGGCCACCC CCTTGGTCCCGCGCACAGCCAACCCGCTTTCCGATCTGGCACAACAGGTCCGGAGAAACGCCCGGGCGCA GCTGGCAGCGCATCCCTGAAGGCTCCCGAGCAGCGCGCGGGGCTGCGACGAGGAGGGGGCCGCGCTTCT GCAGGTCCTCGTCGCTAAGACGGGCCCCGAGACCCTCAGAAGGCGTCACCGCCACCCCGCCCATTCACCA GCGCGGAGGGGGCTAAGACGCAGGCAAAGAAAAACCTACGAATGCTTGCCTTCTCGCCTTCATCTCACAG CATTTCCTTGGAGCAGACCAAGGAACCCTTTTCCTATCCCTTGTTTCCCTGCTATCCTCTATTTTTCAATCC TCGAGATGTTTTTAAAGTCCATTTAAGTCCCTTTGGTACAGATTTTATCTGTTTTCCACCCACAGAACAAAT CCCAGGAATCTCCTTGGGGCGAATAAGATTACTAGGGGGGAAATACACCACACACACACACACACACACA CACACACACACACACACACACACA 200; SW vs I; chr19: 42586165-42586705; 19; ZNF569; DOWNSTREAM GGAAGTATCTTGGCCTGCACGCGGTTTACATCATTGGGAGCACAGGCCTCGCCCTCCGAACTACGAGGCC CAGAGCCCTTCGCGCCGAGCGTTTCCCGCCTTTCCCCTGTCTCAAGTCATTGCCCAGGGCCACTGCGGGC CGTTCCTGCCTGTCCGTGGAGCTGCGGCCCCCGTGTTCCCAGGGTGAACGAGCACGTGCGAGGCGGTGGT GCTTGTATCCGGGATAACCAGGTAGGGCGGCTGCATGCTTCATAGAGGCCAGCCTGTGCCGACCGGGAGC TGTAGGACGGTCTGTGTCTGGGCTGCTTATGGGTATTCGCGTGCGTCTGCCGGTGCGCGGTCCGAGCCTA CTCACGAGAGCGTGTGTGTGTCTTCTGTCTCGTGTTGCTATGAGGTTTGCATCTGTGTGGCTGGAATAGCT TGTTTGTGGGGGCCCGCGCGTGACCTGTGTGTGCGTTACTGTGTGTGTCTAGGCAGGATAGTGACGGGCC GTGTGACTGTGACGCCATCATCAGGTTGGTGAGATGGCGTGACCGCG 207; SW vs I; chr19: 63420090-63420541; 19; ZNF274; DOWNSTREAM CGAGGGAGGACGACAAGCGGGGACGTTGGCGGAGGGGTTAATGGCGGAGTCGCGATCCAGCCGAGCCCA CAACTCTGGGAGGCTGGTTCTGCCTCTCTCCCGAAGCGTCGCCCGGCTAAGCTTCGAGACCAGGACACAC AACCGCCGACTATTCCAGAGCCCACAGTCGGCTTCACGCTGGAGGCCGGAAACGACACGTCCCCAAAGCC CGCGCGCGCGGCCCGCCAGAACTGACCTACCCAATCACCGCACCGCTGCGATCAAGCGGCGACACACGTT GCCGGGTAAGAGTCACGCTTGGCAAATAAGCAACCTGCCTCATCCAATCAGCGTCTCGCCTGCCCGGTTA GTTCCTTGTCTTGCCCAACCAGATTCTTGCCTCCTCCATACCGCTACTTGCGTGTGCCGGTGCCTGGCCCA ATCAGCGTCTTGCGCCTCTTCTCGCTCCCG 223; SW vs I; chr2: 72224630-72228512; 2; CYP26B1; INSIDE CGCTTGTTGCGGTGGATGTCGCCAATGGAATTGGACACCGTGTTGGGGCCCAGCAACATGCGGGTGCTGC GAGGCCACTCGGTGCTCACGAGGTGGTGCTCGCCCATGAGGATCTTGCGCACGTTCTCGCGCCGGTCACG CGTATCAGCGGCCGCCCCAACAAATGCGTCTTGAACACGTTGCCATACTTCTCCCTCCGCGACGACTGGAA GCCAGAACCCTGCGGGAGCCACACCCGGGTCTCTCTCAGGGTGCACTTCTGCAGAGGGCCCGCGAGGGA GGGGCGGCGGACCCCAACCGGGGTACAGTCACCTGCCCCCTCTCCCCACCAAACACACTCACACAGACGA GCACGCAGGTTTTATTTTTCATAGCGTGCACAAGAACTGCGAAGTAGGGCCTAGAGGATAATAAATAATGC AAGGAGGCGGAGGCCCAGGGGCACCCCCAGGAGGCTGTTTTTTGGTAATGCTTTCGAGAGGAAAGAGGTA TCCCGGACAGCTGGACCCGAAGCGGGAGTCTCCGCCCCCACCCCCACCCCCACACCCCCACCCCGCGCTC GGGAGCCTCTCGGAATAAATATTTCCAGGCTCCGGGCCACGGGCTGGCGAGACCCCGCGGGGTGGCCGC AGGCCAAAGATTATTATAGCGGTAAGCGGTCGGTGCCCGGAGGCAGCAACTACAGATGGGGGTTGGAGTT TCCTCCGCTCTCCGGTGTGGCCCGCGCAGGGACCCGGCGGCCCTCGGAGGACTCTGCAGGGCGGGGTCA CGGGCCCAGAGCCGCGATTTTCCTAATGCATTTTGCCCTGGAAATACGGAGACGGACTTTGGTTGCCGCC CTGGAGTTTGGAACCCGAGCGCGGGGCGGGGCGGGACCGGGCAGGGCGACCCGCGCAGGTAACCAGATC CCCGGTGGTGGCGGCGCAAGCCGAGGATGGCGGGGCCGGGGCCGGCCGGACTCTCGAAACGGCTGGCG GAGCCGGCCGGCGCGGGTACCGGAAACCGTGGAGACCTCAGAGGGGCGGGGGCAAGGGCGTCCCGCTCA CCTTTGACGTCGGCACTAGTTACCCCACCCCACGTTAACCCTTCTCCTGCCGGGGCAGCACCCGGCGCAA AGGGGAGGGGCGCCACCTGTCTAGCCGCCCCGCCTGCCAGCCCAGAGCGTACCGACTCGGGCTCCAGAT CTACCCGCTCCTGCACCCCCGAGGG 227; SW vs I; chr2: 104835284-104839920; 2; POU3F3; PROMOTER CGCTCGGCAGAGGCACGATACAGCGGGAGAGAAGGGCAGGCCCGTTCACATTTTAATCGGAGCGCACCG GCGGCCGCTCCTCGGCTGCGTCCTGGGCTGCCGCTCGGGCTCGGGACTGCCAGATGCAGCTCTGGCTGG GGGCGGCGGGCGCAAGCGGGCGCACCCGCAGCTAGGGGTGCGGGGTGCACGCACACGCACGCTCATTAA GAGCCATGTATTTATTGAATGTCCGAGTTGGGTTAGTTCATTGGAAATCCCCGAGGAGGGCTCAATTTGCC CTTGTTTTCGTTGCCACTTTCCTTTTTTCTTGGTTCGCTGAGGTTCCTCTGTGCAGCGTTTCCGCTTGGCCG CGTCCCCCCACCCCACCCCACCCCACCCCCGCTTCTCTCGCCTACCGGGTGCACTCCCCCTCCCATCCCCC TTAACTCTTTCAGCTGGGTTAGAGCTGAGAAAGCATTTGTCGCCGCCAGCCCATCCACCACGCAAATCCAT CTGAGACAGAAAGGAAAGAAAAAAAAGCACCACCATGCCTAAGAATAGAGAGCGAGCAAACCCCCCCACC GCTAATCACACACACACACACACACACACACACACACACACACGAGGAAGCGGTGGAGCAGAGAAGGGCG CGGCTAGCCGACCCGGTTCTTTCGCCCGGCTCCTGCTGCCACAGGGAATTCCTAAAGCCATTGGGGTCGA ATACACTTACGATGAATCTATGGGGGAAGGTCGGACTGATTGCTTTTCAAATACATCGCACGGCTCCGCTG ACCGGCACCCTCCAAACTCACAAGGGCACGCACGCTACTTGCCGAATCCCAGAGGAGGGAGGAGGGAGG AAGGGAGGGAGAGCGAAGGAGGGAGAGAGGGGGTGGAGGAGCCAGGGAGCGGCGGCAGCGAGCGGTCC GTCTCGCACGCGCGGGCACCGCGCTGGTCCTGGGCTGCAGGTTTCCCAGATGATGGCATCCGAGAACTTA AACAAAGGGGCTGCCGCCGGCGCGCAACGGCTGCGGAAAGTTGCGGTGGCGGATTTCCAAGGAGCGTGG CCACGACCAGAGCTCTTGGCGATGCGAGCCCCCGCTTCCCACCCCCGCCGATCAGAGAAGGGGGCCGGCT GGTGAAGGGAAGAGGAAACTTTGAAACCACTGGGGACACACTGTCTATAGGTATTAGCTTGAATGGTACA TCCGTGCCGCGCGCTTTACA 235; SW vs I; chr2: 124498611-124499725; 2; CNTNAP5; PROMOTER GACTCTCATCACTACCACACCCATGTGTCTTTCCTCTCTCCGTCTCCCTGAGACGCCAGTGAACCACCTGG GCTTGGAATCCAGAGCCCCGGAACACCTTGCAGTACTTGCCCGAAGCAACGCGCCACAGCGGGAGGGAGA CGCAGACGCGAAGACCGGCGAGAGGATGTGCGGTGGGAGTAGCTGCGGGGTCTGCAAGCAGGGGAGCGC GCACAACGTTAAACCTTGAAACCAGAAATCCCGATCCTATCGAGACCCATCAGCTTTTCCCATTTGGGAAC GAGCGCAGGGGAAATTAATGCGTAATTCAAGCTCTGTTTTCCCCTCCCCTCCAAAGGTGAGGTGGGGGAA CGCGTCTCGTTAGCTCATTACAAAGCTTTCCGTGGGAAATTCCCTCTTCCTAATGCGTCTGTCTTGCAACT CCTATTAGCATCCTTCGACAGCGGCCTTTGAAAATCTCCTTTAAATTTCATACCTCTACTCGTTTCCCAAAT GGGGGGAAGGGAAGAGAAAGCCGGGGGGTAGAGAGAATTTCCTTCCCCTTTCCCTCCCAGGTAGCCAAAG CGCACCGCAGCGGCTTGGCTTCCTGGAGGAAAAGCGCCCGAGCGGGGCAAAGACCCGCCCAGGCTGCTC TTATAGGCGACGCGGGGCGGGCCTGGCTGGGGGCGGTGCCGCGCGGCCCCGCTCGCCTATAAGGAGCTG TCCGCCACCCGGGTGCTGATTCCAGCTCTCGCGCCCGACGAGGTGGATTTGGCTGTCCACCGAGCTCCGG CGCCTGTCGTTCTAATTGGGTTTGGATTTGCACCGTTAAGGAGGGGGAAGAGAAGGAAGAGGCGGGCGAG GAAGGCGAGTCCAGCTAGCGGCTGTTGCGGGGACCGTAGCCCCAGCTGCAGCTCCGAAGAATCCCCCGCC ACGGTTTCGGTGGAGCGTCTGGGCACGGGATGGAGTGAAAGAGCGAGTGCCTCTCCAAGCGGGGGTGGG AGGGGGCAGGCTGTGCAGAGGAGAGAGACAGCGAGAAGAAGCCGCGGCTGGCTACTGCGAATTTGGGAT TCGATTGGGAGGGACCGCTCACTCGGGGGAAATGGATTCTTTACCACGGCTGACCAGCG 257; SW vs I; chr20: 22505518-22507240; 20; FOXA2/C20orf56; DOWNSTREAM CGTACCCGGCTCTCAAAGGCACGGCACCTTTGAATTAGGTTGCGGAGTGGCCTGGGCGAGGGGACCCGG GGCCATCAAAGGCCCGAGGGAAGGCCGTGGGGCGACACCCGTCTAATGACAAGTAATTAAGGATTCGACG CCGCGCATTACCAGCGGAACGGGAGGCATTAATTATTTAAAAACGATTAGCCTTGCCGTGTGTCCTGCAG GCGTCCCATCATGTTCAGCGAAGATAACCAGCCACCCGAGGCGAGCCGGGGCTCGGAGGGCGGCGGGCG CGCTCCCCAGCAGGCTTCGGGGCGGTGGACACGGGCGCACAGCCCAAGGCACCAGGGAAGGAGAGGAGG GGCCACCAAGGGTCCCCACACAGGAAGGTGACTACATAACACTGACCCTGCTGAACAACGAAACAGATTT CTGCCCACTTGGGTTCGAAGTCTGGTGACTGCGGCGCAGATGGGAAAAGCTTTCGGTCGGGGGTGGTGGG CAATTTCCATGTGCCAGTTCCCTGTCGCATCAGACCAAAGACCCAAAGTAACCCAGCCAGGCACGGGCCT CTCACAGTGCCTGCTACCCAGGCGTTTAAAGAAAAGACCCCAGAGAGAATGTGGATCTGGCGTGGGGGCA GGGATTGGGGGGGGGCCTGGTAGACACCTGGGGAAATACAACTTTATGAGGTTTCAAGGGGCAGCAGCA GAACTACTATTTTTCCGAGGTCCACGCCTTTCCGCAGGCGGCGGAAAGACGCGGCTGGTTCTGTTGGGTC CTACAAACTCGCGTCCTCCGGAATTCCCGAGGGCAAGCCCGGCACGCGCAGCGTGCTCCTGCCCGTGGAA GGGGGGAAATCGGCGACTGGGTTGCAGGGAGAATGCGATGATAAATGGCCCTGCGTCTGCTTTCTGACTT TCTCTCCTGGACCCAGCTCGTAACCCCAGAGGCTCCCCAACCTGCCTGCCGCCAAGCACGGCTGTGCGCA AAAGGCCACCACCGCTTCCTGCAGCCAGAGCTAAGGTTCACTCGCCTCTTAGAAAGGCGCGGCCCCTCCC CTGCTGCTGCTTGATGACGATCCCCATCGTCTCCTCGGCCTGCCTGTGTCCGAGAAAGAGTTGAGACTGG ACTCGAACCCCTGCGCGCCAAGGGGAGGGCGTCACCATGCTCCGCCTCAGCCTCTTCAAACTCCCATGCA CCACGCACATCATTTTCTGCTGA 262; SW vs I; chr20: 54012011-54014085; 20; CBLN4; INSIDE CGACGTCCAGGGACCAGGTGCCCTTCGGCTCCCGCCGACCTGTTGCTCGAAACTTGCCCTGAGCTCTCGC TGCCGGGCTCTGGGCTCCCAAGCCTCTCCCCCGCCGCCGCAGCAGCCTCTTTTAGGGCCCGGAAGAAATG GGAGCCGGGGCTGGTGAGAGGGGTAGGAAGAGGGACGGTAGAAGTTTCAGACCCAGGCATATTTGGGAA GGCGAGTGCTTTACATGATTCCCCATTTCCCAATCGGACCAGCTTAGCCTGGGCAGGCAGCCTCGTGCTG AGGTGCCTGGAGACCGCCCACCCCTAGGTGCTCGCTTCCCCCCGGGTCTGACCTGATCGAAGTAAATGAT GCGCGTCTTGTTGCTCATCTCGGATGGCTCGTGGTTGGTGCTCCGCACCGCCGAGAAGGCGACCTTGGAG TTGGCCGCCCGGACCGATATCCCCAGCGGGGAGGAAGAGGAGCCCTTGGAGTCGTGGCCGGGTTCGAGT CGCACACCACCAGACACTTGCCCTCCAGCACGATGGGCTCCGTGTCGTTCTGTGCCCAGACGGGCAGCCC CGGCAGCGTGAGGACCAGCAGCACGGCCGGCACCGCGGACAGCGCCCGGCGCCCGGAGCCCATGGTGAG CCGTGTGGGCAGCCGCGCCGGCTGGCGCTGGTGCTCGCCCGCGTCGCCTCCTACCCCGGGATCCCGGTG CTCGGGAAGATGCTAGCGGCTAGGTCGACAGCGCTGCAGGAGCGACGGCGGCGGCGGCGCGCACACTTC CACCAATTCTGTGGCTTGAAGTCAAAGTCTCCCCTCGAGCTCTCTCGCTGCTCTGTTACCTTTGTCCTTTAA GGAGCTCATGCAGCACCCTTTACCCTACTCTCCTCCGCCCAAGAATCAGCCCTGCCTGGGGCCCCTGCACC CACTCTGGTTCCTAGACATCTGAAAGTCATCAAACCCTCACATTCACACCTCAAGGCAAAAAATAATAATA ATAATAAATCTCACCCCAAACTCAAGCACCACCAGCTAAACCACGGAGCAGGAACAAAAAGAGGGGACTC AAAGAGAAGCCACAAGGGTGGCGGGTGCCCAGCGGCGCGGGTGCCAGTCCTGTCTGGCTTGCGGCAGGG ACGAGTTACAGAGGCAGAAGGTCCTTCCCAGGCTGAGAAGACGCGAGGCTGTGTTCATGGCCAGGACGCC AGCGACTCCCACTTTCGCCTG 268; SW vs I; chr21: 33316999-33322115; 21; OLIG2; PROMOTER CGGTGCCGGGAGCCTTGCCTCCCGCCGCCACCCCTGGTCAGCTCTGCGCAAGAACGTCGTTCTGTTTGGC AGCCAGGCCGAGACGCAGCCTGAATGTGAGCAGGAACTCGGAGAAGGGAAGGGAGAGATCAGAAAGAAG GCCCGGGAGGGACCCGGGAAGCAGTGGGAGGTCTGCGCCCTGGAGCCCCGCGAGAGCCCGCCGGTTTGG CACGGGCTCCTCCCGGGCCGCCCGGCGGTCCAACAAAGGCCGGCCCCGACACGCACCCGGTCTTTTGTGG GAGAGAAACACAAAGAAGAGGAAAAACACGGAGGAGGCCAACAGCACCAGGACGCGGGGGCCAACCAGG AACTCCCGGAGCCGGGGCCCATTAGCCTCTGCAAATGAGCACTCCATTCCCCAGGAAGGGGCCCCAGCTG CGCGCGCTGGTGGGAACCGCAGTGCCTGGGACCCGCCCAGGTCGCCCACCCCGGCGCCGGGCGCAGGAC CCGGACAAGTCCTGGGGACGCCTCCAGGACGCACCAGGGCAAGCTTGGGCACCGGGATCTAATTTCTAGT TATTCCTGGGACGGGGTGGGGAGGCATAGGAGACACACCGAGAGGTACTCAGCATCCGATTGGCACCAG GGCCAAGGGAGCCCAGGGCGACACAGACCTCCCCGACCTCCCAAGCTACTCCGGCGACGGGAGGATGTT GAGGGAAGCCTGCCAGGTGAAGAAGGGGCCAGCAGCAGCACAGAGCTTCCGACTTTGCCTTCCAGGCTCT AGACTCGCGCCATGCCAAGACGGGCCCCTCGACTTTCACCCCTGACTCCCACTCCAGCCACTGGACCGAG CGCGCAAAGAACCTGAGACCGCTTGCTCTCACCGCCGCAAGTCGGTCGCAGGACAGACACCAGTGGGCAG CAACAAAAAAAGAAACCGGGTTCCGGGACACGTGCCGGCGGCTGGACTAACCTCAGCGGCTGCAACCAAG GAGCGCGCACGTTCGCCTGCTGGTGTTTATTAGCTACACTGGCAGGCGCACAACTCCGCGCCCCGACTGG TGGCCCCACAGCGCGCACCACACATGGCCTCGCTGCTGTTGGCGGGGTAGGCCCGAAGGAGGCATCTACA AATGCCCGAGCCCTTTCTGATCCCCACCCCCCCGCTCCCTGCGTCTCCGAGTGACAGATTCTACTAATTGA ACGGTTATGGGTCATCCTTGTAAC 276; SW vs I; chr3: 148591199-148594390; 3; ZIC4; INSIDE GGCCGGCCGGCCTTCCTTCCTTCCGCCCTCGCCCTCTTCATGCCTCAGAAACGTGGCCTACTCTGCATTCG GTGTGTGCGGAAGCAGCAATCACAGAGGCAGCCCTAATACCGGAGGCGGCGGCGGCGCAGCAGGGCCAG GTGGTAGCTCGGGGCTGAGGATCGCGGCGGGGGCAGCCGCTATGGGGCCCAAGCCCTGACACACGTACC ATTCGCTCAAGTCGGCGGTACGCGCCGCCACCGCCGCCGAGGAGGCCACCTGGGACTTGTGGCCGCAGTC CGACGAGGGCGACACGAGGGAGACGGTGTAGCCGAATCGTAGCCAGAGCTGGGCGGCGGCGAGCGCCCG TGCACCTTCATGTGCTTACGCAGCGAGCTGGGGTGCGTGTAGCACTTGTCGCAGCCCCGCACCTTGCACG TGTATGGCTTGTCGCTAGTGTGCACGTGCGAATGCTTCTTACGGTCGCTGCTGTGGCGAAGCGCCGCTCG CAGCCCTCGAACTCGCATCTGAAGGGCTTCTCGCCTGGCGGAGGCAACGCAGAGACATTAGTGCTTGTGG GTCGTGTTCCCGTCAGGTGCTTGCCACCCTCCCCCATTCGTCTCTCATTTTCTGGAAAAGAACTACAAAAT ATTTTCAGAAATCCTTTCCACGGCGCCTCAGGTCGAGCACCCCTTTCCCTCGTGCAGAGAGCGCCCCCGGT GCCCTCTCTTGAACGCCTCCATCCCTCCCGCCTTCCTCCTCTGGGCTCATGGGGAGGGTATGGAGGAGGA GCGACAGTGACTCCATCTTAGTCGAGTTTCCATCCTCGAAAATCCGATCCACTCGGGTTGTTTCCTCCAAA TTTTCTCCACTTGGAACCAGAAGCACCTCTGCTCGGAAATACATTAACGGAGGAGCTCACAATATAGTTAA CGGGGAAGCTCACATCTGCTCGATTTAAAGTTGCTGTTTCAGACTAACTTCTCTGCCGCTACCCCGCCCAG CCGTCATCCCCCCCACCCACCCCCATCCTGGCCCAAATTGTTTCCTAAAGTAGGTTTTGCGCAAACGCCAA AGCGATGAAATAATTTAAGGATGCGCAGCCGATGCACATTGTGTGTGCATAAAGTGGATTCGTGCTGCAG GGAGAGGTATTCTGAGCAATGATTCACTTCAGAAGGATTTTTACAGGAATGGAGCCCCCTCCCTCTTTCCT TCTACCCCCTGAGG 285; SW vs I; chr4: 122520930-122521740; 4; GPR103; INSIDE GAAATGTTCTGGAGCATGGTGACGGGAATGCAGAAGAAGGTGATGAGCAGGTCACTGAGCGCCAAGGAG CAGATAAAGATGTTGGTGACGGTGCGCATGGCCTTGCTGCGGGTCACCACGTAGAACACAGAGCATTGCC AAAGAGCGCCAGGGCGAAGATGAGCACGCCGGTGAGCACGAGGGCCAGCTTGGCGCGTCCCGGCAGCTC TGGGGTGTAGACGAGCGGTCGCAGCCGGTACAGAGCGATGAACTGCTCCCGCGTCAGGTTGTGGTCCCGC AGCAGCCGAGAGAACTGCTCCGGGTAATGTTAAGCGCCTGCATTGCTGTGCGCTCCCGGGACGCGGGGCC ACCGCCCGCTACTGGCTGGCCATCCGCATCTGCGGGGCAGCGAGGGCTTCGGGGGACCAGCCGGAGGCC GCCTCCCTTCCTCTACTCTGGAGTCAGCCGCGCGGGAGGGCTCTAGGCTGCACCCGGGAGGTTCGGGAAA GGAGAGCAGCTCAGGGATCAAACCCACGATAAAGAGGCGGGAAGCCAAAGCACTGGGAGACTCGATCTC AGTGACCAAAAAATGTTCGCGGTTCAAATAAAGTTCTTCCCTTGCTCTTCCCTAAGGCGAGGCGCCGCCAC GGTCTGGGGTGCTGGACGCCACGCGAGGGTCCTGGCGCCTCTGGCTCCCCGCCTTCTGGCCATGCGATGC GGACGCCGGACCCGCTTGGGGAGCGGTGGAGGGTGGGGCTGAACTCGGTGACGCCTCCCTCACACCCAG CTTCAGTGGCGCCAACGCCGCTTCCCCGCACCCTCAGGGCG 293; SW vs I; chr4: 155881084-155881434; 4; LRAT; PROMOTER GAAGATGAGGTGCAGAAGTAAGCTGGGACCTGTGAGCCTCAATTTCGGCCTCTTCTGCGCTGAGACCCAA GCGGATCTTGCTTGGCCTGTATGCGTTACTGGGGGAAATGGACGTGGGCCTGAGCGCGCAGGTGCGAGG GCGCTGCCCCGGGGCCGACCACCCTGCGGGGACACTGTAGCTGTCATTCCTTCTTCTGCAGGCGGGTAGG GGAAGCGGTGGCCAAAGTGGGAGTCGACCGCTCAGCACAGTCTGTCTGAGTGTTGACCAGGAAAGTCCAG GCTCTTTCTAAATCTCGCCGCAGACCTGGTGACGCATTCGCATGTATTTAAGGCGTTTGCACGCAGAACG 296; SW vs I; chr4: 177159356-177159814; 4; GPM6A; INSIDE CTTTACTCTTGGAGAAATCCCTCACAACAAAGGACAAGGGAGAAGCAAGGGGGAGGGGCGCCCAGTGGAC TTGGCTGGAAGAAGTGAGCGGGCTGGGGTTGGAAGAGTAACTCGGGCTGCGGGCTGACGCAGTCGGCAA CCGCGGAAGAGCAGCATCTCCCCTGCGCCTGTGGATACGCCAGTCCAGGGATGGCGAGTGCTTTCTCCTC CCCAGCTTCTCCCTCGCTCTTCGAGGTGACTCGTGGGACCCTGCGTCCTAGTGCTGGGTGTGAATCGGCT ATTTCACACCCAGTTCTTCCCCCCTCCGCCACACGCAGTCACATTCCTGGAGCTATTCCAAGCTGCCTCCG CTAAGCACCGAATAAGCGGACCCTGCCTGGAAACTTGAGCGAAGCTGAACTGCGCCGAACTCCACCGTCC AGTGACCCGAGCCAGTGTGGACGCCCTTTTAATCACG 317; SW vs I; chr5: 140724146-140724826; 5; PCDHGA5; INSIDE CGCTGTGCGAGCCAGGATCCGGGCAGATCCGCTACTCGATGCCGGAGGAGCTGGACAAAGGCTCCTTCGT CGGCAACATAGCCAAGGACCTTGGGCTGGAGCCCCAGGAGCTGGCGGAGCGCGGAGTCGCATCGTCTCC AGAGGTAGGACGCAGCTTTTTGCCCTGAACCCGCGAAGCGGCAGCTTGGTCACCGCGGGCAGGATAGACC GGGAGGAGCTCTGCGCTCAGAGCCCACTGTGTGTGGTGAACTTTAACATCTTGGTTGAGAACAAAATGAA AATTTATGGAGTAGAAGTAGAATAATCGATATTAATGATAACTTCCCGCGTTTCCGGGATGAAGAGTTAAA AGTAAAAGTTAATGAAAATGCGGCTGCAGGGACACGGTTAGTGCTTCCCTTCGCGCGGGATGCGGATGTG GGTGTGAACTCTCTCCGGAGTTACCAGCTCAGCTCCAATCTGCACTTCTCTTGGATGTGGTAAGCGGAACT GATGGACAAAAGTATCCGGAGCTGGTGTTGGAACAGCCCCTAGACCGCGAGAAAGAGACTGTTCACGACC TCCTCCTCACAGCTTTAGATGGCGGAGACCCGGTACTCTCCGGCACCACGCACATCCGTGTTACGGTCCTC GACGCAAACGAAATGCGCCCCTGTTCACCCCATCCGAGTACAGCG 333; SW vs I; chr6: 101023927-101024343; 6; SIM1; PROMOTER CGAATCGGGAATTGGCATTCCGTAAGGGAGCGGAGGGCCTCAGGCCACTAGGCAGCTCCGAACGCGGGG AAGCGGGAGCAAAGATGAGCTCAGAGCGAGGGTTGCCGGCGCCACCCTGGGCTGCGCATGAGGGGCCGT GGACCCGCCCCGAGACTCAGTGACAGTCGCAGCTTAACCCCGTTGGGGGCGCCGCCCCGCTGAGGTGGTT GCGTCTCCAAGTCGTGAGCCTCCAATAGCTGCTCCCGCTTTCGCGTCGCAACCCCAGGACCCCGGGAAAT TACCACTGTGCTCGTCTGGGCGGAGACCCGGTGCTTCGGAAGCCTGGGGCACATGCCTGGGTCCCACCCT AGACTCACCGCCTCTGGGCCCGAGACATGGGAATCTGCCCTTGAATATCTGGGCGCCTTTGCTGTTA 367; SW vs I; chr7: 121727243-121727884; 7; FEZF1; DOWNSTREAM CGCTCCACAACCCGGAAGGAGCTCAGGCCGGACTTGGCGTGAGGGTCCCTGCGGGGCTGGGTCACCTAC CCGTCCGCGATCACCCCACAGGGGCTGTTAGTAATCTCCCTGCTTCCTAGGCCGTTGAAAGCACTCAGGTC ACCCACTCTCGGTGACCAGAGCGGTCAGTCTTTCCCCGCCATGAAATGTGAGTTCGGGTGGCAGCCGCCG CGCCCCTGCAGTGTCCCCTGCACATCTCCGGTCTCGGTCTCGCCTTTCTCAGCTCCGCGCCGCCTTTTCCT GGGCGCCGCAGGACTCATGAAGTGAGGCGGGGCCACAGATTTAAGTTTATTCCCCGCAACTGTCGGGGCG GTCCCGGAGCTGGTGAGGACGCGCTACGGTGGGTGCAGAAAGGAGATCCCTGGACTCTGTAGAACCTGG GCCCGCGGTGTGGACCGATGGTGGATTCTCCGCGACAACAGCCCTGGAGGGGAGAGTGGGCCGGGGGAG GGGCCACGGGGCCCCTGAGGCCTGCGGGGCTGGCCGCACTGGCCCCGGGCCTGGCGGGGTGGTGGAGTC CGAAGCGGCGAGGCGAGGACCCCGGGGCCCGCTCCCCCCAGTCGCCCTCCCGGGATGTGGCCCCGCTGC AGTAGCACTACG 376; SW vs I; chr8: 9798161-9799053; 8; hsa-mir-124a-1; PROMOTER CGGGCTCCGGTGCGGGACAGGCAGCCGGAGGGAGCTCCAGACCCCTCCCCTCGCGCCCGCGGCCGCTGC GCGGAGGTCTGCGGAGGGCGCCTGGCTCGGTCGGTCGCTCCTTCCTTGGCGGGCCCTCCCGACCCACGGT GCTCAGCCAGCCCCATTCTTGGCATTCACCGCGTGCCTTAATTGTATGGACATTTAAATCAAGGTCCGCTG TGAACACGGAGAGAGAGGCCTTTCTCCTGAGGAAGGAAAGGAGGAAGGAAGGAAGGAAAGGTGAAAGAA AGGAAGAGGGGTGGGTAGAAATGGAATAAGAAAACCAGGAAAAAGAAATAAAAAGCGGCGCGTGTGCGT GCGCACTGACAGCGGGGAGAGGGATGGGGGTGGGGAACGCCGGAGGAAGGGACCACAGCATCCTCCCCG CCGCAGCTCCCCCAATCACACAGACAATGAGATAACAGCGACGTCTTCCAAAGGTCTTTGTTCTCCCCCAT CCTTTCGCATCCAGGCTTTTTCCTGCAAAGCGGAGGGGGTGGAGGGATGGGGGTGTGGGTGGAAGTGGG AGACGGAGGGGTGCCTCCCCCGTGTTAATTACCCCGGCTCCCCTCGCCCCTTTCCCCGCGCCTCGCCTCC CCTGCAGCTCCAGACATGAAAAAACAACATCGACCCCACCTCGCCCCAGCGCAGCAACCCACCCACCCAT GTCGCCCTCTGCTTCGCCCAGGAAACTGAAGGGGACTAGGAGGAGGAAGAAGAGAGCGAAGGACAAGGA GAGCAGCGGGGACTCGGCAGCGGCAGCCGGGGCAGGGCGCGCGGCCGCCCCTCTTTACCTCCATCGCTG AGTGGGGGCGCAGCCGGGCCGGGCGTGCCGCAGGGGCGAGTTGCCGCGGTCCG 380; SW vs I; chr8: 65661156-65662687; 8; BHLHB5; DOWNSTREAM CGCGCGCGCGCGCACCCGCACGCAGTCTGCAATGCCCTCACCAGTCCCCGCAGCTGGGCAACCCCTCCAA GACCCTGTGTTACGCTTAAATTCCTCTCCCTCCTATCGTACCCACCATCCATCCTTAAGCAGGGAGGCCGA GACTCACAGAATTCCCTTCTCCACCAACTCGCACTCTTGGTCTAGCACGCGGAAACCGAACCTTTCTACGC GGCCCGACCTTGCGATTGCTCCAGCATGAGTGGCATTGACTTTTCCAATGTAATGACTTATGAAAGATATA ATCATGTGTTAAATTGATCCTCCGTTTAACTGTTAATGGTGTGCTCTGGGCACATTTACGTATTTGATGCTA TGGTAACTAATTACCACTAGAAAAAAGGATAATACACTTCCCAGACTTTGAAAAATAATCATGAGTTCACT TCCCGGCTCGCAGCACATCGTGGCGGCCCTGCCGGGAGGAGCGAGAAACGAGTGGAAACCCGAAAGTGT GCTCATGGAATGCAGGAGGTAATGAATCCTGGTCAGGTGAGACTACTTAGTCAAACCTTTAATGAAAACGT GATTCACATGGAAAGCAGGAGTGGGAGGGAACAACTACACAAAGGTGCCTTTAAACAAAATTAAATGGCA AAACCTGCTATCAGAAACATGAATAGGTTTCTTTCAATTAAAATGCAGGTAAGACTAAATTATCCACGTGC CAAGCAACTTTACATCAATTAACATTTTTTTGTTGTGTGGGCAAAGTAAATGAGCCCGGCTCCTGTGCTCT CTGTATTGGCATATACAACTTGAAAGTCTCTGGATTTCCAAGCCAATGAGCTGCAGGTTTATTTAAATTCG GCCTTTTAAATCAAACTTTAGACACAGTAGGTGGAAGGAGGGAAAGAGAAGGAAAAACAAGGAGTCAGTA ACTTCAGTTTAACAGTAGAAACAACTCTTACGGTGAGAGTCTTTTTTGCCCGGCAAATCTCTGGCTCTCTG ATCGACTGGTGTTTAGAACCAAGGTTCCAGTAAACAGGGCTGGGTAGGATAACGAGGAGAGTGTTTGTGC TGGGACCTGGCAGGACTGGAGGAGGAAAGGAGCCGCCTTCCAGCAGGTCCAGCATCCCTAGGTTGCAAAC ACACCAAATGACGTCCACGCAGCACTCGCCCCACCGCGCTGTTTTTGCTTGCGCAGTGCTCCCGAAGGGA TTCGGGATC 398; SW vs I; chr9: 121170908-121172141; 9; DBC1; PROMOTER CGTCGGGAGCGCGCGGGGACACACACGCCACTCACTCAAACCCGCAATTAGCCCTTTGAGCCCCAGGCAC AGGAACCCCCTCCCTAGAACTGGAGAAGACTTGGAGGCGGCGGGGCGGCCAGGTGAAAGCGGACAAGGG TGCCGGTAGGGGGAGGGGCAGAGGAGCGCGGGGACGCCCCGAATGCGGCCCGGGGCCGGGTCCAAGGG CAGCGGGGCTGCGGGGCGCTGCACCCGGCGCCGCCTTACCTGGAGTCAATGTCCGTCTTTGGCGGAGAG CTGCGGGAGGACGCTTTTTATTCGCTCGGTGGGAACTTGGGAGAGCCCTGCGTGCAGCTCGCATTCCGGG CACGGCGCGGGGACTGCAGGCGTGGGGGTACCTGGCTCCTAGCAGCCTGGCTCATACTCAGCCGTAAAGT CCCCTTCGCTGGTCCCGAGGACAGGCATGAATCCCGGCTCCGGAAGGCGGTCACTCTCCCTCTGCCTCCC GGCTCTCTCGCTCTCGCTCTCGCTGTTGCTCGCTCGCTCTCTCCCTCTCTCGCGGGTTCGCTCGCCTGCGC TCTCCTCCTCCCCGCGCGCCAGATCAGTTTGCAGCCGTGGGGTCCGGGAGCGAGGCGGCTGGCGAATGGA GAGGGAAGTCCAAGTGGCCGCGGTCTCCGGGCGGGGAGCGGCGGAGGCCGGGCTACGCCGGGGGAGGG ACTTAGCCGGCGACGGCCGAAAATGAATGGGGGAGCGGCGGCCGGGGGGCGGGGAGGGAGGAGCTGAA CGCCGGGGTTGCTTCCGAGGAGTGTTTTGTACATCTTTAGGCGGAGGAGGAGAGAAGCGAGAGGAGGAG AGACGGGAGGCCGCCTCGAGGGAAGGGCGGCCCGGGTGGGCTGGGGCTGAGCCGTAGGGAGTTTCGTGG GTCTGGGGCGTGTAGGGTGTTGTGTCTATGCGCACGAGCATCCAAAGGGACCGCGCATACGCGCAAACCC GGAATCCTGGTGCCCTAAGCGTGACTGTACTGTGTGTGTCGCGAGTACCTGAGTGTTTCTGGGGCGGCAG GTGTTTCCACGGCCGCGTGGATCCATCGAGTGTGGGTTTTGTCTCGGGAGTTGCCCGTGTGGGTCCGTTT GTGTCTGCGCGTCTCTCTGTGAGTGTTTGACACTGTTTGTTTCTCTCGTGTGTAGGCGAGAGCCCACGTAA CCTCCCAGAATGAAGCAAGAGCTTCTC 403; SW vs I; chrX: 50040955-50041296; X; CCNB3; PROMOTER GCGTGTCGCAGCTGTGCACGCTGATTGGTCCTCTGCTGGCCAATCACCACTGCACTTCATGACGGCTGTA GTTTTCAAAATCCCAACTGGGCTGGTGGAGGGTCGCAGGTGTCAGGTTGAGACGGACCGAGTCGCTATAG TAAGGAGCTCCGTTCATTTCCTTGGCCTCTCCTGGTCTAGGGGTGCGTCGATGGTCTTTGCTGTCTGTCCT CGATCTCGGTGTGAGGTAGGCGCCTTTGGGCAAGTACTGCTGGCTCCAGCGTCCGGCTCTGTCGCCTGCC AGTGGGTCCTTGGGCGTCCTCCAGCCCCTTGCTGAATTCTGTTGCTGGGATGCGCGGCG

TABLE 3 CpG islands hypermethylated in (bladder) cancer. Provided for each are: ID; Comparision; Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006); Chromosome; GeneName; Location relative to gene Sequence. 2; ALL;; chr1: 2072175-2072389; 1; PRKCZ; INSIDE CGGGCGCGGGAGCTACGCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAA GTGGTGAAGAAAGAGCTGGTGCATGATGACGAGGTAGGTGCCGCTTCTCATGGGGCCGGGGGCCCGGGA ACGCGCTGCCCTGGGGCCTCCTCCGGGCTTTAGCGGAATTAATCCATGCACGAGAGACCTAGCCTCACGT TGACG 3; ALL; chr1: 2106293-2106715; 1; PRKCZ/FP7162; INSIDE CGAGGAGTCGGTGTGAGGCCGCGTGCGTCTCTGTCGTGGACACGCGTGATTGACCCTTTAACTGTATCCT TAACCACCGCATATGCATGCCAGGCTGGGCACGGCTCCGAGGGCGGCCAGGGACAGAGCTTGCGCCGAG ACCGCAGAGGGAAGCGTCAGCGGGCGCTGCTGGGAGCAGAACAGTCCCTCACACCTGGGCCCGGGCAGG CCAGCTTCGTGCTGGAGGAACTTGCTGCTGTGCCTGCGTCGCGGCGGATCCGCGGGACCCTGCCGAGGG GGCTGTCATGCGGTTTCCAAGGTGCACATTTTCCACGGAAACAGAACTCGATGCACTGACCTGCTCCGCCA GGAAAGTGAGCGTGTAGCGTCCTGAGGAATAAAATGTTCCGATGATGTGGAGCTCCTCTGATGCCTTTTTTC 6; ALL; chr1: 33385564-33385979; 1; chr1: 033385935-033385979; Unknown CGGACGTTAAGCCGCGTCCAGGGCTCCGTGCAGGCGCTGTACTGGTTGCCATCGTGCATCACGATGCAGT AGAAGCCGCGGCTGGGCTGGATCTGGATGCTGCCCTTGCGGCTTGCGGCTTCGTGTGCAGCCCGATCACC CACTGGGTCTTCTCCGCCACCACCACCTCCCAGTAGTGGACGCCACTACTGAAGGCTTCAGAACCCAGCA CCGACACCTCCACATCGAAGCGCTTTGGCGAGTCCTGCAGTGGCTGTGGGTGCAGTTGCCGTAAGCCACA ATGGTGCAGTCGTCCGACAGGATCAGGCGCTGGTGGGCTGTGCCCGGGTCCAGGGTTAGGGCGGCTGGC ACTGTGGGGGTTGGAGGAGGGAGAGAAGATGAGTGGGGAGAAGGCTGTGGCCCACCATGCAGTG 8; ALL; chr1: 47672249-47672972; 1; FOXD2/MGC12982; PROMOTER CGCGCCGGCTTTGCCGCTTTCCCTGAGGGTGTCCAGTTTTGTGAATAAAATTAGAGAAATCTGCGGGCGTA GTTCCCCAAGCCCAGCTCAGGCTTCCGTTTGCAGCCCGGCGCTGGCCGAGCTCGAACGCTGAAAAGGGCC GCGTGCAATCGTTCCGCTGTGCCTCAGGACAAACTCCGCTTCAAGCCAGTGCCGCTCTCCGGCAGTTTCCT GATTGACTTAATTAGATCCGCATAATCGCTGGAGGGCTTTTCTTTCCCAGACCGAGAACAGCTCATTTATG GGGACCAAAAGGAAGAGAGGGAGAGACGACCCGGACGCCACTGATAGCAACGTACTCTTCGCAAAAAACA CTCAGTAACTAGTGGAAAAGCCCAACAGGCATCCCCCTCCGCCCGCAACGCTTCCTCCCAATTGTTCTGGG CTGCACGAGGGAGATGGCCGGGCCGTGGAACAGATGCAGAAGGAGGCCCGGCACGACCAGAGACGCTGT AACCAAGACCCGCAGAGCCTGTGGCTTCCCGCTCTTTGGCGGTGCAGCAGGCATGGTGCTGGAGCCCAAG GCTTCTGGGAAAGAGTCCAGGTTTTCGCGGAGGGAGCGACGGACTCACGCGGGATCGCAGGCACTGCTG CAAGACGCCGAACAGGCTGAGCCGGTAGGCGAAAGAAGTAGGGTCACAGAAGAAGCAAAGAAAACGAAA TAAATTCCGAATCCCGCG 50; ALL; chr10: 21828640-21829645; 10; C10orf114; PROMOTER CGTCCGGGAGCCTCCGCAACTCGCATTTCCCAGTCGCAACCCTGGGTCATTCCTGCCTCCGTCCCAGCTCC CGGACAATTCCCAAAGCCAAAGGCGTCGAGCGTGTTACTGGCTCCCACCAGCCCAATTAATAATCAGCTTA ACTCGTGGAGGCTTTGAGCCCCAGTGCTCCGTTCCCTGAAGCCTCCCAGTGCGGAGCCCGGCTCCTGCGA GGACATCCTTGGAGGGGGGCCGGGGCGCAGGGACGGATTTCCTGGGAAAAATGTCGCTGGCGTGTTGCA CCTAGAGGGCTGTGGGCAAGGAGGCACGCACCAATGTCCCAGTTCTGGGCTCTCAGATCGGGATTCCTCC AAAATCGCGACAGCCGCTCAGGTGCTGGGTGCTCACGTTGGCAGCACAAGCGCCAAATGCACGACCCCGC GCGCCGCGCGCGACCTCCACGCACACTTAGAGCCGAGGTGACAAGGGAAGGCGGCGGGGGTGGAGCCGC TCTCTGGTGGAGCATGATCAATCACTTTAAAGGGTTCAAAAGTTCAAGTTCCCCTTTGGAGGGGAGAGGTA ATGCTTCCCGCGGCCTGCTTCTCTCTGAGACCCGCGGGTTCCCGGCAGCCGCGCAACCACTGGGGATCTC GGCTGCCGCTTGCGGGAGCCCCTTCCGGGGAACACGCTCTCGGGCCGCGCAGCCGGGCGAGGTTGACGC AGCTGCTAGGGGGCAGTTTGGCTTCCCCGGGAGTACCGGAGTCGCTCGGCAAAAACGTGATCTCAGCCTG CAGGGCCCGGGGCGCGCGCTTTTCCCTTTCTCAGCAACGGGAAAGGCCTGTTGGCAGAGGCCGGCGGAG TGCTGGCGGCCTGGCGGCTGGAGGCTTCGGCGGAAACCTGAGCTCCCTGCGACCTGTTCTGCTAGCAGGG GCGGGGGAGAGCCCCAATAAGCCGCCCCAGAGGCGACCGTGCAAATTCCTAAGAAAAAGCCCTCTAGAAA ACACCAAGCCCTTCCAAAAG 54; ALL; chr10: 22804715-22807056; 10; chr10: 022806090-022806137; Unknown CGTCGGCGCTAAGCAGCTCTGGAAACGGGCAGACCCAGCTGTGCAGCGATGTCCAGTGTCGCCGCATCTG CCCCGCGGGGTGCAGCATGAGTCTTCCTTTGTGGCGTGCGGCTCCATCGGAACGCGCTTGCGACGACAAA TTCCTTTTTTCCCCCCCGCAGTTAACAGTTCTGGGGCAGAGGCTGGTGGAGAGGTCCAGAGCCCACTCAG ACCGAGATGAAGATGAGGAAAAGCATGAGCAGGAAGAGGCTGGCGGCTGCGGCGCCACAGGGAAGAGCT CGGTGCGCGGCGCAGCCTCCCGCGACCGCGACTCCTGGGCTGCGTCGAGGAGCCGCGTTGCCATAGGAA CCGTAGCGGCGCCCCAGTGAAACCCTGCGTTCGGACAGGAGAAGCTAACCGGGCCGCCCACTCCCACCCG CGCTTCCTCCCCGCCCCCACCGGCCGTGCGCGAAAAGCAGAGATCCGAGAACCGCGTGCGGTACAAACGG CAAAAGCTTCGCGCGCATTTTCCGGGAGTTGAGCGCGCGGCCGCAGGCGGGAACCTACCGCTCTCAGGCT CCCAGCCCGGGCGCTACGACCCTGTGGGCGCCGCCTGTGCAGCCCCTCCTTCCAGCCCGCTCGGGCGCAT CCCCCAGGCCGGGCCAGCGACGCGGGCACCGGGAGCCCCTCCCCCGGTCCGGGCTTTGGCCCACACCCG GGGACCGCGGAGTGGGAAAGGAACCAAAGCGCGGCGCCTGGCCGACCGCGGACGAAATTCGAGGCCGGA GGGCGTTTTCTTTTTTGCAAAATTGCCCCAAAGCCAGGGCCCATGTACCTACTGTCTCCTTTGCCCCACAT GCTCCAAGAAAATAAGACACATTCTACCCCGAGTCCTAATTATTGGGCCATTTCCTTAACGCGCGGTCTGT CCCCGTGGGCAGAAACATACTGCGAGATGCAGTTTGGTAATTAACAAAGAGACGAGACCTAACTGGGCTT CCGAAATGCTGGATACTGCGGCCGGGTCGCCCCGCATTCGGGCATCGCGCGGTTCCCGGCCTTCGGGACG TTCCGGCCCGGCCGGACTTTGACCGCTGGCGAATTAGGAGAAACGCAGAAGGCGGACGCTCCCCAATTTC CCCATCGAGCCTTCTCCTCCCGAGTCTGCGAAGCCCCTGGCTCAGGAGACACCGGCTCCGCGCCTGGGCC TGCAAATCCGCTTCCAGCGAGCGCAGGCCTGTCGCTCC 87; ALL; chr12: 94776044-94776377; 12; SNRPF; PROMOTER GTTACTTCCCAAAGGGCGTGTTCTCCAAGAACTGCATTTAGCATTTCAGATCAGAGTGACCCGAACTCAAT AGGATTACGACAAAAACTAGTGAGATTCAGATAACACCGTTACATCGAAAGTTTTATCCGTGACAGAGGAA ATATTGCTTACGCCCTTAGGTAATTTCAAATGCACGTATGAAGGCCGTGCGGGTTTCTGCAGGCGAAGCAA AAGAAAGGTGGGGCCGGCAGGGTCGTGGGGCGGGGGTGGGGCATGACACCTATCCCAGACGCAACTCGA CCTCGTTTGCAAGAAATTCTGTATCCAACTCTCTTCAGTGCGTTTCGCCG 94; ALL; chr12: 113657930-113659205; 12; chr12: 113657930-113657987; Unknown GTTCAGTGGTTTATAGAAAATTTCTTTCTCTCTCTCAGGTCCACTAAGACCGAGAGAGAGAGAGAAGTCGA CTCTGGCACACCCGGGCGAGGGGCTGCCGGGATTCGGGAGCTGGCGCGGTTGATTTTTCCGAGAATCCTC CACTTGGGGTGACGTCGGGCAGCGCGCGCGGGCCGTGAGGTTAATGCCCAGGCTTTTCTCTAAAGCGTCC GGGAATGATCCGGCGAATAAAACGGGTGTCTGCAAAGTTAATGAATTGTACAGGAGGCTGAGGGTGGGGA CTTCGACCCGGGGAGCCAGAGGCGGTTCTGGTGGACGCTTCCCCGTGCGCCTAGGGGTGCGCTGGGCTTT CCCAGCCGAGGTCTGCAGAGCGCACCGCGTGAGCTTCATCGATCTCATCTTCTTCCAAGTGGGAGGAGGT GGAGATGCTGGGAGAGTTGTGGGGAGTTGGGAGTGGGTTGGAGGGGGACTGTCTAGATTCTACTCTGGA GGATCCAATCACGTGGTGCTGTTCCCCTGCCTAGAACTTCAAGGTTTCCAACGGTTTGAATAAAACCCAAA CGATGCCCGATGTCCAACGAACGAATGATCTAGCCTCGGCCTACTTCTCAGGACTTAGCTTTGTCCCTGCC CGCGACTTCCCGCTGGGAACGTCGTCCCCGCCACCACCGCTCTGCTTAGGTTCGAACTCTGGGCCACTCTT CCTACTCCCTCTGGTTTCCAGCAGGAGAAGCGCTTCGGAGGAGGGGGCTAGGGGCGCTCAACCTCCCGGG TTAGAGGAAATGCAAGTTGGGCCAATTTCGCCCTCCAGACTCCGAGGCGGATAGGCCCAGGGGGCAGCGG CCTTGCCCGGCGGCCACTGCCCTCCTCCTCCCCCGCGCCCCCTGGCTAGGCTTTGAAGAGCTCATTTTAAG AACTTTTCCATTTTCCTTTTGGAGGCGTGTTGTTCTTCTCAGTCACCTCGCTTTTTTTTTTTTTATGAGCTTC AGCGCTGATCTGCACGTTCTTCCCTCCGTGTAATTTCAATTTGAACTCTCCCCAGAGCGGCCTTTTCCCTCT TGTTGCCTGCCAAGTCGTTTAAGGCTAAGCAAACATTCTTCCTCCCTCCCGTCCGCGCGAGTCTCGGTCTA CACCCGCGAGGGGAGGCGGAGGCGGTTACTCCGAGAGTTCCGGTGGGTTGGAGCCTTTCAGCAGCCGCC TTCAGACTGTTTGGGAGCCGAAAAGCG 99; ALL; chr13: 34950488-34951119; 13; MAB21L1; PROMOTER CTTTGCCGTCATCGCGGGTGAATGCACCACTACCTTTTGGCAGTTGGAGGGGAGACCCATCAGAGCCGGA GAACCTGCAGCCACGACGGCGAGGATGTGCAGTGGTCTCTGGGGAAACGCCGCCTTCGCCCTCACCCGGC GCGTGTGGCCCTGTGCCGTCCGCTCGCCGCCTCTCTCTCGCTGCTCCGCATTCCCGTGCCCTCTTACTTTC CTCTCTGGGCTCAAGATCGCTACGCTTTATTTCTGCGTGAGCTTATTTGAAACCTTACTTGGTGTCCCGGC TTACTCTCCACGTCTGCTCCAGACCACGGTCTGCCCACGCACCCCTCAGCCTGCACCGCCCACGTCCGGCC CAGGTGTGGTCGCAGCCAAGCCCCAGCCGCGGGCCCCTGCGCCCTGGCTCTCTCCCTTGGGTTCAGGCCA GAGATGCTTGCCCCAAGACCTCGCCCCTTGCCTTCTTGGGCCACCTGCAGAACACCCTTGGTTGTCAAGGA CGTGAGACAGCCGAGGACGGGGAGGCCCCAGGGCTGTTCGGGGACCTTAAGTGGGTCCAACGGGAAGGA CGCGGGCCTGCGAGGGATGCCGGTCGGGCCTGGCTGGAGCCAGGCGCGCAGGTGGCGCATCTTCG 102; ALL; chr13: 49595986-49600287; 13; chr13: 049599159-049599206; Unknown CGGGCGGACGAATGGACGGATTCGAGCGAAGCTTATTTCCCTTCTCCTAACGCATCTACCTATAAATAGCG CTCACCGCGCTGAGTCACCAAAACCCCGAGTTTCCCCAAATAGCGCGTAACGACTGTGGGATCGCGTCCC TCGGGGCTCTGTGACAGACTCCAACCACACACCCGCTGGGCTGGACTGCGGGCCCACACGGCCCAGCGG GTCTCTCACCACCCGGCGCCCCAGGGACGCGGGCGAGGCCGCGGTGTCCGGACGAGTCGACAGCGTCGG ACTTCCCGCGCGCGGACGGCGCTCTGGGGAAGGAGGAGCCGGCGGGCGGCTGGACCTGGCCTTGACTGC GCGGGGTCCGCCCCCGCCCCCTCGGGAGCGCAGAGTTGCGGGGGGCCGGCACAGCCTCCGCCCTGCGCC GCCCGCTCACACAATGGGACGCGTCGGGAGGGGGCGGCCGCGGCTCCCATTCCGGTCCCAGGGCGGGGA CTCCGGGCGGCGGGAGAAGCAGTCGGGCTGGGGCCAGAAGGAAAACCCCCTCTCCCTCTGCCCACTCAAA CTGCGAAAGGGCTCCAGCCGGCGGTGCCAGGGGCTGGGGAGCAGCTGGGGAGGGAGCGGAAGTGCCACC CCCTGCAGTCAAGGGTGGTGACGTCACCCCTGCAGCCAGCCTGTAGGGGGGTGTCTGTACATCACATGAC CCGGCCCCCCTCTCCCCGCCGAAGCCCGCGCGCGCGCTCTCTCCCCCAGCCCCGACTCCCACCTCTCCCC CGCCCCCTCTCCCCAACTTTCGCCCTCCCCGCTCCGGCACCGTGTCAACAGCGCCAGCTCCGCCCCCTCCC CGCGCCCTGTGGAACCGCCACGGCGGCGCGGCGGGCGCTCGCGCTCAGGTCCGAGGCTCCGAGAAGCGA GCGTGCCCCGGTTCCACCCTGCCCCCCAGCTCAGTGCTGCTGGCTGCGTGGGCACCAGAGCCAGGGGGCA CGGCGGCGTGCAGCGACAGCGCTTCTCTGCTCCATCCTCCCACAGCAGTTAGAGGACGAAGCTGAGGCGC CGGGTCCGAGCTCGGAGGGAGCGAGGCGCATGCACGGCCTCCGGGCCCTGACGCGTAGCCTCCGGGGGT CGGCCCACGGGCGAGAGAAGCAGCCGGGAGCCCCTCCTCGACCCCAGCAAGGCGGCCCGCGCCTCCGCT CTCCCTACCGCCCGGGTGGCGCACGCCAGTCCCCGTCTTTGGC 103; ALL; chr13: 94152191-94153185; 13; SOX21; DOWNSTREAM CGGAAGCCTCATCCCGCCAAGCCTTCGCCTCCTCGCTGAGACTCTGAGCTGCGCTGGGGTTGGCGGGCAC CCGATTCCGCCCCGGCCCAGACCGGTCACTCAGTGTGTGCATATGAGAGCGGAGAGAAGCGACCTGGAGG CCATGGGTGGGGGCGGGTGGTGAAGCTGCCGAAGCCTACACATACACTTAGCTTTGACACTTCTCGTAGG TTCCAAAGACGAAGACACGGTGGCTTCAGGGAGACAAGTCGCAAGGGCGACTTTCCAAGCGGGAGATGGT GAAGTCTTTGGACGTGTAGTGGGTAGGTGATGATCCCCGCAGCCGCCTGTAGGCCCGCAGACTTCAGAAA ACAAGGGCCTTCTGTGAGCGCTGTGTCCTCCCCGGAATCCGCGGCTTAAACATTCTTTCCAGCTGCGGGG CCAGGATCTCCACCCCGCGCATCCGTGGACACACTTAGGGTCGCCTTTGTTTTGCGCAGTGATTCAAGTTG GGTAACCCTTGCTCAACACTTGGGAAATGGGGAGAATCTCCCCCCCCGCAACCTCCCGCACCCCAGGTTC CCAAAATCTGAATCTGTATCCTAGAGTGGAGGCAGCGTCTAGAAAGCAAAGAAACGGTGTCCAAAGACCC CGGAGAGTTGAGTGAGCGCAGATCCGTGACGCCTGCGGTAGCTAGGGCATCCAGGCTAGGGTGTGTGTGT GCGGGTCGGGGGGCGCACAGAGACCGCGCTGGTTTAGGTGGACCCGCAGTCCCGCCCGCATCTGGAACG AGCTGCTTCGCAGTTCCGGCTCCCGGCGCCCCAGAGAGTTCGGGGAGCGGTGAGCCTAGCCGCCGCGCG CTCATGTTTATTCACGCGGCCTTGAGCAGCCGAGCTCCAATCCATATTAATCAACCGCTCGACCTACACAA GTCTAAGTTTACGGGAGAAAACCTAGTCCCCGAAAGGAAGAACAGCAATCCGGACAAGCAGTTGGCGCCT TTGTCCCG 107; ALL; chr13: 113930978-113931584; 13; chr13: 113931540-113931584; Unknown CGACCCAGCCCCCGAGGAGAACCCAGAACCGACCCAGCCCCCGAGGAGAACCCAGAACCGACCCAGCCC CCGAGGAGATCCCAGAACCGACCCAGCCCCCGAGGAGAACCCAGAACCGACCCAGCCCCGAGGAGATCC CAGAACCGACCCAGCCCCCAATGAGATCCCACAACCGACCCAGCCCCCGAGGAGATCCCAGAACCGACCC AGCCCCCGAGGAGACCCCAGAACCGACCCAGCCCCCGAGGAGACCCCAGAACCGACCAGCCCCCGAGGA GATCCCAGAACCGACCCAGCCCCCGAGGAGATCCCACAACCGACCCAGCCCCCGAGGAGACCCCAGAACC GACCCAGCCCCCGAGGAGATCCCAGAACCGACCCAGCCCCCGAGGAGATCCCCAACCGACCCAGCCCCCG AGGAGATCCCACAACCGACCCAGCCCCCGAGGAGACCCCAGAACCGACCCAGCCCCCGAGGAGATCCCAC AACCGACCCAGCCCCCGAGGAGACCCCAGAACCGACCCAGCCCCCGAGAGATCCCACAACCGACCCAGCC CCCACGGAGAACCCAGAACCGACCCAGCACCTGGGCAACATTCTGC 111; ALL; chr14: 36205192-36206099; 14; PAX9; INSIDE TCAGAGAATTTGGAAAGGCCTACTCTGAGGGGAGTAAAACTTCACCAGGCCCTGGGCTGGAAGCACAGGA GGTCGCGGCTGGGCCCAGCGCCCTCGGGAGGCCAAGGGCAGGGAGCCGACCCAAGGTTAAGCCCTCCAG CTCTCCGTCGCGGGTTTGGGTCCCGTCTCAAGAGTGGGGCGCGCGGGCTGGGCCTCCGGCCTGACACCCT CTCTTCTCTCCATCAGTGAGCGACAGCTCCCCCTACCACAGCCCCAAGGTGGAGAGTGGAGCAGCCTGGG CCGCAACAACTTCCCCGCCGCCGCCCCGCACGCGGTGAACGGGTTGGAGAAGGGAGCCCTGGAGCAGGA AGCCAAGTACGGTCAGGTGAGGAGGCGAGGGTCAGGCCAGGTGGGCCGCGTGCGGCGGGGATTTAGGCG ATGGAACACTTTGTGATGGGTCCCTTTCTGAGCTTCCCGCGAGAGAAGCCCAGGCTGGCGTCCCTTTGCT GCTACGAGCCAGATCCTTCGTGGACTGGGGCGAAGCAGAGGCCTGAGCTTGGAAGGCGGAGCTGGGGCC TCGACCCCCGCCAGGGGCCGGGAGCGCTCGTCAGGGCGCTGGGGGTCTGGGGCGGCAGCTCCCCGGGGC GAGGCTCTGGGAAGCGCCTCCAGGCCTGTCGGCCTCCGGGAGCTTGGGAGGCGGCTCCCGAAGCCCTTTC GGCGGCTCTCGTTGGGGGTAGAGTTAACCAAAGAAGGCGCTTCTGAAGGGCCGAGCGGAGCAGCCCTGG GGCCTCAGAGCCGCGCCTTCACGCCCGCGAAACGCGCGCCCCGGTCTCGGCCCCACGGTGCGACTGCGG CTGCGGGGTCCTCACGTTCGGACTTTCTCTCCGGTGGCTCTCGGACAAACACGCTTGGCCAATCCTGCG 130; ALL; chr15: 94688798-94689131; 15; NR2F2; DOWNSTREAM CGCTACGAATGTAAGATGAATTTAGTGGCGCGGCTGCCTCCCTGAATCCGAACGGTAATGATGGATTTATC AACGGGGATTCGCCTTCAGCCCAGCGAGGGAGGTTTACTCAGCAAATATGTCGGCGGCACCCACCCAAAT GCAATCATTTGACCCCCTGCGGACGATAGCTGCCGTGCCCCTTCCCACCGCTGGTCCTGCTTGGCCAGGG TCGCTGGGGGCCAGAGGCCGGCCCGGATGACCAGAGAGGTGGCCTCACGGATCCTTGGCCTCTCGCCCC CTCCTCTGTTTCCTCCTCTCAGCTTGAGGCTCTCCTGGCAAGGGGGATCGAT 133; ALL; chr15: 94696311-94696840; 15; chr15: 094696796-094696840; Unknown CGGGGGGGTGGGGCGTGGAGGGCGGCCTGAGTGCCGCGCCTGGCCCCTGCCCTGGGTGCGCACCAGGCC GCGAAAGCCGGGGGCCGCCTTCTCGGCTGCTGAAGCCCGGGAGTCAGTCAAGCGCCCTTGGCACCGCGA GGGAGGCGCACCTCGCCTGGTGCAGAGTTGCCGCGACCCGAGCGGGAGGAGGCACAGGACGCAGGGCTC CTGGCCTGGCTGTGGGCTTGGCCTTGGCGCACTAAGCGCTCCCCATCTGCCCGAGCTGGCCTCCGCGGCC CTCTCGGCCCAGTCTACGTTCGTTTAAGGACTTCAGCGCGAAGAAGAGCGAACGTGGCTAGAACCTGTTG ACCTCTCCTCTGGCCTGGAAGTCCGCACAGCTCGTGGCAACACTGGACGGACGGTTGTCAGGGGACGACC GCGGGCAGGTGGGGAGGAGGCCTTGGTCTGGCTCCTGGATTCCACCCTGGGACGGAAGGGGAAGCGGAA ACCTTGACCTCAGCCACACAAGGACACCTATCTGGCTGTCT 134; ALL; chr15: 94705727-94706054; 15; chr15: 094705808-094705853; Unknown CGCCTGCTGCCTGCCGTGGGGCCGCTCCGAGGTGCCAGGAACTCCGGTAAGGGTCCCGGCGGCGGCAGC CCGGGAGTGGGCAAAGAGGGAACATGCGTGTATTTCAAAGAAACCAGCGCGGTCTCTGACTTCCCTGTCT TCGCTCTCCACCCCCGCTCCCCCTCAACACACACATAATATAACAGACGCGAAGATAATCCTGCCATCTGG CAAATCCCAAATTTGGTGACCAAGCTCGGAAAGCAACAGCGACGGCTCATCCCGGAGTAGGTGGCTGGTC CTGCCGGACTCTCCGGAGCTGGGGCAAGGGCCGTGGGCTCTGCCCG 136; ALL; chr15: 94712480-94712812; 15; chr15: 094712480-094712531; Unknown TAGGACCTGAAATTGCAGAGACATAGAAAATCAATACGTGGTCGGGAGTCAACTGCGCGCGACCAAGGGC TCTGCCCTCCCTCTCTCCGTTGATTTGGACGCTGGGAAGCTGCCCGCCGTCCTTCCCACCCCCTTTGCCCA GCCTTGGCAAGACCTCTCCGGAAACATACTCGCGTTAAGGAACTGGGAAAGCTTCCTGGCCCGGAGCTAG GAGCCCGACGTTGGGGCTCCTTGCTGAGTGAGACGCTCAGTCCTGTGCTCCCGCCCCGCCCCAGGCGCCC AGTCCCGCTGGGATCCATCTCCTCAGCCCCGGTTTCCCGCTCTGCGAGCG 145; ALL; chr16: 52873104-52882105; 16; IRX3; PROMOTER CGCGAGGATGGGCGGGCTCCACGTCTGGGGGCGCTGTGAGCAGGGCCAGAGCGAAACCTCAGTCTGAGT TTACGAACTGGGAAGGAGCCTGAACCCCAGAAACACCGTTAACAAAGAGGGCGAACGCAGGGAGCCGAG GAGACGTCTCCTTGGCCTCTGGGGAAGGGGCTGGAGGAGCGAGCCAGCTGAGAAGCGGCTTTGCCGGGT GTCCACTAGCGGTTCGCCAGCCCTCTGTGCGCCCGCAGAGTGACGCAGAGGCCGACCAGTCCCCTCCCCA CTCGCCCCTGGGGCGCCGCCGCACCTTGATCACCCCCTTCGCGGAGGGAACTCCCAAGGCGCGGCGCTGG CCGCTGGGTCCGCATGGCCCAGTCCTGTCGGGCTCCGCTCTGCTGCCGCCGACTTCGAAGGTGTGCAGTG TTGAGCCGTGTCTTGTTCCGTGGCTTCGAGGGGTGTGCGCGCTTCCTATACCTCCCCGGAACGCGCGAGA TAGTCACACGCGCCACTTTGAGGGTCAAACACCCCGCATCTGGCCACATGTACCTTTACTAACGTGGGGA GGGGGCAAAAAAATGTGTCTCTCCTTCTTACCCCGAGGTGTCACTCGCCCAAACACTCCCTACAACTTCTT CAAGTCAAACTTGGGCAAGGTTGGCTGGCTGACTGCGAGAGGAAAAGAGGGCGCGGAGGGGGCGCGGCG CGCGGCCGGGTGTAGAGGCCACGGAGGCGAGGCGCCGAGCGTCCCCTTTGTCCTGTAGAGGGAGCTCCA GCCCCAAATTTCCCTGCTGCCTCCCCCGGCCCGCCCACCCCGGCCCGCCTGGAGCCGGAATCCCGGCTGG AAAGGTGCGGCGGTCTGACACCCCCGCAACCCCCGCGCCGGGGCCTTAGCAGGATGCCTCTTCTAGGGCA CGTGGGAAAACCCACCAGGGTGCCAAGACGCACAGATCTCCCAGGACCCGGGCTCCCCAACTCTCAACTA GAGCTGGGCAGTCACACATCATCTAGAGGATTATGTACCCCTAGGCGACCCTCTTCTCCATATCCGCCTCC ACCGTCACCCCACACCCTGGCATCTATAAAGAGGAAGGGGGGCAACCGGGTTGGAAGGAGGATGGAATCT GGGCTTGCACAGCCTCTTATAGGTAACAGTGAGAAAGCCTCAACTGTGTCGATCAAAGAATGGGGACGAA GGGAGTGATGAGAACACGACCCCGCCACCGCGCAGGCTA 153; ALL; chr16: 86294154-86294408; 16; KLHDC4; DOWNSTREAM CGTGTGACACTTTGGAACGCTTCTCTCGTTACAAACCAGCGTCTTTACTGAAGGTCCTTCCGCTGCAGAGC TGCGCAATGGATGTGTGGACAGAGCTAGTCGGCACGTGGAGGCTCTCCTGGTTTTCAGCAGGAAACGTGC TGTGAGCAGGAATCGCGAGTGAGTTCCATGGCGTCCCCGGGTCAGCGCGCGTGCAGGAATCGCGAGTGA GTTCCATGGCGTCCCCGGGTCAGCGCGCGTGGGGTCCTGTCTCG 155; ALL; chr16: 87372445-87372729; 16; chr16: 087372616-087372660; Unknown CGGCGGGGAATCGGGTGGCCACGCACGTCGGCCTAAGGGGCCCTGGCAGCGCCCGGCAGGACAGCCGTC CACTGCACACCTCAGAGCCGGCACCCGGGACGGTCAGCGTCCCCATGGGCCCGGCACCGCAGCTGCCCA GATCCTCACCCGCACACAGGAAGGGTCCCTGCAACCCAGCGTCCACCGTGGAGAAACATGAACGTGAGCA AAAATACGGCCTGCGGTGGGTGTGCGACCCCACACAGAAGGGCGAGAGGCTCGTGGCCATCCCACACACT GGGAG 165; ALL; chr17: 44074280-44075233; 17; hsa-mir-196a-1; PROMOTER TTTCGCTAGATCATTTGTTAATTGTGGGAAGGAAGGACGCATCCGGGGAGAGGAGATCCAGGGCTGGAAA AGTGGGTGAGCGGCGCTGGCGCAGGCGGCCAGGAGAGAGCAGATGAACCGTTCGTTAGAGCAGCGAGGT AGTCGTGAGCGCTGAGATCCAGAGACTAGGACCCACTCCCTCTCTGAGCAGCAAATTGGGAAGAAGATGC TCACTCGGTAAGGGCGAGGGAGCCCGGCATGGCGCCCCACCACGGGCTCGGTCTTCTGCGCGCCAAGATC CCGCTTGGGGCGAGGCGTTGGGTCAGCGTTTAGAGCCACTCCCTGCGCTGGTGGCTGGACATAGCCTCCC TATCCCACCTCATCTTCCCCCATCCCCGACAGAGGAGGTTGTGAATCTACGGCCCTTGACGTTGAGGCGTC GGAGGGCGCACCTTTGTAATTGCGGCCTCCCTTCGCCCCTTAAGTGCCGCTTCTGGGCGCCTAGGCTGGA TATGAAAGCCCCGTTCCTAATCCTCTGCTCTGGTCCCCTCCTCTGACTGCTGGGACTCTAAGCTAGGCCCT CCCCAGGTTCCATCACTGCGGCGCCAACCCGCGGCTGGGCTGTCCGCAAGAGGGAGTTGAAGGCGCGCG GAATCCCGAGGTGCAGCTGACCCTCCTCTCAACGCCGACTCGCCGCTCCCGCCCGGCCACCTCCCTGTCG GGCAGACTTCCTGTTCTCCTGCTCACAGCAGGGAGGCAGTCGCCGAGCCGGTCAGCAGCGTGCACGGAGA TCTTCACTCTGCGCCCAGCCCCGGGACACAGGTGCAGTCTCCAGCGGAGCACTGCGGAGTGCGCGCCGTC GAGCACTAGGGAATCCTAGACGGAGGACTTGGTCCATTCCACGCAGTCCCAGGCAGGTCCGCAGCGGAGG GACGCAGCGGTCTCCAACTCCTGGTCACGACTTGGCG 172; ALL; chr17: 58865328-58865618; 17; CYB561; INSIDE AGAGGAGGCGGAGACCTGACCCCAGAAAGCAGCACTCAAACAGATGCAGCTGCACCCACGCGCCCGCCT GCTGCCAGAGCCACTCTCCGGAGCCTGCAGTCCTGAAGACGCCTCAGCAGGGGCAGGCAGAAGACACCCC GCGAACCCCCAGGGCCGGCCGGGCGCATCACTGGGAGCCGGGGCTATCTCCCTCCGTCAGCGTCTTGAAG TCCATGGAGAGGGCCTGCTCTTCCGCCTGGGAAGGCCGCTTCCAGTCGGCCCGGTCAAGATGTAGAGCAC CGCCCCACCG 176; ALL; chr17: 73932992-73933361; 17; DNAH17; INSIDE CTTCTGCAGACAGACAAGAGCCCTCCTTACCTTCCATGAAGAGTCCGTACACGTAGGAGCCCTCTCGCGG AGGAGCGGTCATGTCCTCTCGGTTTTTCTTGGTCACCTCGACAGACAGACACATCTTTCCAGGGGCCACTC GTTCTTCCTGGCCATGGACTGCATGATGGCCGTGAGGAACGACTGGGGGTTGAAGAAGCCGGCCAGCCAC ACGGTGGTGGGCAGGGCAAAGTCTGTCGTCCAGGCCTCGAGTTCCTGCAAGGCACACGAGCCGCTAGGA GGAGAGGACATAGAATGACATGGGAACGACCGGGCCTTGGCCGTTCTGAGCAGGGGTCACGCCAGAACC TTCCACGGGCCACTCAGCG 181; ALL; chr17: 75531280-75531546; 17; TBC1D16; INSIDE CGCCTCACGGGGCCTGCCAGCAACGCGCTGTGTGCAGCAGGAAGCCCACGCCAGGTCCTGACGGCTGCAT CCTGTGTGCTCTCCGGCCTGGCCGCCTCAAGACACGCCACCTTTGATGCACACGCGCTCCGGAGGCACAG GAAGGACGGGGGCACTGGGAAGTCCATGTTTAGTCTCCTGACGTCGACCACACAAACCAGACGGAACGGT GTCCCCGGCCCAGGCTGAGCGGAGCACACCATGAGGGCAGAGGCTACAGGTGATC 183; ALL; chr18: 5186244-5187389; 18; chr18: 005186349-005186393; Unknown CGTCGGACGTTCACAACGACCACGCTTTTCCCCGCTTCCTCGATTAGCCTGGCCTCCCTTGCTCCAGTGGG GCGGACTCAAATGCGCACGCACGCACACGCCGCCAAGCCGGTCAACCGCAGACAAACTGACTCTTCGCCA ACTAGTAGCCACGGAGAGCAGCAAAGGGACCAAGGTCCTTCACCGCCTGCTCCAAAAAGACACGGCAACC TCCAGCGGCGCCGCAGTAGCTGCCTCTGTGCTGCAGCCTCCGGTCGGAGTTTAGGTCTAATTCCTTAAGA AGTATCGCTCCTCTGCCCTTCGTCCTACTCCCCTTGGCTTCGCCCACTTCGCCTCCTTCTCCTCGGGAGGC CAGGAGGACCCGGGTCACTTTGCCAATTCTGCGGAGGGGGAAGTAGCGTGAGGGAGATTCCCACGCAAGT AGCCCGAAGCCCACTACTCTTTGCCCCACCTCTCCACTCTCTTGCCCGTGTAGGTGCCGGTGCTGCTGGCG AAAGTCCCAGTTCTTAAGGCTCCTGAGCTCGGAAGGGGTGTGAGGAGCCAGATGGGAAGAGAAGCAGCG GGACGAGGGCGAGGAAGGGCTGGAGATTGTTAGAGGACAGATGGGGCGGGACTGGGGAGAGGGGCGAA GGCGACGCGCCGAGGCACTCCTCCGCCCCATGAGCACAGACGTAACTCCGAAACGCGCAGATGGGCCGTA AGGTAAAGAGGCCTTTTTTCCCTCTCCTCTCCGTCCTCTACCCTGCTCCCCTCCTAGACACTTGGTGAAAA AGCAAGGTGCGGTGTACCTGGAGCGAACACCATGATTCTTCCAGCCGCTACGCCCCCAGATTAAGAGAGA AAGACAGGCAGACGGAGGATGGGAAGAAGGCCGGACTTGGCGGGGTCCGGTGCAGGAGGGCGCGCTGG GCGGGCGGCGGGCGGGGCGGTCAGCACCCCGGACGCTCCCGCCGCTAGATCCTGGGGCCGCAGCTCCAG CCGCCGCCGCGCGCTCTGCCTCCACAATGCGGCCACAGCGGCGGCGGGAGGAGGAGGGTGAATCCCCGC TCAGTCCATCCCTCATTCCTGTGCCAGCTCGGGACGTACACTGCTGCTTAGGGAGCAAAGCACTTCCACCG CTTTCACGCGACGAAGGTCG 193; ALL; chr19: 4059891-4060207; 19; MAP2K2; INSIDE GACCACAAAGCGCTTCCTCATCCTTTCCTCGCCCTTTGATGCCGCCGGCAACGTGACTCTGCGAGCAGCG GGGCAGACGCCAGGTCTCCCTCGCAGGCGGGAAAGGGGCTCCAAGGCGGGTGCTGCCTGCTCGGGTCAC ATGGCTACGTGGGGGCCTTGCTCAAATTCACTTCCTGCCTTCATTACAAAACTGTCAAAGGGGATCGCACG TTTGCAGGGTGTCACCCAAGCATTCTGGTTTTGCAAACGACGCTGTGCGGCAGCGGTCTGATACCTGATG AGCTCGGTGTGGCGGGGTCGGCAGCATTTCCTCCG 209; ALL; chr19: 63784504-63785085; 19; MGC2752; INSIDE CGGTGTCTGGAGGAAGCGGCGCGGACAGTCTCCCGCTCCACCGTGTCGGGCCTGAAGAGGCCGCTGAAC GCTCGCGATTACTGAGGCATCTGGTAGGATCGCAAGGCCATCAACCTACAGGTGAAGCCGAGGCGCTGTG GCGCTTTGAAGCCGGAGAGAAGCTCAGTAGAATCGGGAAGGCGCTGGGGCTGTCCAACTCCACCTTGGCC ACCATTCGTGACAACAAGGAAAAGATCTGGGCGAGTTCCCAGGAGGCCACACTGAGGCGGCCACCAAGTT GACGCGTGGCCGCAGCCTGGTGATGGAGAACATGGAGCAGCTGCTGAGCATGCGGATGGAGGACCAGAG CCAGCGCAACATGCCCCTCAGTGTGGTGCTCATTCGGGAGAAAGCCCACAGCCGTTCGAGAACCGCAAGC AGGAGCAGGGCGAGGGCGCCTAGCCCGAGAGCTTCGGGGCCGGTCGAGGGTGATTCGCTGGCTTTAAGG CGCGCCACAGCTTGAGCAGCATCGGGGCCAGCGGCCCAAGAACGCAGCTGCAAGAATCCAGCGTTAATGC GCAGGGTGATCCCGGAGGGCG 210; ALL; chr2: 19424445-19425131; 2; OSR1; PROMOTER CGGCCGTTCGGTGCTGCGGTATCCCATCCCCCGCCTGTTTAAGAGAAATTGATCACGTTAAGCGGGCCCT GCGTCGCTGCGCAGTGCCCGGACTACCGCTTGGATGGATTGACAAGGGAAGGACGCAGACACCTAAGAGC AACAAGGGTACTTTTTAAGCGAGGTTACATGTGTTTAGGACTCGCGAGGACGTCACGTTTCGAATTTGGTA AAAGTCCTCGGTAGCTAGGACCCAACAGTTCTGCCCTCCTGGAAACCCAATGAGGTGACAAAACTCCCATC TCATTACTGGGAGTCCAGCGCACTCCGCCACCGCGGCTGCAGCTTCTGCTAGCTCGGAGCCTGCGGACTC CAGCCGGCGCGAACTCCGCCGCGACTCTTTCTGGCTCTCTCGCTCACGCCTTCGGGGCGGAACCGCGGGC GCCGGAGTGGTCCCAGACTCGGCTGGGACCGGGCAGCCTAGAAGAAGGGTCCCCTCAGTAGAGACCAGG CCTCCAGCTCTCCGTCCGGCGCTCCGCTCCACAACCCGCCAGTCATGTGAGGTCCGTCAAGGGAGCGATC CCTCCGTCTGCCCGGGCTTCCGGGCTGTGGACCGCACTGAACCCAGTCCCGCAGCAAGCCCTGCTGCCGC CTTTTCCTGGGCACGCCTGCGGTGGTGACGGCCCGCTGCTATGTCTCCACG 212; ALL; chr2: 43251514-43251780; 2; chr2: 043251514-043251559; Unknown AAACACAGTGCCGCAGTGAAAGTGGGACAAACGCGCCTGTGTGCATCCTGGCCGAGGTGCCGGAGGAAG CGTGGTCGGGGCAGAAGTGTTAATGGGCCTCCTTCCTGCCGTGCCCTGCCCGTGCCAGTCCTCGGTGCTC ATCCCGGCTCCCTGAAATGCTCGCTTCCACTCAGGGCCAGCGCACTCCCTCCACGTCCCTGGCCGCAGAT CTGTCCTGCTTTGACAAATAACCCGCTCAGCCTTCGGGTTTATGGTTTTTCCGTCG 214; ALL; chr2: 45249374-45251726; 2; chr2: 045251412-045251456; Unknown CGCTCCCTTTCCCGCACACGCATTGCTGCCTCCTCTCGGGCTTGGTTAATGAGTCTGTGCGCCAAGCCAGG TCGCTCCGGGCAGTTCGCGCTTCCGCGCCTCGGCACTCGGATGACCGTGTCCTATTGTCTCTCTCGTGAAT GTCGCTGAAAAAAAATAAAAGTTTGTTCTAAGCCCGTGGCATTTCCGCGCGCAGATGGAAAGGCAAGTGG GAGAGGAGGGTGCAGGTGCGGGGCGGGCGCGGCGGCCCCTTCAGGCGCCGGGGCTGGGCTGCCCCCGG CCGGGAGCAGCTCCGCTCCGCGCACGTGGCTGTGGGCGCTGCGGACGGGGGACGGCAGGCGGGGGACG GCAGGCGGGGAGTGGAGGGTGCAGTGCCCGCAGGTGCCGACGGCTTCCTCCAGAGCCCTTCGCGCCGCG CCTTGCCTGGCTGGTGGCGCGGGGAAACCATGGCAGCATTGCGGCTCCGGCGGGCGGGCTCTGCGCGGG GCCCCACCGAGCTTTCCGGGAGCCTCTCCCGCAGCCGATGGGCATCTAGGGCGCAGAACGAAGAGTGGG CGCCGAAACGGGTGTAGGCGCTGGAGGCCGACGGGGAGGCCCGGGGCGGTCAGGCTTCTCGGTAGAGAG GGCCGTGCACCTCGCGGCCTGCGGGCTAAGGCGGGGAGCCGCTCCTGGGCGGCCGGGCGCGCGGACTGG AGGGAGGGAAGCGCCACGGACTGGGGAACCGGGGTGACGGGGAGACGGGGGGGCTGGTGGGGTGAGGT CGGCGGGCAGCAGCCAAGTGTTCTGCAGCTCCGAACCCCGCCACCCCTGGGCGAACGGAATGGCACCCG CGGAGACGGGCGGGGACGGGCGAAAGCGGGTTTGCTCCGACCCGAAGCTGAGCCCGGGTTGGAGGGCGA GACCGTAGGCGAGAATGGCCGCGCGGGCTGGGAGACCCGGGCCGTATGGAGTGAGTGGAGCCGCCCGAG GTAGGGTAGTTGGGGATGGTAGTTGTGAAGACAGTCGGAGTCTAGCTCCGGGCAGACGAAACACCGGGG CGCGCCAGGGTCCGTTTCCTCCTTCTCTCTGCTTTCCCACCACCCTGTAGATACGGAGCCAGCAGTCGGGC TAGAGCGGAGGCTGAGGGTCGCGGTTCCAAGGGCGGTCTCTCGCCCCGGGTCAGGCCCCACCCCGCGGT GGCGGTCGCGTGGCGCTGTCCTGGAGTTGAGCTGTCCCGCGCCGCGGCC 217; ALL; chr2: 63134470-63134933; 2; OTX1; INSIDE CTCGAATCTTGGAGACACTGGCTTCTAGTCGCACATCTGCACTTTCTCCCACCTGTGGCCTCTCAGGCTCG GCCGCCCGAGGGAGTTTCTTTTATTCCCAGTTCGGCTTTCTTTTGCGAAGGCCGAGTCTGGGCCTGCCAGG GGCCTGCCCGAGTCCTCTATCGCGGGTCCACGTGGCCACCAATGACCCGCGGCGCCCCCGCGTGTCCCCG CAGCCACTCCGCGGAAGCAGCGGCGGGAGCGCACCACCTTCACGCGTTCACGCTGGACGTGCTCGAGGC GCTCTTCGCCAAGACTCGCTACCCTGACATCTTCATGCGGGAGGAGGTGGCGCTCAAGATCAACCTGCCG GAGTCTAGAGTCCAGGTGCGCACTCCCCGGGCTCCAGGGTCTGGGTAGGGAGCTGAGGCTGCTCGGGGA AGGTCTAGGAAGGCTCTTGAGTAGTTCTTGAGGAGACCATC 220; ALL; chr2: 66525936-66527222; 2; MEIS1; INSIDE CGGTTTGGAGAGGGGAGCGCAAAGCGCTGGACGCATGCGGTACAGTGCCACGGCCGCCGGTGGGCTCCA CTGCCCTGGGGAGCTGAGGCGCGACGAATGAAGCACCAGGGCGCCTGGTGGGCGCCAGTCTCCGGTCTG GAGCCTGCTGGCCTGTCCCTCCGGGGCGCTGAACCCCTAGTGCGGCGTCCTGGGGGCCGGGCAGGAAGG ATGGCCTCTCCACCTGTCTGCGAATGCAGCCCAGCCAGTTTGAGCCTCCGCAGAGGTGCGCTCCGGGACT GGGCGCTTCTCGTGCTGTGAGAACGCTGGGCCTTGTTAGCTCATTAACCCCTCTGTCTCTAGGGCCCGTTG GCGGCACGGTTTATTTTATTTTACCTGTTTTCCTCGGAGGGCGCGAAGACTCCACCCGCGCGGGGACCTG GGATCGACGACTTTGATACTAGGCGGTATCCCGGAGGGCTAAGTCGGCGGAAATCCACTTGACCTTGTAG CGTTAGTCCTTTCTTTTCCTTTCCTTTCCTTTTTCTTTCTTCTCTCTTCCTATTTATTTATTTATTTTAAAAAT AGGATTAAGACACCAGTAGAAGCTGTAATCCCGTTCCTTCCCCCACTCCCAGTCTTCCGGGCCGCCTGGAG GTCCCTGCCGGAGAGAGCCACTTTGGCGGGCGCAAGCCCCTGGGCGCCCTCTCCTGACCGCCGCGCTCTC GGCTCGGCTTGGCTGTTCCGGGCTCCCAGAGGCTAGGGGAAGCGAGGGGCGCCAGGGGCTTCCCGGCCT CAGCGTGGGGCGAGGTCCCGGCTGCGACCCCGGAGAGAGGGAGAGGGGGGCCATGATGCTAGGCGTCGA GGCGAGGGTTGAGCCTGTTTGGCTTCAGAGAACGATGCGGGTTCGACCGGAAGCGGGGCGCGTGTTCTA GGGGCCCTTGGGTGGATTAGGGGGCGCCAAGAGGGTTAGGCGAGGAGAGGCCTGGCCACCCAGTTGCTA GACTTTAGGCCGCACTCCAGGAAGGAGCAGTCGGCTTCCTTCCTAGGCCGCTTCTATTGCGCGCCACTCCT TGAATCTAAGCATTTTCCACTCCAAGAACCGTTGGGAGAGAGGGGAGAGCGGAGCAGAGTCTCTAGGCCC CCAGGGCCGCCTCCCGGGGTGGCCACGCCTGCCGGTAGCGAGCCGAGATTAGCTAGGTCTGTGCTCGGG CCTCAGCGGTGGCCCTGGCTCTTCCCTAAGCAGCGGG 222; ALL; chr2: 70984709-70985764; 2; VAX2; INSIDE CGGGCGCATAACAGGCACCCCGCACATCGCACCGCGGACGCAGCGATCCTCCCATTTGTACCCTAAGGCC TGAGAAGGCCGCTCCACACCTCCGCGTGCACAGTCCCTAGACCAGTGAGGGCGGGGAGGGGAAATCCTTT TGTTTTATATTGGAAACCTTACGCCAAAGGCAGGCAGGAAGCAACCAAAGGAACAACAGGCCGCCTGAGC CGTGGCTCAAACAGCACAGGGCAGTGGCCGAGCACCAGGCTTTTCGGTGGAGCGGGATACCAGCAGGCA GAAGAGGTGGACAACTCTGACCGCAGACTCCCTACAACCCCGCGATCGATGCTCCACCTGCACGCTCAAA CGCACCTGTTTCCCAAATTAATCCAGACGCGAATTTAACGACCGATTTTGTAGATCCGGGAAATTCTGTCC ACCAGCGTCACCCAACACAGCAACTTTTACAGACAATGCGTGGCGTCCGTTCCTGCTCACCCAAAGCGGC CTCTCTGGGCTGACAGCCACCCCTGCGGGTCCTCAAACCCCACTCAAACCCTCCGAACCCCTGTGTCTGG GAGCAGTAGGGTGGGATGACTGCAGGATCCCTTGAAGAAGTGACTCGCTGCAACCCCACCACCAGCAGCA AAAACGCTTTCACCCGGGAGCTGCATGGATGCGCGGATGGCGGGGGCTGAGGGGACGCGTGAAGCCCAG GCCTCTTGCTTGGGCTGGGCGATTCCCGCCGTGGGACGGGTGGGATTGACCTTAGTGGAGTCCAGTCCTT CGGAGAATCCGCGGGCAGTCGGGACCCACGCTCCGGAACACCCAAGTCCGAACTCGTACACACAGCACAA TGGCGTGCAGCCGCCGGGGCCCTAACTCCCAGAGACGCGTCTGAAGAAGCCATACAAGGGGGCGCAGCT TCGGGGCTCTGGCTGGGAGGTTACTGCAGGGACAGCGCCTCGCCTCCAGCAGCCGGGTCCAGGCTCAGG GCCGGCCGGCCTCTGCTCGCTTTCTGCTTGGATTACCAACAGCCACTGGGCTTGGGGAGATCGGCCGGGC CG 230; ALL; chr2: 105864220-105865009; 2; NCK2; INSIDE CGGCAAGACGCGCAGGAAGACCAGCGCGCGGGATGCGTCCCCCACGCCCAGCACGGACGCCGAGTACCC CGCCAATGGCAGCGGCGCCGACCGCATCTACGACCTCAACATCCCGGCCTTCGTCAAGTCGCCTATGTGG CCGAGCGGGAGGATGAGTTGTCCCTGGTGAAGGGGTCGCGCGTCACCGTCATGGAGAAGTGCAGCGACG GTTGGTGGCGGGGCAGCTACAACGGGCAGATCGGCTGGTTCCCCTCCAACTACGTTTGGAGGAGGTGGAC GAGGCGGCTGCGGAGTCCCCAAGCTTCCTGAGCCTGCGCAAGGGCGCCTCGCTGAGCAATGGCCAGGGC TCCCGCGTGCTGCATGTGGTCCAGACGCTGTACCCCTTCAGCTCAGTCACCGGGAGGAGCTCAACTTCGA GAAGGGGGAGACCATGGAGGTGATTGAGAAGCCGGAGAACGACCCCGAGTGGTGGAAATGCAAAAATGC CCGGGGCCAGGTGGGCCTCGTCCCCAAAAACTACGTGGTGGTCCTCAGTACGGGCCTGCCCTGCACCCTG CGCACGCCCCACAGATAAGCTACACCGGGCCCTCGTCCAGCGGGCGCTTCGCGGGCAGAGAGTGGTACTA CGGGAACGTGACGCGGCACCAGGCCGAGTGCGCCCTCAACGAGCGGGCGTGGAGGGCGACTTCCTCATT AGGGACAGCGAGTCCTCGGTAAGTGCGCTGCGCCCACAGCTCCGGCTGCAGGCAGTAAATGCGCCTTGCG CGGTGGGTCTGTGTGCCGCG 232; ALL; chr2: 111591678-111597436; 2; FLJ44006-BCL2L11; DIVERGENT_PROMOTER CGACTCGGTGAAGGATGATGCCCGGAGGGTGATCTCGACCTTTAACATTCCACACACCTACCTCCACGCA CCAATCGCCGGAATCTCCAACCCGCGGGCCGCGTGGGCTTTCTACCCTGCACCGCTGAGCCGCGGCCACG GGAAGAGGCGCGCTCCCGGCGGCCCAAGCTGGGAGCCAAGCTCTAACGGGTGTGGCGGGAAGTGTGGTG GCCCGCCAGCAGCTGCCACGACGCTCGCTCCACCGACGCCCAGAGCTGTGGCCGGGCCGGGGGCTGGCA CCCGCTGGGCCGCCACTCTCGGGGATTTTGGTGGCAAAGCGGAGGTCCCGCCGAGGCTGGCGAGGTGCG CGGCTGGCTGCTAGGAAAGAGATCCAGACGGTCGCCTGGTGCGCTGGATCCCGTGCCCTTTCCCTGAAAC CCAGCCTGGCCTGACTGCAACCTCTCCCAACTTCAGTGCCGGATCCCCTAGACAATCAGGGTGGGCTCCC CGCTGCGAGCGCGCCCCACAGCCGGGTGCCGCCAAAGGTCTCCTGCTGTAGCGGTGACTCACATTCCCAG TGATTTAGAAAAACTGTGGTGCCGAGTGAAAGAAAAAAAAAAAAGCAAACACCCTTAGACAAAAGAAAAA AGCTCCACTCTTTCCGCGAGCGGGAAAAAAGGTTTGGTTCAGCAGTGATGCTATTTCAGTGAATCAGACGC TCTGGGGCTCTGCAAGGAAACGCACGGACTGGGAGAAGGAAGTGGGAGCCTAGAGTTTTGCTCTCGGCAA AACAAGAACTCGGCTTGTCCTCCCAGGCCGGCGGTTTCCTACGGCAAGACAAGGCGCGGAAAACATTTTT ACCATCTGACGCTGTAGTCTGTCCTTTAGAAGAGAATAGGTGAAAAGTTTAATAAAGAAATTAAGCGATGT GGAAGTCGTTCCCGCTGCTTGCAGAGGGTGGGGAGCGGGCCTGGGCAATTTCGGAACTAGGAGAGACCA CGTCGGCAAAGCCTGTGGTCCCGAACAAGGGCCATGGATTTCCCATTTCTCAGATCCCGGCTGCCCGACT TCATTCTTGTTTCTTTCAGCACAAGCCATCCCCCTTCTCCCTCCCTCCACGTCTCTTGGCAGAGACAGAAA GGGACACCGCTCTGCCCGCGTCCAGCGCGAAGGAGGTGACCTAAAACCCATGGGCCCTTCTCACACTGCG TTCTCTGCGCTCCGGCCCAGTTCCGGAGGACCTCCCG 238; ALL; chr2: 156892636-156892878; 2; NR4A2; INSIDE CGGGTTGGAGTCGACATGGGCCCTGACGAGGGCACTGATCAGACTCACCGGGGGCGAAGGGGGAGAGGG CTCCTGTGGGCTCTTCGGTTTCGAGGGCAAACGACCTCTCCGGCCTTTTAAACTGTCTTGCGAACCACTGC AAAGGAAGAGCCCTGTTAGCGCCGCTTTTCCGAGCCCAGGCCCAGCTGCTGCCTCGGTCCCTCCCCGGGG AAGGCCGCAGCCGCGGGGCACCAGGCTGAGCG 240; ALL; chr2: 156893736-156894685; 2; NR4A2; INSIDE TCCTAACCAATTTCATTCTGAACAGGGAAGACAGCTCCTAGCACATGCAAATGACCCTCTTCCAACTCCGG CTCCAGCAACTTCGGGCGGGGGCCAGCCGGGTCGGCTGAATGCGAGGGGGATGCGACCTGGCCTCCCAG TCTTTCTGCTTCCCTTTCTCAGACACCCGGAAGTCCCCGCCGCAGCCCATGGTCTCCTGCAGGGCAGCTTC GGCGGACCCCGGAGAGCTGGGCAGTCCCGGGAGAGCTGGGGCTGGGCTACTGCACCAAGGCAGAGGGCA CACTCCGAGGTCCCGGGCACTAGGGGCTCCCTACCTGCCTACTCCGCTCCCGCCATTGCTCACCTTAAAGA AGCCTTTGCAGCCCTCACAGGTGCGCACGCCGTAGTGTTGGCAGGCCGGTTGTCCCCACACACAGCGCAC AGCCCCTCGTTGGAGGGGGAGCCCCGCGACGGCGGTGAGGGCACCTGCGTGTCGAGCAGCTGAGACGCG TGGCCGATCTGCAGGCCCGGGAAGCCCATGGACGCGGGCTTGCGATGGGGTTGGGCACAGCGAAGGTCT GCCCGTCCACCACGTGGTGGCTGCCGGCGGGCTCCGGGTTCATGGGGACGTGCAGGGGCCCGTCGAAGC GCATCTGGCAACTAGACACCGGGGTGCCAGGGGGCGATTGCTTAAGGAGAAGAGGGAGAGGCGGGAGAC TGGCGTTTTCCTCTGCTCGATCATGTGCGTAGTGGCCACGTAGTTCTGGTGGAAGTTGTGGAGAGATCCC GGGTCGTCCCACATGGGGCTGTGCTGCACCTGGAAGCCCGGGTGGTGGGCGTCGGGGGCGAGGAGGGCT TGTAGTAAACCGACCCGGAGTGCGGCATCATCTCCTCAGACTGGGGGGGCAGGTGGCTGTGTTGCTGGTA GTTGTGCATCTGAATGTCTTCTACCTTAATGGAGGAC 245; ALL; chr2: 171384729-171385226; 2; GAD1; INSIDE ATACAATTACCCACACAACAAAGAGGGCCTCGGGAGAGTCGCCAGCCCTGGTAGCATATGAACCAGGCAC CGGCGTTGGAGCTGGCCAGGGCAGGGCGGGAGGAACGCGAGGCCTGCGCGCCTTTGTTGGTGCTTTCGC CTTGATGGATTTCTTTTCTGACGCTTTCCACATTTCCCGCTCCCTTTTGCCGCCTGGGGGTGGGGGTGGGG GGTTAGCGGGCAGTTGTGTTAATTTGCCCTCCACTCCCGGCGCCCTTACGGAATCCCGGTGGCCGCCAGT CGCCGGCGCAAATGCCAAGTCACCGGTAGGAGACACAACAGAGGCGATGACCTGAATCCGCACGTGGCCT GGTTCGCCTGGAAGCTGCCAAAGCGAAGGCAAGAGAGCCCGGGACCCTGTGTAAAACAGCAAGCAGCAC GTGTCCCAGGCACACTGTTGCGGGCCCTTAGCCTAGCTACGCATCCGCACCCCAGGCTTCAAAGGCGCGC TGGGCG 254; ALL; chr2: 176737610-176738187; 2; HOXD3; INSIDE GAAAGAGATCCGTGGGCTTCTGACCCTGGTTTAGGCAAAACAGGGGGAGGCGCCGAGACCAGCTCGAGC ACTAGCGGATTTTGAGAGAAACTGACCGCAACCTCCATCGCCTTCCCCCTCTCTTTCACTTGGATGGGCTG ACTCTACCCGTCGGTGATTTACGACGATTGCAGCGCTAGTCACAGCCTGGCGCCTGGTGTCCCCTCCCTTC CCAAGCCCCCTCAGCTTTTCCACTGCCACCGGCGTACAAGCAAGTGCCGAGCGGCCTCCGCAAGTCGGAC TAGCCTCCCGGCGTCCGAGGCCACCACGGGCAGCAGATTTTTGGTCCCCAGCGAGGCTGCGCGCGTTCGT CCCGCCTCCGACCGCCGAGCAGAGCTGCTAGCAGAAGCAGGCGCCGGTACTTTATATAATCCTGCTGCTC GCAGGGTGCAAGAGCGGGAAAAGTGCGGAGTAGGGAATTCTTTTGCTGCGCTGCCTCCTACGCGGAGCCT GCTTTCCACTGCTGAAAAGTGCCGGGCCTTGGGAAGTGTTTTTCTTTCATTCCTTACCGAAGCGTTTACTG CCGCCGTGGTCG 259; ALL; chr20: 35582018-35583550; 20; NNAT; PROMOTER CGGCTGGCTACCGGTGCGCGGGGACCACACTCACAAACCGCATTCCGGTCTTCCCGCCCGAAAATCCGCG CTGTGCGAGGGACCCACAAGACTGGCGGTCTAAAAGGGACCCGCCTCACTTGGAAACGGGCTGCGGTAGC CACAACCCTCCGGTAGCGGTAGCGTAACCCCGTTCGGTGATCCAGCCGCACAGCGCAACGGGTACAAAGA ACCCCACTGGCTAAGGCCGACCTACCAGGGCTTGGGGGAGGGGAGCGGAAGACGAGGTCGAAACGACCT GTCCAGCAGAAAACTATCCCCAAGCATATTCCAACCACTTCTCCGTAGAGCTCATTCCTTCCGTGCATACG AAGGGCGCCAATCCTTCCTGTATCCCTCCTACAGATACCGGGTGACTACGCTTTTGCGCCCAAAGCGCAGT GCTCTGGCTCAGCTCCCTACAGTAGCGACCTCCACCGCAGATTCTCATCTCCTCGCTACCGTAAGAGAGAT GTAAAGAATCAGACGGGTTACGCGCTCAGGCACCCTCATGAAGAGAGGACCTGGGCTTAAAACTCATTCA GTATCAGGAAAAGAGCGCCGAGCACGGGCCTATTATGCCAAAGCTTCTGAAAGGGGCACCACGTTTTTTG CTCTATGGGGCAGATGACCCCTCCCTAATTTCGGTTTTCATCCATCCCCAAGGTAGGCTTTGGAGTGGCAC CGGAGACTGAGCTCAAATTTGCAGGCCAGGGACTGGGGAGAAGGGCGCCACACTAAGAGACCTGCACCC CCATTCTCGCCCTGTACTCTACCCAGAGTCGTGGTCCCCTCCATTTTAAAGCAAAATCCAAAAGCAAGCAC GGCGGAATCTTCTGGAAGGGGGCTAAGATGGAACTCAGGAGGCGGGGGTCGGTATGGAAAGAGCAGATG GATTATTTTTTTCCTCTCCTGGCGAATGAGGGCGCCCCCAGCCACCCCTCCTCATAAACACCCCCCAAGGC GCGCATGCGCACTTAGGTGGCGGGCGGGTACTTAAGGCGCGGCCACCGCGGCTGCGGCAGTGCGCCCAA CAGCGGACTCCGAGACCAGCGGATCTCGCAAACCCTCTTTCTCGACCACCCACCTACCATTCTTGGAACCA TGGCGGCAGTGGCGGCGGCCTCGGCTGAACTGCTCATCATCGGCTGGTACATCTTCCGCGTGCTGCTGCA GGTAAGTCTGACGGGGTTTCGGTGGGAGAGGGT 267; ALL; chr20: 60061693-60062033; 20; TAF4; INSIDE CGTCTAATCGATGGTGGGGCGAAGGGAGAGCCACGGCGGCCCTGAGTGCAAGCACCATCCTGAAACCAG GAGCCCATGAGGCCGCGGGAGCCGGAGGACCAGGACCGCCCTCGCACTGCCCTGTGACAGCTCCCGGCC CAGCTCTCTGCCGCTCTGGATCCGTCACTAAGCAGCTCCATTAAGTGCCCGGTCAGGCAGGAGCGGCAGG GAAACACTGGGGCACCCACATCTGAACAGAGAAGATGCCCACCTTGAGAAGGTACCTGGAGAAGGGAGCC ACGAGCGACGTTTATGCTGAGAAGCGGCATCCGTGCACCTCACCTCCGCCCGTCCACGCCG 281; ALL; chr4: 9756136-9756429; 4; chr4: 009756149-009756196; Unknown CGCTCGGGTGGCCGAGTTACACCTGGCTATAAGTCATCCCGTGCACCTGACTAAATGCATCCCGTGCACCT GACTAAATGCGTCCCGTGCACCTGACTAAATGCGTCCCGTGCACCTGACTAAATGCTCCCGTGCACCTGAC TAAATGCGTCCCGTGCACCTGACTAAATGCGTCCCGTGCACCTGACTAAATGCGTCCCGTGCACCTGACTA AATGCGTCCCGTGCACCTGACTAAATGCGTCCCGTGCACCTGACTAAATGGTCCCGTGCACCTGACTAAAT GCGTCCCG 284; ALL; chr4: 111780013-111780343; 4; PITX2; PROMOTER CGCGGAGAGACACAGGGAGAGGGAAGGGAGTTGCGCTGAAAAGACGCAAAGATACGCGCGTGCAACTCC CTCCCCTTTCAGGTTTCAGAGGTTTGCAAACCAGGGCTGAGAGGAAGGGGCTCGGGAACTCACGTTCCTC TCGCCCCCCTTCTGTCTGGAGTCTCGCCCGCCAGAGGCTGGTTAACCCCAGTCCCGGCCGCCGCAGACAC TGCGCTGAGCTTTTGGGTCCTCGCCTTGCCCAGCGCCAGTGCAGCTGAAGTGAGAGCTGGTGGGAAATGC AAATGGCTCCTGGAGAAATAGAAGATACAGAATGATTCTCATTCCCTCCT 302; ALL; chr5: 115810975-115811393; 5; SEMA6A; INSIDE CGCGGCTGCCGCGGCTGGGCTTCCGCTTCTGCTGCAGCGTTGGGGTTGACTCTGGGGTGGGGAGGGCCG TCAGGTCCAGGTGGTGCTGGTCTGCTTTAATGAGCATCTTGGCCGTGTTGCCGGGAGTGCGAGCTTGCCG TTGTGCATGAGTGGCGTGAGGATGGCCTCCGGCTTTGGGTCTTTGGATTGAGTGTCCCCAAAGAGGCCGC TGAGCTTGGTGACGCTGCTCATGGAGCCCCGGCGCGAGTGGGTGAGCTCCTTCTCTTGCGCTGCACCACA GCCACGTCTTTGCGCCGATGATCACAGACGCAGTAGACGGTGATGCCCGAGAAGACGGCCCCCATGACGA AAGCCAGGATGACTGCAATGGCCAAGAGGGTGACGGGAACCAGCTGGTCGGGCCTTTGAGGTAACTT 304; ALL; chr5: 122461778-122463450; 5; chr5: 122462228-122462286; Unknown CGGCCAAGGCTGGCGGCGGCAGGTACCCGGGTGCCCCGAGGGCCACCCGCCGCCCCGCTCTGGCGCATC CATCAGTGGCCAGCTTTCACCGTGTCTGCCAGGCGGGACTCGCCAGGTGTCAGGCTCATGCCATAAGCCT GACACTTGCGCGGGGTCGCCGTGGCTCCTCAGGGAAGCTGGGCCAAGGAGGCTGGGTCGCGCCGGCGGG CGCCGAGGCCACCTTCTCGGGGCAGGCCATCCGCGCTGAGGCGCAGACACGGCGGTCCTCCAGGCCCATT AATAACCCGGAGGGCGCTGCGATCCGACAGCGCAGTCGCCACAGGCTCTATTTCCCGTGGCCGCCTGCCT CCTTCCAGCCCAGTTCGAGTGGAGGGATACTGGGCGCCCACTACCGCCCGGCCGGAGGGTGGGGGTCCC TCTCGCGCAGGCTGCTTTGGAGAGTGTCGGAGAGAGACAGCTTTATCTACAGCTTCACCCATTGTATAGCA CAACAGAATCGCATTTAGCCTGGAGAACAGCCGTCGGGGCAGGAGTTGTGCCTTCTCTAACAATTAGGCT GATCGTTAAATTTGCTATTCCTTTCTTCCGGCGTCTAGGGAGAGCGTGCACACCAAACCCTCCAGAACAGC ACCCCGGTCCCCCACCCCGCCCCACCTGTCCCCGCCCTGCTTAGTGCCTGGAGGGAGAACTGACTGGTCG CTTGAGGGACCCCATTTCGGGCGCGCCCTTGGAGTCCTGGGGCTGCGGCTCCTGCTCTACCGGGCTGCAG GCTTGCTCTGCCCCGTCCCGTGGCGTTTGGGAGGCAGTGAGGAAGCCTCCGAGTCTCTGGGTCGAAGGAA GTGCGAATGGCACCCGCGATAGACTGGCCGTCTCCCCCACCCCGCCCCGTCTGGTGATTTTAAATCGTCTC CTGTGTAATTGTAAAAAGAGGAAAGCTGAATACCAGACGACCAGTATAGAATCTCTTCGAGACAGCAGATT GGGCAAGAGACGGGCTTTTTTTCGCAATACAAGGATAAACACATCCTGAAACTCCAGATAGAAACCTCAG GAATGGGCGAGAGGGTCAGAAGGAACGAAGACAGTAGGGAAGAGAGAGAGAGAGACAGAGACAGAGGG AGAGATGCAGAGAGACTGAAACGGGAGGAAGAAGCCTGGAACTGTCGGTTCCGTGGAGAGCGGACATGC TATCTGCGCCCAGATCCGAAGGCTTTTGGGGAGCCTAG 311; ALL; chr5: 134390896-134393045; 5; PITX1; DOWNSTREAM CACAGAAGAAAAGGCAACCCCAGGCATAAAGAGGCTCTCAGCAGCCCCTGCCCGAACGCTCCTGGCAGGC AAGGGCCCCATAGCACCCTGGGGCCTCGAGGGTCACCGCAGACCCGGCCTGGGAAGAACCCGTAGAGTC CCGCAGCCGCGGAGGGAGGGGGTTCTCGCTAAGGCGTCCCGCGGACAACGCCGAGAGGCACAGCTTAGC GGGTGCGCACCGGACAGGCTCGCAACGCAGGACGGTGCCCTCATGGGAGCCAGGCGAGCAGGTCAAGAA TGGTGGTGGGGAAGCGGGGTAGGCAGACCTCGGCGGGGGCTGCCTCGGCGCTCTGCTCCTACCCAAGGG GCCCGGTTCCCTTTCTACCCACAGTTCCCTTTCTATCCGCCTCCCTCCTCAGCCAATGAAGCAGTCGGGGC TCAGCAGTGCTTAGCACGCTCGGACTATGGTTTTAATAGACGTACATGGACAAGTCGATATAGACAGATTT ATTACAGTCAGTCCAACATACACAGGGACGCTGTAAACAGGGGCGCGGCCGGAGAGCGGGTGTGCAAAGT GGGCGCAGGGCCCTGGGGCCGCGCCCCTTGCTCTGCCGGCTCGACTCTTGCACGGCGGGCGGTGAGGAG GGGGCTGTTCGCCCAGACAGAGGGCCACCTCCTAGCCCGGGAGCGAGCAGAGGGCCTGGGCCTGCAGCT AAGCTCAAGGCTGGGGTGTTCTGAGATGGACCTCCCCCACCTCCCGCCAGGCCCGCACTGCCCGCTGTCG CTCCGTGGCCTTAATATAGGGCTCCGGGGCGCGGGGCCAGCAGGCTCTACCAGGCGCGCCGGGGCCGTG TGCGGCTCCACTGAGTGCCCGATCCTGGGCTGGGGGCACCGTCCCCCCAAACCCAACGCCCGCCCCAACA CGGATCCGACTCGAGCTAAGGCGCTCTCGGCCGGGCCTGCTCGGAGAGGGCAACTTGGTTTGTACGGGGT CGGGAAATCCTAGGCAAGTCCAGGCCCCGCACATCCAGTCCGCAGGCCCGGCCACTCAGTCCGGATCCAG CGCGGCGGGGACGCGGGATACGAGGTCGTCCTCCCCGGCCGCTGGGCCTCGGCGCTCGCCTACCGCGCC GCGTGCCCTCCGCGGAGTGGGCCTCCGGGGCCCGTGGGAACACACACACCACCCGCGCCATCCCGAGAG AAATTGCAACTCATCCATTTTTTCGCGGCACTTTCTCCGACGT 314; ALL; chr5: 135442969-135443206; 5; chr5: 135443148-135443192; Unknown CGCGCGGGACCGGAGGCGCACACCGGAGGGGAGGTGCCCCCACCAAAATTTAAGTGCGGCGCAACATGC ACCACAGGTAGGGGCACTACCAGGGCAAAAAGACTTGGTGAATGCGAGGGCCGGGCCTATCAAAGGTGC GTATGGTGGTACCAGAGCAAGGCGGAACAGCTGCTCAGTGGTCCGCAACCGGGTCAAGGGACAAGAAGA CGATTCTGGATTGTAGGCCGCCCGAGAGCG 319; ALL; chr5: 174091287-174092335; 5; MSX2; DOWNSTREAM CGGTGACTCGGAACAGAGGCAGAAAGGATGCGAGGACTTCTTGCTGCGTAAACAGCGCGGCGGGCAGAT TGGCACCTGGCACCTACCAGGACTGGCGCTTCGTCCCGCGTTTCCATTGTGCCCGCACCACTTTGAAAGTG GGCGCCGGAAACTCCGTTTTTCTTATGGGGCCGGGGTCGGGCAACGTGGTTCAGAGGTTTCACAAGCTCC AGCACAGAAGTGATCCAAACCGAGGGGTCGGCTCGAAGTCGGAGGCTGATTTTTCTTGCTCAGTCGCTCC GCCGGAGCTGAGCCGCTGGAACGACCCAAACCTACCTGAAAGCGCGTCTCTGCAGTCCCGCTGGACTTCT CCGGCTCGAACTCCTAATCTCAGCCCGGAATCCAGCCATATTCATTTAAGATTGCGTTTTCCAAAGGCCAA AGCCTTTCCCGGTTTCGTCATCAGCCGCCAGGTTGGGTCCCTAATTAGCCTGTCCACCGAGCTTCCTTCCC GGCGCCGCTTGGACCCCGCAGCCCCGGGCGATCTCAGCCCGGGGGGGAATCCGGAGACGCCGGCTCCGG GTTAAGACTCTGCTCGTCCCCAGGAGGACGGGGTCGCGATCCAGAGTGCGATCCGGAGAAAAGGGCTGCA TCTTGCGTGGCTGGCGGGTTAGACTGGAATCCGTCTGGGGACTGCGCACCATCCCCATCGCTCCAGACGC CGAAACAAAACCTGAGGCTCGGAGAGGGGAAAAAGAGTTGTTCAGGCTCGAACATACGCATCCCAGCCTC ATAGGTGGATGGGGTTACCGAGCTGAGAACCAAGCCGAGGTCCGCGAAGCCGGGCCGCCCCCTTGCTCTG GGCCTCCCTTCAAGCCTGCAGTCTGGGGATGGGTTCCGAGTCACCGCGGTCCGGGCCTCGGTCAGGCTTG GTCGGGCACACAGGGCGTTTCAGAGGCCAGATGACAACCTGTGGCGGCAAAAGGACTCTCCCTCACCAGG GACCCGCGAAGGCGCGCATTGCAAGATGTTAGCGTGCGGGCTTTAGATATCCTTGCGTCCG 324; ALL; chr6: 1549606-1560865; 6; FOXC1; PROMOTER CGGGGTCCCACGCGGGCGGCGCGGTCTTCCCCAGGCCTCCTTCTCTGGAGACCCGGTTCCCAGGGGACGC TGTGCGGGGACAGGCGGAGCCGGCCCTTGGAGCCCGGCGCGGGCAGAGGCGCCGCGGGACAACGCCTCC GACGGCAGGGGGCGCTCGTAGCACGCGCAGTGCGCGGTGCGGGCGCCCAGGACGGCTGCCTGGCCCCGG GTTCCCGAGGCGCGGGACCTGCCGGGGTGAGGTGCCCCCAGCCTGAGAGCCCCAGCTGGGTCGGCCAAG GGGCCTCCGGGCTTCCACATCGTCCCTTTTTCTGCTGACGCTCGCGGGGAAGCGGCGGGAAGCCTGTGAG GGGCGGCCTGGGAGCAGACGGACCACCAGGTCACCGGCGCGCGCTGCCAGGCCCGACCCACTCGCGAGG ACCAGCGGTTCCCGGAGGCGTCGGCCCTCAGGTCCTCGGGGGAGGCCGGCTGCACCGAGCCGGGTGTCG GCCTTGTCCCTGTCCTGAGAGGTGCAAACACCGGCCCCGGCCCAGGCCCCGGGGCTCCTGCCCAGAAGGC TCAGAGCTGGGGGCCGACCGCGCCTTACCCGCAGGAGGCCCGGCGGTGCGTCCGCGTTGGTGCCACTCC CCGGCCGGGGTGAGGGACGTCGGAAGGAAGGTCCCAGGGCGCAGGGTCCGCGAAGGGAGCACTCGGAA GGAAGGCTGGCTGCGGCCCCGGCGCCTGGGTCCGCTGCGGCGCCGGGCCGGAGACCTGGGAACAGCCAG CCACCTGCAAGGTTGCAGCCCACCTCACCCCGCCGGCGGCTCCGGGCTGTCTGTGGGTCTGTCTCACGGG GCAAAGCCTTTCTTCCCACACCCACAGCCAAGGCGCGTCCGTGCAGGGGCACACGCCTTCTGCTCCAGCC CCAGGAAGGCGCTTTCGCCCTGCAGTCCTCCGACGGCCGGCTCCGCCGCACCGCGCACCCTGGCTCCGGC AGACTCTGGGGCCTGGGGACTCGCCCACCCTGCGCGGCGCGCCCCCCACATGAGCCGAGGTTGGGAGGC TGCGGGGCCTCTGTCCTCCCAGGCCGTGGAGTGCGGCGGCGCTCTGAGTCCGCTGGGGACCTGGATGGA GAGAAACTGGGGCTCGTTCGCGCACACATGCACCATTTGTTCTTTCCGATCATCTATCCCTTTACGAATTT TATTTTTATTCCGGATTGTTAATGCAAGACGACAGTTGAATCTCCA 339; ALL; chr7: 1481682-1482268; 7; chr7: 001481829-001481873; Unknown CGGCCTGCGGTGGGGAAGCGGGTACGGGAGGCCCAGCTCTCCCCACCAGGGTCACTGGAGAGGAGCAGA CGCAGCCGTCCGCCAAGACCCGGGCACGAGTCCCCAGCAGCTGTCACTGCCCCAAACTAACGTGACCCCA CGTCCACCAGCAGGTGAACAGATAAACCAACGGCCGATCCACACAATGGCAGGCCACCCAGTGCCCACAA CACCACGACTCTCCAGACTGTGCGAGCAGAGCACCCGCAAGCTCCCTCGGTATAAACTCAACGCAGACAA ACCCACAGGGCCACAGGGCGGCGCGGACTGGGAAGGGGCAAGAGGGGTAGCCGGCGATGGCCATGTACA CTGTGGCCTCCGCCCTCCCTCCCTGCCCGGCCAGGGCACCTGGGACGGCGGGGGGAGCGGCAGAGTTGC GCCCTCACCTTGCAGACGCTGCTGCTGGCAGCCCCTTCGCTGTGCAGTAGGACCTCAGGCACGGGCACCC GCAGCTCCGGCCGCTGTAGGTAGAGCTGCAGGAGAAGGTCTCGGCAGCCCTGCCCAGCACGCTGGAAGA GGTGGAGCAGGGCTCACCAGGCGGACG 340; ALL; chr7: 2082782-2083345; 7; MAD1L1; INSIDE AACACAGTTATGACACAGTGAGCCCACAGCACAGTTAGCCTGCAGCACAGTGAGCCCGAGACACAGGTAT GACACAGCGAGCACATGGCATGGTGACCCTGAGACAGGGTTACGACTTGGTGAGCCCCAACATGGTGAGC CCAAGACGGTTACGACATGGTGAGCTCACGGCACAGTGAGCCTGAGATGGTTACGACACGATGAGCCCGC AGCACGGTCAGCCTGAGACGGTTACAACATGGTGAGCCTGTGGCACGGTGAGCCAAGACAGGGTTACGAC ATAGTGAGCCCACAGCATGGTCAGCCCGAGACAGTTATGGCACAGTGAGCCCGCGGCACGGTGAGCCCGC AGCATGGTGAGCCCGAGACGGTTATGACACAGTGAGCTCACGGCACGGTAGCCCGAGACAGAGTTACGAC TTGGTGAGCCCGCGGCATGGTGAGCCCAAGACAGAGTTACGACTTGGTGAGCCCGCGGCATGGTGAGCCC GAGATGGTTACGACATGGTGAGCTCGCAGCACGGTGAGCCTGCCATGGCCTCAAGGGTTAAGATGTAAAC 345; ALL; chr7: 2724511-2724848; 7; AMZ1; DOWNSTREAM CTTCTCAGCAAAGGCCAACACGTCTTTCTCGAGTCCAAGACCATCTCCCGTTCAAGGGCCCTCACCGCGCT TTGTGAGTCTGTCTCGTGGGCCTCCTTCAGTGGTCTGTGACCAGCGGGAATGAATGGGACGTGTTTTGTTC AGCCCTGACTCTTGGACGCTGGTGGCAGCCGCGGGCGCCCACTCACCTGGCACGTGGACGAAGGTGATGA GCGCGGCTGACGGCTCCCGGGGGCAGTGTGGGGTCCAGTCTGAAGCCGACGCCCTCTCGGTCAGGCTTTC AGCAGCAGAAGGCAGTGGACTCTTCACCATTTCTTCCAACACTTTCTCACGTAG 349; ALL; chr7: 8449587-8450236; 7; NXPH1; INSIDE AAACTGAGGCAACCAACTTATTCGCAAGAGTAAAACCCTATGGGGAGAAGCGATTCCTGCCCCTCTTCCCC CGGCGAGGAACACGGCTGGAGCCACCCAGGCGCCTTCCAGGCTAAGGCGCCTTTAGGGCGCGCAGGGGT GAGGGAGAGGGTGGGGAGAGTCCTAATTATTATGAATTTCTAAAGGCGCAGTAATTATTCACGGGGAGCA GGACAAACCATGGCTAGGCAGGGAAATCGATATATTTGCTATCGAAAGTTCCTGCTCGCCTTTAATGCAGA CGAATGGGGGATGCAGCCTCATTATTTTCCGTGGTTAGGCTCGCCAGCGTGGGGCCTGATGCAGCGTGAA ATCTATCATCATTAGACCCGGGATGGAGCGGCGGGGGGGAGTTTCTCTTACTTACCAAACCGCAACAACA AACAAACAACGACGAACAACCGCCCCCTACAAACACTCATTCTCACACAACGTTGCCCTACCTCCCTCGCC GCTTGCCCTGGCCGCTGTTGCACACTCCCCTGGGGGCTGTCTGACGCCCTAGAGCAGACACTGCGGTCAC TTAAAGTGCGCCCAGTTCCTCCACCGCAGCGGTCACACCGTTGATTTGATCCAGAAATAAGACGGATAGTA CCGAGCGTTGGCG 354; ALL; chr7: 27164708-27165039; 7; HOXA7; PROMOTER CGCCGCCGCCGTCTGTCTAGACTCAAGCGACTGAAGGGGCCAACAGAGCTGGTGTTTAAAGTAGAACCTG CCCAGTCCAACAGCCCGAGCAGGGAGCGATTTCGGGGATCGCGGGAAGGAACGCACTCGCCAAGGGAGG GCCGGGTGCCCTCGCCACCGGCTCATTCCTGCTCCGGTTTTGCCCGATGCGCGTCCAGGAGGTTCTGGCA GGACGCACTGCCCCTCTGCCCCGGCCAAGGAGGATGCGGATACTGCCCGCAAGGTTCGGCCTTTATGGAC CCAAGTCAGCCAACTGGGCCGAGTCCTGCGGACACCGAAACCTCCCTTTCG 358; ALL; chr7: 27251165-27252762; 7; EVX1; INSIDE CGCCTGTGCTCTGGACTCGCTGTGCAGGGTCCGGCTCCGAGGCGCTGGTCGGCAGTCCGAACGGAGGGA GCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCTGGCTGCAGCGCCAG TGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTAC CGGGAGAACTACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCGCCGGAAACCACCAT CAAGGTATGCGGGGTCCAGGCTGGGGAGGCGGGTGTGCACCTATTTAGCGGGAAGTAAATGCCAACTGCC AACTCCCTGAAACGCAGGCCAGGAATCTGGGCCTGGGGTCTCCCTGCCCGGGCGTGCAGATTGACCCTCG TGACAGCTCCTAGGCAGGCATTGCTGCCATGTGGCTGACTCTGTCCCTTTCCTGGTTAAATAGACAAGGGG TGGGCGTGGGGGAAGGGGATAGAGTGCCTGTGCGGGTGACAAGGAATTTCTGGGGACACGCTCTCTGCG GCCGCAGACCAATTGAGTCCATGTCCTTTCACTGCTCCTCCCATACACACACTGGCCTCTGGCACCCCGGG GGCCTGGCCACCTGGGCAGAAGGAAGGAGGGAGCGGGCTGGATCACTCCCCAAACCTCTCTCGGAGGGA TTCCAGCTCCAGGTGGTGGTGGTGGGGTCGGTCTCTACCCGGCTGGTGTCTGCTTTGGCTGTTCCTGCCC TGCGAACACTGTCCCCGGAGCGGGACCAGACTACTGGCCCTGAGCATCGGGCCAAGTCCAGCTACTGAAC CTGCTCCGCTCCTCTCCCCAGGTGTGGTTCCAGAACCGGCGCATGAAGGACAAGCGGCAGCGCCTGGCCA TGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACCTTACATGATGAGCCATGCGGCGGCCGCGGGCGGC CTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCG CCGCCTCCGCCGCCGCCTCGCCCTTCAGCGGTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAG CCCTACCCGCGGCCCGAACTGCTGTGCGCCTTCCGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGAC TGGGCGCCTCTGCCGGCGGCCCCTGCTCTGCCTCGCCT 359; ALL; chr7: 32768010-32768497; 7; chr7: 032768257-032768301; Unknown CGGACTTGTCCCCGCAGCCCTTGCGGACCTCCTGGTCGTCATGGCGACTGTGAAATGTGGGGTGGGGAGC ATGCGTTCGAAGCCATTTGCGCGGGCAGTCCCTGCGTGTCCCCCCACGTGCTCCCCACACTCGCAGGACC CCCGCCTCCGAGCTTCCCTGAGCGTGCAGCTTCCAGTGAGGGCAGCCCCACGCACAGCCCCCCACACCCT CCCCAACGCCTTCAGCCCCCGGTGCGCGTAGTCCCCAAGCCCACACGTGCACTTCCACCTTGCGGCAGCT GCACGTACAGCCCCCCACACGCTCCCAGCCCCACTGGCGCAGAACCCATCACCGCTCGCCCTTCACGCGC TTCACTGGGAGTGCAGCCCCCACCCCGAGCGCGCAGCTCCACGCAGCCTTCCACACTCTCCCCAGCGCCT GCAGCACCCCCAGTGCGCACAGCTCTGCCAGTCGCTTCCCCGCGTGCCGCCCCTGCACCACTTCG 362; ALL; chr7: 55040457-55041024; 7; chr7: 055040965-055041024; Unknown CGAGCACGGCCTCGGAGGCTGAGAGGCCTGGGAGGCAGGGCCGCGTCCTGCGGGCTCCACGAGAGCCCT GTGAAATGCCAGTCAGATCCTGGCCCAGTGCCCCAGGTCCTCCCGCAGCCTCGGCAAACCCTCCCCCGGC GCTGGAAACCTTCCCCTGCCAGGCGCAGAAGGCCGCGCGCAAGCACGCAGCTCACAGTCACCGCCACCTG CTCTGAAACCCCAGGTTCAGCGCAGGATCAGAGTCCCCCATCCCCACCCCACGCAAGGGACGCAGGATTG ACAGCGACCCTGAAGAAATGCAGTCGAGAGCTATTGTGAAAGGGCGCTGGCCCGGAGGCCCCCCAGCCC GCGCAGGACAGGCCAGTTAATCGCCTTGGTCCCAGGCCCCTATTAGCGTGTCATCTGCGACAGCAGGACA CGCCTTCCCATGCCAGCCGCTTTGGGGCCCGTGCGGCCCTTTTTCCCTCGCAGCTGCTGCAACAAATAGCA GTTCTTTTGAGGGAAGGAACAGTGTGGTCCTCAAAGTTCATAATGAAAATCTTGGAGAAAAGTCATAGTTG CTAA 364; ALL; chr7: 96488158-96489591; 7; DLX5; INSIDE CGAGCGGGACGAGCCCTGGGGCTCCCACACCGCTGGAGACTGCGGCGAGTTACACGCCATTGGGTCGCT GGAGCTGGGACTGTGCTCCGGGGGCATCTCCCCGTTTTTCATGATCTTCTTGATCTTGATCTTTTGTTCTG AAACCAGATTTTCACCTGAGTTGGGGAACAAAGGCACACGTTACCGGGACACTCAGAGGTCGCCCGCGCC TTCCCCGGGGCGGCGACTGGAGGCATCTTCGGACCTCTGGGCGGCCCAGCCCTCCTGGCGTCTCCCCGCC GCTTGCGGCCTACCGCCAAGAAGCTATGCCTTAGGCAAACCATGGAGCTCTGGCCCCAGAGGGCGCCCTG GCCGGCTCGGGGCGCCCCGGCCCAGCGAGGCCACGACCCCAAGGCTTGTTTTTGTTTGGGCTGGGGGTG GGGGACGCCAGCGCGGCGGGTGTGCGCCCGAGTGTCCTCGGCGGCGGCGCGCCTCGTGTAAGCCTGCGC AGGACGCGCGGAACGCGGCGAAGGTCTCCAAAACAATCGCGCGAGCCGGCGGGGAAGGGGCGTGGGGC GGGCTACGCGCGCCTGTGGTCAGAAAAAGGAGCGAGCTCCCAACCTCCCGTCCTACTCCCTTCACTCCCT CTGCAGCTCAGAGAGGCCAGAATCTGACTGCAGCTCTTGGCGGCGCTCGAACATTCTTTATGCTTCCGTAG GCCCCAGCTGGGTTGGAGGAGTAAAAGGAATGGGACAATCCAGGAAGACTTCTCACGTACAATAGCGCCC CCCACCTCGCGACCCTTCGGTGGCCGTGGCCTGAAGCTCCGTAGGCTCAGGGCACGACCCTTCAGTTTCT CCGCTCCAGGCGACGTTCTCAGCCTTTTCTTAGCCTGAGACCACCGCGAGAACACCAGGCCTTGCTCACCC CCGAGGAGGCTCTACATTGTTAAGAAAACCAGATACTGCTCTGGGCTGCCTAGGCCGCCCTAGAAATAAC CCTCCGCTTGCTTTCAACCCGCGAAATTGGCCCCACAGCTCCGGAGGCCCGCTACGGGGTGGGGGCGGGG GGCGCGGTTAGTGGGAGGTATCTCCAGACCGTGATGAATACCATCCCCACCGTCTCAAGGCCTGACTCAC CGAGTTAAAGCATAGGGGCTGATGTCTTTGGGTCTGTTAGTTTCTCACGGGTACTGTCAAAACAGCTCCAG TCCCATCGAGACTGAACCGCGCGACCAACCAGACGTG 369; ALL; chr7: 155266364-155266696; 7; RBM33; INSIDE CGATTCAAAGATGCCGGCGTCCCGCAGTGTGCGGTTCGTGCCCTTAACCACCCGCTTCTTTGTTTCCCGCC CCTCTGCTTTCGCAGGAGCTCTTGTGCTTGAGTTCAGTGTTAGTGGTAGCGTGGCTACTCCACTTGGAGGT GGCGGCCGTCTGACCGTGTGTTACTGCTTTGCCGACGGGGCCTCCCGGCCCTGATGCGTGTACACTCTGC GGGCTGCACCGGGTGGCTCTGGTTGGGGGCGAAGCTGTGTTGACTGGGAGACGTTGGAAATTGAGACAT GGAGAGATGACGGGAGTGCGTTTCTCTGGGTTTGATCTCCATCCTGTTTT 371; ALL; chr7: 155288454-155292175; 7; SHH; INSIDE CGCGGTGGCCCCCGCACCCGGAGCGTCGGCAGCACCTGGAGCGGTTAGGGCTACTCTGCCGCCGCCGCC CCCGCGGTCCCCGCCGCCGCTGTCCCCGCCGCGGTCCGTGCGCGCGGGCGCCAGTGCACCAGGAGCGCG TGCGCCAGGCGGAAGGGCGCGAAGGCCCGGTGCGCCCAGCTGTGCTCCTCGATGACCGCGTAGCACGAG GCCAGCACCCGGTTGATGAGAATGGTGCCCTGGGCCGTGAGCGGCGCGTAGGCGCCGCGGCCTCCTCGC TTAGGGTCACGCTGTGCACAGCGGCGGGCAGGAGCCGGCGGTCCCCGTCACGCTCGGCCACCACGTACA CGCGCTGGCCCGGGCGCACGCGGCTGGCGAACAGCGCCCGAGGCCCCAGTGCGCCCCGGAAGGCGGCCC CGAGCCCGAGGACGCCTCGGGCTCCCCGGTGGCCGAGTCGTTGTGCGGCGCCACAAAGAGCAGGTGCGC GGCGGTGAGCAGCAGGCGCTCGCGCGGCTCCCGCGTCTCGATCACGTAGAAGCCTTCTTGGCGCCGTCGT CGCGGTCCAGGAAAGTGAGGAAGTCGCTGTAGAGCAGCCGGCCCTGGTCGTCCGCCGCCAGCACGCGGT CCCCGGGGCTCAGGTCCTTCACCAGCTTGGTGCCGCCCTGCTCCAGGTGACCGTGGCCGAGCCCGGGAAG CAGCCTCCCGATTTGGCCGCCACCGAGTTCTCTGCGGGTGAGGAGAAGGGAAAGAAGAGAGGACAGGGC ATTGAGTTCCGAGAGGGAGGCGCGTCTCGGGGAGGAGGGCGCACGCTGGTGCCCGCGCTCCTAGGCCAG GGGTGCGCAAGGCGCGGGGCGGGGCGATTGATTCCAGGCGGGTCCCGCACACACCTCCCTCCCCCAACC CCACTGCCCCAGGGACAGGATTCCGACACATTCCTTAACGACTCCTAAGTCTGGGCTGGCGGTCACAGAG GTTGGCTGGCGTTTCCTGCAGAGGCCGGTGACACTCTTTCCTTCCGCCTTCCTCCAACCCCACCCCCAGCT CCGCACACACCCGGCCTCGCCGCGAATCCATCCAGAGGGGTTTGCTCTGCACTTGGATTCCTCAGGAAGC CTCCTTGAGCTCCCGCGGGCGCCGGGCGCACCCTCCTTCCCTCCCGCCCCGGCGCGGGGCGCGGCGCCT GCTCGCGCACTCAGCACCCGGGCTGCGCGGCGGAAACCCTGGCCCGC 390; ALL; chr8: 142288380-142288718; 8; SLC45A4; DOWNSTREAM CGCACGGCCTCCTCGTCCCTCTCGGGCAAGGCTATCAGCCAGAGCACCTCCCCTTTGACACTGACCGGCG TCCCCAGCCCCGCCTTGTTACTGCATCCGTCTGAGGTACAAGGTTAGAAGCCACAGAACCCGAGCTGCAG CCTGACCCACACAAGCTGCGGGCGCAATGGCGCTTTGCAGACAAGACAGCCTGCCCGTCTGCCCTTCTTC TCGGCTTCCCTTAAGACACAAGGTGACGACACGGACGGTTTCAAGTGAGTGCATCTGGAAATAATCTCAGT GCAGGGGAGGGGTTGAGGCCAAAGATGTCGTGACCTGGTCCCCGCTGTGGCCAGGC 402; ALL; chrX: 39749470-39754050; X; chrX: 039752648-039752692; Unknown CGAGGTATAAAGACCAACGCACGACGGGCGCCGGGGCGCCGTCACCTGCCTGGGTTAACAGTTCCTGCCG CGGGGGCAGGGAGAAAGGCGCTAGAGGGGCGCGGGGTGCCGGCGGGGCCGAGCCCGGGCGCGGGCGAG CCCTGGGTGCCAGGCCCTGCGCCGCACGCCACTCTCGCAGCGCTGCCGCCGGGAAAGTGCCGGCGCTGG CTCTCCCTCCCCTCCCGGGAATAGCGGGCGCAGGCACGCACATCCACACACATCCAACACACACACACAC CGCACACTCACACACCCGGGTGGCCGCGCGGGGCTCCGAGCCGCGCAGGCCTCCTTGGCAGACATCTTCC TGTGGGAGGATTTCAAACGAGCCGTGAAAGCCAGAAACTACACGGGTTACAACTCCGGAATCCCTGGCCG GCCTCGGCCTCCCTCCCCACCTCCGGCCCGGCCCCCTCCGTTCGGCCCGTGGCCAGGAGCCCCACCAAAG GACAAAGCTCACACGCCGAAAGCGCGGGGAGATCCGGGGGCGCAGAGATGCCCCGACGGCCCTTCTACC TTCTGACCCTGGGACCCACGGCCAAGTGCCGCGCAGCCGAGGTCGGCCTTGCTGATCTGTGGTGGCCCAG GGCGACCCGAAGCGCACCGGCTTCAGGGTGCGCCCTGGCCAGGGCTGGGGTGGAGGGTCACATAAGCCA CCTGGCATCCGAGGGTGGCCGCCTCGCCCCCTCAACGCCGCTCTCCAGGGAAGGAGGCGGCGGGGTCAC CAGGGCGCAGCTGACAGCCCCAGGCCCCGGCCAGGGCGCACCCAAAGAAGAGGGAGGCTGCTGCCTGAA CTGGCCTGGGGGCAGAGGGAAGTGGGCCCCGCGCTGTGGAAGGCCCCAGGCTGGAGCGCCGGGGACAGC TGTCCAAGCGGCGAGGGCTAGGAGTGGCCTCGCCTAGCGCTAGCCGGCCAGGCCCTGGAGGTGCTCCGC GCCTTCTCGGCCAAAAGCCAGCTCCGCGCCGCTGGCGGAGTGGGAGGGAGGCGGCCAGGCGAGCGCCCC GCCTTCGTCGCCCGCGGTCACAGGGGCAATTACACTCCTGCTGCAGACGGTTACCAGCTCGCCCGCGCAT CCCTCTCTCGGCTCCCCTCTCCTCCCCTCTCCTCTCCTCCCCTCCCCTCCTCCGCGGAACTGCTGGCTCCA TATTAGCGAGGGTGCCCTGGCAGCGCGACCGAGGCAACTACCCCT

TABLE 4 CpG islands hypermethylated in NMI-BC FGFR3 wt vs mut. Provided for each are: ID; Comparision; Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006); Chromosome; GeneName; Location relative to gene Sequence. 4; SW vs SM; chr1: 2211959-2212429; 1; SKI; INSIDE TAGGCAGGAGGAGGAGGAGGAAGAGGGCACCTGCTGAGATACTTCACTGGTCTGAGGGCCCCTTCTGCCC CAGCTAGCGCTTGGGTGAGGGTTGGGCTTGCGGAGCCGTCCTGTAAAGCCGGGGATGCAGGACGCATTGT CACCCCCTCCTGCCGCTCTTACGAAACACTCTTAATTGAGTCCGATTCTTGGTGAATCAGCCTTCCAAGAA CCGCGACCGCAGCATCCTGTGCCGCTTCTGTGTTCCGCATTTTTCTCTTTCTGCAGCGTTTCCTCTCATTCT GGATGGAAAGCCTGTTTGTCTCCCTCAATCTTTGGCGAGGGTGGCAGGCAGCCAGGCGGCCATTACGGGC CGCGCCTCCCACCAGCCAGTCGCTGGCAGGAGCGTCCGGGGAGGGAGCAGACCCCGTTCACCCTCACCCC AGAACTGAAGCAGCGAGGGGACCCAGACGAGCTGGAATGCAGGCG 5; SW vs SM; chr1: 2226303-2228929; 1; SKI; INSIDE CGCGCTCCGCCAGCAAGACCTGGCGTCTGCAAAACACAGGCGTGAGGGGCGTGCTTACTAATGCCTGGTG TTCCAGAAGGCGGCTCCCGCCAGGCCTCCCGAGTAGGAAGGAGAGGGCTCGGCCCGCCAGACACACACA CACCCACCTGCACACGCTGCTTCTCTGGGCTCTGCCTCACGGTTCTCACGCTGCAGCTCCGGTCTCGCGCC TCCTTTTACGTTGTTTAGGTTTCTTTCTGACATGACTGAGGGAAGTGCGGTTCACAGGCAGAGCTGCCTGG GGAGAGAGGTGGCAGGCGGCCCGTTGTTCACCGGGCCCCGGCCTCGCTAAATTCACACCTCGGCGGCGTC TGGCAGCTTCCGCGGCGTGGGCTTTAGCACAACACAACCCCGTCGGCCCTCAGAGCTGCAGGGTTGCCGA CGTGCCCTCCTGCGCGTGCCAGTCCCTCGCCCCAGCCGTCCCCCGCCACTGTTGTCCTTGATTCTGGTTGG AGGTGTGATTTCCCACATACATATTCATGTGGTGTGTTTGCAGCGTGGGGTGTGAGTCACACGGATATTTT AATGGGGAGAGTGGGGGGGCTTGCGGAGGCGCCGGGCGGATGGACGTGTCCATCTGGCTCGTGGGGAGA CCCGGGGCCCTCAGATGGTGCGATGTCTGAGGCTGCCCTCCTCACATTGATGGGAGCCAGGGCCTACTTG GCTTGCTGCCCCCAAGGGGAACGTGGCCCTAGATACCGGGGGAGGCCCCGCCGCAGCCTCAAGTGACTG ACTCAGGCCCCCAGGTTAGCACAGCTGCCACAGGCCTGGCGGAAACTCCGGATGGGGGTCTGAAAAGCCT TTGTGGGGTCGGGGCACCACACGGGTTGGGCTGATGGCGCGCTGGGGGCGGGGCTCCAGGGCACATTGT CAGATAGATGACCCCACGGGGTGGGCTGAGGACTGCTGGTCAGGTGAGGGGTGTGCTGGGACCGGCTGG GCAGTGACCCCGAGCCGCCTCCGGCCCCCAGGAGCTGGAGTTCCTACGCGTGGCCAAGAAGGAGAAGCT GCGGGAGGCCACGGAGGCCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACGAGAA AAGATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGAAGCGGGAGCTGGAGCAGGCGCGGCAGGCCCGG GTGTGCGACAAGGGCTGCGAGGCGGGCCGCCTGCGCGCCAAGTACTCGGCCCAGGTATGCGGGTGGGGA GACTGAGGCACGCAGCACGGTGGGCGTGAGCCGCCGTGGGCCCCGGTGGCCAGTCCTGCCCAGCCGGAA 19; SW vs SM; chr1: 92718496-92725197; 1; GFI1; INSIDE CGAGTGCACGGCTTTGTGCTGCTCCAGGCTCACCGCGTGCCCGAAGGTCTTGCCGCACATCTCGCAGGCA AAGGGTCTGGTACCGCTGTGGGACCTGCGCACGTGCACCTCGAGCCCGTGCGGCGTGAGAACACCTAAGG CGGGTGGGGCCAGAGAGAAGGCCGCTGAGAGGGGCCGCGGGGCGCAGGCGAGGCGCGGGTAGGGGAAG CGGGCGCACGGCAGGCGAGGTGGTGAGCTCGGGAGCCTCACCTTGCTGCACTTGATGCACTTGTAGGAGC CGCCGCCCAGCAGCGGCGGGTGCACAGCAGCTCCGACTCCACCTTGACGCCAGCGCCCTTGTCTGCGTGC AGCCCGTGGCCACGCTCGGGGTACAGCAAGCCCGCCGCTGCCGTGGGCCTCTCATACAGCCCGGCTGCCG CAGACCCGAAGTCGCCGTAGAGCCCTAGGCCAGGGCCAGGGTGGCACCGGCCCCTGCGCTGCAGCTCCC TGGCGCCCCGGCCCCCGCGCCGCCGGCAGCCCGCTTCGGGCCGTACAGCGCGGCCGGGTGGCCAGGCTC CGGGGCGGGTTCGCAGAAGAGGCCCAGGCCAGCGCCACGCTCCAGGGCCCCACACGGTCGGTAGCTTGC ACCAGGTGCCGCAGGTCAGAACCCGCCAGGCCGCTCCATGAGTACGGTTTGAAAGGCAGGGGGAAGGGC TGGGCTTCGTCCAGCGATGGGCACATTGACTTCTCCGAGGCTGTGGAGGCACAAGGGGAGCGTCCGGTCA GGCTTCAGACGGCAGAGCGGAGGCGCCGGGCTGCGGCTGCGAGCGTGGCGTGTTCGCGGACTGCGGGGC ACCCAGCGCTTGTAGAACACTGCGTGCGCCAGGTGCCAGGCTCGCCCCAGGGTAAAACGTGGCCCGGGCC CTGGGGCCTCGCAGGCCACTATAGGAGGCAGAACAGTAAACAGATCATTAAAAGACCTCGGGAGAGGAGG TCGTAAATTCTGTGCGAGTGCAGCGGAGGCGCTCGGCGTTCCGAGGATCTTTTCTGGCTGGACCCGCGCA CCTGGAGATCCTACAGGGAAGGGCGCATCTATAAATGCCCGTAGTTGAGCTGTTAAGAAGGAGAAGGTGG CGGCGTTCGGCCCCTCACAGCACTCAAGGGCGGAAGGGTCCAGCCACCAGCGCAGGCACTCTCCCAGCCC CTACATGTTCCCATTCAATTCTTTTTCTTCCCAGAATCCAAGAGGAAGGAGGGAGAAGGTCCATAAATGCG GCCCCGAACTACCCGAAAGGCTGCTGTCGAATAAACCCGAAGGTATTAAGATTTCACGAAGTTAAGTGCC 24; SW vs SM; chr1: 163590111-163590435; 1; LMX1A; INSIDE CGAGAGGCCCGGCCACCGGCTCGGGAGCTGGGCCGGTCGCTTTGGGAGCGGATGAGGAAGGTTAGGAGA AGCAGCGAGATAGATCCCAATTTTACAATTCTATTTTCTTTCGGTAGGGTCTCGGCGTCTGGGCCACGTTG AGAGCGAACGTGGGCCGAGCGGAGGACACAGAGTAAAAAGCGACGCCCGCTGTATACATAAATCCGCACC CGCTGCCCGCCCGGGTACTGCCTGCTCTGGCTTCCGCTCTCTTCCGAGGCTGGGCAAGTCCAAAAGTTCC CGAAAGGGGGGTCAAAGAGGGGCGCTCAGTGCACGTGATTTCG 29; SW vs SM; chr1: 219134035-219134808; 1; HLX1; DOWNSTREAM TTCTTCCCTCTTTACTCCATTCCCTAACTCCTGCCTCGTAGGCAGCGGTGGGGAGCCGCAGGCTGCTCCCC GAGTCCCAACGCTACTAGGGTGCTGTAACAGTGATGAGGCGGCGTTGCAGTCTGGCAGGCGCTGCAGCGG GCACCAGCTACGTTTTGCTGTCGGCGGCAGTTACCCGGACGCAAGTTAAGGGGTAGGCGCGCAGAGGCG GTTGGAGGCGGGCGGCCGGCCCCTGACCTCGGAGAGCTGCGCCGAGCAGGGCGGAAAATTTATGGTCTG TGTACACTTTCTGCTCCAGAGCCCCGCGCACCAGAAGGATGGGGCCCTGCGAGCGCGCCCCAGGCCGCGA GCTGGGGCCGCAGGCGCCACGGCCATGTATAGTGCCCACCCGACTCTGTTCTGCAGCGCTGTGGTCATAA ACCTTCCCTTAGAGGGCGCGGCTGTAAACGAAAGTCCGGCGAGAGGTGGATGCAGGCCTTGCCGCCCGGA CCCTCAGGTATAATTCTGGAAACTTGCACGGAAGCCTGGGTCCCGCCATCTTCCCTGTTGTGGTGGGGTAA GAGGATAGTTTATACTGGCTGTTTGGAATCCCGCGCGGTGGATGCAAGGTGGGATTCCAGCCAGCGACGC GCCGCGTGGCCGGGAGTGCAGACAGGTCACCGGTCCCCGGGTGTCTGGACCGCGCCGCTTCCTACTGGG CTTACTTCGGGATCTAGACTTCGGCCTCCGTCCTTGCAAGGGCCCAGATTTGATTCCGGTTCGTCGAGGCG 35; SW vs SM; chr10: 845627-845967; 10; LARP5; INSIDE CGAAACCCTCGAGGAGCGACCACATGACCCCCGCGCTGTGAGCTGCTGGCGGCCAGCGCCCTCGCCTCGA TTGTCTGCAGCCCTGTAGTGGGCCGCGAGGCACGCAAGCCGCAACTACAGCTCGCCACGGGGCACACAGA CAGGCATGCACCACCACTACCCGTCGCCCGGATACACTGAACTGGTTTTGAAGCCTGAACTGCAGAGATC CTAATATAGCAACGCAGGACGTTTACGGCCACCCGCCAGTGACAGCCGGTGATGTGATGACAGGAGGGCC TGGGTGAAAATGCAAGACACTCACTCTCAGAGAACGACGACTCCACTTGAAATTCATGT 38; SW vs SM; chr10: 3150889-3151107; 10; PFKP; INSIDE CGGCCGGGTGGGGACCGGCGTGGCGTCCTGCGGACCGCGTGGAGTTTGGGGTGTCTGACATCGTTCTCC ACGTGGCTATTTTCAGCGTTCTCCCGGGGAAGTACTTGGAAGAGATCGCCACACAGATCGCACGCACAGC ATCAACGCGCTGCTGATCATCGGTGGATTCGAGGTACGTTACCGTTTCTCTCTTGCCGGTCTTGCAGGTGT GAGCCGCG 42; SW vs SM; chr10: 7489383-7495345; 10; SFMBT2; INSIDE CGGCAACCGAGCCAGATCCAAGAGGGGTCGGCCTCGTCTAAATTGGTTTCCCACCAATGGCCTCGGATCA GCCGCGGCTGTGCTGCGGGAGCCCTCAGGACGCGGCTGGGGTTGGTGCGCGGGGCCCGGAACCCCAAAC CCGGCTCGGTTCGGCAAGGTTCAGGGAGACAAGGTAGAGAAGGCTGGGGTGAGCGAGAAGTCGGGCGGC CGATCGTCAGGGCCACGAGCCTCGCCTTGCCTTCTTGGAATCCCACCCAACTTTAAAGGCCCAAAGATCCT GAAAATTCCGAAACGAAACTGCGAGCTGGTCTCCAGAAGTTTGAGAACGGTCTCCCAGGCTTTCCAGCGT CGTCCCGGGATTCTCGGACACCACAAACGCCATCAACCACGAGCACCGGTGTCCGTGGCTATTGCCCCGA ATGGTCCCCATCCGCGTCCCCGGGAACTCCCTCGGCTTTCGCGCATCCAGGTCCCCAGCCCCAGCTACTG GTGCGCCCCGAGCCCCTAGGTGCCAGAGCGGTGGTCGGCCGGGCTCCTGCCCAGTCTCGGCTCCTCCCTC CTCCCCACCAGAAGGAAAAACTTGGGCCCTTCGAGAACCCTGTGGAATGTTCTTTGTAATCAATGTACATC CGCTTCCACGGCACGGCCTCGTGCAAAATCGCGGGTTTCGGGGCCTTGGAGCAAATTGCGCTTGTCAGCG GCGACGTCAGGAGGACAAGGGGAGGGGTTCGCGGCTGAAACTGCAGCTTCGCAGCACAGAGCCATTTTA GGCTGCTCCCCACCTCGCGGGCCCATGGGAAAGCCGGCCCCGGGAGGGCGCGCCCAAACGCAGGCTGGA GGAGCCACGGACGCGTCCTGGCCGGCGTGTCGCCATCGTTCAGCCTCGCTGCCCAGGTGGGAGGGGTCA CCTGCCGCGGGGTCTCCAAGCCAGTGCCGCTTGCTCCCGGCCCCCCCCACTGACAGCACGGCGTCCGAGT GACCCTGTCTAGCCTCGTTCTGCGCTCCTGCAAACCACGTTGCTGCGCTAACTACAAACCTGGCCAACATG TCTTTGTAACCCTATCATTTAAAAACGCTTCCAGGCACCTGGCCGCTGCCAGATCAGGTTCGCGGGCCCGA GGAGGTCCTCCCACCTGCCCCCGCCAGCCCCGGGGACCGTGCGCGGCCTCCGTGTGGCCCCCGCCCACG AGGTCCCTCGGGCAGGAACCGCCGCGCGACCTCTGTTCAGCGGCCGCGTCCTGGCCACGGGCGACCCCT GTCGGGAACCCTGTTCCCGGCTAAGTGCGTTCCCGCATTCCGGTGGCTCTCACCCGAGCTCGCGTTT 44; SW vs SM; chr10: 013553837-13554175; 10; C10orf30; INSIDE TACAGTTGATACCCACCATCCCCATCATCGCTATTAGAATTGGGGTCAATACCCATCATCACTGTTAGACT TGAGGCCGATACCCGTCATCACTGTTAGACTCGGGGTCGATATCATCATCACTGTTGACTCGGGGTCAATA CCCTTCATCACTGTTAGACTCGGGGTCGATACCCGTCACCACTGTTAGACTCGGGGTCGATACCCGTCATC ACTGTTAGACTCGGGGTCGATACCCGTCATCACTGTTAGACTCGGGGTCGATACCCGTCATCACTGTTAGA CTTGGGGTGATACCCATCATCGCTCTTAGACTCGGGGTTGATACTC GTCATCG 45; SW vs SM; chr10: 13556159-13556753; 10; C10orf30; INSIDE CAACATCTGTCATCGCTGTTAGATTTCGGGTCAATATCCATCATCGCTGTTAGACTCGGGGCCGACATCCG TCATCGCTGTTAGACTCGGGGTCGACACCCATCATCGCCGTTGGACTCGGGGCTGAACCCGTCATCGCTG TTAGATGCGGGGTCGATATCCATCATCGCTGTTAAATTTGGGGTCGATATCCGTCATGACTGTTAGATTTG GGGTCGATATTCCTCATGACTGTTAGACTCGGGGCTGATATCTGTCATGACTGTTAGACTCGGGGCCGATA TCTGTCATCCTGTTAGACTCGGGTCAATACCCGTCATCACTGTTACACTCGGGGCCGATACCCGTCACCGC TGTTGGACTCGGGTCGATACCCGTCACCGCTGTTGGACTCGGGTTGATACCCGTCACCGCTGTTGGACTC GGGTCGATACCCGTCACCGCTGTTGGACTCGGGCGATACCCGTCATCGCTGTTGGACTCGGGTCGATACC CGTCATCGCTGTTGGACTCCGGTCGATATCCGTCATCAGTGTTGGGCTCAGGTCGATACCCGTCATCAGTG TTGGACTCGGGTCGATACCCATCATCG 47; SW vs SM; chr10: 15294510-15295293; 10; C10orf38; INSIDE CGACAGCTTCACAGTAGGATTATTGTGATAAAAATGACTCAAGCGATGCAAAAAGTTTCATCTGTTCCCAG AATCCGAGGGAGAACTGAGGTGATCGTTAGAGCATAGCGACATCACGTGCGGTTTCTAATGTCCCTGGTG GCGGATACGCCGAGTCCTCGGAAGGACATCTGGACACCACTTTCAGCCACCTCCTTGCAGGGGCGACATC CGCCAAAGTCATCCTTTATTCCGAGTAATAACTTTAATTCCTTTCTAACATTTACACGGCAAACAGGAATGC AGTAAACGTCACGTCCGTCCCACGGCTGGGCTGCCGTTCCGTTTCCTCCACGAACGGGTACGCGCTTCCA TGAGAAAGGATATTTGGCAATTTTATATTCCACAGTCAGGTGGGTCTGCGATAGCTCATTTAATGTTAAAC GCCATCAGGGGCCTCTCCTCCCGTTTCTGCCAGGGCTTTTCTTGTCTTCTCCTTGGTCATCATCATCATCGT CTTCCTCTTCCTCGTGGGCAGATCTTCTCTGGTGGGGGCTGGCTGCTGGCTCCGAGGGGGCATCCGCAGT CCGTCTGGTCGTCTCCTCCTGCAGGCTGGGCAGCTGGCCACCACTTCTCCGACTCGCCCCTCCAACAAGC ATCGCAGGGCACTGTCCTCGGGGGTACAGACCGTGGTCCCACATTCGCTACCACTCTGTTCCACGTCATCC AGGTACACGAGCTGCGTGTAGGCCGTGCTGTCTGGGGCTCGAGGCTCTTTCTGCTGGTGCTCTTGGACGG GCG 64; SW vs SM; chr10: 88112905-88117344; 10; GRID1; INSIDE CGTGAACGCCCTCGCCTCGCACCTGTGGCGCCTGCCGCGGGGCCCGACCGGAGGCAGTGGCTGTGGACA AGGGCGGCCCCGGCGTAGGCCAGGATTTCCCCGCAGCCGGACCGGCCCAGCTCCGCTCTTTCCTGGGCGA ACAGCGCCCACCTCCGGCCCAGGCGGCGGCGCCTCCGCCCGCGGCGCGGACAGCGAGAGAGAAACCGGC TCCTCCAAACCTGGTGGAGGAGCGCTGCAGAGAAGCGCCGGGCTGAGGCTCTGGGGGCCGCGGGGCGCG AAACGCCGCGCCTACAGGTTATGCCCGGGAGAAGGAGACAGGTCGGGCTCCAGCCGCTGGGCGCTCCTC ACCTCGAAGCGAGGAAAACACCGGGCCACTGAGATCAGGGGAGGTGCGCCCGATACAGGTACCCGGCAC GCAGACACGCCCACCCCCAAACACCGAGAAACAAAGACTGCCCGAGCCACGCACGCCTGCGCGGCCAGC GCTGGGCGCACACCCGCGCCCACACAGCCCGAAGGGCGCCACGCAACCCGCAAGAACACCAGCTCCCCG CGCTCGCAGGCTCTCCGTGCCGGCCCGCAGCGCAGAGCAGTCCCGGCGCCGCTGCCTAGGTGGGCCGGG AAGGCGCGCCACCGCGCATGGCACCGCGGCTGCCGAGGAACAGAGGGTGCCCTGCGCAGCCCAGCTCGT CCCAACCCCTCCGGTGCCCACTGCTGCGACGCCTCGCAGGCCGTGTCCCAGTGGGCCCTGGGCACAGCGG TCACTCACCTTCCTGCACAGCCTGGATGGGTTGTTGGCCTCGATGACCTTGATGGAGTAGGTGATCTTCTC GCTCTGCAGGATGTCATCGTTGAGGCTCAGGTCGGATACCGCCAACTGGAACACCCTGTCGTCCTTGGCC GCGTTCTCCTCGAAGATGGCACCTGGAGGAGAGAAGGGATCAAGACCGGACTGGACAAGAACCCTCTCCC CGCTTCCCTTGGCCCGAGGGTCAAGGCACTCGCAGACCGATGATTGCCGGGTGGTGGGAAGTCTGAACTG GGATTTCAGCTTGGCGGGGTAGATTAAGGCTCTCCGATCTCCACCTGCACAGGAATATGTTCCCCTCCCCC CACCGCCCTCAGCGCACACGTGCACACAGTTGACATGAGTTACACATGCACATCCCACAGGCTGCCACCA GGTCACACACGTGTCTCACAACCAAGGCACCACATGTCCTAGCCATGCTCCACACAAGGGACTAAGCCAA GCTGGGGTGGCCCCAGGCAGCGCCCAAATCCTTGACATGGTTCCATAAATCCCATCCCAGGAGCCAGGAAG 71; SW vs SM; chr10: 102986025-102986636; 10; LBX1; PROMOTER CGGGGGGCGCCGGGCGCAGGCCGGGCATGGGGCCTGAGCTTAGGCCAGGTGGAAAGGTGGAAGGACCTA GTGGGGACAGACGAAGAGACCGAGGAGCCGCCCGCCCGGCTAAATGGACACAGGAAAGCCTGAGTCAGG CTTCTCATAATAAATAAACTGCACGTGAATAATTCAGCAGTCGCGCGGGGGCCGGTTGCATCAGCGCCGC CGCCGCCGCGCGGCGCCCAATTCCCCGCGGAGGGGAGTAGCCAATTAAGGCACTTGAAAAGGGAGTCGG GTGGAAGATCCCCCGCCACCAGTATCCTGGATTTACCCAGGTCGAGTTCAGAGAGCCTCCCCGGTCCCAA CCCCCTCGGGCCCCATGGGTCAGGGGGCCGCCTGCTGGGAAGTGCTACCTCAGCTAAGCCGCTCAGGTGT CCCGAGACTCCGGGCAAGGGAAGACAGGCGGCGAGACGGACCAGAATAAGGGATGCGGACGTCTGACCT GTGGAAAACCCAGCATCTGCAGTGCCCAGCCGCACAGGGAACGTGGGCGGCGTGGTTCCAAGCACAGTG AAGACGCCAGGCTCGGATCTGTGCTCAGAGCCGGGATCCCTCCGGGCTGCTTCG 108; SW vs SM; chr14: 28317076-28317375; 14; FOXG1B; DOWNSTREAM CGTAGCGACGACGTGGTCCTTGTAGGACCAAGCATTCTTGGCATTCTGTCGAGATTGAGATTCCAGAGCAT CGGATGAACGGGACTTATAGCTAAGGCGTACTCACCCACCCCTCCCTTCGTCTTTTACGCACGCAGCAACT CGTCCTCACGTGCATAGGGGTAGTGGACAGTGTTGACTTGAATTGCTGTCCCTCGTTCCAAGCCTTTCCTG TGAATGAACCCGAAAACACTCGACAGGTCGTGAATAATCGTTTTAATGAGTGTGCAAAGCGTGCGACGGG GTGCACCGACTGTCG 126; SW vs SM; chr15: 58079172-58079459; 15; FOXB1; PROMOTER CGCTGGCGGGGGTAGGGGGTGTGGGTGGGTACGGAGTCCTTTCACTGCCCGTCGGCAGTTGGCACCAGA GCGGAAAGTGTGTCCCCTCCCCCGCCTCTCTCCCTTGGGCAGTTTGATTTCCCGCCAGCTCAGTCGGAGTG GCCTGGAAGAGCGGGCTCAAACTCCAAAGGCAGTCGTGGGAGAGTCGTAGCGGATACGTTTCCCCTGACA TGCGCCGGGTGCTCGTCTCTGCCCCCCACCCGCCCCCAAAACCCAAACCTGCAAGTCGATGTTGTCCGGT GACCCCG 127; SW vs SM; chr15: 58083339-58085812; 15; FOXB1; PROMOTER GTGCCTAAAGTTACCTAACGATACAAACCGGATACAACGCAGAGGAAACAGAATACCCCAGCCAAGCAAT TTCCATGTCAAACATCATCCGCGCGGCTGCTCCATCTGTGAACGTGAGTGGTCGCCTGCTCCCTCTTCCGC GGCGGCCGCTTCCTCATACCTTCACACGGCGCACACCGGCCGGCGCGTCCAGCTGCCTGCCCAGTGGCCG AGGCTCTTCCCCCTCGCCCAGTCTTGAGCTGGAAGTGATTCCTATTGGCCAAGGTGTCCATGTAAATAGGT GTGAAAGAAACAGAGCTGGCCGGGCTCTCCCTTCTCGCTCAGTCCCCTCCCTCTGCAGCCCCCGCTCCCC CTCCTCTTCCTCCTCCTCCCAAGGCGATTGTCATATGATAGCTAAGAAGTGGCACATTAATGAAGCGCCGC TACAGGGGTCTTTTCTGCTCCTGTCACCGCTTAAACTATCAGATGGTTCGAGGGAGGACATGGAGGCAGC CACCTAGCTCAGCGGAGACGCGGAGCCCACAGCAGCGCCCTCCGGAGCCCTAACACGTCGCTGCCACCAT CCGCGCCGGGACTCCGCAGCCGAGCTCGGCCGCCCGCAGGACGCTCCAGGAGCGTCGCGACCGGGCGGC ACGGGACGCTGCGGGGCTGAGCTCAAGAGCCCAGGTTCGCGCCGAGTCCAACCGGACCCGGACGCTGCG CGCGGAGTGCGCGTCGAGTGCGCGCCGAGAGAGAAGCGGCGCGCAGCGGCGTCCTCCCGGATGCGGACG CGCAACTTGAAGCAACTTAAGGTGAGCAGCTCTCTGTTCCGTCCCTGCCCCCTATTCTGGCCCCAGTACCG ACTTACTTCCCGGCTATCCTCGCGCCGTTCGCCGGCTTCCCCTCCCGCGCCCACTAAGCCCGCAAAGTTGC TGGCGAAAGAGTCCGGGCGCTGGCTGATCGAGCGCCGCAGCCCCACCCCCGACCCCCGAAGTCTGTTACT CGGTCTGGCTGACCCCGCCGGTGTCTCTGTGCATCCATGCTACCTTTCCCTATTACCCACCCCCTTCCCAG ATCCGAGCAGTCCGCCGGCCCGCGCGGACCCAGAGCAAGAAGAGGGCGAGGAAGAAGATGCCTCGCCCG GCCGCAACACGTACAGCGACCAGAAGCCGCCCTACTCGTACATCTCGCTGACCGCTATGGCCATCCAGAG CTCTCCCGAGAAGATGCTGCCGCTGAGCGAGATCTACAAGTTCATCATGGACCGCTTCCCCTACTACAGG GAGAACACGCAGCGCTGGCAAACAGTCTGCGCCACAACCTCTCCTTCAACGACTGCTTCATC 167; SW vs SM; chr17: 47590175-47591465; 17; CA10; INSIDE CGACGGGAAAACGGGGGGAAGGGGGGAGCCCGACACGGCACACACACATACACACTCGCACACACTTCC GAGCGAGTGCACACTCGCACTCCCACCCGACAGCCGGCCAGGGACAGTCACCCCCAAGTCAATATCGCAG TTTGAATTGTTCCGGCAAATCTCCCCTCGGGCTCGACGGATGTGCGCCCCAGATGTGCTGACACATGTCCG ATGCCTCGCTGCCTTGGAGGTCTCCCCGCTCGCGTGTCTCTTCTCTTCGCACCAGCGGCGGAAACCGCACT AGCAGCGGCGGGGCGGCGGCGGCGGCAGCAGCCACCTGAAGCCACCAACACTGGGCTCTTCCAGCAAAA ACGAGACCCCGATTCGTCTGGCGCCCCAAGAAGACATAGACGATAGCCCCCCGCCGGGCTGCGCCGTGCA ATTCCGGGCTCCCGGGAGCGCGTAGCTCGCTGGCTAACCCAGGCAGTCCGCGGCAAGTTGCCCTCGAAGT CCGCCCCCCTCACCGGGGCATGGTCGGAGGGTGGCTGCTGCGCTCCGGGGCAGTTCTTCTCCTGCTTCCG GGGGGCGGGGAAGGAGCAGACACAGCAGACACACAGAGAAAGAGAGGCAGGGATTATTGCCCAAACCGC CAGCCGCCGGCAGCCTCCGCCGACCCTCCCTGCTCCCCAGGTCCGCGCGCAGCCTGCAGCCTCTCAGCCG GGTTCCGGCAGTGCGTCCAGGGCGCCGAGGGGAAGGGCTGGGCCCCGGGGACTGGGGCGCGGTGGGGG CACACAGACTCTCCAGGTCGGCGCGCCCTTCCTGCTCCTCTGCTATTTTCCTGAACTCCCCAGAACCCCCA GTTGCCTGGCTTCCATCGCCCGCAACTAGCGCCGCTGTCGAGATTTTCCGCAATACAACTGCAGGGGTCG TTATTTCCTCGCCTACGGATCCCTACGCTTCCCAACTCAGAGAGAGGAGGACAGGTGGGGGCGGGAGGGG GAGGAGGAGAAGGAGGCTTGGCCAGGTGAGCGTCCTCGCCGCCGCCGGGCGTCCCAGCGTCAGCTCCGC AGCCCGGCACCCGGGGGCGGAGGCAGGAGGCCCGGGCGGGGAGGTGAGGCTGAGCGCGGCCATGAGGA GGGGAGGAGGAGGCTGGGTGTCACAGCTTCAGGCCACCTTGGCCGCCGCCTCGGCCCCAGTCCCTGGCA GCCGCCTCCGCACTCCGCCCCGCCCTGGCTGCCTCTGTTACCCTCCAGGATTTTCGAGTTTCTCTTCTTAA AAAGAACTTCGTGCTGCGGGTTCGGCGG 174; SW vs SM; chr17: 67623575-67623903; 17; SOX9; PROMOTER CGTGGGTCCGCCTACCCCAAGCACTTTTTGTGACGTCACAGCTCCGAGGACCATCCGGGGGCTTTACTCTC GCGGAAGCCCAAAAGTTGGGGTTTGACCTCATGACCTTGGCCTTCCCGGGGGGCGGAGGCCCTCGGGACA GGACGCGCTGTCCCCGGAGTCCGGAGCTCAGGCCAGTGGCAGTCGACCCAGCCCCCGAGACTCCCTCACG CCGCTCCAAAACCAAAACGGAGCCCAACACGAAGCTGGGTGAAGCCGTAGCTTGCAGGAGCCAGGGAGAT GCGCTCTGCCCGGACTTCCCGGGTCCTGTTGAGACGGAAAGGATCG 175; SW vs SM; chr17: 67627870-67631593; 17; SOX9; INSIDE CGACTCGGCTGACGTTTTTGACCCGGCCAGGAGGCAAAGACCAAAACGTCAGAGCAGTAGCCCTGTTACT GAGGAGCGTCGGCAGGGTCGCGGGTAGAGGGGGCTGGAGAATGACTTGTCAGAGCTCAGGTCGATGTGG CGCGGGGCGGCCTCGAGAGCGCCGGGCTCCTGCGTGGCCACGGCCGCCGCTGCCAACCTTCGCGGGGAC TTAGCTTTGCTTTCCATTGACTCCCTTTGCAAAAGCGCAGCAGAATCCTGACCAGCCGCACCAGCCCCGGC GAACCCGAGCATGTAATCTATTTATATGGATTATTACGGAGGAACAGCGGGCGTTGAGTCACCAAAACATT TGCTTCAAAAGACTATTTCTAAGCACTTTTGCAGGCAGGCAGGCTCGCTCCAGGCGCGTAAACTCGGCTAC GCATTAAGAAGCGGCTGCTTTTCGAATACTGCAAACCCAGCTAAGTCCCCGGTGCCGCGGAGAGAGCAGT GAAAAGAAATGTCGGAGGTGGGGGTAGATCCTAGTCTAGACACACACACTTGCGCGCACACACACACACA CACACACAAGATTCGCGCGGAGAAGGCACTAAAATTCTGGCATTCCGAGAGTACGACAAACTACACACTT GGAAGTCCCGGGTCCCCCGCCTTCCCCGCAGCACCCCCCGCCCCCCCACCCTACCGTCCGCCCTTTGGCT GCGATCCCCTCCCCTCTCCTCCCCTCCCGCCTCGTCACCCAGCCCAGTGCCACAATCCTCCTCCCTCCCCA AAATCGGGTCCAATCGCTGCCTGCCAACCCTGGGACTGCTGTGCTGTGATTGGCGGGTGGCTCTAAGGTG AGGCGGAGTATTTATTAAAGAGACCCTGGGCTGGGAGTTGGAGAGCCGAAAGCGGAGCTCGAAACTGACT GGAAACTTCAGTGGCGCGGAGACTCGCCAGTTTCAACCCCGAAACTTTTCTTTGCAGGAGGAGAAGAGAA GGGGTGCAAGCGCCCCCACTTTTGCTCTTTTTCCTCCCCTCCTCCTCCTCTCCAATTCGCCTCCCCCCACTT GGAGCGGGCAGCTGTGAACTGGCCACCCCGCGCCTTCCTAAGTGCTCGCCGCGGTAGCCGGCCACGCGC CAGCTTCCCCGGGAGCCGCTTGCTCCGCATCCGGGCAGCCGAGGGGAGAGGAGCCCGCGCCTCGAGTCC CCGAGCCGCCGCGGCTTCTCGCCTTTCCCGGCCACCAGCCCCCTGCCCCGGGCCCGCGTATGAATCTCCT GGACCCCTTCATGAAGATGACGACGAGCAGGAGAAGGGCCTGTCCGGCGCCCCCAGCCCCAC 199; SW vs SM; chr19: 42586101-42586705; 19; ZNF569; DOWNSTREAM CGATTGGGGCCTCAGCCTTAGTTCTTCCAGCTGGACCCTGGGATGGTGCGGGGCTGTGGCTCTGGGAAGT ATCTTGGCCTGCACGCGGTTTACATCATTGGGAGCACAGGCCTCGCCCTCCGAACTAGAGGCCCAGAGCC CTTCGCGCCGAGCGTTTCCCGCCTTTCCCCTGTCTCAAGTCATTGCCCAGAGGCCACTGCGGGCCGTTCCT GCCTGTCCGTGGAGCTGCGGCCCCCGTGTTCCCAGGGTGAACGAGCACGTGCGAGGCGGTGGTGCTTGTA TCCGGGATAACAGGTAGGGCGGCTGCATGCTTCATAGAGGCCAGCCTGTGCCGACCGGGAGCTGTAGGAC GGTCTGTGTCTGGGGCTGCTTATGGGTATTCGCGTGCGTCTGCCGGTGCGCGGTCCGAGCCTACTCACGA GAGCGTGTGTGTGTCTTCTGTCTCGTGTTGCTATGAGTTTGCATCTGTGTGGCTGGAATAGCTTGTTTGTG GGGGCCCGCGCGTGACCTGTGTGTGCGTTACTGTGTGTGTCTCAGGCAGGATAGTGACGGGCCGTGTGAC TGTGACGCCATCATCAGGTTGGTGAGATGGCGTGACCGCG 204; SW vs SM; chr19: 57082579-57083180; 19; ZNF577; INSIDE CAGCAGACCCCTTTTTAAGTACGCATGTGATAAGCAATGAACACGAACTGCCCAGAGCAGTCTCCAACACT GACACGATTCGCTTCCCCACCACGACGCCCTAGCGCTACTGTGCAACGAAGACCTCCAAGCACTGGTTCC AATGCGGAGACCATGGGCTCCCAGACTCTGGGAACTCCAACACGACTGCGAAACGAACTCCGAGCGAGGA CTCCCCGAGAGCTCCCCGCAACACGGACCTCACGCGCTAGCGAACAACAGAAAAAAAAAAGCGCGCTCTC CCTGCCCCTGAACATTCCCAGAAGCCCACGCAGACCAGACCGATGACCTGTCTCCACTGCTGGAGGCGAG TCAGGGACCCGAAGTCTCTAAACACTCGCCTCTACCCGCCGCCCCGCGAACCCCACACACTGCAGACGCG ACACTCGCAAGTTTCGGGGATGGCGGCCGGCGAGGGCATACTGCGTCTTTCCGGAGACACGGAATACGGC ACCAGCCGTCCCTTTATGATGCAATATGTCTGCGCCCAGGGGACGCTTGCTGGGAGCAGCCATTTTCAACC CTACTGCCGTAGAGCAGGCGGAGTCCCTCTTTTCGCG 233; SW vs SM; chr2: 119329502-119332035; 2; EN1; PROMOTER CGAGGAGGCTGCAGGGACGCGCATGGAAGAGCCGGTGCGTGGGAGGGTTTGCGGGGGGGACATCGCGCC CCCTAGGGGTGACCCCAGTGGGTCCCGTGTGCTCTCCGCGGAGCCGGCGGAGCCTTGTCTCTGCACCCGG CGCGCAGCGGCCCCTTAAACAGTGGAACCGTGAGGCCGCTCTAAGCCGAAGGGCTGGAATCTGGGTTTCT CGGGTTTTATTTTAGACCATTCGGCACCAAGCCCGAGCTCCCCCGCCGCACCGCTTCCAGTCCCCTTTCTT TCCATAGAGCGACCGAAGCCGGCGGTGGCGCAGGGAGCCGAGTCTGATGAGCTCGCGGGCGGCTGAAGG CCGGCTTCCCTGTGGGGAACGCGCCACCTGTCGGCGCCAGTGAGAACTGCGTCTGTGTGGCGCCCTCGGG GTATTCGGGGCTGCGGGGAGATGTGTGCCTGAAGCCCTCGCTTGCGGTGGGGACGTCCGGCCTCTTTCCT GGCAATTGACCCCTGAGGCGGGAGAGACAACGGAATTCCCACAAAGGGATCCTTCTCGGGATCTCCCCAC CTCAAGACAGCTAAAGCTGGAGGAAAAGCCCCTCCGGGGGGTGGGGGGTGCGGGTTTGCCCTGGATTCC GAAAGCAGAAAATACCCGAGCCACACAGGGACGGGCGCCGCGTTGGTAGTCGGGGCTACGTTCCTACTCC CTCTACCTCCCCCGCGCTGTGTGACCCTGGGCGGAACCCCGCTGCTCTCTGGGCCTCAGTGTTCTTATTCG TAAACTGAGGGCGTTGGAGAGATTGGTCCTCTCCCAACTCTGACCTTGAAACTGATACTGAATCTGAGCAG CGTCTGTAGACACCTGTGCCTTGCCTTCTATTTCTAGCCTTGAATAAATCCTGGACTTTTATGTGCCATTTA TATCCTAATCTCATATATATTTAATGTATAACTGCTGCCATATTGTTTTCTCAATTGTCTAGGTTTTCATTTG GATGGGGTTAGGATGGTCCAAATTATCCCGATAAGTGCCCATTAACTTAAACCTTTTTAAAAAATGAAACC AGTAAAACTTCATTCACTTTGCAGTGTGGACACTGCTGGAGAGCACCCATGTCGTGGGTCCGCGAGGACA CAAGGAGGGGCTTAGAGACATGCGGGAGGCTTAGATGAGAAGACAGCACCCGGGCAGCGGTCAGTGTTA GAGAGAGGACCCGTAAGAAGGGCCGAGGCTAGAGGGAGAGCGAAGACTGAGCCAACGACGCACCTGAGC CCTGGGGTGGGGGTGGAGCGTGGCTCCTAACCCAAATCTCCCTGCCAGGCAGTGTCCGAC 264; SW vs SM; chr20: 54633629-54640196; 20; TFAP2C; PROMOTER ACCATGAGCTTCCAGTTCCTACGGGTGAGAAAAGAGGTGTCTGTGTGGAGGGCAGGTGCGACCCCGGGG GCTAGCAGAGAGGAGAGGCTGCGGGAGGACTCGCTGCGAAGGGCGAGGGGTGGCGCTGGTGGGACGGG CGCCTGGGGCCGTGCAGGGTGGCTCCTGGGTGCTGCCCGGGCTGCCTGTCGCCCAGTACTGGCGCAGGA AGACGGGTCCGCGCAGCGTCTGGCAACAGTGGCCTGCTCCACGCCTGGAGGCGACCAAGTTCTGAGTTAA AGGCGCCGGGCTTAGCGGGAAGTGTATGGCGACCCAGAACACGGAGCGGAGAAGGCCTCAGGGGACACG AGGCTACCGCCTTAGTCCTCGGGCCTGCGCTCCGAGCGGTTAGGGTGCGTACGGATGGGCTCCGGGATGT TAGTGGAGAGGTGACAGGAGTCTACCATCCCACGGCCAAGCGGTGAGGCCTCCGGCGGGCGGGGGTCCC CCCCGGGGCAGGGCAGGGGGAGAGTCAGGCATGTCTCTAACGGGCTCCCTAGTAGAACCGCTAGGAAAG TGGCCTTCAACCCTAGGCACCTTTGTGGCTTTCAGGTAGTTGGGCGACTAAAAATTCACTTTTGCCTGCGT GAAATGGGACAGGTGGTTGTCAGGTTAGAGACTGTGCCCACGAAGTCTCGTTTGGCGGGCCGGGACTGAC GTGGACCCGGGCCCTCCTCGGAAGCTTGGGAACCTGTGAGCCCCTCAGCTCCTCGCCTCACTTTGCCTGT TTGAAAAAAGGAGTTGTTTGAGAGAAGAGTTAAGGCTCAAAAGGTTCTAAACGAAGAGCATGCGGCCTGA CGCGGAGCGCAAAGAAGCGAGCAGTGAACTGAATCTGGTGGGACTGAGACCAGAGGCGTCTGTATGCGG CGGCCGCTTCGCGCCCTATTAAAGCAATCTGTTATTTACGATAATCATTTTGTAATTATTTTGGAGTGGCTG TGACTTGATGTCTGTGGTGCCCCAGGGCATGCCCTTACTGGACATAGATACTTCAGGGTGCCCTTTGACGC CAGTGTCGGTCCAGTGGGTGCCAGTGCCGCGAAGGGAGGGTGGCGGGCGTGAATGCCCCCTCCTCCTGG GTTGCCGCAGGCCCCGGCCTTTCCACCTTGCTTGATCCTGGCGGGTCTGCCACTTACTGAGGTCCCTACCG GCGCTCACGTTGTCCCGAGAGGCGGGACAAACGTCCGGCGCGTGGCGCGGAGTCTGCGAAAGCGCTCGG GGGCCTCCATCTTCTGCTCGGGAGTCCCTCCCTGGGGCGGGAAGAGGAGTCGCAGATCTGCCCGAATCT 280; SW vs SM; chr3: 148619483-148620015; 3; ZIC1; DOWNSTREAM GAGTGCGTAAAGGGAAATTTTTGCATTGGTGGATTTATTGAAAGCATGGAAACAGTCTTCGGGGGTAGGT GTAGGGGGTGCAACAGCGAGACTTCCCCACAACACCTCCACCGAAGGCTGGGTCGTCGCGTTTGAGGGAC CCTCCCGCCACCCCGCAGCCTGGCGGGGCGCTTTCCAAATCGTCGCGGCAGGCTCTGGCCGGGCAGGGC GAGATGTGCGCATGCGCGGCCTGTGGCCCGAGGTTCCACGTGCTGATGAATATGCATGAGACTCCCCCGC CCTCGCGGGCTAGGAGAGAACCAAGCAGAGGCTCCGGCCTGTGAAAGTCGCTGGCTAGGCTCCCAAAATA GTGCGGCGGGGTAGCTGCACGTGTTTGTTTTCAAACCGCGCTGGTTTAAGTGAGTTCACACTGCGGAGCC GACAGCAGAGGGTAGAGCAACCTGGGGCTGCTGCCATTGAACGGCGAGTTGAGCGGGCCTGTCAGGGCC TCTCCGCCGAGGGCCGGGGGCTGCATGGTGCTCGAGCCCCAG 289; SW vs SM; chr4: 134288613-134289892; 4; PCDH10; PROMOTER CGCGTTGCCCCTGCGCCTCCGGAAGGGGCACTCACAGCTGGTCAAGCGCGTCCTTCGGAACTCGGGGAGG CTCCGTTGGGGCTTACACAGAGCTAAGCCCTGGGCCAGGGAGGATGGATGCAAGTACGTGCATGTGCAAA CGTGTTCGCAGATACCCGCAGCGGTGCACACTCGGGCCCCTCGTGTGCACGGGCCCTGCCCACCACCCCG CCCGCGTTCGCCGCCGCCCCACTGTCCTCATCCCGCGGGCTGACCCCAGGATTGGCAGAAATCAGTGGTC TAATCTAGCATGTGGGTAAAGGGATCGATCTCCAATTGCCAAAAAAAAAATAGAAAATAGCCGGTGTTCCC AGCCGCTGCGTGGCACTTGGCCGCACAAGGCGCAGGGATATCAGAGGCGCTTTGCAGCGCTTGGCGGTG CTGTGTGCCGGATGCCCCAGAGCCCGGCGTTAGGATGCGGGCTTGTAGGAAGCGGCTCAAATCAACTCCT CAGTCACTGATGAACGCGCTCACGGCTCGAAGCTAGGTCCTCGAGTGAGTTAATCTACTTGGTAAGTATTT TGTGAATATGTATTTTGGGAGGAAAGAAGCACGTCGAACGCGTCTGCCCGTCTGTAAGCGCGTCATCCCC ACATCCTTTAGCGTGAATTCCTCCGCTTTTTAGGAGTCACCTCCACCCCCTACTCCGTATGCTTCGCGCCTT TCCTCACGGCCCCGTCAGACCCCCTCACCTTTAGATTGACACATGCCATATAATACTCACTTTTAAAATGC CCTGCCAGTCTCTCTAGGGTCCCTTAATTAGGTAACCCTTGCCAATTAGTGGGCCCTGCGCTACTTTTTCC CTTCTCGATGATTTATTTCCATGATGCGTATTAGGGAAAATACCTTAAAGGAAAAAGAATGTTAGCATCAT TGGAAATCCCGCTCCTAGGAGAGGATATCGCAGCTGTGCTATTATGTTTTCGCATTTGCTGATGCAAACAG GGGAACCTCTCTATTCCCTCCCCATTACCTGCGGCTGGGGACTGGGAACTTTCCGCGGCATTGTCCCCAGC CAGCGCCTCGGGACCTGCGGGGCTGTTCTCGCTCTCACACTCACACTCACCCCGGCCGCCGGGCGAGAGT TCTGTCCCGCCCCGCCCGGCTGCCGCGTGACGTGTCTGTTTGGCGGCCAGTTTGGCCAATCATCGGCAGC TCGGTGGGTGGTGCTCCTGGGCGATTGGTTGGCAGAATGAGGGCGCTGCGCAAAAACGGAGAAGCCGAG CGCTCG 290; SW vs SM; chr4: 134291113-134293078; 4; PCDH10; INSIDE CGGAGCCAGACCTGACGGTGGAAATCTCTGAGAGCGCCACGCCAGGCACTCGCTTCCCCTTGGAGAGCGC ATTCGACCCAGACGTGGGCACCAACTCCTTGCGCGACTACGAGATCACCCCCAACAGTACTTCTCCCTGGA CGTGCAGACCCAGGGGGATGGCAACCGATTCGCTGAGCTGGTGCTGGAGAAGCCACTGGACCGAGAGCA GCAAGCGGTGCACCGCTACGTGCTGACCGCGGTGGACGGAGGAGGTGGGGGAGGAGTAGGAGAAGGAG GGGGAGGTGGCGGGGAGCAGGCCTGCCCCCCCAGCAGCAGCGCACCGGCACGGCCCTACTCACCATCCG AGTGCTGGACTCCAATGACAATGTGCCCGCTTTCGACCAACCCGTCTACACTGTGTCCCTACCAGAGAACT CTCCCCCAGGCACTCTCGTGATCCAGCTCAACGCCACCGCCCGGACGAGGGCCAGAACGGTGAGGTCGTG TACTCCTTCAGCAGCCACATTTCGCCCCGGGCGCGGGAGCTTTTCGGACTCTCGCCGCGCACTGGCAGAC TGGAGGTAAGCGGCGAGTTGGACTATGAAGAGAGCCCAGTGTACCAAGTGTACGTGCAAGCCAAGACCTG GGCCCCAACGCCGTGCCTGCGCACTGCAAGGTGCTAGTGCGAGTACTGGATGCTAATGACAACGCGCCAG AGATCAGCTTCAGCACCGTGAAGGAAGCGGTGAGTGAGGGCGCGGCGCCCGGCACTGTGGTGGCCCTTTT CAGCGTGACTGACCGCGACCAGAGGAGAATGGGCAGGTGCAGTGCGAGCTACTGGGAGACGTGCCTTTC CGCCTCAAGTCTTCCTTTAAGAATTACTACACCATCGTTACCGAAGCCCCCCTGGACCGAGAGGCGGGGG ACTCCTACACCCTGACTGTAGTGGCTCGGGACCGGGGCGAGCCTGGCTCTCCACCAGTAAGTCGATCCAG GTACAAGTGTCGGATGTGAACGACAACGCGCCGCGTTTCAGCCAGCCGGTCTACGACGTGTATGTGACTG AAAACAACGTGCCTGGCGCCTACATCTACGCGGTGAGCGCCACCGACCGGGATGAGGGCGCCAACGCCCA CTTGCCTACTCTATCCTCGAGTGCCAGATCCAGGGCATGAGCGTCTTCACCTACGTTTCTATCAACTCTGA GAACGGCTACTTGTACGCCCTGCGCTCCTTCGACTATGAGCAGCTGAAGGACTTCAGTTTTCAGGTGGAA GCCCGGGACGCTGGCAGCCCCCAGCGCTGGCTGGTAACGCCACTGTCAACATCCTCATAGTGGATC 309; SW vs SM; chr5: 133887842-133891327; 5; PHF15; PROMOTER CGAGAGAAGGTGAGCTCGGCGGGCGCAGCGGGTTGGGTGGGTGTGGCCCGCGGCTCCGGGAACAGACCC AAGGCCCCGCCACCGCCGGCTAGCAGCCCGACAGCCCGCCCGCCTGGCGAGCGCAGGCCTTCTTCCAGAA ACTGCGAGGATCCGAGCGTACTGTTTGTGCACCACAAGGTCAAGTCGGGAAGTGGAGCCGGAGGAGGAG GGGCGAGGAGGCGAAGGGTGGGGAGAGGGGCGCCCCGCTTCCTCGCCATGTGCCAGCCTTTGGAAGTTA CCCCTCGGTTTTTAACTTTCGGGGTAATGGGAAGGAAGAGCAAGGAGGAAGGGGTCGCCCCGGGGCAAAA TCCTGCTGGGGCCAGGATGTGCAACCACCCACCCACCCGCTCATCACTGCCTTCTCCACCCCCCGGAAAT GCGGGGCAGCGCTAGGCGCCAGGAGGCACCCGGGAGGGGGAGGGGGCGACGAGCCCAATGGGGACCCT CTCTACGGACCGCCCCTCTTTTCTTGAGGTCGCCTACAATTTCAAGTTCCCCCGCCCGGAATGTTAGTTTT CCATTTGGAGTGGGTGCGGGGAGGAGGGCCGCGCCCCCTCCCCAAGACTCGCGTTCGCCCCTCCACCCCC TCCTGCCAGCACTTTCTGCTCACTTCTGGTGCTGCAAAACGCCACGCAATTTATTCGATTCGCATTTTAAAA CCAGCGATTCAGAAGCAGGGCCTAGGGCGAGGGTCTTCCAGCGCTGGAGCCCCGGGGGGCGGGGTGCTC AGTGCAAACCTCGTTCCCTCGCGAGTGTCGCCTCCAGGCTGTTATTTGCAAAGAAACGTCTTTTTGACGCA GGGAGAAATGGCAAATTTTAAGTACGTCATTAATATGGCGCCAAAAGATTTTTTTAAGTATAAGCTCGCTT TTTTTTTTTTTTAAGGTTGCGGGGGGCGCCGCCCGGGTCTGGGCGCGTAGGGGGCGGGGTGTGAGCAGAA AGTGTGAGTGAAAGAGTGGAGGGGCGGGGTATGTGTGTGAGTGTGTGAAGTGTGAGCAGACCTGATGGG ACTTGCACGGGCGCAGCCGCCGCTCGGGCCCGGCCCTGGGGACAGGGCGGGCTAGGGGCGCCCCAGAGT CATGGGGAGTCCGGGCCCAGGGTGCCAGCAGGCGTGGTGGTGGGGCTGCGAGGGAGGGCACCCTTCCCC CACGGGGCCCGCAACGCTACCTGGACTCCCCGCCGGAGCCAAACAACTGGGCGGGGGGTTGGGGGGGCG GCGACGGGGGTGTCGGGAGCGGAGATCGAGTGAATAAGAAAAAAGTGGCTACTCCCCCTCCCTCGCTCC 328; SW vs SM; chr6: 5080084-5080849; 6; LYRM4; INSIDE ATCCCTATTCCTTCTCCTTCCTCTCCCTTGGTAACGGCACTCCTAGGGCTGTGGAGGGTGCGGTTCACTCC TGGGACTGTGGAGGGTGCGGATCACTCCCGGGACTGTGGAGGGTGCGGATCGCTCCGGGGCTGTGGAGG GTGCGGATCGCTCCCGGGGCTGTGGAGGGTGCGGATCGCTCCCGGGGCTGTGGAGGGTGCGGATCGCTC CCGGGACTGTGGAGGGTGCGGTTCACTCCCGGGACTGTGGAGGGTGCGGATCGCTCCCGGGACTGTGGA GGGTGCGGATCGCTCCGGGGCTGTGGAGGGTGCGGTTCTCTCCCGGGGCTGTGGAGGGTGCGGTTCACT CCCGGGGCTGTGGAGGGTGCGGTTCACTCCCGGGGCTGTGGAGGGTGCGGTTCACTCCCGGGACTGTGG AGGGTGCGGATCGCTCCTGGGGCTGTGGAGGGTGCGGTTCATCCCGGGACTGTGGAGGGTGCGGATCGC TCCCGGGACTGTGGAGGGTGCGGATCGCTCCCGGGGCTGTGGAGGGTGCGGTTCTCTCCCGGGGCTGTG GAGGGTGCGGTTCACTCCCGGGGCTGTGGAGGGTGCGGTTCACTCCCGGGACTGTGGAGGGTGCGGATG CTCCTGGGGCTGTGGAGGGTGCGGTTCACTCCCGGGACTGTGGAGGGTGCGGATCGCTCCTGGGGCTGT GGAGGGTGCGGATCGCTCCAGGTGTGATTTTCATGGGAATGGAACTGGCTCCCTAGGTGGTGTTCATTTC 379; SW vs SM; chr8: 65653638-65653908; 8; BHLHB5; PROMOTER CGAACGCCGGGGGAGGGACGGTGGGAGGGGTGCGGTGAGCGAGGGGCTGCCCTGCATGTAAACAGCCTC GGGGTCCCAGACGAGACAAGTGGGACCGCTCAAGCCTGCAGAACCCCCGGTCTCGGTCCAGGCACAAGA GCCTCCCGTAGCCCCGCCTGATCTTTCTCAGTCTTTAGGTTCCAGGACATCCAAAGGAGCGTAGGTAACCG ACGTCTACGTAGTATTTCTGTCCCCGGAAGACTGGATCTCAGGGAATTATTATGGAAGATA 386; SW vs SM; chr8: 72916429-72917309; 8; MSC; INSIDE CGGGGCAAGGGCGCGTTCCCTATCGCAGGATCACTTGCTATGGTAAGCCGCCCACCCTGCGCGCTCCTCC GCGCGGGGAAGAACCTGCGCGGCAGGACGTGGTGTTGGAGTTGGGGCGCCCGGAGCGGGAGTGGGGAG ACCTGATGCAGAGAGTCTGGAGTCGGAGCTGGGGGTGCTGCAGGTAGGAGCAGGAGCGGGGCGGAGAGG GAGGCCCGAAGAAGACCCCACACAGGTTGGCGCAGCGGGGCTTGGGGAGGCTTCAGCCCAGAAGTGGAG AGGGTTGACAGACGCCGCCTGATTAGAAAAAGCCGGGAGCTTGGGAAGGAGACGGGATTGAAGAAGCCA CCCGGCAGGGAGGCCGAACGGCCCAGAGCTCTCCGGGTAAAACCCGCCTGCGGTGATCTGGGAAGTGTG TCTCCACCTAGCCCTGCGAGCAGCGGCCTTCCTCCCGCCCGTTGAAGGGCGCTGTGCTGGAGTACGAACC CGGCCCAGAGAAGCCACTCGCCCTTCTTTGTCACTTAAAACCCTGTCCCGACGCGGATCTCACGTCTAGAC CTCTGTCTTTAAAGCGGATGTAGAGCGCGTTCTAACCGTTCCCTAACCATTGTGTCACCGCGAAAGGCGGG GCTGTGTGGAACCGTCCCGCACGTGTGCGATGAATCTGGCTCCGCTGAGAACGGATCCGTGGGCTGTCTG GCGCGGGCTGGGGCAGCAGCCGAGAGTTAGTCTACAGAGCTAGGGCCCGAGGGTGGACCTGCGTCCGCG TCTCGTCACGAAAGGAAGCTCTTTTGGAGAGGCAAAACGTGGTCGCCCAGATCCGGCGCAGCTGTAGCCG TGGGCGCTGTGCAGTGACAGCCACACCCGCCACCTGTCACG 400; SW vs SM; chrX: 2845926-2846236; X; ARSD; INSIDE TTTCTCATCAGGATACAGTTCCAGCGTCGCACAAACCCGAAGGAGGAGTACCAAGAGATGAAAAACAGGC AGCCCACGCCGGCCATGCCGGTGACTGCTCTCGCGGAGACAGAGAAGAAACCGCAGGCTGGCCGGCAGC CAGGGTGAGAATCCCCAGCGCCAGGAACTGGGTGTAACCCCAGAGCTGCGCCCTCAGGGCGGCGTCCACT TCGGGGGGCCTGCCTGGGTCACAGTCGTTTGTGAGCGTGAAGGGCATGCCGTAGAAATAGTCAAATCCGT GGTTCAGGGGGTGTGGCAGTGATCCCCGCG

TABLE 5 CpG islands potentially involved in progression and death of disease. Provided for each are: ID; Comparision; Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, Mar. 2006); Chromosome; GeneName; Location relative to gene Sequence. 406; DOD/alive; chr2: 115635091-115637285; 2; DPP10; PROMOTER AAAAAAGAAATGAGTATCAGAGTCTTATCATCATTACAGTTCTTATGGTTTTTAACCGACCTTTAGGAGTTC CACCGACGTGACCCAAGCAGCTGGTAGGAGAATCTGGGCTGGATTCGGAAGGCGCGCTACAGGACGCCC GCTGCCCCGGATCGGAAGGCGCAGCACCTCAGGCCACAATCTCAGACACGCCCTCGGGTCCCGACAGGTG TTGCCCGCCTCCCACGGGGCTCCGGGACCCCGGTCCCCGGGCTGCCCCCTGCCTTCTGGGGCGCTGGAGC GCGCGCAGTGGCGGAGCTGAGCCACCCAGTGCTTCGCACGGGCGCGCTCCGCTTCTCCGGGTTTTAGCGG AAGCCTGCGGGGGGCGGGGTAACCGCGGAAGCCGGCGGCCGTGGGCGCGCGGGTTGGGGGCTCTCGCG CCGCTCCGGGCTCTCCCCCCCCCCGGCTGCGGTTGCCGAAGAGAGGCCGGAGGCGGCGCCCGGCTGCTC CACCTGGCGCGCTGAGCACCGCGCGGGGAGCCCCCGGGGGCGGGCGGTGGGGGGCGCGGACTGCGGGA AGAAGGCACGAGGCGTCGCCGCAGCTCGGTCAGGGGCCGGGGCCCCGCCGCTCGCCGCTGCACTAACTT GCCGCTTGGTCTCGCCTCCCGCCGCGGCTCGCTGCGCTTTGGGTGGCGGGGGGCGGGGAGAGCGGGGAG TCAGAGGGTCTGCGGTGGCCGAGGGAGGGACCCTACGACGGGGAGCCCGCCCGGTGCCGCTCTTCTTCC CCTCCCCGCCCCTCCGCTCCCCCCACCCCGTCCCTTCCGCCGATTCCGGGAGGACGGGCGCCCGTGACCT GCGAACGCTGCCAAGTGACGGTCCCCGAGTCTGAAGCGCCCGCGAGGAAGCGAGCGCCAGCGCGGGCCG CCGGCGATGACGGCCGCGAAGCAGGAGCCGCAGCCCACCCCGGGGGCCAGGGCGAGCCAGGCGCAGCC GGCGGACCAGGTGAGAGCGGCAGCCGCGGCCAGGCCCTCCCGGGAGGGGTGGCTCCAGTGCGCGCTCCG CCCGCCTCCCGCTTCCCAGGCTGGGCTCCCGCGCCTCCCTCTTCTCACCCTCCCCCGCCCCGCCCCAGTTC CAGGCTCTCCTGCTTCTCCACGGACTCTGCGGGAAGTTAGAGCCTCTGCTGCGCTCCGGGGCCCGGCGAG AGGATGCGCAAGGTGGAGAGCCGCGGGGA 407; DOD/alive; chr3: 62330280-62330608; 3; FEZF2; INSIDE AAAATTGGTGCATTTAGGAAGGAAATGCTATAAACGCCTAATTCCTTCTCGTTCTTTGGGGTTGCTGAGCT GACCTCGCCGCGAGGGGAGAGGGGGAAAAAAACGCGCACTAATGATTCTGTTTATTAGTTATATATGTAT ATATTCCGTGTTCGCTTGTACAGGAGGATTTACATGGCTGTATAAAGATGGCTAGGGGCGCCGCGCTCTTC TGGGGCGCTCACGGTGACAGGCTGGGGTTAAAACTGGCTGCCCCAGGAGAAGCGGAGGCCTGGAATTAA ATACGTTTCGGCGCACTGATTTAAATAAGTTTCCTGAATATACAAA 408; DOD/alive; chr3: 62331767-62332398; 3; FEZF2; INSIDE AGAGCTTCCCCCTACACCAGGCACAACCCGATTCTAAAGAAATGCTGCGCCCGCGCCTGCAGATTTCGCCT TCTCTCTCCAGATCCCTCTTTGCCTTCCTGCCAGCCAGCCGCGACCCGAGTCCTGAGTGAGGTGAGAAGA GAAGGCCTCGCCTGGCACGTTACCTTTTTGGTGAAAGCCTTTGCCGCAAAATTCGCAGACGAAGGGCTTG TAGCCCGCGTGGATGCGGATATGCGTGTTGAGCGTGGAGCTGCGGTTGAACGCTTTGCCGCACTGGTTGC ATTTATGTGGCTTTTCCTAGGAAAGGGGCGAGTGCACAGTAAGGAGAGGCCACCTCGGGAACACCTGGAA GGGACATCCCCCCCACCCCCACTCAACCCTAGAGGGTAAGGGATAATCTTTGGCCATCGTATCCCCGGTG TTATCACTAAGATTCTGGGGGTTGCGCGCGGGCTAGGCCCGACCCGGGGGCACGTACCTGGGTGTGGATA ATTTTGTGCCTGCAGAGCGTGCTGGCCTGGCGAAAGCCTTTGCCGCAGACTTTGCACACGAACGGTCTGG CTCCGGTGTGGACCGGCATGTGGCGGGTGAGATTATAGTGAGCGTTAAACACCTATGGAAAGACATGG 409; DOD/alive; chr20: 22514762-22515148 20; chr20: 22514762-22515148; Unknown ATCTTTTGCTGCTGAAATGCAGATGGTTTGGACACTTCATAAAGAGGGCATTAATAAGCCCGCCGAGTGAG CGCCAGGGCGGGATTCTCCCACAAATTCAAGGTCTGTATCTCCGCGGAAGCCGTGCTATCGGTCCCCCGA GTGCTGAAGGCTCCCACGAGGGGCAGGCCAGCCCGGTGCGCCAGGGAAGGAGCTTGATGGTGTGTACGG CTACGTAGTGAACGTGGAGGTGTGCGCAGCGGAGTCAGAGGGGCTAGATCCCCAGCATTTCCCACGGGGT CCCACCTAGCGCGTGGATGGAGCAACTTCATCACTCCACCGAGGGCAGGGAAAGAGGAGTAAGCATTGGA GCTCAAAGAATGAGCAATTTTTCAAAGCTTTCTCC 410; DOD/alive; chr20: 22510737-22514165; 20; FOXA2; PROMOTER CGGGTGGTTGAAGGCGTAGTGGTGTTCCGGCTTCAGGTGGGCCTCAGGCGGCAGGCCCGGGTGGTGGGG CGGGCCCAGCAGGTGGGCCGCGGCCTGCTGCTGCTGCCCGGGAGAGGGCGCCGGCTCTGGGGGCTCAGC GCCGCAGCCGGCGTCCCCTTCAGCTCTCCCAGGCCCCCTCGCTTGTGCTCCTGGCACGGGGAGGCGCTCG AGTGAGGCGACTCGGTGCCCGCCGGAGTCTCGGAGGCCGGCCCGGCGGCCTCCCCGAGTTGAGCCTGTG AGGCCTGGGCTCCGGCGGCCGCTTCTTGCCGCTGCCGGCGGCGCCTGCGGCCTCCTTCAGCGCCAGCTGC TTCTCGCACTTGAAGCGCTTCTGGCGGCGCAGGTAGCAGCCGTTCTCGAACATGTTGCCCGAGTCAGGGT GCAGGGTCCAGAAGGAGCCCTTGCCGGGCTTGTCGGGCGAGCGGGGCACCTTCAGAAACAGTCGTTGAA GGAGAGCGAGTGGCGGATGGAGTTCTGCCAGCGCTGCTGGTTCTGCCGGTAGAAGGGGAAGAGGTCCAT GATCCACTGGTAGATCTCGCTCAGCGTCAGCATCTTGTTGGGGCTCTGCTGGATGGCCATGGTGATGAGC GAGATGTACGAGTAGGGCGCTTTGCGTGCGTGTAGCTGCGCCTGTAGGTCTTGGGGTCGCGGGCGCGGCT CAGGCCCGCCTGCCCGTACATGGGGCTCATGGAGTTCATGTTGGCGTAGGGGGCCAGGCCGCCCATGGCC CCGGCCGCCTGCCCCCCGAGCGGGCTCAGGCTGGGACTCAAGTGCGGCCCATGCCCGCCACGCCGGCCG CCCCGGCCGAGCCGCCCATGCCCGCCATGGCGCCCGCGCCGGGGGACATCCCCGCCAGGGACGGGCTCA TGCCAGCGCCCACGTACGACGACATGTTCATGGAGCCCGCGCTCATGTTGCCCGAGCCGCTGCCCATGGC GGCCGCCGACATGCCATGTACGTGTTCATGCCGTTCATCCCCAGGCCGGCGTTCATGTTGCTCACGGAGG AGTAGCCCTGCGGACAGAGCCCCGGGAGGGAGGCGACAGCGTTAGCACCGCGGCTGGAGGGTGCCCAGA CCTCCCACCCACCGCCCAGGCCTCCGCGTCCGGGGAGGCCTCCGGGGGCCCTTTCGTCCCCGATGGCCCA GTCTCCGGACTCCGAGTCTGTTTCATT 411; DOD/alive; chr8: 57520625-57522095; 8; PENK; PROMOTER ACAGAGGACTTCTCGGGGTTCCCGAATTCCCAGGGTTAAAACAAACTTGGTTTGTGCGGCGACACCGCTA CCCTTACCGGTCCCCAGATAGTCGCGGATCCCCGAAGCTAAGAGCCAGGGCAGGACTCAGTCAGTGTTCC AGGAACAGCTGAGACACCCAGGTCACCACGGGCTCGCGCCGCTGCGGCTCCGACCCGGTGCGAACCGCC ATACGCGCCGCGCGGTGGGCCGGAGGCAGTCCGCGTACTGTTGCGGAAACTCTGTCTCACAAGGTGCGCA ACACTCGCCGCGCGCAACACCACCAGGAAGTTGATGTCGGCCGGGCGCACTAGGCGGTAGCTGCACGTCG CGCAATCCTGGCTGCATTCGGCCCGCACGGTCGCCAGGAGCCCGGGGCCGAGCAACAGCAGCCAAGTGC AAAGTGTCAGGAACCGCGCCATGGACTGCGAGGAGAGAGGGACGCGTGCTTCGGCCTGCCTGGGCGCAG AACGGGGTCCCTCGGCAGGACCCTCGCCGCGACAGCCTCAGCAGGGGATCGTCGAGCAAAAGCCCGCAG GAATGCTCCTTTCTGGGGCCCCGCCCTCCCGGCCGACAGCTTTTAGGTAGACGTGGAGGCGACTCAGATC GCCTCGCGGTTCCCGGGTGGCGCGGTCGCCCCCAACGCGAGGCTGCCTGGGGCACCCGGCTCTTTTCCTG GGCGTCCGCGGCCCAGGGCAAGATTCCGGAGAGAACGCCGCAGACCAGGGGCGAGAGAGCGGGAGCCG GGGGAGGCAGGACATTGACTGGGGTCACAAAGAAGAACCAGGGAACGCTGTGGGGAACCCATGCAATGA AATGTGAAGGGAAAGAGGGCGGGCAGACGTCCCCAAACCCGCTCAGCAAAGACAAGCTTCGGGCAAATTC ACTCACGTTGACGCTGTTCGGATGGAGCAGGCCAATTGGAAAAGCCGGGTTCAGACACGACTCTAGAGGG AAGAGAAGAAGGCAGTGTGAGGAGGGCGGGCGTCGGGGAGAAGCGGGCCCGGGTGTGCTGGCGGACGT AGGGCCTCACCGTCGCGGTCCTCAGCGTCTCTGCGGGGTCACGGGCCAGGCTGCGGGGCTCTGAGCGCC TGCCTCGCCGTCCCGGGGCTTAACGGCTGCTGGAGCCACTTTATAATTACCCCAAACCGAAGGAGGCGCG CGCGCCCCAATCGCCGGCGGGCTGCAGCT 412; DOD/alive; chr17: 24303411-24303889; 17; PHF12-SEZ6; DIVERGENT_PROMOTER GATCTGCTCTTCAAGAGGAAGCCTAAAGTGGAGAGTTTGTAATCCTGACAACGCCCAGCTACCTGCGTACC CCGGACTCCAACTCCCAGTTTGCAACGCCAAAGGGTCTAAAGGGCGAACGGGGGCGATTGCATCCTGGGA GCAAGAATCGCGATAGGTCTGATGGATTGTGGGAACTGTAGTTCCATGTGCGTGCGATGCACTCTATGGT AGGATAGACCCGGGGAAGAGTCATTTGCCGGCCAGGAAGGGATACTTTTGAGAGCGTCAGTGCTGCATGC CGGGATTTGTAGTCTGAGGCCCGCCTCGCATTCTGGGCGGGGATTCATGCTCCTTTTCAGGGCGCCCGCT CCTCCCCTTGGTATTGCCGTCAGAGATGGGCGGTTGGTTATTGCTGCCTGATGGTGGATGAAGCAGTGGA AAAGAGAATTGTATCGTTGTGCTTGACACTAGGGGTTTAGTTGGAATTGTGCTTC 413; DOD/alive; chr1: 149638545-149639227; 1; PSMB4; PROMOTER TAGGATTACTGCATGTTCAGCTACGACCTCATCAACATGGCTGCTGGAAGTCGTCTACAGGAAAAAGAAAG AAATGACACTGAAGGATCACTTCCGCTTCCGTTGGCGCAAGCGCTTTCATTTTTTCGCTACCGTGACTAAG ATGGAAGCGTTTTTGGGGTCGCGGTCCGGACTTTGGGCGGGGGGTCCGGCCCCAGGACAGTTTTACCGCA TTCCGTCCACTCCCGATTCCTTCATGGATCCGGCGTCTGCACTTTACAGAGGTCCAATCACGCGGACCCAG TAAGTTCTCGGCGCTTCGTTTGCGTAGCGGGAGGGACCGTGGGGCCTGGTGCTGCCGGCTGGTTTTGAGA GCCCGGGAAGGTGAGGCGGGGACCCCGGGGGCGCGCGAACGGCAGGGGAGCTCAGGGCGCGGAGTCCT GGAGAATGCAGAATAATTGGAAGGAATTATAGAAAATCAGAAGCGCAGCTAGTGCGCGGAAAGAGGGCGC AGTCCATCCCCCCTCTCAGCTCCCACCGTTCTCACTCTTTAGGAACCCCATGGTGACCGGGACCTCAGTCC TCGGCGTTAAGTTCGAGGGCGGAGTGGTGATTGCCGCAGACATGCTGGGATCCTACGGCTCCTTGGCTCG TTTCCGCAACACTCTCGCATTATGCGAGTCAACAACAGTACCATGCT 414; DOD/alive; chr21: 36990008-36995832; 21; SIM2; PROMOTER TCCTTAGTGACAAGGTCTCTGATCTCCTGCTGCCACTGCAATAGCCTCTCCCATCCCGCGGGGAACGGCCG GAGTTCTTCCCTTGATCTCTCCCGAGTCGGCTTCCGCTGGGGATGGATCGCAGGTAGCGCCGGCGCGGCC TGGGGAAGAACAGTTGCGGAGCATCTGAAGCGGAAAATCCAAGCAGATGTGAGGCGATCCGGGCCCGCC TCGTTCCTCTTGGGGCCTGAATTTCTTCCAGATAAGTTTCCTAATGGAACATTTCTAAGAGGTGGGGTACG AGGCGGCTTGCTCGCACGGCAGTGGGACAGACTGCGGGTGGGGACGTACTGAGAGGTCCGGACCTCAAT GCGTCCGACCCGTCTCCACACCGCCCTTTTCCAGCCCCCAGTCTCCTTTCATTCCCTACTCTTCAGGCTCC TTTGGGGCCAGTGGGTGAACCGCCATTTAGAACGGTGCCTCGGACTCGGGGTCGTGCGCTCCATCTCTGC CTCCCCCCTGGGGCCCGCGAGGCTGGTCCGGGCTTTCTGAGCTGGGCGTTCGGCTTTAGGCCCAATACCT GGACCAGGAATTTCTTCTCCCCGCGCCAGAAGGGAAAGACATAGGAGGTGTCCCAATCTGCGGTCACCGC CGATGCTCCTGACACTCTAGTGAGCACCTGCCCGGTACTTTTCCATTCCAACAGAGCTTCCAGCTTCATAC TAACTATCCCACATACGGCCTGTGGGTATTAGCTCTAAGTGTCCTTTTCCGAGGGCCCGAGGCTCCCCCTC CAGCAGGGAGAGCTCCGGGACGGCCCCCACCAAGGGTTGGGTTCTTCCTTCACAATTCCACAGAGGCATC CCTGTCCTTCCTACCTGGGAAACCTCGAGGTGCGGTGCCCGTGTACTTCTGGTACTTTGCGTGGTGCCATC AGGGACCCCAGAGCCACAGCTGCGTGTGTGTGTGGATGTGTGTGTGTGTGTGCGCGCGCGCGCGTGTACG GCGAAGGATGTGCTTGGGGGAGCCGAGTACACAACGTCTGCTTGGGCAGCTGCTGGGCAGGCGTTGGGC CTGGAGGTATCTCACACCCACGTATCTTCCAGTCTTCAAACACGGCATTGCTCTGCCTCCCGTAGCGCGCT TCGAACCTGCCTCGCGGACACGTGAACAGAGGCTGCCCTGGGAAGATAAGTGCGCTTTCCCGTAAAATCC GGGAAATTTGCCTTG 415; DOD/alive; chr1: 232106869-232108183; 1; SLC35F3; PROMOTER AAGTACTGAACTGGGAGCGGCAGGGTTTGAGTCAAAAGAGAAGGGTGGAGGAGCGCGTCCGGTGCCCCA AGGCTTCCAGGCGGAGCGCGGGCGCGAGGTGCGGGCTCCGGGGCGGAGCGCACGCCCGGAGGCGGGAA GTGGGCAGCAGCGCCCCCGCCTGGCCCCTGTGCGCCCCGACCCGACGCCTCCCCGCCCGACCAGGTGCCT CGAGAGCGCACAGCTGGGAGGGCTCTCCCGGTCGCGGCGAGACTCACGCCTGCGGTGTGCTAGGGCGGC GGCGACGGTGACGGGCGTGGGGCCGGCGCTGCCTCGGCTGCCGGGTCGTTGCGGCGAGCGCGCGGGCC GGCCTGGAGTCACCGGGCTGAACCGCCGCGCCTGCATCGTGCCGCACGCCGCGGAGGCGCTCGGGTACA GACCGCGCGGGCGCGCACAAAGCGGCCCGGGGCGGCCGGCGCGGCGCAGACCCTCGGTGGCAGCGCACT CCAGTCTTCCCAGGCTAGCGGCTGCAGGGAGCTCCGGCCCGCGGCCCCTCCGCCTCAAGTCTGGGAGCTG CCGGTCCCACTCTGTCTTTGCCTATGGGGATTCGAGAGTTTCCCAGCGGCGCACCCAGGGGCAAGAGCAT TGCCGTGTGAGTAGCGCCCCGGCGTGGGTGAGCGAGCCGGCGGGCGGGAGGCCGGAGCGCCGGGGTAG CCCTTTGCAGCTGGGACACTGGGCAGTCTGAGGCTCGGGGAAGGGCGGCGCGCGCGGTGGAGCTGCTCG GGAAGTTTCAGTCATTCTTTCCCTCGCCACTCGCCCCAACCCGCACTGCCCCGAGAGCCCAGGATAGGGC ACTGGGGACAGCTGCCCGGGGAAGTGGGTGAGTGGCGGCGGGAAGGGAGGAGCGCGGGCTCTGCCGCG GCGCTCGCCCCCGGAGGGCCCCGGCCGCGCTCTTGCTCTCGCCCTGGGATCTGCTCCTCACGAATCCCCT CCTCTCTGTCCATGCTCCCCTGCCCACCCACCTGCCCGTGGCGCCTGCGACCGCAGTGGCATGAGGAGGT CACCGGACGTCAGCCCCCGGAGACTGTCCGACATCAGCCCCCAGCTCCGGCAGCTCAAGTACTTGGTGGT GGACGAGGCGATTAAGGAGGATCTGAAATGGTCGCGCTCCGTGGAGGATCTCCCAGCGGGCCGGTGGGG CTCACGTCCATCGAGGAGCGGATCCTGCGCATC 416; DOD/alive; chr6: 21704622-21705099; 6; SOX4; INSIDE TGCATCACCACCTTGGTTTTGTTTTATTTTGCTTCTTGGTCAAGAAAGGAGGGGAGAACCCAGCGCACCCC TCCCCCCCTTTTTTTAAACGCGTGATGAAGACAGAAGGCTCCGGGGTGACGAATTTGCCGATGGCAGATG TTTTGGGGGAACGCCGGGACTGAGAGACTCCACGCAGGCGAATTCCCGTTTGGGGCTTTTTTTTCCTCCCT CTTTTCCCCTTGCCCCCTCTGCAGCCGGAGGAGGAGATGTTGAGGGGAGGAGGCCAGCCAGTGTGACCGG CGCTAGGAAATGACCCGGAACCCCGTTGGAAGCGCAGCAGCGGGAGCTAGGGGCGGGGGCGGAGGAGGA CACGAACTGGAAGGGGGTTCACGGTCAAACTGAAATGGATTTGCACGTTGGGGAGCTGGCGGCGGCGGC TGCTGGGCCTCCGCCTTCTTTTCTACGTGAAATCAGTGAGGTGAGACTTCCAGAC 417; p-np; chr1: 160220156-160220709; 1; OLFML2B; INSIDE TTGGGGTTGTAGTCTATCTGGGTCGTATAGGAATACTCATTCTCGAACAGCAGCCTGGGGACGATCTGTGT GTTGGTGTGGGTGTCGAAAGCGTAGGAGATGTTGGCATTCCGCTGGTTGTAGCTATCACGGCATACAGCA CCCCACAGATGACGAAGCAGTTGCCGTAGAAATTCCTCCGGAGCCCCGTGCGCCATGTGGTCTCCTTCTG TGTGCTCAGGTCCGCGGCATTGAGCTTGCTCAGGACAATGACCTCCTGGCTGAAGCCCTCATCGTCCAGG GCCGGGTAGATGAGCCATGGCCATTCTCGTCCACAGCAAAGTCCACGTCTGAGTGGCCCTGCCATCGCCA GGGGGTGGCCTCCTCGTAGGCCACGTCATGCAGCATGGCCCAGGCAGCCACGTAGCGCTGCTTCAGGTCG TACTTGATGATGTTGCGGGTGAAGGCGCGATTGTAGTAGAAGGCGCCATTTATACCACGTGGCCTGTGCC GATCCAGCTGTACGGGAGCTTGTAGGAATTGCTCCAGCGACCTGCAGGTGGGGAGAAAAC 418; p-np; chr3: 129688131-129694023; 3; GATA2; INSIDE TCACAGGCCAGCTGGAAGTGGGCAGAAACCCTGTGGGTCCCAGACCCTCCCCAATCGGCCGCTGCTCCCA CCTCTCCCGCCCCAATTTTTCAGCAGCTCGATTCCTGCGGATCCTACATCCGGGAAGAAGCAGACGGGCC CTCCTCCCCTCCCTCGCCTGGCGCGCGGCGCCTGGGTTCTCATCACCACGGGCCCAGTGCTCACCGTGCG CGGGGCTGTAGGAGACGCGCGCCCGCGCGTGAGCGGGGTTGGCATAGTAGGGGTTGCCCTGCGAGTCGA GGTGATTGAAGAAGACGTCCCCTCGTCTGGAGGCAGCAGCTGCGCGGGTTCCATGTAGTTGTGCGCCAGG CCCGGGTGGTGTGAGTCGGGGTGCTGCGCATTCAGCACGGCCGGGTGCGCCATCCAGCGCGGCTGCTCG GGCGCCACCTCCATGGCCGGCGGCGGCGGCTCAGGGTCTGGGTGCAGACGGCACGGCCCTGCGCGAGGA AGGGGGAGTGAGGCGTGCCGCCAGCGCCTGACACCCCCCAAAGTCCCACCACGAGGTGTCCCGCACGCC ACGGAGCCCCAGCCCAGATCCGGCGAGAAAGAGCACCAGTCCCGGGTGGGAGGAAAGCCCAAGGCTCAA AACGAAAGGAAGGCGGGGAGGGGGTTCAGCCACGCACACTCACGTGGTGACCCGCGGCTCCAGAATCAC ACACCCGTGCACATGGGGTCACGCCCGGGGACGGGTCCCGACACCAGTGACCCCAACAAACGCACAGAG CAGCACTTCAGTCAGACACTCACACTGAGCCCCCCCGCCCGGTAGACAAACAATGAACACAGACTCAAAA GTTGGAGACAGGCGCCCGGGCACCCAGTGTGGCACTTGATCCCAGCGACACGCACACACCCACACTTGGC GCCAGATACACATACTGATCTCAACCCCGAAAACATGCACACGCAGCCCCCTGAGCGCAGTACTAAGCGG CACAATCAGGACCTTCAACAAAGCACACCAAAGCAGTCGCCCGCAGCCTGGCCCCCCGCCCTAAGTCCCC CCAGAGTCCCCTCAAAGCTAGGAGCGCCCCAGGCCCCCAGCCGGCTCTCAAACCCCAAACTTACACACGC AGCCGTGGGGAGGGGAGGGACTCGGCCTCTGAGAGTGAAGGAGTTCGGCGGGAGCCCCGAGGGCGACG GGCCCAGGGACAGCACGTCCGGAGGCTG 419; p-np; chr6: 26312699-26313302; 6; HIST1H4E; INSIDE GTCTGATCTGTGAAGGGTAGGGCCAGCAGGCAGCACCAAAGTTCCCGTATGCGCGTTTTCAGTCTTCATTT AGGTCCGAATTCCCGGCATATAAGAATACTACCGTCGCTTGTTTTTCAGATTTTTGGGCTATTTTCGTTGGT GTGTTGGTCATGTCTGGTCGCGGCAAAGGCGGAAAGGGACTGGGTAAAGGAGGCGCTAAGCGTCACCGT AAGGTCCTGCGAGATAACATCCAGGGCATTACCAAGCCTGCCATCCGGCGCCTTGCTCGTCGCGGGGGTG TCAAGCGCATTTCTGGTTCATCTACGAGGAGACTCGCGGGGTTCTGAAGGTGTTTCTGGAAAACGTGATTC GTGATGCTGTGACTTACACGGAGCACGCCAAACGCAAGACAGTGACAGCGATGGATGTGGTCTACGCGCT GAAGAGACAGGGACGCACTCTTTACGGCTTCGGCGGCTAATGCTACCGTTAAACGACTCAGCATCTCGAC TTCCCAAATCAAAGGCCCTTTTCAGGGCCGCCCACAGTTTTCCGCAAAAGAGCTCATGACTTGTTAGACGA TTGGTTGGTCTCTTTATAAGTTAATTGTTCCTGTCAA

TABLE 6 Primers and probes for MEIS1 MS-SnapShot. BSP Primers (MEIS1) Fwd. 5′ GGGTTTTTAGAGGTTAGGGGAA 3′ Rev. 5′ CAACTAAATAACCAAACCTCTCCTC 3′ MEIS1 A/B SNAPSHOT Probes Size Probe Sequence (5′-> 3′) (bp) Strand UM MT μM* MEIS1 A T21 GGAGAGGGGGGTTATG 45 sense T C 0.2 ATGTTAGG MEIS1 B T14 GTTTGTTTGGTTTTAG 34 sense T C 0.2 AGAA

TABLE 7A Differentially labeled CGIs between subgroups relative to blood CGI Gene Name Probe location Subgroup chr01-2072175- 

PRKCZ chr01: 002072146-002072190 NMI-mt vs Ref chr01-2106293-2106715 PRKCZ chr01: 002106497-002106541 MI vs Ref PRKCZ chr01: 002106664-002106715 NMI-wt vs Ref chr01-47672249-47672972 FOXD2 chr01: 047671905-047671953 NMI-wt vs Ref FOXD2 chr01: 047672191-047672235 NMI-mt vs Ref FOXD2 chr01: 047682633-047682689 MI vs Ref chr1: 63554983-63563059 FOXD3 chr01: 063559476-063559520 NMI-mt vs Ref FOXD3 chr01: 063559476-063559520 NMI-wt vs Ref chr01-68288825-68289104 DIRAS3 chr01: 068289060-068289104 NMI-wt vs MI DIRAS3 chr01: 068290072-068290116 NMI-wt vs Ref chr01-71284766-71286392 PTGER3 chr01: 071284980-071285024 NMI-wt vs Ref chr1: 90955098-90955445 BARHL2 chr01: 090955137-090955181 NMI-mt vs Ref chr01-119333484-119333719 TBX15 chr01: 119333484-119333528 NMI-wt vs MI TBX15 chr01: 119333569-119333613 NMI-wt vs Ref chr1: 163590111-163590435 LMX1A chr01: 163590167-163590226 NMI-wt vs Ref chr1: 173258989-173259419 MRPS14 chr01: 173259418-173259462 NMI-mt vs MI chr01-178464743-178471598 LHX4 chr01: 178470479-178470532 NMI-wt vs Ref LHX4 chr01: 178470597-178470641 NMI-wt vs MI LHX4 chr01: 178470597-178470641 NMI-wt vs NMI- mt chr1: 196153712-196154414 LHX9 chr01: 196154203-196154247 NMI-wt vs Ref chr1: 219117072-219117487 HLX1 chr01: 219117515-219117568 NMI-mt vs Ref HLX1 chr01: 219121301-219121352 MI vs Ref HLX1 chr01: 219134113-219134157 NMI-wt vs Ref chr1: 241719037-241719368 SDCCAG8 chr01: 241719439-241719492 NMI-wt vs Ref chr02-19424445-19425131 OSR1 chr02: 019415391-019415435 NMI-mt vs Ref OSR1 chr02: 019424965-019425009 NMI-wt vs Ref chr02-45249374-45251726 SIX3 chr02: 045013420-045013464 NMI-wt vs Ref SIX3 chr02: 045015982-045016033 MI vs Ref SIX3 chr02: 045015982-045016033 NMI-mt vs Ref SIX2 chr02: 045085251-045085298 NMI-wt vs Ref chr2: 54536404-54537878 SPTBN1 chr02: 054536311-054536361 NMI-wt vs Ref chr02-63134470-63134933 OTX1 chr02: 063134470-063134515 MI vs Ref OTX1 chr02: 063134470-063134515 NMI-mt vs Ref OTX1 chr02: 063134803-063134847 NMI-wt vs Ref chr02-66525936-66527222 MEIS1 chr02: 066525898-066525942 MI vs Ref MEIS1 chr02: 066526023-066526067 NMI-mt vs Ref MEIS1 chr02: 066526791-066526835 NMI-wt vs Ref chr02-70984709-70985764 VAX2 chr02: 070985519-070985563 MI vs Ref VAX2 chr02: 070985519-070985563 NMI-wt vs Ref chr02-72224630-72228512 CYP26B1 chr02: 072227412-072227461 NMI-wt vs Ref CYP26B1 chr02: 072227537-072227583 NMI-wt vs MI chr2: 73004709-73005568 EMX1 chr02: 073004783-073004827 NMI-wt vs Ref chr2: 85213468-85216104 TCF7L1 chr02: 085215511-085215555 NMI-wt vs Ref TCF7L1 chr02: 085216153-085216212 NMI-mt vs Ref chr02-105864220-105865009 NCK2 chr02: 105864372-105864417 NMI-wt vs Ref NCK2 chr02: 105864443-105864487 NMI-mt vs Ref NCK2 chr02: 105864906-105864950 MI vs Ref chr02-111591678-111597436 FLJ44006- chr02: 111592037-111592081 NMI-mt vs Ref BCL2L11 FLJ44006- chr02: 111593125-111593170 NMI-wt vs Ref BCL2L11 chr02-115635091-115637285 DPP10 chr02: 115636612-115636656 NMI-wt vs Ref chr2: 119329502-119332035 EN1 chr02: 119330694-119330738 NMI-wt vs Ref chr02-156892636-156892878 NR4A2 chr02: 156892639-156892683 MI vs Ref chr02-156893736-156894685 NR4A2 chr02: 156894489-156894533 NMI-mt vs Ref NR4A2 chr02: 156894576-156894620 NMI-wt vs Ref chr02-171384729-171385226 GAD1 chr02: 171384729-171384773 MI vs Ref GAD1 chr02: 171385019-171385063 NMI-mt vs Ref GAD1 chr02: 171385019-171385063 NMI-wt vs Ref chr2: 172653235-172653630 MAP1D chr02: 172653288-172653332 NMI-wt vs Ref chr2: 174907710-174910885 FLJ46347 chr02: 174910857-174910905 NMI-wt vs Ref chr2: 176652334-176656692 EVX2 chr02: 176655532-176655591 NMI-mt vs Ref EVX2 chr02: 176656139-176656183 NMI-wt vs Ref EVX2 chr02: 176656517-176656563 MI vs Ref chr2: 176720618-176720921 hsa-mir-10b chr02: 176720535-176720594 NMI-mt vs Ref hsa-mir-10b chr02: 176720535-176720594 NMI-wt vs Ref chr02-176737610-176738187 HOXD3 chr02: 176737609-176737653 NMI-mt vs Ref HOXD3 chr02: 176737609-176737653 NMI-mt vs MI HOXD3 chr02: 176738050-176738094 NMI-wt vs Ref CENTG2 chr02: 236438664-236438711 NMI-wt vs Ref chr3: 11721578-11721824 VGLL4 chr03: 011721492-011721547 NMI-wt vs Ref chr3: 12983649-12984210 IQSEC1 chr03: 012983600-012983644 NMI-wt vs Ref chr3: 25680561-25681574 TOP2B chr03: 025681366-025681410 NMI-wt vs Ref chr03-129688131-129694023 GATA2 chr03: 129692644-129692688 MI vs Ref GATA2 chr03: 129698463-129698509 NMI-wt vs Ref chr03-148591199-148594390 ZIC4 chr03: 148592447-148592499 NMI-wt vs Ref chr3: 148613030-148613264 ZIC1 chr03: 148613058-148613102 NMI-mt vs Ref ZIC1 chr03: 148619483-148619541 NMI-wt vs Ref chr4: 4910534-4911092 MSX1 chr04: 004910620-004910670 MI vs Ref MSX1 chr04: 004910620-004910670 NMI-mt vs Ref MSX1 chr04: 004910620-004910670 NMI-wt vs Ref chr4: 30330303-30333940 PCDH7 chr04: 030333744-030333788 NMI-mt vs Ref PCDH7 chr04: 030333834-030333878 NMI-wt vs Ref chr4: 41678680-41678940 WDR21B chr04: 041678597-041678646 NMI-wt vs Ref chr4: 85636684-85639823 NKX6-1 chr04: 085637474-085637518 NMI-wt vs Ref chr4: 94974810-94975333 ATOH1 chr04: 094974874-094974918 NMI-wt vs Ref chr04-111780013-111780343 PITX2 chr04: 111780048-111780092 NMI-mt vs Ref PITX2 chr04: 111780288-111780343 NMI-wt vs Ref PCDH10 chr04: 134291474-134291518 NMI-wt vs Ref NR3C2 chr04: 149586403-149586447 NMI-wt vs Ref TRIM2 chr04: 154436244-154436288 NMI-wt vs Ref chr04-155881084-155881434 LRAT chr04: 155881084-155881128 NMI-wt vs Ref LRAT chr04: 155881330-155881378 NMI-wt vs MI HAND2 chr04: 174687934-174687985 NMI-wt vs Ref chr4: 184255825-184258373 FLJ30277 chr04: 184255924-184255968 NMI-wt vs Ref chr5: 360287-360592 PDCD6 chr05: 000360593-000360637 NMI-wt vs Ref chr5: 1161803-1162051 SLC12A7 chr05: 001162056-001162100 NMI-wt vs Ref chr5: 3647468-3656054 IRX1 chr05: 003654466-003654525 NMI-wt vs Ref chr5: 5192442-5193941 ADAMTS16 chr05: 005192514-005192558 NMI-wt vs Ref chr5: 6790705-6791004 POLS chr05: 006790682-006790728 NMI-wt vs Ref chr5: 54554812-54555385 UNG2 chr05: 054555175-054555219 NMI-wt vs Ref UNG2 chr05: 054555391-054555442 NMI-mt vs Ref chr5: 114542616-114544119 TRIM36 chr05: 114542773-114542817 NMI-wt vs Ref chr05-115810975-115811393 SEMA6A chr05: 115811349-115811393 NMI-wt vs Ref chr5: 127899858-127900162 FBN2 chr05: 127900012-127900056 NMI-wt vs MI FBN2 chr05: 127900012-127900056 NMI-wt vs NMI- mt FBN2 chr05: 127900101-127900154 NMI-wt vs Ref chr05-134390896-134393045 PITX1 chr05: 134390896-134390940 MI vs Ref PITX1 chr05: 134390896-134390940 NMI-wt vs Ref PITX1 chr05: 134391093-134391137 NMI-mt vs Ref TRPC7 chr05: 135720277-135720321 NMI-wt vs Ref Chr05-140724146-140724826 PCDHGA5 chr05: 140724562-140724606 NMI-wt vs Ref chr5: 140780945-140781256 PCDHGA11 chr05: 140781192-140781236 NMI-wt vs Ref PCDHGA12 chr05: 140791316-140791360 NMI-mt vs Ref PCDHGA12 chr05: 140791441-140791494 NMI-wt vs Ref chr5: 141235749-141238152 PCDH1 chr05: 141237048-141237094 NMI-wt vs Ref chr05-174091287-174092335 MSX2 chr05: 174091297-174091341 NMI-wt vs Ref MSX2 chr05: 174091410-174091454 MI vs Ref MSX2 chr05: 174091473-174091517 NMI-mt vs Ref chr6: 1326743-1330210 FOXF2 chr06: 001329813-001329866 NMI-mt vs Ref FOXF2 chr06: 001329813-001329866 NMI-wt vs Ref chr06-1549606-1560865 FOXC1 chr06: 001551371-001551415 NMI-mt vs Ref FOXC1 chr06: 001551429-001551473 NMI-wt vs Ref FOXC1 chr06: 001551500-001551559 MI vs Ref chr6: 5947471-5950124 NRN1 chr06: 005947569-005947613 NMI-wt vs Ref chr6: 10498025-10498551 TFAP2A chr06: 010498473-010498517 MI vs Ref TFAP2A chr06: 010498473-010498517 NMI-wt vs Ref TFAP2A chr06: 010498811-010498870 NMI-mt vs Ref chr6: 22677564-22678684 HDGFL1 chr06: 022677587-022677632 MI vs Ref HDGFL1 chr06: 022677587-022677632 NMI-mt vs Ref HDGFL1 chr06: 022677587-022677632 NMI-wt vs Ref chr6: 25834434-25834701 HIST1H2AA chr06: 025834650-025834695 NMI-wt vs Ref HIST1H2BA chr06: 025840937-025840981 NMI-wt vs Ref chr6: 41176454-41177326 NFYA chr06: 041177112-041177165 NMI-wt vs Ref chr6: 50895246-50896050 TFAP2B chr06: 050896068-050896112 NMI-wt vs Ref chr6: 75968300-75968853 COL12A1 chr06: 075968669-075968713 NMI-wt vs Ref chr06-101023927-101024343 SIM1 chr06: 101024299-101024343 NMI-mt vs Ref SIM1 chr06: 101024299-101024343 NMI-wt vs Ref chr6: 101953488-101953856 GRIK2 chr06: 101953514-101953560 NMI-mt vs Ref GRIK2 chr06: 101953514-101953560 NMI-wt vs Ref chr6: 108592365-108597232 NR2E1 chr06: 108595517-108595561 NMI-wt vs Ref chr6: 126122028-126122524 HEY2 chr06: 126122132-126122176 NMI-wt vs Ref chr6: 166499964-166503413 T chr06: 166502963-166503011 NMI-wt vs Ref chr6: 169801163-169801511 WDR27 chr06: 169801059-169801108 NMI-wt vs Ref chr7: 1029023-1029492 hsa-mir-339 chr07: 001029489-001029533 NMI-wt vs Ref chr07-2082782-2083345 MAD1L1 chr07: 002083155-002083200 MI vs Ref MAD1L1 chr07: 002083155-002083200 NMI-wt vs Ref MAD1L1 chr07: 002121288-002121332 NMI-mt vs Ref chr07-2724511-2724848 AMZ1 chr07: 002724511-002724555 MI vs Ref AMZ1 chr07: 002724511-002724555 NMI-wt vs Ref AMZ1 chr07: 002724629-002724673 NMI-mt vs Ref chr07-8449587-8450236 NXPH1 chr07: 008449587-008449636 NMI-mt vs Ref NXPH1 chr07: 008449587-008449636 NMI-wt vs Ref NXPH1 chr07: 008450192-008450240 MI vs Ref chr7: 19113449-19113833 TWIST1 chr07: 019113860-019113907 NMI-wt vs Ref chr7: 27149139-27152087 HOXA5 chr07: 027150566-027150625 MI vs Ref HOXA5 chr07: 027151311-027151355 NMI-mt vs Ref chr07-27164708-27165039 HOXA7 chr07: 027164869-027164913 MI vs Ref HOXA7 chr07: 027164869-027164913 NMI-mt vs Ref HOXA7 chr07: 027164944-027164988 NMI-wt vs Ref chr7: 27170441-27172987 HOXA9 chr07: 027170467-027170515 NMI-mt vs Ref HOXA9 chr07: 027170467-027170515 NMI-wt vs Ref HOXA9 chr07: 027170998-027171042 MI vs Ref chr7: 27198331-27199622 HOXA11 chr07: 027198283-027198327 NMI-wt vs Ref chr07-27219187-27220360 EVX1 chr07: 027245650-027245694 NMI-wt vs Ref chr07-27251165-27252762 EVX1 chr07: 027251482-027251527 MI vs Ref chr7: 35263447-35264743 TBX20 chr07: 035263668-035263712 NMI-wt vs Ref chr7: 96469320-96469736 DLX6 chr07: 096469212-096469266 NMI-mt vs Ref DLX6 chr07: 096469526-096469572 MI vs Ref DLX6 chr07: 096469776-096469827 NMI-wt vs Ref chr07-96488158-96489591 DLX5 chr07: 096489129-096489173 NMI-mt vs Ref DLX5 chr07: 096489475-096489520 MI vs Ref DLX5 chr07: 096489536-096489591 NMI-wt vs Ref chr7: 119702299-119702721 KCND2 chr07: 119702676-119702723 NMI-wt vs Ref chr07-121727243-121727884 FEZF1 chr07: 121727241-121727285 NMI-wt vs MI FEZF1 chr07: 121727336-121727380 NMI-wt vs Ref chr07-155288454-155292175 SHH chr07: 155291537-155291581 MI vs Ref SHH chr07: 155291593-155291637 NMI-mt vs Ref SHH chr07: 155291751-155291795 NMI-wt vs Ref chr7: 158509937-158510390 VIPR2 chr07: 158509989-158510033 NMI-wt vs Ref chr08-9798161-9799053 hsa-mir-124a-1 chr08: 009798455-009798508 NMI-wt vs NMI- mt hsa-mir-124a-1 chr08: 009798593-009798644 NMI-wt vs Ref hsa-mir-124a-1 chr08: 009800023-009800077 NMI-wt vs MI chr8: 10624024-10624296 SOX7 chr08: 010624244-010624300 NMI-mt vs Ref SOX7 chr08: 010624319-010624366 NMI-wt vs Ref chr8: 11597006-11600365 GATA4 chr08: 011599544-011599588 NMI-wt vs Ref chr8: 25955253-25955609 EBF2 chr08: 025955446-025955495 NMI-mt vs Ref EBF2 chr08: 025955446-025955495 NMI-wt vs Ref chr8: 55532724-55535078 SOX17 chr08: 055533948-055533992 NMI-wt vs Ref chr08-65661156-65662687 BHLHB5 chr08: 065661235-065661282 NMI-wt vs MI BHLHB5 chr08: 065662258-065662302 NMI-wt vs Ref chr8: 72916429-72917309 MSC chr08: 072917197-072917241 MI vs Ref MSC chr08: 072917336-072917380 NMI-wt vs Ref chr8: 140700279-140700514 KCNK9 chr08: 140700520-140700564 NMI-wt vs Ref chr08-142288380-142288718 SLC45A4 chr08: 142288398-142288442 NMI-mt vs Ref SLC45A4 chr08: 142288610-142288657 MI vs Ref SLC45A4 chr08: 142288610-142288657 NMI-wt vs Ref chr8: 145014900-145015187 EPPK1 chr08: 145015195-145015240 NMI-wt vs Ref chr9: 959530-963276 DMRT3 chr09: 000959621-000959665 NMI-wt vs Ref chr9: 21979774-21980108 CDKN2A chr09: 021979951-021979995 NMI-wt vs Ref chr9: 23812413-23812667 ELAVL2 chr09: 023812373-023812424 NMI-wt vs Ref chr9: 37024136-37028341 PAX5 chr09: 037024964-037025008 NMI-wt vs Ref chr9: 101621613-101627382 NR4A3 chr09: 101627386-101627439 NMI-wt vs Ref chr10-7489383-7495345 SFMBT2 chr10: 007491431-007491476 NMI-wt vs Ref SFMBT2 chr10: 007491576-007491626 NMI-wt vs NMI- mt chr10: 13556172-13556753 C10orf30 chr10: 013556159-013556211 NMI-wt vs Ref chr10: 15294605-15294858 C10orf38 chr10: 015294592-015294641 NMI-wt vs Ref chr10-21828640-21829645 C10orf114 chr10: 021828885-021828929 NMI-wt vs Ref C10orf114 chr10: 021828954-021828998 NMI-mt vs Ref C10orf114 chr10: 021829373-021829417 MI vs Ref chr10: 76825135-76839606 ZNF503 chr10: 076834917-076834976 NMI-wt vs Ref ZNF503 chr10: 076837381-076837425 NMI-mt vs Ref chr10: 88112905-88117344 GRID1 chr10: 088115612-088115656 NMI-wt vs Ref chr10: 94441310-94441717 HHEX chr10: 094441395-094441439 NMI-mt vs Ref HHEX chr10: 094441744-094441795 NMI-wt vs Ref chr10: 99068802-99071038 FRAT1 chr10: 099070245-099070298 NMI-wt vs Ref FRAT1 chr10: 099070376-099070420 NMI-mt vs Ref chr10: 101277153-101277910 NKX2-3 chr10: 101277900-101277957 NMI-wt vs Ref chr10: 102974173-102980053 LBX1 chr10: 102975940-102975999 NMI-wt vs Ref LBX1 chr10: 102976227-102976273 NMI-wt vs MI LBX1 chr10: 102976227-102976273 NMI-wt vs NMI- mt chr10: 106389558-106392802 SORCS3 chr10: 106392567-106392611 NMI-wt vs Ref chr10: 124891898-124892607 HMX2 chr10: 124892023-124892067 NMI-wt vs Ref chr10: 128863581-128864054 FLJ45557 chr10: 128864100-128864145 NMI-wt vs Ref chr11: 22319439-22319953 SLC17A6 chr11: 022319657-022319701 NMI-wt vs Ref chr11: 31776637-31777992 PAX6 chr11: 031776609-031776653 NMI-wt vs Ref chr11: 68274244-68274755 MTL5 chr11: 068274304-068274348 NMI-mt vs Ref chr11: 117983446-117987106 PHLDB1 chr11: 117984800-117984844 NMI-wt vs Ref chr12: 1844001-1845219 CACNA2D4 chr12: 001844114-001844158 NMI-wt vs Ref chr12: 40253533-40253742 PDZRN4 chr12: 040253480-040253529 NMI-wt vs Ref chr12: 52726910-52727810 HOXC4 chr12: 052727781-052727833 NMI-mt vs Ref HOXC4 chr12: 052727781-052727833 NMI-wt vs Ref chr12: 79634857-79635257 MYF5 chr12: 079634813-079634857 NMI-wt vs Ref chr12-94776044-94776377 SNRPF chr12: 094776044-094776094 NMI-wt vs Ref chr12: 95164929-95165298 ELK3 chr12: 095165171-095165220 NMI-wt vs Ref chr12-113657930-113659205 TBX5 chr12: 113325125-113325174 NMI-wt vs Ref chr12: 113609113-113609535 TBX3 chr12: 113609153-113609207 MI vs Ref TBX3 chr12: 113609259-113609303 MI vs NMI-wt chr13-34950488-34951119 MAB21L1 chr13: 034950488-034950532 MI vs Ref MAB21L1 chr13: 034950709-034950765 NMI-wt vs Ref MAB21L1 chr13: 034950955-034950999 NMI-mt vs Ref chr13: 35817738-35819004 SPG20 chr13: 035817882-035817927 NMI-mt vs MI chr13: 57101588-57102323 PCDH17 chr13: 057101685-057101729 NMI-wt vs Ref PCDH17 chr13: 057105585-057105629 NMI-mt vs Ref chr13-94152191-94153185 SOX21 chr13: 094152286-094152330 MI vs Ref SOX21 chr13: 094152463-094152507 NMI-mt vs Ref SOX21 chr13: 094152463-094152507 NMI-wt vs Ref chr13: 105943410-105943788 EFNB2 chr13: 105943362-105943406 NMI-mt vs Ref EFNB2 chr13: 105943488-105943532 NMI-wt vs Ref chr13: 111763361-111764235 SOX1 chr13: 111764262-111764315 NMI-wt vs Ref chr13: 112249708-112249928 TUBGCP3 chr13: 112249984-112250030 NMI-wt vs Ref chr14: 19992581-19993863 APEX1 chr14: 019993551-019993604 NMI-mt vs MI chr14: 23710894-23712060 REC8L1 chr14: 023711936-023711980 NMI-mt vs Ref chr14: 28317076-28317375 FOXG1B chr14: 028317289-028317343 NMI-wt vs Ref chr14: 33338698-33340189 NPAS3 chr14: 033339869-033339913 NMI-wt vs Ref chr14: 36122289-36122589 NKX2-8 chr14: 036122225-036122274 MI vs Ref NKX2-8 chr14: 036123184-036123232 NMI-wt vs Ref chr14-36205192-36206099 PAX9 chr14: 036196442-036196486 NMI-mt vs Ref PAX9 chr14: 036205602-036205647 MI vs Ref PAX9 chr14: 036206112-036206171 NMI-wt vs Ref chr14: 37137198-37138958 FOXA1 chr14: 037137114-037137159 NMI-wt vs Ref FOXA1 chr14: 037137543-037137587 NMI-mt vs Ref chr14: 56347822-56348040 OTX2 chr14: 056347712-056347756 NMI-wt vs Ref chr14: 60045486-60047933 SIX6 chr14: 060046995-060047041 NMI-wt vs Ref chr14: 60173732-60174416 SIX1 chr14: 060173710-060173754 NMI-mt vs Ref SIX1 chr14: 060179528-060179574 NMI-wt vs Ref chr14: 98781593-98783184 BCL11B chr14: 098782637-098782681 NMI-mt vs Ref chr15: 50867751-50870991 ONECUT1 chr15: 050870481-050870525 NMI-wt vs Ref chr15: 58083428-58085812 FOXB1 chr15: 058084349-058084393 NMI-wt vs Ref chr15: 62984853-62985116 ANKDD1A chr15: 062984784-062984834 NMI-wt vs Ref chr15: 65902540-65909629 LBXCOR1 chr15: 065908791-065908850 NMI-wt vs Ref chr15: 72206924-72210097 ISLR2 chr15: 072206870-072206914 NMI-wt vs Ref chr15: 74414579-74414893 ISL2 chr15: 074414745-074414789 NMI-wt vs Ref chr15: 88158407-88159577 ANPEP chr15: 088158433-088158477 NMI-wt vs Ref chr15-94688798-94689131 NR2F2 chr15: 094688839-094688885 NMI-wt vs Ref NR2F2 chr15: 094688901-094688949 MI vs Ref NR2F2 chr15: 094689087-094689131 NMI-mt vs Ref chr16: 727072-727328 NARFL chr16: 000727383-000727427 NMI-wt vs Ref CBLN1 chr16: 047869472-047869516 NMI-wt vs Ref chr16-52873104-52882105 IRX3 chr16: 052879704-052879750 NMI-mt vs Ref IRX3 chr16: 052879918-052879974 NMI-wt vs Ref IRX3 chr16: 052880382-052880426 MI vs Ref IRX5 chr16: 053528320-053528364 NMI-wt vs Ref chr16: 66071900-66072846 ATP6V0D1 chr16: 066071973-066072017 NMI-mt vs MI chr16-85098883-85102729 FOXF1 chr16: 085098933-085098977 NMI-wt vs Ref CNTNAP1 chr17: 038089272-038089316 NMI-mt vs Ref CNTNAP1 chr17: 038089272-038089316 NMI-wt vs Ref chr17-44074280-44075233 HOXB5 chr17: 044026017-044026069 MI vs Ref HOXB5 chr17: 044026017-044026069 NMI-wt vs Ref hsa-mir-196a-1 chr17: 044074404-044074448 NMI-wt vs Ref hsa-mir-196a-1 chr17: 044074457-044074501 NMI-mt vs Ref chr17-58865328-58865618 CYB561 chr17: 058865281-058865326 MI vs Ref CYB561 chr17: 058865281-058865326 NMI-wt vs Ref CYB561 chr17: 058865512-058865556 NMI-mt vs Ref chr17: 67627870-67631593 SOX9 chr17: 067630891-067630945 NMI-wt vs Ref chr17: 71582000-71585125 GALR2 chr17: 071583191-071583235 NMI-mt vs MI chr17-75531280-75531546 TBC1D16 chr17: 075531439-075531483 NMI-wt vs Ref chr17: 75936057-75936582 C17orf27 chr17: 075936313-075936368 MI vs Ref C17orf27 chr17: 075936313-075936368 NMI-wt vs Ref chr17: 76404186-76404427 KIAA1303 chr17: 076404103-076404162 MI vs Ref KIAA1303 chr17: 076404103-076404162 NMI-wt vs Ref chr17: 77537903-77538626 ASPSCR1 chr17: 077538538-077538583 NMI-wt vs Ref chr18: 894579-899574 ADCYAP1 chr18: 000899042-000899087 NMI-wt vs Ref chr18-5186244-5187389 ONECUT2 chr18: 053259508-053259552 NMI-mt vs Ref ONECUT2 chr18: 053259508-053259552 NMI-wt vs Ref chr18-68359955-68362770 CBLN2 chr18: 068361299-068361343 NMI-wt vs MI chr18: 74837994-74842232 SALL3 chr18: 074838538-074838582 NMI-wt vs Ref chr18: 75565313-75565933 CTDP1 chr18: 075565319-075565363 NMI-wt vs Ref chr19: 898548-898981 ARID3A chr19: 000898650-000898694 NMI-wt vs Ref chr19-4059891-4060207 MAP2K2 chr19: 004059891-004059935 NMI-wt vs Ref MAP2K2 chr19: 004060122-004060166 MI vs Ref MAP2K2 chr19: 004060122-004060166 NMI-mt vs Ref chr19: 9131907-9132918 ZNF317 chr19: 009132692-009132736 NMI-wt vs Ref chr19: 12985960-12986259 NFIX chr19: 012986040-012986084 NMI-wt vs Ref chr19-42586165-42586705 ZNF569 chr19: 042586544-042586592 NMI-wt vs Ref chr19: 55553586-55553895 NAPSA chr19: 055553837-055553881 NMI-wt vs Ref chr19: 57082654-57083180 ZNF577 chr19: 057082979-057083023 NMI-wt vs Ref chr19: 60283718-60285792 EPS8L1 chr19: 060285492-060285536 NMI-mt vs Ref chr19: 60907042-60907388 EPN1 chr19: 060907107-060907151 NMI-mt vs Ref EPN1 chr19: 060907320-060907364 NMI-wt vs Ref chr19: 62043096-62043807 PEG3 chr19: 062043010-062043054 NMI-wt vs Ref chr19: 63321122-63322053 ZNF329 chr19: 063321824-063321868 NMI-wt vs Ref chr19-63420090-63420541 ZNF274 chr19: 063420437-063420481 NMI-wt vs Ref chr19-63784504-63785085 MGC2752 chr19: 063784639-063784683 NMI-wt vs Ref MGC2752 chr19: 063784804-063784848 MI vs Ref MGC2752 chr19: 063784804-063784848 NMI-mt vs Ref chr20: 9444472-9444893 C20orf103 chr20: 009444951-009444998 NMI-wt vs Ref chr20: 21433933-21444714 NKX2-2 chr20: 021439947-021439991 NMI-wt vs Ref chr20-22505518-22507240 FOXA2 chr20: 022505822-022505866 NMI-wt vs MI chr20-22510737-22514165 FOXA2 chr20: 022505888-022505938 NMI-wt vs Ref chr20-22514762-22515148 FOXA2 chr20: 022507864-022507908 NMI-wt vs NMI- mt chr20: 23294035-23294650 GZF1 chr20: 023294489-023294536 NMI-wt vs Ref chr20: 25011839-25013525 VSX1 chr20: 025011908-025011952 NMI-wt vs Ref chr20-35582018-35583550 NNAT chr20: 035582918-035582969 NMI-mt vs Ref NNAT chr20: 035582918-035582969 NMI-wt vs Ref chr20: 36785545-36790786 SLC32A1 chr20: 036787891-036787941 NMI-wt vs Ref chr20: 38749965-38753401 MAFB chr20: 038753128-038753174 NMI-mt vs Ref MAFB chr20: 038753269-038753318 NMI-wt vs Ref chr20: 49542203-49542863 NFATC2 chr20: 049542266-049542311 NMI-wt vs Ref chr20-54012011-54014085 CBLN4 chr20: 054013134-054013178 NMI-wt vs Ref chr20: 54411932-54412178 CSTF1 chr20: 054412143-054412187 NMI-wt vs Ref chr20: 55680656-55681057 TMEPAI chr20: 055680906-055680952 NMI-wt vs Ref chr20: 56860125-56860442 GNAS chr20: 056860480-056860524 NMI-wt vs Ref chr20-60061693-60062033 TAF4 chr20: 060015181-060015225 MI vs Ref TAF4 chr20: 060062094-060062139 NMI-wt vs Ref chr20: 62371744-62371958 PCMTD2 chr20: 062371900-062371944 NMI-wt vs Ref chr21-33316999-33322115 OLIG2 chr21: 033318624-033318681 NMI-wt vs Ref chr21-36990008-36995832 SIM2 chr21: 036991619-036991663 NMI-wt vs Ref SIM2 chr21: 036999107-036999151 MI vs Ref chr21-43350621-43351134 HSF2BP chr21: 043902052-043902096 MI vs Ref HSF2BP chr21: 043902052-043902096 NMI-mt vs Ref chr21: 45511336-45511549 POFUT2 chr21: 045511551-045511595 NMI-wt vs Ref chr21: 46892946-46893236 PRMT2 chr21: 046893181-046893225 NMI-wt vs Ref chr22: 18453364-18453931 DGCR8 chr22: 018453720-018453764 NMI-wt vs Ref

TABLE 7B Sequences of differentially labeled CGIs between bladder cancer subgroups relative to blood CGI: 561 range = chr1: 63554983-63563059 CGGGCAGGCCCAAGCTGCGATGTGGAGAATTCGATGTCCGAGCGACCTCCTCGGAGGAGTGGGTCGAGTTAAA TATAACCGCGCGAATGGAATGGCGCTAAAAATAAGGCAGCAGCTGGCCTGTCCACAGCCCTGTCCCGGGAGGG GCGGGGGCCCCAGTGGTCTTGGGCAGGAAGGCCGCGTCCGGCCCAGGGGCGAGAAGGCTGCGGCGTCCGCAGC CAGGGCTGGAAGGCCTGGGAGGCCGCGCTCTGTGGGCCCCGGGGCCTCCATTCGGGCTGGGTCGCGGGCCTGG ACGGGGACTGTCCAGAGGCATCCGAAAGCCAGGCCAACTTGCCTGGACGTAACAAGACGGAAGGGCTGGGCGC TGAGGTCCTGCCAGCCCGGCCGCCAGAGGGAGCTGAGCGCCAGAGGAGGACAAGCCGAACCCTTCAGGAGGCC GGGCGTCTCCGGAGACCGAAGCGCCGGAGGACCCGAGGAGGTCTGCCCCGCGCGCTGCTCTGGAGACTCCCGG GGCGGGTGGCGCTCGGCCTTTCCGCTCCCTTCCTTCCCACAAGTCCCTTCCCGCGCGCGCCCCACGGCCCTGC CCGCCCTCCCGCGTCAGCGCCCCAACCGTCAAGCCAGCAATTGAAACGTTTCCAAAACGGTCTATTTATTTGC TCCCAATAAATCGATCGGCGGTGATTAAAGAATCGATGTGGCCTGGGTGGGCGAGTCGCTTGAGGGGAGGGAT TGGGGGCTTTCGCCCGGCGCCTGCAGGGAGGCCGAGGGCGGGCGCGGGCCTGAGGGAGGCGTGTCCCGCCCGG GCCACACCCGAGGACCCGACACCTGGGCTGGCAGGCCCCGGCAGGCAGCGTTCCCTCCGGCGGAGAGGGGCGC GCGCCCGCCGCCTGCTTTCCTCGGCCCCTCTCGCCTTTCTCGCGCGCCGGGGAGGCTGTGGCCGCCAGTGGCT GCGGAGCTGCTCAGAGGCTTTTGTTGCTCCTCGGCCGGCTGAATGGGGATTTTGTAAAGCGGGACAGATAAAA ATGAGCAGCATCATATTGTTTGACAGAATGATCTCGCATGATGAAGTGTCGGCTCCGAAGGGGGTGAAAATGG TGAATTCCTAAAAACCCAGCCCTGGGCTCCTCCTCGAGCTGCCGGTAGCCTGGAGGGACCCAGCGGACAGCCG GGCCTGGCCGCATCGCTCCAAACGGTGTCAGAAAGACTCCGGCTTTCAATGCCAAGTCATTTTTAAGCCCCGA TCCTGTCCAGGACCTTTCTCCTCGTGGATGAAAAGAACAATTTTCGAGAGAAAGGCTCGTTTTTATTAAATCC GACATGCTGCTGATAACTCCATGCTAATGTGAAATAATTAACATAATAGCCATAATTAAAAGCACGCTAACAA TGCCATAAATTTATCACACAATTTTACTAGCTTTCTGCCCCTAACTGCTCTCTCATCGTTAATTAAACGTGTT GCCTTTTACAGAATGGATGTTTATATATTTCCAATATAAATAAATTCGAAACCATCCTCTCTCTCTTCCTCTT TCTCTCCTCCTTTCCTTTTGGTCTCTCGCCATTTACAGGCACGCCTTGGCGTGGACCCTGAGTGGCAGACATC TTGAAAATAAATGAAGTTTTGAGATGCAAATCCAAACAAGAACATTAAAATAGCCTCTTTTTTTCCACCCCGA AAAGATCCGGAGAGGTATACAAGGGGGTAGTGGTGGGTAAGAGAGTTGAAAATCCCCCGCTTTGGGAAATGGA AGTAATCTGGGTGGGTTGGGGCCTTGGGTACCACCTCTGCCCTTTCCCACCTTCCTTGGTGGCGGCCATCCAG ACAAAGAGGCCGGTAATAGTTTAACAAATCTATGAAGATTTTCAAGAAGCAGCAGACTTTGATTGTTGCGGGC GCGGGGGTGTTGGGGAGAAAGGAGGGGAATTTTTCTAATAGTCCCACCCACGTTTTGCTCCCTCTTGGACAAA GAGTAACTACTCTTGGTGGGGGACGCGCCCTTCACTCCGCGGAACCTGGTCCCAACTCCCCGTATTGTAAGAA AAGTGCACCCGCGCGCGGGCATGATGATTCTATCTCACATCGCGCCAACGACTTATTCAAGCCACTGGCACTG TCTCTGACTTAAAAGAGGAGAAAAGAGGCATATGGGTTCACTTGGGCCTGGTGAGGGGTAGGTGGGCAATTCC CGCCTTCCGCACTCTAACCGTGCCCCTCCTCCAGTGTTGACCACCTAAGAACCCAAAATGAGCTGTAATTAAT TTCCCTTTCTCCATCATAAATTTTTCTATCCATTTCTTCCCCCCCATCCCCCCACTGGACGCACACACTAAAT CTCCCCTCCCCTGGAGACGTCTCAATTTCCTTCCTATCGATCCGGACTCCATTCTTCTTGCCTCCTGTTGCTA GAACCTAGATCCCCACTCCCCGCACCCCTCATTCCCACCGCGTCCAGGTGGCTTTCCCAGCGGGGTACCATGT ACTCTGCCCGCTCCAGAGGAACCGAAGGGGTTTCATTCCATTCTCCTTTGGTTGAAACATTTCAAACATTTGA GCAGGTGAGGCAGCTGGCTGCCATCTTCCTTTTTAAATCTCTCCTGGGAAGTTCGCTTGTTGAGACTCAAAGA GTCACTCAAACTCATAATTGCGTGTGTGTGTCTACTCATTCTCCCTCTATCTCTCCAATAACCCTTTGAGACT CAGAAACTTTTTATCCACATACACCCTTTATCACATTTTCTTCCCCCCACTACATGTGTCTCACTTTCTCTCT GTATCTGTCTCGCTTCTTCCGTCTCTGTCCTACAGCTTGGCGGTAACTGACGACCTGTGAGCTTTTAGCTGCA AACTGCAACTACGCGGCAAACAATTTATTTAGCCCGACATCTAGCCGGTCTCCGGCAGGACCCTGCACCGCGT CGGGATCGGACCCTTCCGCTGGGGCGGCCTCCTGCGTCAAGGCCAGCAGGAACCTTCCTGTCGCCCTCCCCGG CCGCCGCTTCGCCTCCTTCCCGCCCCCGGAGGTTGTGCAGGCGCTATGGTCCGCCTGGAGGGAGAAAGCCGGC GGCCGGTTCCTGAGCCGAGAGCGGCCGCGGAAAAATCCTCTGCCTCCGCTGGAAATCGATATTAGGCCGGCGC GGGCGCGGGACGTCGGGGCCGCAGCCAGTAGGTTGTGCACGTCTCATCATTTAGCTAATCGAGTCGAAAAGTT TCTGTAAGGGCCGGACCCAGCATCAGATGGTAACACTGATTGAACAAGAGATTAGCACAATAGATCTCTAACC GAGGGGAAGCGTTGCTTTTCACGCTACGCGCCGTAATTAATGGTATGAATCAATTAATTTGACTTTTATTGTG TCGAAGGAAAAAAGCGCAACAAATGGAACCGGCAGCTGGGAGTTGTTCGTCCTCCACCCCCTTCCCCAGGGAG GTTCCAAGGAGACACCGGGGAATGGACGGATCAGGCTGGGCCGTGGCAGAGGGAGGGTAGGAGGCAGCGACCA GCAGCGTGGAGGGAGTCCAGAGAGCTAGCCTCTGCGGACGGCGGAATCGAAATTAGGCTCATTTGGAGACTAC TTCGAGACCGGTGAGGGGAGCCCTGTAGCCACCATCCTCCGGCGCGCATCCACACATACTAGTCCACGCGGGC CCAGCCACCAAGGCCGCGGCAGGGCCAGCGCTGCGCCCCGGGCCCCTGCCTTTAGGGCTGGGCAACCCAAGCA GAGCAAAGGAGGTTCCTGAATGTGTAAATTTCCGCTTTTTAGCTTTTTTTTTTTTTTTTTTTGGACCTTCCGA CACTTCGGTTGCTGAGGCAGTTGCAGACGCGACCTCTGCAGTCCTGGGCGATGGCCAGCCAGCTCAGCTCGGG TCGGTTTCGCGGAAAGCTGTCTAGACGGCATTGTAAACGGTTCGGAGCCTGCGGGCCACAAAGCTGTGGAGCT ACGGAAATCAACTCTGAGATGCGTTTTAGGGCCGTGTGCAACCTCGGGATCATTTAGATAAAGAAAAACTGTG GAGGTTGGCGGGCGTCTCAGGATAGTGTCACCACCCCCTACCCTGCTCCCAGCCTCAGATGAGTAGTGTTATA TCCTGGGAAACTGTCTAATGGGGATGAAAGTCAATCTGTGTGTCTCAATGCCTGTAATGAAGCAAGTTTACAG ATTTTTAAATTTTTATTTTTATTTTATTGAATTATTTTTGGTGTGTCTAGGCCAAGGAAAGAGGAGATCGTGG GTGGGGAAACAGACTGAGGGAATCAGAAGCACCACTGTCCATCCGGAATTAAATCCACATCCCAGCATCTTCT GCAAATATTTCACTAATTATTTCCTCTCGGAACTCCTCCCCTCGTGCTCCTTCCTCTGGTGAGGCCGGCGCTC CCCTCCCAGGCCGCAGCGGACAGACAGGGATTGGGTTCCGTGTGCCTGCCACACCAGGCAGGCTCTTGCGGCT CCCAACTAGGCGGCCTAAATGAGGGAGGAAAGAGGAGGCGCATCGCTGATTCACCGCGTCAAGAGCACTGACT TTCCTTGGAGGTGTGAGGTCCACGCACCCCAGCCACGCACTTGGGGGTCGGTTTGCGGTGCCTCCCCCTCCAG TCCCAGTGAAATCCCCACAGTTTTTCCTACTATCACTGACTTGCCTTGCACTCCGCGTGCATTGGCCACACAT CCTCGCCTCCTCCACCCGCTCCGCCGCCGGTTTTCTTGGAAGTTAAATCTTGGAGGATTTGTCCACACCTTAA GAGAAGAAAATCCACGTTAGCTGGCAGCAACGGAGATCCCAGCATGCTGGCATGCCCAAGTCTGCCCAGGTTC CCCCAAGGCCATGCCCGCCGCCCGGGAAGTCACTGCCCGCACCCCTCACGTTTCTTCAGCCGCCCCTGGGCGC TGCGTCTAACCTGAAGACACCAGGCCTCTTCCCGGATCCACTCGACTTACCCAGGCCGCTGCCAATCCCAGCT CCTTCCCCAGCGCCTCATTTCCGATTTTTTCATATGCTAAGTCGTTTAACAACTCCAAGTAGCCAGTTATGGC TTCTTTATTTATAGGTTCCCTGCTATTTTACGTCGTTTTTATTTCTCTCGGCAACTATTCTAGTAGATTAATC AATAGCCATTTTCTGACCTTCGGGAACCCCAGCTGATGCTTTTTGTGGCCGCACGAAAAAATACATACAGGAA AACACGCCCGCATCAAGCCGGGAAAGAGCAGGTAGGACCTGAGTGGTTTGGTTGGGGGAGGGGGAAAAAGACA TCTCAGCAGGTGTCTTCCCCGGAATGAGCACTGAGGCCAGAGGGGAATCTGAAATCTAATTAGCAGGAGGGAG CCGGGTGCGCTGCTCTTACTCTTTAAAGCTAAAAACAATGAAACAAAAAGCAAAACAGAGACTAAGTTTTGCT TTTTAAAACACGATATGGGAACCTCGTTCTAGGTCGCCCAGTCCCTGTCTAAGGAGTGTGACAAAGTGGGGGG GAGAAGGGCGGAAGGGAGAGGGGGCGGGGAAGGCAGGGCAGCGACAGTCGCACAGTCCCGCGGACGCTCCCAG GCCCACGCCCTGACTCGCTCACACCCACCCACACTCACACCCACCCGCTCCCTGGGCCCCAGGGCCCGGATCC AGCCTGGGTGGGGGGGTCTCCGGGCGGGCCGCAGCGCCCTCCGTGCCCCGGGGATGCTGGCGCACAGTGCGGA GCGGAGTTGCGCGTCTCTCGTCCCTTTGTTGACAATTCCCTGAACCAACTTGAGTTTGGCCGGCTCGGCCGCG GCCCTGACGTCACGCACGGTCACGTGGCCCCGCCTCCCGCTGGATCTTTAAGTAGAAAGTAATCTATCAGGCC AGTCCTTAAAACGGGACTTTCGACTACCGGGGCTTCGGCGTCCCTGACACCCAGCCCCCTGCCCCCCCGCTAC TGTCCCTGCCCGCGCCCTCCCGAGCTGCTCGGCGCCCGGCGTCCCGCGCCCGCCTGGACCGCTCCTGCGCCCC ACGCCAGGGCCAGAGGCCGAGGAAGGCGGGCTAAGTGAGGGGGCGCGGCGTGGAGAACCGCCGGGGCCGGGAG CGGTAGCGAGCGCCTAGTACCGAGCGCCAGGGACGGCAGGAGTTCGCGGAGCGCGGCCGCTGGGGGCGGACGG CAGAGCCCGCGCCACGCGATGCGGGGCCGCCGAGTGTGAGCTGAGCCCAGCGGGCCCCAAGCCACCTGCGGCC CCCTCCCCTCTCCCTGCCCCCCATCTTTCGGGGGCACTCAAACCCTCTTCCCCTGAGCTCCGTGGCAGCCCCC GAACACCCTCATCGCCCGCTGCCCCCTCCCCGCCGCCGCTACCAACCCCGAGGAGGGATGACCCTCTCCGGCG GCGGCAGCGCCAGCGACATGTCCGGCCAGACGGTGCTGACGGCCGAGGACGTGGACATCGATGTGGTGGGCGA GGGCGACGACGGGCTGGAAGAGAAGGACAGCGACGCAGGTTGCGATAGCCCCGCGGGGCCGCCGGAGCTGCGC CTGGACGAGGCGGACGAGGTGCCCCCGGCGGCACCCCATCACGGACAGCCTCAGCCGCCCCACCAGCAGCCCC TGACATTGCCCAAGGAGGCGGCCGGAGCCGGGGCCGGACCGGGGGGCGACGTGGGCGCGCCGGAGGCGGACGG CTGCAAGGGCGGTGTTGGCGGCGAGGAGGGCGGCGCGAGCGGCGGCGGGCCTGGCGCGGGCAGCGGTTCGGCG GGAGGCCTGGCCCCGAGCAAGCCCAAGAACAGCCTAGTGAAGCCGCCTTACTCGTACATCGCGCTCATCACCA TGGCCATCCTGCAGAGCCCGCAGAAGAAGCTGACCCTGAGCGGCATCTGCGAGTTCATCAGCAACCGCTTCCC CTACTACAGGGAGAAGTTCCCCGCCTGGCAGAACAGCATCCGCCACAACCTCTCACTCAACGACTGCTTCGTC AAGATCCCCCGCGAGCCGGGCAACCCGGGCAAGGGCAACTACTGGACCCTGGACCCGCAGTCCGAGGACATGT TCGACAACGGCAGCTTCCTGCGGCGCCGGAAACGCTTCAAGCGCCACCAGCAGGAGCACCTGCGCGAGCAGAC GGCGCTCATGATGCAGAGCTTCGGCGCTTACAGCCTGGCGGCGGCGGCCGGCGCCGCGGGACCCTACGGCCGC CCCTACGGCCTGCACCCTGCGGCGGCGGCCGGTGCCTATTCGCACCCGGCAGCGGCGGCGGCCGCGGCTGCTG CGGCGGCGCTCCAGTACCCGTACGCGCTGCCGCCGGTGGCACCGGTGCTGCCTCCCGCTGTGCCGCTGCTGCC CTCGGGCGAGCTGGGCCGCAAAGCGGCCGCCTTCGGCTCACAGCTCGGCCCGGGCCTGCAGCTGCAGCTCAAT AGCCTGGGCGCCGCCGCGGCCGCTGCGGGCACAGCGGGCGCCGCGGGCACCACCGCGTCGCTCATCAAGTCCG AGCCAAGCGCGCGGCCGTCGTTCAGCATCGAGAACATCATAGGTGGGGGCCCCGCGGCTCCTGGGGGCTCGGC GGTGGGCGCTGGGGTCGCCGGCGGCACTGGGGGTTCAGGGGGCGGCAGCACGGCGCAGTCGTTTCTGCGGCCA CCCGGGACCGTGCAGTCGGCAGCGCTCATGGCCACCCACCAACCGCTGTCGCTGAGCCGGACGACTGCCACCA TCGCGCCCATTCTTAGCGTGCCACTCTCCGGACAGTTTCTGCAGCCCGCAGCCTCGGCCGCCGCCGCTGCTGC GGCCGCCGCTCAAGCCAAATGGCCGGCGCAATAGGGACGCGCCAATGGCCGGGACCCAGGGTCCGGCGGCGGC CTCGAGCAACAAATGCACCTCCAGGCTGCGCGCCCTGTCCCAAGCCCGGTCCCGGTCCCGCTGCCCAATCCTG GACTCTGCCTCTCCCCAATTTCCTTTCCCCTGAGCCCCCAACGCCTACCTTCCGCGGCCTCCATCCCCTCGCG CACACCTAAGCTGGTCGAGCAAACTCACCGCGCGCCCGCCGGGGATAGCTTTCCATACAGGTAAAACCGAAAA CCGAATTTTCCAAAAATGCACCCCGACGGCGCCTGCTCTTAGTACCG CGI: 26 range = chr1: 90955098-90955445 CGCGTCTGCTACCAGATGCGGCTCCGGGGGCTCCATGGTGACTGAGATAGGAGAAGAAGGCGCCGTCCCTACG GTATCAATCTCCGAACAGGGAGATGGGGTGGCCTGACTCCTAAAATCCGCGGTCCTGGCCTCACCGAGCGGGC GGAAATCTCCATTCATCATGCCTGGGCTGCCTGAACTGGCACTGGACAAAATCGTGTCTATTCCAAAACTCGA CCCGCTGGCCCCTTCCATTGTCATTGCTACATGAGGTCCACGCCACTCCGCCGTTCAGCAGCCGCCCCGAACC AGCGAAGAAAGCTATCGATCGTAAAACAAAATAAACACCAAACAATGTTGCCGCCG CGI: 29 range = chr1: 163590111-163590435 CGAGAGGCCCGGCCACCGGCTCGGGAGCTGGGCCGGTCGCTTTGGGAGCGGATGAGGAAGGTTAGGAGAAGCA GCGAGATAGATCCCAATTTTACAATTCTATTTTCTTTCGGTAGGGTCTCGGCGTCCTGGGCCACGTTGAGAGC GAACGTGGGCCGAGCGGAGGACACAGAGTAAAAAGCGACGCCCGCTGTATACATAAATCCGCACCCGCTGCCC GCCCGGGTACTGCCTGCTCTGGCTTCCGCTCTCTTCCGAGGCTGGGCAAGTCCAAAAGTTCCCGAAAGGGGGG TTCAAAGAGGGGCGCTCAGTGCACGTGATTTCG CGI: 32 range = chr1: 173258989-173259419 CGCGGAAGAGGGCGGAAGGAGAACCCCTGGACTGGTCCTCACCGAGCACTACAGGTGGCAGAGCCGTGGGGGA CCCGTGGGTTATGAGATTCAGCGGTGAGGGGTAGCGGTGTGGATAAAAGTAGAGGCCTGACCTGCTTGAACGT CCGCAGCAGCGAGCCCAGCATGAAGGCCGCCATGTTGTCCGCTACAAACTACAAACCGCTGAAACTTTATTGA CACTGCCGAATAGCGCAGGACACGAGGGGCGGGGCCTGGGCCGCCTGGGGCGGAGCTGGGAGGTGGGTGGGAA TGTGGCCTACAGGAAAGCGGGGTTAGTTTTGGGATCGGAGCTCTCGCGATATTTCACGGAACTTGGGCAAATG ACAAATCTGAAGGCGCCGCGTTGATGCTGATGGCGCAGCCAGACCCGCCCCGTGTGTTGCAGCCCG CGI: 58 range = chr1: 196153712-196154414 CGTCTGGCCAAAGGCGCCCAGCTCAACGGCCGCGACGCGGTAAGGAAGGGCTCCGCCGCGGCGGTAGCCGGGC ACCCCTGCGCCCTCTGTTAAACCAAGCCGACTCCCTGGCCGGTGGAGAACCGGAGCGGCGGGTCGTAGAGACG TCCGCTTGAGGGTGGCGGGTGAGTTTTCTCCCGTCCACCTATGCCTACAGGGCTAAGAAACGGTCGTTTTTCT GAATCGAAATGTCTGCAGCTGGCTATCCTCCGTCGCAGCTGATTCCGAAAGAGCAGGGAGAGGAACTGGGAGG AGGTGGGATGGGGGGTGGTGGCATTCTCTTCTACAGACCTCAAGGTTCCCTTGATTCCGGGGCAGGCGTCTCC CCGGCGAGGATCCGCAGCTCCGAGGGCAAGCTGGGCATAAGCAATAGGAGGACGGCGCGCTGCCGAGGCGTCC GAGCCAAGCAGGAGCCCAGGTGGCCTTAGTCTCTGGGCCTGATGACCGGACCTGTGGAGTAGATTCCGACGCG ACTGGGTCATTTCCAGTTCTCTAGACGCTCGGGGCTTGGGACCCCTAACCGAGAGAATCTCAGGGTTTCTGGC ATCCCGACTCAGTCCCTCTAAGGAGACAGCACTACGTTTAGCGCCAGGACCCGGCGGGTGTCATGTGTAGGGG GAAATCAAATAAAACATACGGAGGAGCGCGGCACCCAGTCGAAACG CGI: 43 range = chr1: 219117072-219117487 CGGCGGGGGTCGCTCCAAAGACTTGTATTTCGCGTTTGCCTCCGGGAGCTGGGAGTAAGGCCTTGGATGGCGC CGACGCGGTTGCGAGGAAGCTGAGGCCTGGGAGAGCAAGGGGCGCGCAGGCGAAGTTGCAACTTGCACTCCAG CCGCGGGCCTGGCGGAGAAAGGGAGGCTCGCGGCGCCGCGAGGAGTCGGCGGGCCTCGGGGCCTCGCTTTCGC CGCATCTGCCCAGCGCTCCGGGCCTTGAATCTCGGCAGATGCGAGTTGTGGGCACCTAGGGAACCCTGAGGAC TCGCATTCCCCCGGGTCTGTATCCCGTGCCCACCCCGGAGCGTCGCAAACCTTGGAAAGGGTGAAAGCTGATA GGGGAGTCTTATTTCTTAAGAGAGAGGGTGAGGGCGCGCGGCGCTGCCTCG CGI: 25 range = chr1: 241719037-241719368 CGGAAGAGGTGGACCGGCTGCGGACCCAGGTACTGTGCAGAACGCGGCGCAGGTGGGAGTCCTTGGGCGGGCG TCTACAGGTGGATCTTTTATGCACCTCAACAGGCCGGCTTTCTCACGGATCACATCGGTTAGCAGTAAGCTGG GAGGGAGGTCCCGAAGACTGTGCTGGGCACAGTGCAGGACCCAGAGAAGCGGAGCCATGGGCCCGTCCTGGTG AGGGAGTTAAAGTCCGTGCAGGTGAACAGACCCCGGCCCGCGAATCAACGAACCACACCGAGTGCCAAGTTGC GCCGTGCAGGCTGCGGAGGGTGCGAGAGCAGGGAGAAGCG CGI: 132 range = chr2: 54536404-54537878 CGAACGCAACATCAAGGGCGAAAAGAGGCTGCACAAATCACGTAGAAAATTAGACCGCCTCTTTCCATGGCGA TAATCGAATTAGCCTCAAATTAAACGTGAAATTGGCCCTCTCCGGCTGTGGAGACAAAGCCCCTATTGTCCTG CTCGGGTAGCGGCAGCAGCAGTGCCCACCCCGCCCCGGCCAGCCTGGTCGGTCCCCGCCGCTGGGAGGATGAG GTCCGGGCTGGACCCGGGAAGAGCCTCAGCTGGAGAGGACGTGGACGCGCCCGAGGCTCGGCTCCCTGGGCGG CTGCGGGGCTCCGGGCAGGAGGAGAGGGCGGGCGAAGCAGAGGGAGCGGGCGGGAGTGGGGAGGGAGGAGTGC GGAGGGCGGAGGGCGTGCGGGAGGGATCCCGGGAGTGCGCTTGTGTGTGTGTGCGCGCGCGCCCGCCCCGCGC GCTCCTCTCCCCGCCCCTCGCCCCCTCCCTGCGAGCGCCCTCCTCTCCTCCTCCCCCCGCCCCCCGCGCTCCC GCCCAGCCCCCGGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCT CTCCTCCCGGAGCGAGCGCGCAGCCCTGCGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGC CGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCCGCCGAGGAGCGGGAGGAGGACGGGACCC CGGCGCCCCCACCCCATCCCCGGGAGGTAGGTAGGGGGCCCGAGGCAGGGAGATGCCAACTCACTGGGGCTGC CTCCCGGGTGGGCTCCGCGGCGGCGGACGGGCGGGAGGAGGGGCGCGGGCCCAGGGCCGGAGGACGCCGCTGC CCGCCTGCCCTGCGCCCGGGGAGCCGCGTGGGGGCAGGGAGGCTGCAAAGCCCGGGCGGGGGCGGCGCGGGGA GCCCGGGTCGCGGGTGCTCATTGGTACTCGGATGATGCGGGACGAGGGGCGGCAGGCTCTGCGGTGAGGCGGC AGCAGACCCGCCGTGCGCACCGCTGCCGTCCGGCCCCAGCCCCGGCGCGGCGCGGCGATTCCTCCTCCCTGCC TCCGCCGGCGCCTCCCTGCAGCCGGGCGCGGCGGCCCCTGACGCGGAGGCCCCTGGCGCGGAGGTGGGTGCGG AGCGGACAGCGGACAGCCGGAGGGTCTATTTTCAGGTGCCCTCTCTGTGGCCCCGCGGGTGGGGAGCGGGGGC GGCGGTGACAGGGCCGGGCTCTGCGCGTAGCGGTGCAGGGGATGCGGCCAGGCGTGGTCCCGGCTGCGCCGCG CTGCAGCTGAGCCGGAGGCGGCGGCCCCGCGCCCCCACCTCCGCCCCATCCCTGCGCTTGCTACCCTCGTGCG CCCGCCCCCCCCCCGCCCTTTCTGCCGTCCCCACTCTCCCAGGGCTGGGCGTGAGCCGCCTCCGGGCGCCGAG CCGCCGCTGCGCCCG CGI: 77 range = chr2: 73004709-73005568 CGCGTTCCCCCGCGGAGTGGCTCTCGAGTGCGGGGAGGTGTTGCGGAGGGGAGTGGACTTAGGGAAGGGGCGG CAAAAGGGCAAAGGGAGAAATGGCGTGTGTGTGCGTGTCAAGGAATGGAGAGGGCAGGGCGCTTGGGAGCAGG GCGCGAGGCCAGGCTCTGTTGGGCCCCGGCTCACGGCGCCCCTTCTCTCTGTCTGTACCTGCGTGTGTTGCCG TCGGCGGCGGGGCCGCAGCCAGCGACGTGCCCCAGGACGGGCTGCTTCTGCACGGCCCCTTCGCACGCAAGCC CAAGCGGATCCGCACGGCCTTCTCGCCCTCGCAGCTGCTGCGGCTGGAGCGCGCCTTCGAGAAGAACCACTAC GTGGTGGGCGCCGAGCGGAAGCAGCTGGCCGGCAGTCTCAGCCTCTCCGAGACGCAGGTAATCACCCCCGGTC GCGGCCTGCCCTGCGCCCGGAGCCCGGGTGGAGGTGAGGGTGCGCGGGTGCAGGAGAGGCCCTGAGCCCGCCC CAGCCCAGCCCTGCTGGGTTCCAAAAGGCCCCCATTCCCCGCGGCGCTGCGGTCAAGCCCGTCTTTAGAGCCT CTTCCTCGAGACTGCGTGCAGCCTGCTGAGCCCGCAGGACTTTTGTCAAGCGCTAAAGACCTAGCAGGAGGCA GAGTAAATGCAAACTGTATCCCGAGCCCGGCTCCCAAAGCTCCTCACGGGGGGACCAGGTTCCCTGGAGGAAG CGGGTCGCCTCGGGAGCGGGCAGCGCAGGCAGCACCGAGGCCACTGGAGCTGGCTCCAGCCCTGGCATTCCTG CAGCCCTTTTCCCGCCACTGTGTCGGGGCGCTCATAGTCCTGCGGGGAGCCGGTCCG CGI: 221 range = chr2: 85213468-85216104 CGGGGGTCGCGTTGGAACCCCACAGGAAAAAGGCGCGGAAAGCCGCCGGGCATTTTCCGGGGTTCCATAGATG TCCCCAGTGTCCTAGTCCGTGCATCAGCTCGCGCACTCGGAGGGACTCTAGGCAGGGGGAGGGCCCCGCGGCC AGTATGTGCGTCCGAGGCTTTCCCGCAGGGGGCAGTGCCGCCCGCCCGCGCGCCGATACGGTGGGAGGGGGTG GGAACCTGCGCGGAGTTCTGGAGGTTCTTTGGGAGAAAGTTAGGGGATGCGGAGGGGTGGGCGCAAGACTTCC AGGACTCCAGGGAGGCCGTGGGGAGGGCCGCCGAGGGTGCAGTGTGAGGCGCAGGAGGGGGTTGGGGGCGGTG CACGTTGCAGGGAGACGCAGCCCCTGGAAGATGCGAGTGTGAACGTGTGAGTGTGAGTGCGTGTGTATGTGTG TGTGTGCGCGCGCACCGCAGCTCTCCGGGTTCCGCGAGGCGCGCGGGTGTCAGCTTGCAGCCGGGGCTCCTCC CTCCGGCCCCCCTGCCCAGCCCGGCGGTCCCTCCTCCCTCCCTCCCCGCTCGCCCCTCCCCGGCGGGCCAGGG GCTGGGACGCCCCGGCGGAGCAGGCGGCGGCGGTGGCGAGTTGGGGAGCCCTAGGCTCGGCGCTGCCGGAGGG GCCCGAGCCGAGCCGCCTGCGCCCCGGCCGGGCAGCGCCGGGCCCGCTTCCCGCGGGGCCACGCCCTGTCAAA CTTTGTTGCGGCGGCTAGCGCAGCGGGCCCGCAAGCGGGCGGGAGGGGCGCCGGGCCGGGCCGGGCAGGGCGC GGGCGGCTAGGGGCTCCGAGAGCGGCGGCCCCGGCCCGCGGCCCCACCATGCCCCAGCTCGGCGGCGGGGGCG GCGGCGGCGGCGGCGGCAGCGGGGGAGGCGGCGGCTCCAGCGCCGGGGCGGCCGGCGGAGGGGACGACCTCGG GGCGAACGACGAGCTGATCCCCTTCCAGGACGAGGGGGGCGAGGAGCAGGAGCCGAGCAGCGATAGCGCCTCG GCGCAGCGGGACCTAGACGAGGTCAAGTCGTCCCTGGTCAACGAGTCGGAGAACCAGAGCAGCAGCTCGGACT CGGAGGTAAGGAAGCACCGCGGCCACCCCCGGGGGATCCCGGCCCTGCGTCCGCTCACCCGCTCTTGCCTTTG TGTCTCCTCCGCAGGCGGAGAGGCGCCCGCAGCCCGTCCGGGACACTTTCCAGAAGCCGCGGGACTATTTCGC CGAAGGTATGTGCCCGCTGGGACAGCCCCCCACTCTCGATTCCCGCTGCGCTCCGCTGCTCAGCCCGGGCGGC CCACCGTCCCCCTTGCTTGGGTGGACGCACCCTTGCCCTCCGCCTTTATTGGCGGCAGCCCCCGTGGGGCGCG CGTGGGGGGCGCTGGGGTCCCCAGCTCCCGCCTCGAGCCCCCTGCCGCGGCGCTGTCAGTCCCGGGGGCCTGG GCCTCACCTCGCCTTGGTCTTGTTCGCAGTGAGAAGGCCTCAGGACAGCGCGTTCTTTAAAGGACCCCCGTAC CCTGGGTACCCCTTCCTGATGATCCCGGACCTGAGCAGCCCGTACCTCTCCAACGGACCCCTGTCTCCCGGAG GAGCGCGCACCGTGAGTGCCCGTCGGGCGCGCCGGGGAGGGTGGGAGGCCGCGGCCCGCAGGATGCGCCCCCG GGCTTGGCCATGGAGTGGGGGATGGGGCCTTCTGCGCCGATCCCAAGCAGAACTTGTTTGCGGAGTTGAACTA CTCTCTGGCGGCCGAGCGCGAGGCTGCGCTGGCCAGTGCCTGGATGAAAGTAAAGTTACTTTAACTTTTCCCC TCTTGCGGGTTGAGGTTTTGGAGTCCACCTCTGGGATCTTCCTTGGCCTCCAGAATTCTTCGCCTGCACCGAA GGAAACTTGGATTTGTGCCCGCTTTGGGGGGGTCTCGCTTTCCTTCTTGGAAATCGGTCAGCTTTCTCTGGCA GTGGGGCAAGGGGCCTAGGGAGCTGGGTTGGCGACGTTGTCCTCCGACTCCGGGTTCACTGGGCGGCTGCAGG CTGGTTCCTAAGAAACCCAGTTTTCGTGGCGGGTTATTCACAGCCCCCGTTCCCACCCCCAGCCCTCGCACCG GGGCCTCAGCTTTTCTGCGGAGCTAGCTCCGAATTTTAAACTCGCGTAGATGATTTCGAGGCGACCCAAGGCA TTCTTCAAGTTGAGGAACTTGGCTTTTTCCCCCTTTTGTCGCCTGCTTTTCTCATTTAAAGCGAGCGCTGCGA CACTTTAAACCTGTTAATGGGCGCGTATTGTGTGCTGCCCGCTGGCATTTAGAGCGGTGATTAAGCAAATTGA CCGGGCCCCAGACGACGTGCAAATGAGGGCGGATTCCTTCGCCCCCTCTCTCTGGCTCTAAACTCCCGCCCCC CGCGTTGCGAGGGGCGCAGCTGGGGGCTGGCGAGGCCTTTGTGTCCCCCAAGCCGCCACTCCACCCCTAGGCT CCCTGCCCAGGTGCTGGGTCCGATGACAGATGTTGGGTGAACGCCTACCTACTGTGTGCCAGGTTCCCGCGTG CTGCTGCTTGGGCGCGATGTGAATCGTAGTAGTTCTTTGCTTCCCGCCCAGATTCCCATTGCCTGCCACTTCG CTGTCGACG CGI: 173 range = chr2: 119329502-119332035 CGAGGAGGCTGCAGGGACGCGCATGGAAGAGCCGGTGCGTGGGAGGGTTTGCGGGGGGGACATCGCGCCCCCT AGGGGTGACCCCAGTGGGTCCCGTGTGCTCTCCGCGGAGCCGGCGGAGCCTTGTCCTCTGCACCCGGCGCGCA GCGGCCCCTTAAACAGTGGAACCGTGAGGCCGCTCTAAGCCGAAGGGCTGGAATCTGGGTTTCTCGGGTTTTA TTTTAGACCATTCGGCACCAAGCCCGAGCTCCCCCGCCGCACCGCTTCCAGTCCCCTTTCTTTCCATAGAGCG ACCCGAAGCCGGCGGTGGCGCAGGGAGCCGAGTCTGATGAGCTCGCGGGCGGCTGAAGGCCGGCTTCCCTGTG GGGAACGCGCCACCTGTCGGCGCCAGTGAGAACTGCGTCTGTGTGGCGCCCTCGGGGTATTCGGGGCTGCGGG GAGATGTGTGCCTGAAGCCCTGCGCTTGCGGTGGGGACGTCCGGCCTCTTTCCTGGCAATTGACCCCTGAGGC GGGAGAGACAACGGAATTCCCACAAAGGGATCCTTCTCGGGATCTCCCCACCTCAAGACAGCTAAAGCTGGAG GAAAAGCCCCTCCGGGGGGTGGGGGGTGCGGGTTTGCCCTGCGATTCCGAAAGCAGAAAATACCCGAGCCACA CAGGGACGGGCGCCGCGTTGGTAGTCGGGGCTACGTTCCTACTCCCTCTACCTCCCCCGCGCTGTGTGACCCT GGGCGGAACCCCGCTGCTCTCTGGGCCTCAGTGTTCTTATTCGTAAACTGAGGGCGTTGGATGAGATTGGTCC TCTCCCAACTCTGACCTTGAAACTGATACTGAATCTGAGCAGCGTCTGTAGACACCTGTGCCTTGCCTTCTAT TTCTAGCCTTGAATAAATCCTGGACTTTTATGTGCCATTTATATCCTAATCTCATATATATTTAATGTATAAC TGCTGCCATTATTGTTTTCTCAATTGTCTAGGTTTTCATTTGGATGGGGTTAGGATGGTCCAAATTATCCCGA TAAGTGCCCATTAACTTAAACCTTTTTAAAAAATGAAACCAGTAAAACTTCATTCACTTTGCAGTGTGGACAC TGCTGGAGAGCACCCATGTCGTGGGTCCAGCGAGGACACAAGGAGGGGCTTAGAGACATGCGGGAGGCTTAGA TGAGAAGACAGCACCCGGGCAGCGGTCAGTGTTAGAGAGAGGACCCGTAAGAAGGGCCGAGGCTAGAGGGAGA GCGAAGACTGAGCCAACGACGCACCTGAGCCCTGGGGTGGGGGTGGAGACGTGGCTCCTAACCCAAATCTCCC TGCCAGGCAGTGTCCGACGAGCATCGACGGCAGGCGTCGAGACCAGTGCAGGGTAGCTCAGACCTCAAGCCAC GCTTGACCTTTCCATGAAATGAATAAAACTCGAAAGCCAGGGAAAGGGGACAGTACTTTGATCCGGAGATCGC TTATAACCTCTGCTTGGAGTTCCGAGTTCGTGCGGCTCAAGGGAGGCTACAGTCCAGCAAGCTCTGGGCTCCA AGCGTGGGGACGGCAGCCCCCAAGCTTGGCGCACCCCTCGGGAAGCCCCGGAACGGTCCTCGCCAGACATAGC CGGCTGTCCTGGTCCTTAGCTTCAGGCTGGCGGCGCAAGGCCAGAGCGGCTGCCTTCTAGGCACCTGGGTGGA GGTCTCGCATAGCATTCCCTGAGAAGCGAAACTGCCCTTGGGGCCGCAGCGAGCCTGCCACATCGAACTGGAG ACCCTCTGCTTTCGGGATAGATGGGACGTTTCTGCTCTGTCCTTCTTGGAGTCCCGGAATCGTTCTGGGGCCG CGTGCTGCCTGGAGGCGGTGAATTTCAGGGTCTTGAGAAGCCGCGCACACACGGGATTCTGGGCGAGCGTCCC GTCTCTTAATTCCTATTAAGAGACGGGAAAATCGAGGGACTGGAGGTCCCATCATTGTCGCGTGAGCAGCCTC CTGAACACCAAGCGAGACCTGAGGGTTCCGCTGGGGCCTCGCCCTGACACCCGGGCCCTCCGTGTGGTCGAGA GTTTGCGCCCGCTCCCGCTAGGGCAGCGAGGTCCCACTTGCGGCCGGCTGGGGCATGGTGGCACCGGTTGTCT ACTCCCCACTTGTGACACCGACAGCTTCCAACTCCTCAGACCCACCCCGTGGAATTCTGGACTTTGTGAGGGC CGCCGGGGTCCTGGCCCTGGGGTCAGCTGCCATCTGACTAAGCCAGGACGGCGGAGCTCCAGGCCTTGCTCCA GCACTGCCGGTGCGTCGGGGCCCGCGGAGAGCCCAGGGCGGGAGCTGTGGGCTGAGCCGGGTGGCCGCGTGGA CACAGATGCCCGGCCGGACTGAGCGGCAGCCAAGACTCTCCGTCCATCCCGCCGCTGGACTCGACTCTCCCAG ACCCGCCACGGAACCCAGATTTGAGCACGCAAGATAAAGACGCCAGAGGCGAGTGCGCGGCGGAGAACTGGCC GCGACACGGGAAGCTTCTGGGGCGCAGAACGCTGGCTCCGACTCGCGCGGCG CGI: 36 range = chr2: 172653235-172653630 CGACGGCGCGCTTGTGGCCCGGCCGGAGCTTGCGTGCGCGTTCTGACGGCTGGGTGCTGTGTTACAGGTCGGC GCAGTTCGAGCACACGGTTCTGATCACGTCGAGGGGCGCGCAGATCCTGACCAAACTACCCCATGAGGCCTGA GGAGCCGCCCGAAGGTCGCGGTGACCTGGTGCCTTTTTAAATAAATTGCTGAAATTTGGCTGGAGAACTTTTA GAAGAAACAGGGAAATGACCGGTGGTGCGGTAACCTGCGTGGCTCCTGATAGCGTTTGGAAGAACGCGGGGGA GACTGAAGAGCAACTGGGAACTCGGATCTGAAGCCCTGCTGGGGTCGCGCGGCTTTGGAAAAACAAATCCTGG CCCTGGACTCGGTTTCCCAGCGCGGTCAACG CGI: 295 range = chr2: 174907710-174910885 CGCCCTCGCCCCCCCCCCGCAAGTATCCCCCACTACTCCCCCCCACCCCCGCGGCCCTAGCTAGCTGACTTGA CTGGCACGCGCCGGGAGCCCGGGCTCGGGCCCCTCGGAGCGTCTGATTGGCTGCGGGGCAGCTCCGGTCTGCT CTGCCTGCGCCCTCATTGGGCGAGAGGCGCAGCCAGCGGCACTTCAAAGCGGGTGCTCCTCGCACTTAGGCTG AGTTTAGCCGGCGGGAGCCTGGAGTCCGCTCGGCACGAGCGCGGGGACGCGGGAGCCGCGCGGGACCCAAGCA GTTTTTCCGAGCAGCCGCCAGGCTCAGCCCCGCTCCCAGCCTCGCTGCGCAGCCAGAGACCTGCTATGGCCAC GTCTATACTCGGGGTAAGTCGCAAGCGCGGCAACGCATTTGCTTGTTTTAACCGGAGTAATTTTTCGTTATGG CTTCTGGGGTCTGCGGCTCCGGAGAAACTGTTGCTGCTAGACTGCAGCTTCAGCTTCTATTAGCACTTTCCAC ATTTCTGGGACTGATTTTTCCCCAAGTTTTTGGAACCCAGAAAGATGCCTTTGCAAGAAAAGGCCTTCTTAAT CAAGTCCTTTTTCATTTGGTTTCAAAAAAAAGCTAGAGGTTTCTTTTCTTCCCCTCGTGATTTATACCCCATC CCCCGCATTGCTTTGGGGATTTTGTTGCAATTATGCGACAATGGTGTTTCCAGAAAACAGTCTTAATCGTTTT GCAGTCCATCTAGTCACGCTAATAAACATTTACATTTCCGCGGCTCCCCAATTCGCCCATGACTTTGAAATCT GTCTCTGGCCGCTTATCCTCGGATTATTGTTTTCATAATCGCTGTTTTTGTGTGTATGTAAACTTTAAAACCA AACGTTTTCTATTAAAAAAGAAAAGTCAAGTCGTAGCCACCCTGGGAGAGCTGCAAGTTTCGCCCGTCCCTGG CAGCTGTTTCGGCCGCCTCCGCCCTCACCCGGTGTTTGTTGTCTCTGGTCTCTGTGTTTACCTTCGCGCTTCA CCCCGAAGGGCGACTTGGGGTCTTCTGGGAGATGAGCCGGTTTACGGCGACAACCCAAGTCCGGTTGTAGGCA GGGTTGCAGCGGGGAACACGGAGGCATCTTTGATTTATAGCCTCAGCGAAGTGCAACTTTCCGGCGCCTGGAC CTTCGCCCGGGTGATCGCCCCTGCTCCGCGCCCGGTGCGGCGACTCCTCCGCGGGCGCGTGGGGAGGAGGCGC GAGGCGGGGAGCCAGGACCCCCCGGGAGCAGCCGCAGGGGACGAGGCTGCTCACGGGTGCACTTTGTTTCTTC CCCCACTTCCTCTTGCCCTCCTCCTTCTTGCTCCCTCCCCCATCCCACCCACTCTAGGAAGAGCCGCGCTTCG GAACGACCCCGTTGGCCATGCTGGCGGCGACCTGCAACAAGATCGGCAACACGAGCCCGCTGACGACGCTGCC AGAGTCGAGCGCCTTCGCCAAAGGCGGCTTTCACCCCTGGAAGCGCTCCTCGTCCAGCTGCAACCTCGGCTCC AGCCTCTCGGGCTTCGCGGTGGCCACCGGGGGCCGTGGCTCGGGCGGCCTGGCGGGCGGCTCGGGCGCCGCCA ACAGCGCCTTCTGCCTGGCCTCCACGTCGCCCACGTCGTCCGCCTTCAGCAGCGACTACGGCGGCCTCTTCTC CAACTCGGCGGCTGCCGCGGCGGCAGCGGCCGGGGTGTCCCCGCAGGAGGCGGGTGGCCAGTCGGCCTTCATT TCCAAGGTGCACACGACGGCAGCCGACGGGCTGTACCCGCGCGTGGGCATGGCGCACCCGTACGAGTCCTGGT ACAAGTCGGGCTTCCATTCGACGCTGGCGGCCGGCGAGGTGACCAACGGCGCGGCGTCGTCGTGGTGGGACGT GCACAGCAGCCCGGGCTCGTGGCTGGAAGTGCAGAACCCCGCTGGGGGGCTCCAGAGCTCGCTGCACTCGGGC GCCCCCCAGGCCTCGCTGCACTCGCAGCTGGGCACCTACAACCCCGACTTCAGCTCGCTCACGCACTCCGCCT TCAGCTCCACGGGCCTCGGCTCCTCCGCCGCCGCCGCCTCCCACCTGCTCTCCACCAGCCAGCACCTGCTGGC CCAGGACGGCTTCAAGCCGGTGTTGCCCTCCTATTCGGACTCCAGCGCCGCCGTGGCAGCCGCCGCCGCCAGC GCCATGATATCGGGCGCCGCGGCTGCCGCCGCCGGGGGGAGCTCGGCACGCTCTGCCCGCCGCTACTCGGGCC GCGCCACCTGCGACTGCCCCAACTGCCAGGAGGCGGAGCGGCTGGGCCCGGCCGGGGCGAGCCTGCGGCGCAA GGGCCTGCACAGCTGCCACATTCCGGGCTGCGGCAAGGTGTACGGGAAGACGTCGCACCTGAAGGCGCACCTG CGCTGGCACACGGGCGAGCGGCCCTTCGTGTGCAACTGGCTCTTCTGCGGCAAGCGCTTCACGCGCTCGGACG AGCTGCAGCGGCATCTGCGGACTCACACGGGCGAGAAGCGCTTCGCCTGTCCGGTGTGCAACAAGCGCTTCAT GCGCAGCGACCACCTGAGCAAACACATTAAGACGCACAACGGGGGCGGCGGGGGCAAAAAGGGCAGCGACAGT GACACGGACGCCAGCAACCTGGAGACGCCCCGTTCCGAATCCCCCGACCTCATCCTGCATGACTCCGGCGTCA GTGCCGCCCGGGCGGCGGCAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGCGGCCTCCGCGGGAGGCAA GGAAGCAGCGTCTGGCCCCAACGACTCTTAGAGGCCGGGCGAGAGGCGCGAGCACACAAGCGAGTAGAGACAC CGAGAACGAACGAGAGGTTCGGAGGGCGAGCGAGCGGGAGGCGGGAGGGCAGGGGCTTCAGTGACGCCCCCAG GGCCCGGGCTGGGCGCGAGGTGGAGCCGCTCAGGGCTCCCGGGCTGCGGTTCGCCCGCTGTGCGAGGAGCTCC CCTCTGCCTTCCGCGCCCGGATAAGAATCGAACGCGTGGTCCGGAAACAAAAGCGAACCATCCTCCGACACAA ACACTTTAAAAACTGTACTCCCAGACGTACACATACACCGGAGACCTACAACCACAAGCACGCACACTCGCGC GCGCACACACATACCACTCGCCCAAACTTCTCGAGCG CGI: 289 range = chr2: 176652334-176656692 CGAAAAGGAGGCGGCGCAACGGCCACCCCTTCCAGCACCTCGGCTTTGTCCTTCCCGGGGAAGGCGGCCACAT CCCTACCCGCCTTGCTCCTGAACGTAGTAAACAATCTCACAAACAACCACCGCTGCCCACGCTCTCCATCCGT CCTCCCGGCCTTATCAGACCTCCGTTCTCCCGCACTCTTCGGGCAGGGTCCCTAATAAGCTCAGGCTGAAAGA ACGTTTGCCACCTCCCCCACCCTCGTTGAAAGAAAAGGAAGAAAAACAGCAGCAGCGAGAAACCTCCGGGGCG ACTCCTCCCCCGCCCCCAAGCACCAGCGCACAGCATCCCCCTCTGTCTTTGTTGTGGTTCTCCGTTGCTTCGG GCCACGCCGTTCAGCCAAGCAACCCGGACCTGAGAGTGCACAGCCAGGACTAGCTTAGGGGGCGAGGGGTTGG TCTTTGGGAAACCAAGCGCTCAGGACAGAGGTGGAAAGTGGGTCCCGGGAGCCAGAAAAGAGAGAGAAGGGCA GACGGCTGGGTGGCAAATACAAAAATAGAAATAATTTAGGGGGATGCCCGCCAGGCTTTTGCGCCTGCTCCTT CTCCCCCAATTCGGAGCAGGTTCCCTTCGGCCTCCCGCGCCCCGGGGCGCCCCCTGGCGGCAGCGGCAGCAGC GGGCAACGCGCGGAGGGCTCAGGGGGCGCACAGGGGACTCCCGGGCACACTCAGAGAGGCGGGCGCGGCCCCC TGGCGGTGGCGACGTAGTTATCTGGTGAGCGGAGCCTCGTCCCTCTGGTCCGGCGGGCTCACGGCCGTCTTAC TAAGCACCGCGGCCGAGTAGGGCAGGAAGCCGCTCTCGGAACGCGGCGCCGCCGCGCTGCAGCCGAAGTCCGA GCCTCCCCCGGCCCCGGCGCCCCCGCCGCCGCCGCCACCACCACCACCGCCGCCGCCACCGCCACCCCGGGAA CCCAGGGCTGCGGCAGCTGCTGCCGCGGCTGCCGCCGCCGACTGACTGCTGTGGCAACTGAGGCACGAGCAGG GTGCAGAGCCGCCGCTGGGGGGCGCGCCGGCCGCCGCCGCCGAGGAGGCCGCAGCCGCTGCGGCTGCCGCGGC TGCCGCGGCAGAGGCCGCGCTGTTGAGCCCCGCGGCGGCCGCGGGAGCCTGGTAGAGACCAGGGTGGCGGAAG CTACACAGCAGCTCCGGCCGAGAGTAGGGGTGCGAGAGGGCGCGGAAGGTGTCCAGTGGCCGGATGGAAGTAG CGAAGGGCGACGAAGCCGCGGCCGCCGCGCCTGAGGCTGCAGCCGCGGCCGCCGCCGCCGTGACGCCCACGTG CGGGTAGTAGTGCAGCGGCACGTGCGAGTGGAAGGGGTAGGGCAGGCTTCCGGTGGCGGCCGCGTGCGTCATC ATGTAGGTGTAGAAGCTGGGGTCGGCTGGGTGCGGCCAGGACATGGCCAGGCGCTGCCGCTTGTCCTTCATGC GCCGGTTCTGGAACCACACCTGCGGGGAGAGACGCGCCGCAGCCTGGGTTAGGGAGCGCCCCGTGTTCCCAGC TCCTGTCCCAGGACCTCTGCCCCTTCCGGACCTCTGAATGGCTTGGTCTACTTCTCTCCGACCAAGCCCAACC CCGAGTACCCTGTGGTCTCCCAGCTGGGAAAGTGTGGACGGCAGTGTGTGGACCGCCGTGGGCACACCGTCCT CAACGAAGAGGGTCCTCTCCCCCGCGTCCGGCTGCTGCTGCTCCTCAGGCTTTTATTCCCTTACTTCTTGCTG CACTTTTTTGTCCCAATCCAACCTTTCCTCTCCCTCCCGCCACCCACCAGTGCCGGTCTCGCTGAGCACCCGT CTCTCAATCCCAGGATTTGTACGGGGATTCTGGGCAGCCTTTGAAGAGAGGCTGCCGCTCAGCTTTTCTGAGA GGTCGCCGCGCGAAGTCTTGAGCCCTCCGAACTGCAAGGACCTGCCCCTAGGGGCACGGGTCCGATTTTGATA TTGAAGGGATGATTTTGTTGGAATCGTTTGCCTTAAATGAGTGGGTAGAGCAATGTCTCCATAAACGGGGAAG GGGACGTTTCCACCCCTCCCAACACTATCTAATAAAGACATCATTCGTCACAACTCTAAATTAAAGAAAGCCC GATCAAACCAGAGGGAGACTTCCACACTCCTCCCCTACCCCGTGGAGATTTTTTCTTTTTTCTGCAGTGTCGA ACGCTCCATGAAGGGCTCACCAAATCGCCTAACCTCCCGGCTATCTCTCCCAGACGTATAATAAAATTAATAA CCTAAAGTTATATATAAATAAGGACAATTTCGTTGCATTTTTCCCCGCAGGAGGTTGCCCTTTTTTCGTTGCC CAAGAGGAAAATGTTCAGGAAACTACTGTCTCAAACCAATCGATTTTAAAGATACAGTATCCTTTTCTCCGTG TAACGATTTATGCGGAAAATAAATCTCCAAGCTCAAGAGCAAATGAAAAGTTTCACCTCTGGTTCCTGCTTGA GGAACAAAGACCAACTGGGCTTGCCGCCTAGGGGAAAGTGGGGCCGTGGGTATGGGCGAGGGGGCATCTGGCC AGGCGTTGGGCACAATGGAGCAGGGGCGAGTGCTTTCAGCATTGGAGTCACCATTCGGGGGCCTTCTTAGATC CGTCAGGCCGGACAACCGTTCGGATTCGGTGGCCGGGAAATAAATAAGCCAATTCCTTTGGTGACTACCCCCC GCGGATTTCCAGACCCTTAGCTAAATCTAGCCACCCAGAAAGGGGAAAGGGGAAAAAGAAACAATCAACCCAG ATGCCCCCGGGGAGGCCAGAGCAGGCATGCACTGGAATTGATACCTTGATGGTGGTTTCGGGCAGGTTGAGTG CCGCGGCCAGCTCGCACCGGCGGGGCCGCGACACATAGTTCTCCCGGTAGAACTCCTTCTCCAGGCGCGCGAT CTGCTCGCGGGTGAACGCCGTACGGTAGCGCCGCACTTGATCCGCGCCAGAGCCGGAGCCACCCAGCGCCGCG CTCCCGCCGCTGCCTCCGCTGCCTCCATGCAGGCTTCCGAGGCCTGAGCCCGACGCCGACGTCGTGGTGCCGG CAGCCGAGCCGCTCTCTGCGTACCCTGGCAAACAAACGACCAACAGCGCATGAGTGGCTGTAGGACCAACAGC CCGGCGCTGGCGCTGCGCGCGGATCGGGGAAGCCCCGTCAGGAAGGAGAGTCGCTGCCGGAATTGATGGGGTC TGTCATGCTTACAAATTGCTGCCGTTAATGGAATCAATAAAGTTTGGGGAGCCCTTCATAAGCAAATAATAGA AACGGAATTAGGAGATTTCTTTTTTAATAATTAGAAATTTTCAACCAAGGAGGAAAAGTGGCCGAGGGAAAAT GCCTACCTCTGGGCGCAGTTTGGGAAGCTCTGGGTTTCCCATGGTCTGGAGACCGCAGGGCAGCTTTTTATAC GGCCTCTAACCTTTATCTGAGTCTTCGGGGTTTCAAATATTTTAAGAGTTCCAACACAGCAGTAGCTCAAACC CAAGCCAATAGGGGGTGAAATATACTTTTCAACTCTTTCTCCCGCTGACCTAAACAGAGACGCCGGCGAGGCT TCCTCCGACTTACCCAGAAGAATGCCCCCTCCAGCCCTGAGGGCACAGGGGCAGGGGAGTTCAGAGTAGTTGC CCAGGGTACCTTTCCCAAAAGCAACTCGGCTGCTGACTAGGGGTCTACCGGCTCGCTCGGGCTCTTAGACACG AGCGCAGAAACATTTTCTCGGACTCAGGAGCGAGGGCGGGTGGGCCTGGTGTTCCAGGCTCCGCAGGCCTGAG CCTGGCGGGAAAGCTCAAGGAGCAGAACTGGAAGGCACGGTCCCAGACATGCGTCCCGCCCCCGCCCGTGCTA GCTCGGTGTAGCTTGCCTGTGGAGGGTCTGAGAGGGGAAAAGGCACCGGGAAAGGCTGGCGGGGGCCGCGGAG GAGCAAAGAGGATGGGACTGGAGAGCGCGGTGCGGCCGGCGCGGTTACCTTTGCCATTGTTTTCCTTAAGCTG AGCGGCGCCGAGGCCCCCGGGGGAGCGAAGCGCGGAGCAGCCCACCTCCACGTCGCTGCTCATGTCGGCCTCA GCGGCCGCCTCTGAATAATGGCCCGGCTTCTTGCGGCTCTCGGCGGCGGAGGAGATTTCGGAGGAGACGGTGC TTTCGCTGCCCGTGTGCTGCAGGTTGAACAAAGTGTCTATTTCGAATTTGCCCTTGGCGGGGAGTTCTCCCAG AGCGCTGTGCAGGGGGGCAGACGGCAGGCGCGGGCTTAGGCGAGCCGGGTGCTGCGAATTTTCCAGGGCCTCG AGCACAGCATTGCCAGCCGAGTTGGACAAATTGGAGAATCTCTTGCCCGCCG CGI: 25 range = chr2: 176720618-176720921 CGCCGCTGTAAGTACCTTCCCGCTTCTTCCGAATCGCGAAGAGACGGTACTGATCGCGGGGAAGTGGTGGGCT AAGGGGCCAAGCCAGCGGAGTGGGCGGATAGAAGAAAGGCCCTGCCTCCCCCACCCCACCCCCACCCTCCACC CCCGGCCTCGCTCTGCGAGGTTAGCCCGCTTCGGGAGGTGGAGGCGCTAAATCGAGGTCCCGGAAAGCTTTTC TGGGGCCTGGTTCACAGACACCTGCCTGAGAGAACGGTCCGCGGGGTCTCGCCCTTGTCTCCTTGGGCCTCCC TAGACCTTCGCG CGI: 20 range = chr2: 236438623-236438823 CGAATCCAGTCCCGGCCGGCGCTTTGAAGCCTGTGCTGTGCGATTTTCTCAGCAGTGAGGTAGGAATAGACGC GGCTAATGACAGGAAGGTCGCGCGGGTGAGCTGACCTGTGTGTGGCGCAGCCTTGGGTTCCGCAAATAGGGCA CCCACAGTAACACGTGTGGCGCCGACCCCGCCGTGCGCAATCGGGGCTTTATACG CGI: 22 range = chr3: 11721578-11721824 CGATGGGACCGCGGCTTGACACGCATTAAGGAGCCACTGAAAACTCCATCTAAGCAGAAAAGCGGCTTAGTCA TCCATGCGTTCTGGGCAAGTTATCCTGGCCGCACCACGTGGAACGGAGTAGATAGAGCTCGGGAAGCTGAGCG CAGGGCGGACAACGGGAAGGCCAGAGCCGTGGGCAAGCACGCGGAGGGCAGCGAGGGGCACTGGCACCGGAGC CGCGGGGAGGCAGGAAAACGCAGAGGCG CGI: 68 range = chr3: 12983649-12984210 CGCTCCTGTCCCAAGGGCGCGTCTCTCTCTCCCACGCACAAACTCGGGTCCTGTTTGCTCTTCTCTCACCCAA ACCCACAGTCTGGCGGACGCACCCCGCCCCGCAGGCAGCTTTCTCTCGCACGCCGGGCGCCCGGTCCCGACGG TCACCCGCACTCCCGCACAGGCATCCCCACAGCCTGCGCCAGCCCACCGCTCAGCACCCGGGAAGGCCGCTCG CCCCGCGCCGCGCCCTCACCCGCTGTCAAGCTCTAGCTCCAGAAGGGACTGGGTCCTCTCCGAGTTGCAGTGC AGGCACCACATGGCGGCCGCAGTGGGAGCGGGCCGGGCCGGGAGCCGGGACCCAGGCCCAGCAGAGGCCGCCG ACTCCCGCCAGCGAGCCGCCGGATCCCGGGGCCGACACCCGGCCACCCGGAGACCCGACCACCCGCCACGCGA TCACGTCGGGGCTCCTGGTCCAGCGTCCGCCGGCTCCCGCGGCTCCGGCCCCAAGTCCGAGCCCCAGGCCAGC CAAGCCCGCCCCTCCGCCGCCGCCCGCTTGGCGCAGCGCGAGGCCGGGCCG CGI: 120 range = chr3: 25680561-25681574 CGCGGGGAGCGGGCTGGAGGATTCTGCAAGCACAGGCCCCTATGGAGCGCCCGTTCGGGGGACGGGATTTCCC TCCCTTTCCCCTCCCCCGCCCGTTCGGAATTCCGCCCCCGCCGCGGGCCCGGAACAATGCAGCCGCCCGTCCC GGGGACCAGCCACTTACCACCCAGGTCAGTGCCCCGTTGCCGCCGCCCACGCCGGCTCCCGCGCCGCAGCCAC CCGACTTGGCCATGGCGAGTGCCTCCAGCTCACAGGCCCTGAGGCCGCAGCCGCCGCTCCCGCCTCCCTGCGG GCCGCTGGGCCCCGCCGCTCCGCACCCACCGCTCCACTCGCCGCACTCCTAGCCGCGCCGACCCCCGCGCCCC ATCGCGAAGATCCGGAGCGGACGTCCAGCCGAGCCCGCTGAGGAGGCCGCGCCGCCGGCTGCCCTCAAACTCG AGGCGCGGCGTCCGCGTCGCCCGGGCCTAGCGCGGCGGCTGAGGAGAAAGCAGGGAGCGACCGGCGGCGGCCG AGCGGCGGCGTTGCCTTCTCGCCCGCCCGCGGGCGCCGCTGCAGGCCGGGCTGAAGCCCGGGCGTGCGAGCCG CGAGGGCGGCCGGGGAGCCCGAGGCGCTCGGACGTGGCGAGGACGCAGAGGTGCCTTGTCCTTCTCACACTCC GCGAAGGCCAGCCACTCGAGTCGCCAGAGTAGTCGTCCCGGTCGCCGCCGCTGCTTCAAAGGCAGCCTTAGCC TCGCTGCAGCCCCGATTTCCTCACACACACACACCGAGAGGGACAATAAACAGAGCCGCCGCCGCCGCCGCCA CGGTCACCTCCCTCTTGTCCGGCATAACACCGCACACACACATTTGCACACCGGGGAGAGAGGGAGGGCGCGG CGGCCGCCCCCGCTGTCAGTCAGCGCCATGCTGTCCAATCCGGGCCTTGTCGCCACAGCCTCTCGGCCAATCC CAAAATTCCAAGCCCCCTGGAGGGGCGGGACCCGAGGGGGGAAACGTCATTGCGGGTAGCAACCG CGI: 23 range = chr3: 148613030-148613264 GACCGGCGCTTCGCTAACAGCAGCGACCGCAAGAAGCACATGCACGTGCACACGAGCGACAAGCCCTATCTTT GCAAGATGTGCGACAAGTCCTACACGCATCCCAGTTCGCTGCGCAAACACATGAAGGTAATCGCCGCACTCTC GTCGCCCCCTTTGAGGCAGGAGCTCTCTTGGCTCTCGGCTTGGGGTCGGGCGGCGAGTGGCAGACAGGCGGTG GCGGGAGCCAGAGGAA CGI: 41 range = chr4: 4910534-4911092 CGGGCAAACCTCCGGAGGCCCCGGTGCACCGCGCGTCCAGCCGGCCCAACTCGAGCTAGAAGCCCCAACCACT GCCCAGTGCCTGAGTTGCAGTCTTGGGTCCTTTAGAAACCTGGAGATGTGCGTAAAATTCAGATGCCGGTATT CCCGAACTTCCCCAGGCCTCAGCATATCTCGGCGGCCTGTGGACAGATGGGAGGCTACCAATCGCTCCGGCGT CCGCAGCCCGACCCCTGCCGCCAGACCCCGGACGTCTTCCGGATAATAAAGTTCCCGCTCTAATTCATTTTCC CTAATCTGGACGCCCCTAATCTACAGCTTTTATTGCGCCCAGTTAAAAGTCGAGGGAATTCGCTGTCCCTCCG CGCTCGGATAATTACCCCTAAATGGCCACGGCAGCCCCTTGTGTTTCCTGGAGATTAGAACCCCGCAGTCATC AATGGCAGGGCCGAGTGAGCCGCCAATCACCTCCGCTCACTCCCTGAGAGCCGCTGGCCTGGGCCGCAGGAGG AGAGGCCATAAAGCGACAGGCGCAGAAAATGGCCAAGCCCCGACCCCG CGI: 300 range = chr4: 30330303-30333940 CGAGCGCGGCGGCTGGCTGACGCTCCCTCCCGCCTCCTTATCCCGGGCCCTCCTCCCTCGCTCTCTCCTAGTG TGTAGTTTCGGCGGCTCGGCTGCTACTGCCGCCGCCGCTGCAGCAGCAGCGTCAGGGACAAGCCTGATCCGTG AGCGAGCGAGCACCCAGCAGCAACCACCACTTTGGGCAACTTGCGGGTTTCCTGCTCGCGGGTAGCGAACGGG AGATTCCCACTAGCGGTTCAGTGTCTCCGAGCCGCTGCAGCCCGAGGGGCGGCGGGAGCGCCCGCACCAGACT CTCCCAGACGCGAAAAGGGACGAGACAACTGCGGAATTCACCAGCCGTGCCAGGGCACTTCCGAGGCCACAAC CGACTGACACTTTTTCTCCCCTTGGCAAACTGGATTTTTTTTTTTAAGCTACTTGGCAGCTGTCTCTGACTCC ACCTCCCCCTCCACCCCCGCCCGAAAGCCTTTGGCTTTTCTTCGGAAATCCAGACAGAATTGGGCATCTTTGT TAATTGCCGTTGGGGACGCCCGGCCGTGCGCTTTCGCCGGCTAACGTCGCCTGTGCTCCGAGCCTGGTTTGCT CACCTTTGAACTGCAAAGGGATCAAGTTCAGCTTGAGTTCCCTGCATTGGGAAGGAGAGAGAGCGTGCAAGAG AGCGAGTGGGAGAGGGGGAAAGGGGAAAGGAGAGGAGGGAGGAGAGAGAGGAGGGAGGAGAGAGAAAGGGAGG GAGGGAGGGGAGGGATCGAGAGAGAGCGGGGAGAGAGAGGCTGCAATCTCCTCCCTGAATCGCGCACAGCGCT GCAGATCCCACTGCTCCGACATGCGGGCCGAATGCAGGTGAGAAAAGGCACGGACTCTGCGGCTGCGAACCCA AACTTGGGCACCGCACGGTGCGCACTGCTCAGCCTTCGCCCCCGTGGGCGAAAGGCTGCTGCGGTTTCAGGCG GCTGCTTCGTGACTAATGACCTTGCGCAGAGTTGTTAAGAAAAAAGAGAAACCCGCGCTCTCCGGGGTGAGAA GGGACTGACTCTGGGCGTCTCTGAAGATGGCTCGGGCTTCTCTTTGGCGCGCCGGGGGGACCCTGACACTGAC CGCTCTGTGACGCGAGTAGTCTCCCCTGCACCGTGCCCGAAGCGACGTGCCGGGGGATTTTTCATTCTCGATC TGTTGACTGGCTCCCCCGCTGCATGAGCAGAGTCGGAGTTGAGACTGGCTTGTTGCTGGCCCCAGCGCCTGGT GCAGGAAGCGACTCACGTTTGTCTGGGTGGCCGGAGCCGGAGCAGAGCCTGGGTTTGGAGTGAGTGCCTGGAA CGTGAATTGGACTCAACTCGAGTAGCAGCAAAGACCAGCGGGCTGGCAGGCGGGGGAGGCTGCAGGCTCATTC CCCACCTCTTCCCAGCCCCACTGCCCGTCTGCCGGAGCGGTTCTGGCCCCTTCCGACAGAGCGGGGACTAGAG CCGGGGATTCTCCGCCCGCTGAGGGGATGACTCTGGGTTGGGGGAGCGCCGAACCCGCGGCGCGCAGTGTCCC GTGAACTGTGAGTACTGCGACTGAACGGCGGCAGGCGAGCGGGCGATTAGCACCCATTGCATGAATTATGAAA CAATAACTTTCGGAAGAAGCAGGAGGAAAAAAAGAAGCATCTATCGCTGCCCTCCCACCCCCATTCCCGGCCA ACTCTCCACGCCGCTTTTGCCCCCTCCCTCCCCTCCCTCTCGCTCCTTCCTTTCCGGGAGAGGGGAGAGGACT CGGGGGAGGGCAGGCGGCCGGCCCCGGAGGAGGGGGGCGCCGAGGGGGCTGTGGTTAGAAGGAGCAGTAGCAG CAGCAGCAGGAGAAGATGCTGAGGATGCGGACCGCGGGATGGGCGCGCGGCTGGTGCTTGGGCTGCTGCCTCC TCCTGCCGCTCTCGCTCAGCCTGGCGGCCGCCAAGCAGCTCCTCCGGTACCGGCTGGCCGAGGAGGGCCCCGC CGACGTCCGCATCGGCAACGTGGCTTCAGACCTGGGCATCGTGACCGGATCGGGTGAGGTGACTTTCAGCCTG GAGTCCGGTTCCGAGTACCTGAAGATCGACAACCTCACTGGCGAGCTGAGCACGAGCGAGCGGCGCATCGACC GCGAGAAGCTGCCCCAGTGTCAGATGATCTTCGACGAGAACGAGTGCTTCCTGGACTTCGAGGTGTCGGTGAT CGGGCCCTCGCAGAGCTGGGTGGACCTGTTTGAGGGTCAGGTCATCGTGCTTGACATCAACGACAACACGCCC ACCTTCCCGTCGCCCGTGCTCACGCTCACGGTGGAGGAGAATCGGCCGGTGGGCACACTTTACCTGCTGCCCA CAGCCACCGACCGCGACTTCGGCCGCAACGGCATCGAGCGCTACGAGCTGCTCCAGGAGCCCGGAGGCGGCGG CAGCGGCGGCGAGAGCCGGCGCGCCGGGGCGGCCGACAGCGCCCCCTACCCCGGGGGCGGCGGGAACGGCGCG AGCGGCGGCGGCTCGGGAGGCTCCAAGCGGCGGCTGGACGCATCAGAGGGCGGCGGCGGCACCAACCCCGGCG GCCGCAGCAGCGTGTTCGAGCTGCAGGTGGCGGACACCCCGGACGGCGAGAAGCAGCCGCAGCTGATCGTGAA GGGGGCGCTGGACCGCGAGCAGCGCGACTCCTACGAGCTGACCCTGCGAGTGCGCGACGGCGGCGACCCGCCT CGCTCCTCGCAGGCCATCCTACGGGTCCTCATCACCGACGTGAACGACAACAGCCCCCGCTTCGAGAAGAGCG TGTACGAGGCCGACTTGGCTGAGAACAGCGCCCCGGGGACCCCCATCCTGCAACTGCGCGCAGCCGACTTGGA CGTGGGGGTCAACGGGCAGATCGAATACGTGTTCGGGGCGGCCACCGAGTCGGTGAGGCGGCTGCTGCGCCTT GACGAGACGTCCGGCTGGCTCAGCGTCCTGCACCGGATCGACCGCGAGGAGGTGAACCAGCTGCGCTTCACGG TCATGGCCCGCGACCGCGGGCAGCCCCCCAAGACCGACAAGGCCACCGTGGTCCTTAACATCAAAGACGAGAA CGACAACGTGCCGTCCATTGAAATCCGCAAGATTGGGCGCATCCCCCTCAAGGACGGGGTGGCCAACGTGGCC GAGGACGTTCTGGTCGACACCCCCATCGCTCTGGTGCAGGTGTCCGACCGAGACCAAGGCGAGAACGGGGTGG TCACCTGCACCGTGGTGGGCGACGTGCCCTTCCAGCTCAAGCCAGCCAGCGACACCGAGGGCGACCAGAACAA GAAAAAGTACTTCTTGCACACCTCGACCCCTCTGGACTATGAGGCCACCCGGGAGTTCAACGTGGTCATCGTG GCGGTGGACTCAGGCAGCCCCAGCCTCTCGAGCAACAACTCCCTGATTGTCAAGGTGGGAGACACCAACGACA ACCCGCCCATGTTCGGCCAGTCGGTGGTGGAGGTTTACTTCCCTGAGAACAACATCCCGGGCGAGAGGGTGGC CACGGTGCTGGCGACAGACGCAGACAGCGGTAAGAACGCCGAGATCGCCTACTCGCTGGACTCCTCTGTGATG GGGATCTTTGCCATCGATCCCGATTCTGGGGACATCCTGGTCAATACCGTGCTGGACCGCG CGI: 21 range = chr4: 41678680-41678940 CGTCACCAGTTACTCCCGTTTAGCCAACGAGCTGCGTGTGAGCTGCATGGAGCGGAAAAAGGTCCAAATTCGG AGCTTGGATCCCTCCTCTTTGGCGAGCGACCGATTTAACTTCATTCTGGCGAGTACCAACAGCGACCAGCTCT TCGTAGTGAACCAGGTCGAAGTCGAAGGCTCCAAGTACGGCATCATCAGCCTGCGAACTCTGAAGATCCCTTC GTTCCACGTGTACGTGCTCAGAAACCTCTACGTCCCCAACCG CGI: 217 range = chr4: 85636684-85639823 CGCAACTTCCCGCAGTTACTGCCGCTCAGCCGCACTAAGGAGGTCCGGAGACTTGGAAGAAACTTCGGAGACT CGCTGAAAGGCGAAGAACTGAGCGAGAAAAGGACCCCAGGCTGGGCCCTGAAGTCCACCTGGAAGGCTGGGAG CCTCCGCGGCGCTGCGGCCTACTACCCCGAAGACTAGCGTGATCTTGGGGCAACTCAGTTTGCCTCAAGCAAG GTCTTTGCGGGATGGTACATTTTCCCCAGGCCGTGTCCCTTCATCTCACTCTTCTCCTGGCTCGCTCTTGTGT TAGGGTGTTGAGCTCCACGATGTCCCCAAATGTGCCCGGACGCAGCGTGTGCCAGCCCCCAGAGTGGAGGCAG GTGGGAAAGCGCGGGCCCAGCGCTGGTGAGCGGCTGGAAGCGCTCGCCCTGCCCTGGGGACGCTGGACTGTCT TCAATGGGCTCACCCAGGCCGAGTGTACTCGGGCGGCGAGGGCGAAGAGGTGAGGTGGGGACACCCCAGGCGG AGACGTGCATGCAAATACACTCACTTCCCGGGCGGTGGAGGGCTCACCGCTGCCGGGCCTCACTGCTTCGAAG AGAGGCAGCGGGTTAGGCTGGCGAAGGCGGAATGGGGCGCTGGACGACAGGGAGGAGCCGGGAAAGCAGAGAT GCAGTGGCCTCTCCTCCCCTCTCCTCCCCATCTTTCTAATCCAGGCCAGGCCTGCGGTCCTGGCCAGGCCGTT TCAGGAACAGCCAGGGCCTCGGACGAGACACACGTCCCTCACCGCGTTGTGGTCCACACGAACACACACACAC CGGCTCAGCCCAGGCGTACTCAAGACTTAGAGAGAGGGAGGCGCTTGGATACAGCCACGCGAGCTCAGAAAAG CGAGAATCCCTTTCTGGAAGCCCTGGCCCAACCTAACTGGTGTGATTCCGGCGCTGTCAAACTACTGGGGCGG GCCACAGGATGGACTGAGCGGCATGCACACCAGGGGCCGCGACCCGGGAGTGGGCAGAACAGGCACGGCAGGC AGGCATCGGGGCGCGGGTGGTAGTACTCACGAGGGGTACAGGCCAGGCGTGCGTCCCTCCAGGGCGGGCTCTG CATCACTCCGGGCCAGAAGATGGGCGTCCGGCCAGGCAGCTCAGCCAGCGGCTTGGGGTACCGGCCCACGGCG GCCACGGCCGCGGCGCTGGGGCTGAAGTAGAGCCCGGGCGGCGGCGGCGGCGGGCTCAGGCTGCTAAAGCGTG GCAGTCCGGCCAGCAGCCCCGCCGGGGATGAGGCGGCGGCTGCGGCCGCGGCAGCAGCCGCGGCGGCGGCAGA GGCGGAGGAGGCAGAGGCGGACGAGGAAGAGGAGGAGGAGGAACCGGAGGGCGAGGCGGAGGGCAGGGCGGCC CCCGAGGCCACGGGCATGGAGGGCCGGCTCAGGATATCGTTGATGCCGTGTGGGGTGGCGGCCGAGAGCTGCT GCGGGGGGCTGCCGAGGGATGAGAGCCCCCCCGTGGCCGGGGGCTTCAGGCCGCCTGGGTTGTGGGTGCCCAG AGGCGGGGAGGGCGACGAGGAGGACGACGACGAGGACGAGGAGGAGGGGGGGCCGGCAGGCAGCGGGGGATAC GCGGCAGGGTACAGCGGGGTCTTCATCTCGGCCATGCTGTGCAGGGCGGCCAGGGGAGGGCTGCTGAGCAGGA ATGCGCTCTGCCGGGTGCCCTCCATTGCCCCCACCGCTAACATCCCACGGCCACGCCGGAGACCGTAGCCTTG CAGCGAGGGCGCTGGCTGGTGCCCCCCGCGGGGCTCAGAGGAGCCGGAAGCGCCGAGGGCGCGAGCGGAGAGG CACTCGGCGCGCCCGGAGGCGAGCTGCCAACTGAACCAAAAATGCCGCTGCCGGGAGTTGCTCGCCTAGCTGC GCAGCAGAGATGTCCAAACCCTCCACGCGGGAGGCGGCAGCTCGCCGAGAAAAGCAGGCGTCCCGGCGGGCTA GGCAGTCCTTTCGTTCCGCGAGTCCTAGATTCGATCCCTGGCTATTCTCTCTTCCTCACTTTTCCTAGCTGTT CAAAGTGCGCTACTTCTCATCTTCTGCCCCCGGGAAATAAGCAAAACAAAACCCAGGCTGGCTCCGGAGAGTT TGTAGCAAAGTTAGTTGCCGAATCTCCACTTTGAAGTTGGAGGGTGGGGGTGGCTTGCTTTCTTTGGGGAGGT TCAAAGGACGCCTTGTGCAGCCCGTGGCGCTCCTCTGATCTTACTGGGATGCTCTGCTCTTTCGGTCGCGCGG CTGATTCGCATTCGACGCTCACTGTGCCCGGGGAGAAAGCGCATCCAGCCCGCGGGAGATCTAGCCTCTGTGC GGGCTTCCTCCGCCCACGCTGCCCCGGGCTGCTGCGCCAGAAAGGGCAGTGCCACGGATCCCCGCGGCTCCCA GGTCCTCACCTCCACCCGCCTTGCCCTCTGGCCCACGGGGCACTGGAGTTGCAATATTGAAAAGAAAAAGGGG GAGGAAAAACACAGAAAAACAAAAGACTAAGTGTGAAAAGTCTGACGGCTGGGTTTCGGCGCCGCTCGTCAGT CCACTTCTGCAAACGGGCCCGGCGACCCCCGCCCCACCCCCGCTCCCTCTCTCCCTCTCACTCTCAGCCTTTG ACTCTCCTCTCTGGCATTTTCTTCGCGGCTTCCCAGGCTTCGGTCTTCTAAGTCCTGTCCTCTGGCCAAACTG ACCCTCTCCGCGGCTCCTCCGCTCTTTCTCTCCTTTCCTCTCTCCCTCCGGGCCTGACAGTTCAGATGAAGCT CTCAAAGGTAATAAAACATTTGCATCACTCCCTACCCCTCTTTAGCTGGGGGACGAAAGGGAGGGGGAAGTGG GGGACCAAAATGAGAACTTTGAGGGACGTCACTCCGAGGCTGCGGGGGCCGGCGAGCCGGGCGCAGGCCGGGG GCGTAACCACCGTGTCCAATAGCTCGCCGCCTCGATCCTTGCGTCGCCCCTGGGGCTCGCCCACTCGGGGGCG CCGCACCCTCTGATTGGCTGAGGCGGGCCAGGCGTAGGGCCGCGCCCGCCTAGTCCCCTCCCGCTCCCTACTT CTTTCTCCTGTGGGCGGGGCCAGGAGGGGCGGGAGCTGGTGAGTGGTGCGGTTCCGCGCTGGGGCCAGTGGCC G CGI: 39 range = chr4: 94974810-94975333 CGCGGTGCGGAGCGTCTGGAGCGGAGCACGCGCTGTCAGCTGGTGAGCGCACTCTCCTTTCAGGCAGCTCCCC GGGGAGCTGTGCGGCCACATTTAACACCATCATCACCCCTCCCCGGCCTCCTCAACCTCGGCCTCCTCCTCGT CGACAGCCTTCCTTGGCCCCCCACCAGCAGAGCTCACAGTAGCGAGCGTCTCTCGCCGTCTCCCGCACTCGGC CGGGGCCCCTCTCCTCCCCCAGCTGCGCAGCGGGAGCCGCCACTGCCCACTGCACCTCCCAGCAACCAGCCCA GCACGCAAAGAAGCTGCGCAAAGTTAAAGCCAAGCAATGCCAAGGGGAGGGGAAGCTGGAGGCGGCAGAGGCG GCGGCGGGAGAGCTGTGGGGTTGTTCAGGAAAAGTTGGGCTGGGGGCTGAGGCACCTGAAGCAGTGAACCAGG ACTAGGTAGGAAGCAAGAGCATCCTCCTGCGCAAGCGGAGACGCAAACGCGCTCCTGAACCCATGCAACCGCC CGGCCCAGCGCCG CGI: 162 range = chr4: 134291113-134293078 CGGAGCCAGACCTGACGGTGGAAATCTCTGAGAGCGCCACGCCAGGCACTCGCTTCCCCTTGGAGAGCGCATT CGACCCAGACGTGGGCACCAACTCCTTGCGCGACTACGAGATCACCCCCAACAGCTACTTCTCCCTGGACGTG CAGACCCAGGGGGATGGCAACCGATTCGCTGAGCTGGTGCTGGAGAAGCCACTGGACCGAGAGCAGCAAGCGG TGCACCGCTACGTGCTGACCGCGGTGGACGGAGGAGGTGGGGGAGGAGTAGGAGAAGGAGGGGGAGGTGGCGG GGGAGCAGGCCTGCCCCCCCAGCAGCAGCGCACCGGCACGGCCCTACTCACCATCCGAGTGCTGGACTCCAAT GACAATGTGCCCGCTTTCGACCAACCCGTCTACACTGTGTCCCTACCAGAGAACTCTCCCCCAGGCACTCTCG TGATCCAGCTCAACGCCACCGACCCGGACGAGGGCCAGAACGGTGAGGTCGTGTACTCCTTCAGCAGCCACAT TTCGCCCCGGGCGCGGGAGCTTTTCGGACTCTCGCCGCGCACTGGCAGACTGGAGGTAAGCGGCGAGTTGGAC TATGAAGAGAGCCCAGTGTACCAAGTGTACGTGCAAGCCAAGGACCTGGGCCCCAACGCCGTGCCTGCGCACT GCAAGGTGCTAGTGCGAGTACTGGATGCTAATGACAACGCGCCAGAGATCAGCTTCAGCACCGTGAAGGAAGC GGTGAGTGAGGGCGCGGCGCCCGGCACTGTGGTGGCCCTTTTCAGCGTGACTGACCGCGACTCAGAGGAGAAT GGGCAGGTGCAGTGCGAGCTACTGGGAGACGTGCCTTTCCGCCTCAAGTCTTCCTTTAAGAATTACTACACCA TCGTTACCGAAGCCCCCCTGGACCGAGAGGCGGGGGACTCCTACACCCTGACTGTAGTGGCTCGGGACCGGGG CGAGCCTGCGCTCTCCACCAGTAAGTCGATCCAGGTACAAGTGTCGGATGTGAACGACAACGCGCCGCGTTTC AGCCAGCCGGTCTACGACGTGTATGTGACTGAAAACAACGTGCCTGGCGCCTACATCTACGCGGTGAGCGCCA CCGACCGGGATGAGGGCGCCAACGCCCAGCTTGCCTACTCTATCCTCGAGTGCCAGATCCAGGGCATGAGCGT CTTCACCTACGTTTCTATCAACTCTGAGAACGGCTACTTGTACGCCCTGCGCTCCTTCGACTATGAGCAGCTG AAGGACTTCAGTTTTCAGGTGGAAGCCCGGGACGCTGGCAGCCCCCAGGCGCTGGCTGGTAACGCCACTGTCA ACATCCTCATAGTGGATCAAAATGACAACGCCCCTGCCATCGTGGCGCCTCTACCAGGGCGCAACGGGACTCC AGCGCGTGAGGTGCTGCCCCGCTCGGCGGAGCCGGGTTACCTGCTCACCCGCGTGGCCGCCGTGGACGCGGAC GACGGCGAGAACGCCCGGCTCACTTACAGCATCGTGCGTGGCAACGAAATGAACCTCTTTCGCATGGACTGGC GCACCGGGGAGCTGCGCACAGCACGCCGAGTCCCGGCCAAGCGCGACCCCCAGCGGCCTTATGAGCTGGTGAT CGAGGTGCGCGACCATGGGCAGCCGCCCCTTTCCTCCACCGCCACCCTGGTGGTTCAGCTGGTGGATGGCGCC GTGGAGCCCCAGGGCGGGGGCGGGAGCGGAGGCGGAGGGTCAGGAGAGCACCAGCGCCCCAGTCGCTCTGGCG GCGGGGAAACCTCGCTAGACCTCACCCTCATCCTCATCATCGCGTTGGGCTCGGTGTCCTTCATCTTCCTGCT GGCCATGATCGTGCTGGCCGTGCGTTGCCAAAAAGAGAAGAAGCTCAACATCTATACTTGTCTGGCCAGCGAT TGCTGCCTCTGCTGCTGCTGCTGCGGTGGCGGAGGTTCGACCTGCTGTGGCCGCCAAGCCCGGGCGCG CGI: 308 range = chr4: 149582663-149586506 CGGATTACGCAGCCACTTCTCCCTGCAAAGTGCACGCTCCCGCGCCGCGGCCGCACGCCGAGCACGGCAAGCG GTGCCCCGCCGCGCGCCCCTACACACCTGCCTCGGCCGGGGTCCGTCTCTCGCCGTCTACCTGTTGCAGCGCT TGCCACCGCCACGAAACCCCTGCTGCGGAGCCCCCCTAAATCCAACCACATCCAGGCCAGCGAGTGCCGCTCT CCCTGCAGCGGGAGAGCCCGAGGCAGCAACGCTCTTGCACCCAGGTGACTGACTGCACGGGCTTCCTCTGAGC AGCCTGAAGTTGGCTCCCGTCTCCCGGGCCCAATGACACCCCGGGCGCGGAGGGGCTGAGAGGAGGGGGCAGG GGCAGGGGCAGGGCCAGGGCGGGCAAAAAAGGGAGGGAGAGAGGGCGGGCGAAAGCCCGGAGGGGGAGTGGGC CAGCTGGAGGGCTGGCCCTTTTAAAAGCGGGTCACATGTCCAGATAAAGTTCAGGTTGCTATCCCGCCCCCCT GAACCCTTCCTATTGGCCCGAAGAGAAGCAAGGCTCCACGCCGCACGGGTCAGGCGGGCTTCTTATTGGACAA TCCAGGCTGTCAGTCACCAGGCGGGCGACATGACTGATACAAAGTTGCTGCGACACAGCCTGGACTCGGCAGC TTCCTTAAAGCCGCAGCCGCGGCGGGAGCTTGGGGTGCCGGGCGGTGGCTACATCAGGCGGCCTCCGCACGCT GCCCCCACCCCCATCGCTCGGCCGCCCCAAACTTGCTTACGTCCACCCTGCTCTCCTTCTGACCGACCCCAGG ATATCTGGAGAGATGTGAAAAGTGTGCTGACGCGGAAGAAGTCGGTTTTTCCGCGAGCAAAGTGTCGTCCCCT CACGCTCTCCACCTGCAGCTCCAGGTGAGCTGCAGCCCAGACCCTGGCGCCGCCCAACAGCGTCCGCGCGCGG GGAGGACTCTGGGTGGGCTTCACCCGACCCTCGAGGTTCCTCTCCCAGCCCCTTTCCACTGTCTCCAGAGTTA CCTCTCAGCAGAGCAGCAGCAGCCTTCGCTGCCAGCGAGCAAGACGATCACGTTCACTCGATTTGAATTTAGT TGTTTTAACCGTGCTGGAAAAACCCTTTAAACACAGCTTTCCTCCCATCCCTTAGACCCCTAACACCAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAGAGAGAGAGAGAAAGATAAATGAAAGAAGTGGCAGGGTCAAGAGCTG CTCCTCTACTTCCTTATAATTTTGTCACTGTACTTACTACTTTAGTATTGGATTTTTCCACTAGTTCAATTTG AAAGCAAGCTTACCATCGAGGATATTCACGTTATAATGGGTGGAGGGGGTGGGTCACATAAGTGGGAGAAACA GACAGGAGGGGGGAAGGAACCAAACTGTTTTCTAAGGATCGGTTGTCTGCATGAAGAAATTTCGGTTTCCCTC CAACCGCCCCCTCCTCGATTCTCCTCCCGCCCACCCAAATGCTGCAGTTACTAAGCAAAAGGATGGGGTTCCT AACTTTGATTTCTAAGGACTTTTAGGCTTCTCATGTAAGGCCCCGTTTTAGGCTCCCCGCTGGCCCGGAGTCA GCATCAGTGACGTATACACCTAAATCTGGTCCCCCGGCCCTCGGCGACCCGCAGCCCGGCGGCGGCAGCTGTG CGGCCTCCCGCCTCACCCTCGCTTCGCGCCCGCCAAAGCCCGAGGCGGGGGACCGGGGGACACCCTGTGCCCA AAGGCCCCTCCTCTCCTTAACAGTTAGTTAAGCTCCGGGATTCCGGACCCCTAACCCAGGGCTGAGACTTGAA CTCTCAGCCGCTCCAGTCAGGAACTCCCTGGAGATAGGGGCGACAGCGGCAGCGCCGCGAGCTGGTCCTGACC CCAGACTCTAATGCCCCTCGGTCCCCAGCTTGGAGCTGCCCCCGGCGTCCCCGCAGCCAGGAGTCCCCGCCGA GCGTCCCAACTTTCCCGCGGGGCCCACCGTCACGCGCACTCTCCCGGCCCAGCGAACTGGGCATCGATCTCAC GTCGGCAGAGCGCGGGCGGCGGGCGGGAGCAAGGGGAGTCCCGGACCTAGAGCCTGGGCACGCGAGGCGGCGG CGGCTCCGCAAGCGTTGCCGAATTATTCATTATTAAAGGAATGGACGTGTCTCTTTTACTAAGTTTTTATCTC CTTTGAGGAGGGCCGGTCTTGCCCTGGATCTCAGCTTCTTGCAAAATCTAGGTTAGAACCGTGCAGGGGCAGC CGCCGCGATCACTCGCCCGCCACCCAGCACCCTTGCCCCAGGGCCGCCAGCGGGCAACTCGTCTCCTGCCCGC ATCCCACCTCCGCTCGCCAACCCGCGCCCTCTGCCCTGGGCGCGCAACCTGCCTTGCCCGGGGCCGCCCCTGC GCTCTCCGGACCCCCTCTCGCCGCTGTCAGCGCAAAGTGACTGTCGCTGCACTCACCTTTTCTAGGACATGGT GGGGAGGCTGGGGCGGGGGAAGGGGAACGGCTAGACTCCCGCCGCCGCTGCTGCCGCCGCCACCAGCAAGTCC AATATTGGCTGATCGGCGGTGAGGATGGAGAGGATGATAATCCCGGCAGTGGCAGTCGCCCTGCTGACGGTGG GTAGAGCAATAGTGCTGTTACCCTACAAGAGGCGGCGAGGCAGCGGCGCCAAATCGCGCAGAGGGGGACGCGG GCACCCGCCCGCCCCCAGCGGCGGCGGCCGGGCCTCTGGCGGGCCCCTCTCCCGGGGCTGCGCGTCCGCTCGG CGTTGACAGCGGCGTCCCTGGGAGCCGGGAAGTCCGGCAGGAGGATCCCGCGCCCGCCGCTCCGCAGCGCCAC TCTCCGCGCCCCCTCCCCGGGCCCTGGGTGGCCGGTGACAGCTCCGGCGGCCGAGCGCGTGTGTGAGGGGGCG GTCGCAGGGGGAGCCTGCGCCCCCCTCCCCGGGTCACGCCCTCACGAGCGGGAGGAGGCGGCACCGCGTCCGG CCACCCGCGGGTGGGAAACGGGCAGGGGCGCCGGCAGCCGCCCTCCCACTACGGCCACTGACAACCTGGAGGC CAAAGGAAAACTGAGCCCAAATGCACGCACCCCCTTCAGCCCTGCCCGCAGCCCTCCAAAGTCCGGCCCTGAC CTCGCGCCCGGCTTCAGGTGCAGTTCCCACCTGCGGGGGGAGGCGAGGGCTGGGGACCTCGCGCGGGGGGCGG GAGGGAAAAGTTTTCTTTTCCTGCTCCTCGGCTGCCCACCCCGCCAGGCTGCTCCTCTCCCCGCCCCTCTCGG GCTCGCCGCGCCTCTGCCCCACCCCCGCCGTGGGGGGGCGCCGAGGAGGGAGCGGGCGTCTGTGCGCGGAGGC GTGCGGGGAGCTGGCTGGGGCGCTGCGGTCGCGACCGGTCCCCTCGCTCTGACGGCGGCTCAGACGCCCGCGG AGGCGGCTCGGCGGGGCAAGCCGAGGAAGGGGCCGAGAGCCGGGACCCCTCCTCCTCCGCTCGCGGCGCGCCG CGCGCCCCCGCGTCTCCTGGCGCGCCCCCGCGCCCTCGTGCCCGCTCGGGCAGACACCTACGCAGACGCGAAA GTGAAAGGGGGGCGACTGGGCCCGGCAGGCGGGCGGCCGGCGGCGCGCGGGCACGCGGCAGGGGACAGAGGAT GGATGGGTGAACCCGGATCCCGGGATTCTCCCGCGCCCGCTGCCCCTCTGCGGAGCCTCCCCGGAGTCCCACG CCCCCACCCCGGCCACGGAGATCACCACGTCAGGAGATATGTATGCGTGTGCATGTGTGTGCGCGCGTGTTCA CGCGCGTGTGCGAGGTACGCTTCTGCCCCAGACTCTTCCCCCGCACCG CGI: 44 range = chr4: 154436043-154436665 CGAGAAGCTGAACGAGCTGGCCGACCAGGACTTCCCCTTGCACCCGCGGGAGAACGACCAGCTGGATTTCATC GTGGAAACCGAGGGGCTGAAGAAGTCCATCCACAACCTCGGGACGATCTTAACCACCAACGCCGTTGCCTCAG AGACAGTGGCCACGGGCGAGGGGCTGCGGCAGACCATCATCGGGCAGCCCATGTCCGTCACCATCACCACCAA GGACAAAGACGGTGAGCTGTGCAAAACCGGCAACGCCTACCTCACCGCCGAACTGAGCACCCCCGACGGGAGC GTGGCAGACGGGGAGATCCTGGACAACAAGAACGGCACCTATGAGTTTTTGTACACTGTCCAGAAGGAAGGGG ACTTTACCCTGTCTCTGAGACTCTATGACCAGCACATCCGAGGCAGCCCGTTTAAGCTGAAAGTGATCCGATC CGCTGATGTGTCTCCCACCACAGAAGGCGTGAAGAGGCGCGTTAAGTCCCCGGGGAGCGGCCACGTCAAGCAG AAAGCTGTGAAAAGACCCGCAAGCATGTACAGCACTGGAAAACGAAAAGAGAATCCCATCGAAGACGATTTGA TCTTTCGAGTGGGTAAGGAGAGGGCTTCTGTGCCCGACG CGI: 122 range = chr4: 174686622-174688044 CGGCGGGTACGTTGGGGATGCACTCGCGCAGTTCGGCGAAGGCGCTGTTGATGCTCTGAGTCCTGCGCCGCTC CTTGCGGTTGGCGGTGCCTCGGCGCTTCACCGGGCGCGGCCCCCCCAGGCCCGGGGGCCCGGCGCCCGGCGGC ACCCCCCCGTAATGGGAGTGGTCCAGGCCGGCGGCGCCGCTGGCATACTCGGGGCTGTAGGACAGGGCCATGC TGTAGTCGGGGGGCGACATCTCGGGGTGGCCGATGAGCCAGCCATGGAAGTAGGGGTTCTCCTCATGGCTGCA GCGGCTGGCGGCGGCGGCGGCAGCTGCGGCGGCGGCGGCGGCAAACGGGTAGCCCTCGTGGTGCACCACCGGG TGGTGGGGAAAACCACCTACCAGACTCATTTCGCCCTCCGCGCCCCTCCACGCGCCCCAGCGTGCGCGCAGCC CCGCCGCGCCCTCGGCCCGGGCCCCTGCCTCAGCGCTCGGCGTCCTCCCCCACCCCCCACCCCCCAGCCCCCG GGCGCCCGGGCCCGCCCGGCAGCCGCAGAGGGGGCTGCTGCAGCCCGGGCCCCGTCCCCCCGCCTGGCCAGCC GGGCCCGCCTCAGCAGCGCTGCGGCCGCCGGCTCCCCATGGGGCGCGGCGAGCTGGTCCTGGCACCGTGCGCC CCTGGCCGCCGCCGCCGCCGCCTCCGGTTCCCGCCTTGCTCCACGGCCCGCGCTTCGGCTCCTGCTTCCCGGG CTGCTGCGCGGAGGCAGAATCCTCTCGTGCTCATACAAAGGTGCCGGGGCTCCCGCGAGGCTGGTACGCGGAG TCTCGGGAATCCAAGCCCGGGCCGCGGTCCTGGCACCGAAGCTAACCCGGAATCCAGGGGCGAGTCTGAGCCG CGGCTGGAGGAGCCGGTCCAGCTGTGCCGGGGGGCGGCGGGGTCGACTGCTCACTGCAAAGCTACCTCCGTGC GACCCTCCCCTTCCCGCCTCTTCCCCTCCCCCCACCAGCCCGATCTGGGTTCTTGGGCGCTTATTGTTTTAAT GAAATTTTTGGTTGTTGTTGTTTTGGTCCTTAAATGTGATTTTAGCTGCGAGTAACGTGTCCTCGCTCCTCTC GCGCTCTCTCGGAGGGTTTTCAGAGAGGTCTCAGTGCATCCATTTTCTCAGATCCTCTCCTTTCGGGGCAAGG ATCTGGGGCCCTGAATGAGCCTTGGAGCTCGAAGACCGCGGCTCGGGCTCTCGGAGGGCTCTGCGCGGTGGCC GAGGAAGCTCCGGGGTGACGGCGGTGGTTCTCCTGGGCTGGACGACGTGAGGGGAGCAAGCGGATTTTCCCAG CAAGATCTCCATGTACAGCTACATCTTTAGGGCCGCTCGGGTTAATATATGTCGTCAGAGGCTCCTCACGCCA ATCCCGGGGCGGCAGGGGCGGCGCCTCGAGCTCTCG CGI: 245 range = chr4: 184255825-184258373 CGAGATTGGCCGCAGATGCCCCGACGGGATGGCCTGGGGAGCCGAAAGCTGTCCCCAGCCCCGGACAGCTACT GCCCACGCCGCGCAGGCCAGCCTCACACAGTAGCGAATCTCCTTCACGCGACTTCCTCGCAGGCCTGTGAACC CGCAGGGGAGGCGGAGGTCGGTTCAAACCCTGCGAGAGCCCCTGCCCAGCGCGGAGTCCTGCACACGGTGGAA AGTCCTTACGCATTAGCGGGCAGGATTAAACGACTTCACACCACGAGGTGCAAGACTGGGCTTCGGGGCCTTC CTCGGTGTTGCTATTTTAAAAGAAGCTGCTCAGTAACCCAGAAGAAGATGACGGGGGACGGTGGTGTAGACCC GGCTGGAGAGGAGTCCAGGGCCTGGGAGGCGCCCCCTCTGACTGAGGGGCTGGGGACCCTGAAGCTTGGCGTC CAGGCCCCGCCAGCGCTGCACCCGGCATTGTCCCGCCTGGGGCAGGCGTCCGGTCCCTCGGCAGTGCGGGCCA GCACGTACGTAGTAGCTGCTGAATAAATAAATGCCTATGCAACAGGGAACGTCCCGGCCCACCCCGGCCGGGC CAGGGCCTAGGAAGGGCGGGCGTCCGGCGCCGCCGTGGGTCCCTCCGGCGTGGCCGCCCACACCTCCTGGCCA CGGCGGGGCTGCGGTGGGGGGACATCCTGGGGCGGGCGGCTGGACGGAAGGGACTAGAGTCGGGGCGCGTCCA CGGCCAACCGCCCCGAACCAAGCAGGGGAGGCCAGGGACCAGGAGCTTCCGGGGCCCCGCGGCTGGAGCGCCC GGACGCGAAGGGGCGGCGGGTGACGGGGCGCGGTGCGGGCGGCTACAGGGCCGGACGGGAGTTCCTCCGCTTT CCGCCGCGCGGCTCGCGGTCTCAGCCGAGGTCATCGAGGGCCAGGAGCCCTGGCGGAGGCCCCGCCGTCCCGG ACCCACCGACGCACTCCCAGGGCTTGGCGCTTTCCCACCACCCCGGACCGCCCTTGGGGTGCCGGAGGGGCTC GGGGCGCGGCGTGGGGAGCCTTTGTGCCCTCTCCGCTTGTTGAGGTTTTTTCTCCGGAGGAGAGCTCCCCGCC CGCCACCCCTTTCCTCTCGAAAGTTTTGTGGTTTCCCTAGAAGACGAAAGAGGTTGAGAAGGTTGCGGAGACT TTTGCAATCTTCCCCGTCCAGAAACTCTAAAACCTCTCGGCGTTTGGCCCAGGGGAGCTATCTGGGGTCAAGG GGAGGGAGCTGGCCGCACATTCCTTCGCCCGCCTTCCTCCCACCTGGAGCCGCGGCCCCGCGGGGCAGTGCGT CCGAGCTGGTGCGGCGACGCCGGCAGCGGCGGGGTTAAGCTCAGGAATGCGGCGCGAGGAATGCGCATGCAGA TGAGGCGGGCGGGCGCATGCTAATCGCATGCAAATGAGGGGCCCGCCGCTGCCGCGGCAGCGCCGCAGCTTCC CGGATCCGAGCCCAGACGGCGGCGGCTCCGGCAGCCTGGGCGCCGCGACCCTCGGCGGCCAGAGGGGGACGGG GCGGAGGAGGAGGAAGAGGCGGAGGCAGCGGCGGCGAGGGGGAGGAGGGTTCGCTCGCCGGCTCCGACGCAGA CATGGTGGACTGATCCGCAGCGGGGCCGCGAACAGCGTTTCCTGAGGCACCTCCCGCGCGTGGTTCCGCCGCG CCCCGCGCCCTGCGCCCCTCAGCCCCTCGCCGGCGCCCGCGTCGCGGGTTGGCAGCCTAGCCCGGCAGCCGCG TTCCCGCCGCGTCCCGCGCCCGGTACCTATGGAGGCGCCGCTCGCCGGCGAGGCCGCCGACCATGCCTAGGAG GGCCGGGAGCGGTCAGCTGCCGCTGCCCCGGGGCTGGGAGGAGGCCAGGGACTACGACGGCAAGGTCTTCTAC ATTGACCACAACACCAGGAGGACCAGCTGGATCGACCCCCGGGACAGGTGGGCGCCGGCCGCGGGGGCGCGGG CCCGTTCGGACACGGCGGCTGTTGTCCCGGAGACCCGGCCGCGCGGGGGGCTGGGGCGGCGCCGGCCCGCGGT GCCCCGAGGGGTCCCGGGAGGGATGTGGGGCTGGCTGCTCCGGCGGGGCCGAGGAGCCGCCCGTACCCGGGCT CCTCCGCCCACCGGCTTCCCGACGCCCCTCCGGGGACCCGGCCCCGAGGCAAGGCTGGAGTCGCTGCCCCGGG CCGACGCCGCGCGCCAGGCTAACGGACCCGAGGGGCCACCTGAGCCCTGTTAGGAACTTCCCTAGGCTTCGAG GTGCCCACGTGGAGGCTGCAGGACACCTTCGGCCTCTGGGCGGCGGGGGTGGGCTAGGGCCTCACTGCCAGTT GGGGAACGAGCCCTCCGGGCCACCTGTGGCATCCCTCAGGCCGTCCTTGGCGCGGGAGCCTGGGCTGCGAGCT CTTGGCGGGGGCGCCCAGACTGGCCGGAGGTCCCGAGCTGGGAAGGGGCTCCCGCCCCCCGCCGGGCCCTGCT AGTGGGTGTGACTGACTTTGCCCCTCAGAGTTTAAAAACGCGCGTTTGGGGGTTTCGCTGTCTGTCG CGI: 33 range = chr5: 360287-360592 CGTGCGCCTCAGAAGGGGCGTTAGGCAGAACGCGTGCCCATTCTCAGGTGTGCTCGGCGTGTGTGTGCTCGGC GTGTGTGTGCTCGGCGTGTGTGTGCACACGTGTGCCGTGCGCCTCAGAAGGGGCGTTAGGCAGAACGCGTGCC CATTCTCAGGTGTGCTCGGCGTGTGTGTGCTCGGCGTGTGTGTGCACACGTGTGCCGTGCGCCTCAGAAGGGG CGTTAGGCAGAACGCGTGCCCATTCTCAGGTGCGCTCAGCGTGTGTGTGCTTGACGCGTGTGCACACACACAT GTGACGGTGTGCCG CGI: 18 range = chr5: 1161803-1162051 CGACCGGCGTGCACCGTCTCGCCATTCCCAAGGGCAGTGCAGAGCATGGCACCCAGCACCCGACAGGCGAGGA CGGCCCAGGACAAAGCGGCAGCTCTAGCTGTCCTCAGATTTTGGGAGGGGGCTCCCAACACGGACACGGTAGG TAGTTGGAGCAGGAGGGACGGGCAGGCCACTGACCACGCAACCGGGCCTCTGTCAGCGGCCAGGGGCAGAGGG AGGCAGGACCGCCCCTGGACAACCGACACG CGI: 584 range = chr5: 3647468-3656054 CGAGGCTCCGTGAAGAGAGGGAAGCGAGGCAGGGGGTGAAGGGACCGCCTGGCCGGTGTCCAGGATACGGGTG GCTCAAACCACCAGCAGAACAGCATGCCGACTCTGGCCCGATGGCCGCCTTCATCCCGTAGCCCCAACCCGGC CTAAAGCCGAGAAGACGCCAGAGTGCGCTGCTGAAATTCCCGCGGAGTCCGGTGTGCTGGAGAGCCGCAGCGG GGTGAACTCCCGGCCCCGTCTCTGCGTAGGAGGTGGTTCGCAAAGTGGCCCCGGGAGCCGGGACTGGTACCCG GTTCCCCACGGCACCGTCCGGAGCTCTCCAGCCACGAGGCGCAGAAGTGGCCTGCCAGCGCCTTCCCAGGCTC AGGGAGGCGAGGAGGCCCGTGCACTTGGCATCTTCTCCCGGGAGCCGCACGGCCAGGGCCGCGGCGAAACGGA GCCCATCTCAAGTGCGCCGCGCCTGGCCGCGTCCTGTAGCCCGACGAGGCTGAGGATGGAGAGGGGAGACGCA GGGAGAAGAGGGACGCGGGACTTGGACCCAAGAGGCCGCTCCGTTGCCGGTCTGGCGGCGGCGCCGACTCGGG TTCGCGCGTTCCACACAAGTTTCCTGTCTGCCTCTGCACACCTGGTGGACAAACCGGGCGTCCAGGCCACACC GTCTTCCCCCTTCGCGGGGGCGCGGGGGATGTTTCCCTCCGGCTGCCAGGGGGCTTTCTGGGTGAAGAGAAAG CCCCTCCCCCCGCGTCTCCCCCACCCCTCCCTCCGAGAACCCGCGGCGCCGACTGCGCCTGCTTCCCCCGAGC TGGCGACTTCTCCGCGGGATTTGCCCTCGCTCAAAGTTTGCACAATTGAAAGAGCCCGCAGAGCTCGGCCGCT CCCCGCTTCCCCAAGGGCGGCGAGGCCGGTCATTGGCAGACGATCGGTTACTACCCAGTAGGGGCCCACGGGA ACCCGCATCTGGAGTCGGGGGTGTCACGCCACGCCGGTTCAGTGGCTCGCGGAGAGCGTCCGGGTGCACTTCT GCCAAAGATGTCCCCTGGAGGCCCCGGCCGCGCGGGACTCGGGGGAGAGGCCGCTCCCCCCTCGCTGTCACCA GCGTCCAGGCCGCCGGCCCCTTCCCCGCTGCCCAAACAGTAGAAAAGCAGGCGCCAAGTTGTTTTTGTTAAAA AGGGGACACACCTCGGCCGCGAAACTGCAAACCCGGTGTCAGACAGCTGTAAACCCGTGTCGACAGGTTGTCA GACAGCTGCGGGGGCTGGTCGGGAAGGAGCCCACGGCCTCCGGGCCCACACCCCGCCGCCCCGACGCGCGCGC CCACCGCGAGAGTAGCTGGCCGGGCCGGCACGGGGCACCACGTGCTCGCGGGAGGGGCGGGAGCGGCCGGCGA GGGCGGGCGGGAGGCAGGGAGGGGGCGGGAGGGGAGCCAGGGGCGGGGCCTGCGCTCAAGGGGATGCCAATCA AAGCATCAACTTCAAATTGTGTCTGAAAGCCCCGCCGCCGAGCGGAGGGCGGCCGCCGCAGTCGGCGCGCGAT TGCGGATCCGGGCGCAGCCGGGAGCCGGGCGCCTGCGAGCACCGGGCAGAGGAGCCGCGACCGGCCTCCATCT CCCGGCCCGCCCGAGCGCGCCCGGCCGGCCGCCCGCTCCTCCCTAGACCCCTCGCGGCGCCCCCTGCAACCCC CTCCGGCCGGCCTCCGCCTCCCTCCCCGCGCCTTTAATACTCGCCCGCTGCGGCGGTCGCCGAGTCCGCGGAC ATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAGCGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCC CGGGGGTGCTGGCCGCGGCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACCGGGGGCCGCGGAGCTGGG CGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTGCTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGCG CCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCGCAGATGGTGAGTGCGCCCGGCC TCCCCCGCTTCTCCTCTGTCTCACCCGCGCCAGGGCAAGGGTGGCGGGTCGCCCGGGAGGGAGAGACTACGGG TGGACCTGGTCCGGAAGAGGAACTAGAAAGGTCCGGGGGCAGGTTCCCGGTGGCCGAGGCCGCGGCCCCCGGG GACGCAAGAGGGCTGGGAGGCCGGGCGGGTGACGGCTGGGCCATCTCGGCCTGGGAAAGCGGAAGGCCCGGGC CAGGGAGCGGGTAGCGAGTGAATTCAGAGAGGCCGCAGAAGCAGGCCCGTGGAGCGGTGCCCGCGCTGGAGGT CGGGGGCAAACTCGCCTGGCTCGGCCAGGGCGCCCGGGCAGGCCCACGGGGTTCCTGCAGGTCGGCCCGGCGT AGCGTAGCAGGACTTCCCTTCCTGGCCGCGGGTTCCACTCGCGCGGCCTCTTTAGTTTTCGAACCGAGTCTGG AAAACTTGGTTTTCTCCCTCTTTAGCAGCTCCGAGATAGTTGTATCCGAGTTTGCCAGACAGACCCCTTCTAA GCCTGGTAGAGTCAATCAAAATAATCTTAACAATAGAGGTCCAAAGGGATGGAGAGGTCTCTCCACGGCGTGA GTGCGAATTTGAGATTAAACAAAAATTAAGTTGCAGTAATGTGCTGGTGTCTGAAACGGTGTTTGATTTTACT TTTGTAAGTTGCCCAAGTTTTCATTTCATTTGCACAGAAAGAAAAGCACTTTTCTTCCTGCGTTACATAATGG AGGATTAAAGAAAACAGTGTCCCTTGGCTTAAAACAAATGGTGTCCTCTTAGTCTCCCGTCCCAGTGGGCGTT AGATGTCGGGGCAGGCGGCTGCACACTTAATTCTCCGCGGGGGCATTGGCCTGTCTGCCGGTCCAAATCATCC ATTTTCCTTGGTCTGACTGCAAGGTCGGTGCTTAAACTTCGGACGGCTGGTGAATTGTGCGGCGGGCGCGGGG CCCTGGGAGGCAGCCCCCTCCTGGGTCGCTGCCCGCGGGATAAAGCAATTTCCAAGCACCCGCGATATCTCCC CGCTCCCCGCAGGAGAAGCGGGGAGTAAACGCCCCTCAAGTGTGCACAAGCAAAGAGCGGGTTTCCCTGTAAC TTTTCTTGTAGTTTTGAAAGAAAGCGGCCCGGCTGCCTTTCAGGTCTCTTACTATCGAAAAAGATCAGCCCCC ATTTTGTTCAGGCGGCGGGGAGGCCGGGACGCGATGAGAGATTTACAAGGTGTCCTTTCAAAAAGAATTCCCA GTGGAGACGAGGCTGAAACGTCTTCTTTACAATTACAACCAAAATAATTAGAAAAGCGCAAAGTACATTTTGG AACGATTGGGCAAAAACGAAATCTAGCCGCAGAAATGTTTTCTCTGCGGCCTCAGTCACCAAACTAATTAGTC CAAGAAATCTTCTGGTCTTTACAACTTTCTCAGAGTCCGGAACTCCCTTTGCTAACATTGCAACTAGACCATT TTTTCAGAGGATGAATATTTTTTACAGAAATTGCGAATGCAGTTGTGTGCCATTTGGGAACCCTGCCTGTGTT TGCGGGGGAGGGAGAGAGCTTCAGTGTGAGGACCTGCACCCTTTGTGGAGAGCTGGGGAAGGGAGATGTTTGC TGTTCTGAGTTGTTTTTCCCACCTAGAGGGATAATATGTAAAAATTATTCCCACCCAAAAGGTGTGTGTTTCT CCAGCTCTCCCACTGGTTCTGAGAGAGTAAACTCAAACCCAAACCCTGATTCTAGGCCTAGGTTTCCAAGCCA TTATAATTGGGTGTTTGGAAGTCAAAAGATAAAATTGTATTTGAATGTCTGTCTGCGCAATTTATGGTAATAA TGAGGCCTAATGAGGTTGTTAGAAAGATAAAATGTTATTTACCAAAAAACCTGATGGGATAATTTGACTTGCT GTGTTTTACTACTGATTATAAAAAGAATATCGATTGCAAATAAATCAGCGCCTCTAAATGCCTGCAAACAGCT AGTGTTTGCTCCCTCCAGATCAAAGTCAAACTTAAGAGATGAAGTAACTGAGAAGAGGCCTAGGATACTGAAC CGGTTCCCCTCCTGGCCGCCGGTGGCTCCCAGCCCTTGCGTTAATATTTTACAGGCTAAGCCTTCCTTTTGTA TTAAAAAAAAAAATGGTGTTTTTGTTATTGTTGTCGATGATGGCCGGGATTAAAATTTTAAATTACCTGTCAC CTCTAAAGACCTTTTAATGTGGGTAAACCATTATATGCAGATTAATTTGGAAGGCAAAGGACTGTGCTTTCGT TTTAAATTGCTGGCGGATTTAGACCGGTAGAAAACCCGGGATGGTTTATTTTGATTGAGCCCCCTCTGGGTGG CAGAGAGGAGGCTTGGGCTCTGGGCCCTTTACGTTTGGAGAAATGGCTTTATCAGCTCAGTTGAAAGGTTTTT CCCTCTAGCTAGTGAAAGATAAACTTGGAAATGCAGGTTTCTCCAGCGGTTGGTGGTGGGGACAGGGGTCGCC TAGGGAACTTGCAGGGGCCGCGGCCTCTGTTGTGCTCTTCTGGAGAGTGCACTGTTTGTGGAACTTTTCTAGA GTGGCAAAAACGATCTCCACTGTCGGTGAAAGGGCAGTTCCTGAAGTCAGCTCATGGTCCTGGCTCCCCTTCT CCCCAGCAGTGAACTGGGGGTGACTTCCTGATCTGCCCAGCACAGGAGAGCCCCGCAAAGCGCCTGGGAGGCC CTCGAGTCCATTGAAGCGGCTGCTTCCCACTCTCCCGTCTTGGGGACTCATGTCTCTCTCTCTCTCTCCCTTT CTCTCTCCACTTCCCTCCTCTCTCTCCTCGATGGATCTGCCCTGTGGCTTCAGGGCTCGCAGTATGAACTGAA GGACAACCCTGGGGTGCACCCCGCCACCTTCGCAGCCCACACGGCGCCGGCTTATTACCCCTACGGCCAGTTC CAATACGGGGACCCCGGGCGGCCCAAGAACGCCACCCGCGAGAGCACCAGCACGCTCAAGGCCTGGCTCAACG AGCACCGCAAGAATCCCTACCCCACCAAGGGCGAGAAGATCATGCTGGCCATCATCACCAAGATGACCCTCAC GCAGGTCTCCACCTGGTTCGCCAACGCGCGCCGGCGCCTCAAGAAGGAGAACAAGGTGACATGGGGAGCGCGC AGCAAGGACCAGGAAGATGGAGCGCTCTTCGGCAGCGACACCGAGGGCGACCCGGAGAAGGCCGAGGACGACG AGGAGATCGACCTGGAAAGCATCGACATTGACAAGATCGACGAGCACGATGGCGACCAGAGCAACGAGGATGA CGAGGACAAGGCCGAGGCTCCGCACGCGCCCGCAGCCCCTTCTGCTCTTGCCCGGGACCAAGGCTCGCCGCTG GCAGCAGCCGACGTTCTCAAGCCCCAGGACTCGCCCTTGGGCCTGGCAAAGGAGGCCCCAGAGCCGGGCAGCA CGCGCCTGCTGAGCCCCGGCGCTGCAGCGGGCGGCCTGCAGGGTGCGCCGCACGGCAAGCCCAAGATCTGGTC GCTGGCGGAGACAGCCACGAGCCCCGACGGTGCGCCCAAGGCTTCGCCACCACCACCCGCGGGCCACCCCGGC GCGCACGGGCCCTCCGCCGGGGCGCCGCTGCAACACCCCGCCTTCCTGCCTAGCCACGGACTGTACACCTGCC ACATCGGCAAGTTCTCCAACTGGACCAACAGCGCATTCCTCGCACAGGGCTCCCTGCTCAACATGCGCTCCTT CCTGGGCGTTGGCGCTCCCCACGCCGCGCCCCATGGCCCTCACCTTCCTGCACCTCCACCACCGCAGCCGCCG GTCGCTATTGCCCCGGGGGCACTCAATGGAGACAAGGCCTCGGTCCGCAGCAGCCCCACGCTCCCAGGTACAG CTCCAGGCCGCGTCCACCTGTCCCCTAGCTGGGAATGCAGAGGCCTGGCTAGGTGTGGTAGCGTGGGGTGCAG CATGAGCCGGGAGGGTACCAGGCAGTGGCCGCTGAGCCCTGGGGCTGCGCTTAATCCCTGCTTCAATTTAGAA AGCCAGACAAGGCCCTAGGGCTCTCCCAAGAGAGCTTTGCCCTACCGGCGGGCCTGCTACGGGGTGGTGGTGG GGTGAGGGGTGACGTTTTTCGGCGAATCTGCCTGGGCAGCCGGCAGAAGTTGGTGGGAAGGAGGCCTGGGACC TCTCCCGCCCGTCTCTCCGTCCTAACTCTGCCTCTTCCGATCTCTCGCAGAGAGAGACCTCGTCCCCAGGCCA GATTCGCCGGCACAGCAGTTAAAGTCGCCCTTCCAGCCGGTACGCGACAAGTGAGTGCTGTTTGCTTTTGCTA TGGGAGAAGGCGGTGGGGAGGGGGGAGGAGGAGTGGTCGGGACCCGGGCGGAGCTGGCTGGGTGGCGGTGGGG GTCGCGCAGTCCTAGTTGAAGGAGCGCTCCCCGCCAGCCCTGGGCGCCGGGCGAGCCGAGGAGACTGGAGTTT CTCCCCAGCCGGGAGCCGCGCTGGCTGTCGACCCCGCCCCCAGGGCTCCGCTACTGGAACCGGCGTCGCCCGG CGCTGCGTCCCCCACTCACAGTGCCCCTGTCTTCTTGTCTCGCTGTGTTTCCCATGCAGCTCTCTGGCCCCGC AGGAGGGAACGCCGCGGATCCTAGCAGCCCTCCCGTCCGCCTGATTAAGGGTCTTCTTTTACTTTTGCGGGGG GGAGGGGGGAGGAGTTGGGGAGGGAGGGAATGTGGGAGGAATTAAGACAAATATTTCAGACTGGTGTAAAGGA CAAATATGACAACGACGTCAAGGACTCGCATCCGTCGCTTTCTGCAGAAAGGGGCTTCTTCGGTCCCGAGCTC GCGTCCAGGTGGCCAGGCCTCTGCCGGCGGCTCCAGTGGCTGCGATTATCGGGTTCGGTAAATGCCCCCACGT GCTTGTGTCTCTTTCCCCCCTTTTCTGTATATAGAGTGGTTTCAGATTGTAAATAGCGCGTCAGCGAACTTGT CTAAATCATATATTTTTGTCTAATAAACTAAATGAAATGACACCCCCTCCCCGCTCCTGCTGCTGTGTGCCTG TCCAGCGTGTGTGTGAGTGTGTGTTTGTGTGTGAATGTGTGTGTGTGAGTGTCTGTGTGGCAGAAACAGAGAC AGAGAGAGAGAAGTGGGGGATACAGGGATCCTGGAACCCTGGGTGGGACCCAAGGGTCTGTGGCTGGGGGAGA TGGGCTTCTCAATGGGGGCCTTTAGAGACTGTTGCCACCCAAGACGCAGGTGCTTTAAACATCTCTTCGTTGT TTGTGGTTGTTGTTGAATTTTTAAATATTGTCACTGTGGCAGTTTCTTGCTGGCAGTTCAATTGCTTTCACGA ACATTTTTCTGAGACATAATTTTCTCAGGACATAAATAAGTTCAATTTGAGGCAGTTTTACAAAACGATTTTA TAACGTCGGTAAAAACAGAGGAAAAAGAATTTTTATTGCGACCCCAGAGGAGAACTTCGGATTAGAAACCAGT TTACAACTAGTTGTCTCAACGGCGCATCGTGGCGCCTGGTCGTTTTCTGAGTTGAGTGTGAAAATAATGGAGT ATCGCTTTGCATGTATTTTTAGTGATTCGGTTAAATCAAACACGGGAAGAAATTGGAAGGCTCTTTAAAACTC CACAGATGGGCCAGCCGGGATGCGGTGCGGGGCTTCTCTGCGGTGTGAGGTGTGAACGAGGGGCTGAGGCTGT GGTGGGAAGCGAGAAAGAGGAGGTGGCTTTGGTCTCCCAGGGAAGCCCCTTTACACTTGGGCTCCACGGACTG CGTCCTTTGCCCTCAGGCGCGCGCACCGCGGGAGTCCAGAGCAAATTGCCCTTAGATGGCCGCGGCCGGGCAG CGGGGAGGCAGCTGGGAGCAGCGATGTTGGGAAACACTCGCAGCGGGGCTGGCCTCGGGCGCGCGCGAGTGGG GAAAGGCCTAGGAGCCTGGACATCGCTGCGGATCCGGGACATCAGCATCAGTGGGTTCGGAGCGGGACGCGCG CCACGCGCCGCAGCAGGCACCTTCAGGAGGCTTTGCGGACCCGGCGCGGGGCCTTCAGGGCGCAGGCGACTCA GCGTTGAATGCGTGAAAACTGAGCCAGCAAACATTTCCAAAACTGCCAGCGAGGATGTGGGCTGCCGGGAAAA ACGGTCTAGTGGGGACAGGGCCGAGTCCCGAAGTCAGAGCCGAGTCCCGAGGTCAGAGCGGCCGTCCTCCGCT CGCACCCCCAGCCTGTGACCCGCCCTTCCCGGCTTGCTCGAGACCCACTGGCGCCAGTGCTGCGCGTGGGGAC TCCGTGCATGGCCGAAGCGAGGGGGAAAGTCGGGGCGCTGGTGTCTTTTCAGAGGTTCCAGGAAAGAGGGAGG CTCGCGTTAGGACTAGGAGGTGCCAGTCCACGGCTCCTACCCGCTCCCGACGCCCGCATCCTTCTACAGCCCT CCACCCCGTTCCTGGTCCCTGTAGAGGGGAAGGTCCTCTCCCTGCCCCGAGGCGGGAGGAAAAGCGGCGAAGA GGAGGCTCGAAGGGCGCCGCGTAGGGCAAGTGGGCCGAGGACACCG CGI: 140 range = chr5: 5192442-5193941 CGTGTACTCGCGCACACGCAGTCAGGTGTGGATGTACACCCGCGCACACCCAGGCACATGTACACCCGCGCGC TCACACACCCCATCCAGCTACAGCAGAATTCTGGCCAGGCTGTTGACCGCACACCTGCTGCCTCCTTGGCCAC CCTGTCCACACAGTAGCCCGATCGACCCCCGTGGCGGCCGAGACCCAGGCCCATCCGCAGCCCTGAGACCTCC CTAGGGATTGCACCCAGCAGCCAGTCACCGGCCTCCGCGGCCTGGCCAGTTGAGGGTGGCCGTGACCGCGGGG CCAGGAGCGCCGCCACATCTCGGGGCAAATGGCGCGGGGGAAGAGTTTCCTCCTCAGCCTCCCCGTCTCCGAT CGCTCCGCAAACTCCAGAGCGAGGCACGCGCCTTTAAAGGCAGGTCCGCGGCTCTCCCACGTCCTGGCGCCCG GTTTTCCGCACCCAGTGTCCCCACAGCTGTGCCCGGGCACAGAGGCGCGGCCAGACCGCACTCCGCGGGCTGC AGGTGTCCCGGCCTCTGGCGGCGCCGGTGCGGCCCGGAGGTGGGAGCCCGCGGAGCCACTGCAGTAGCTGGAG TCCCGCCGAGTCCCCAGCCCCAAGGCAGGGCAGGAGCGCGCACCGGCCGGAGGTCCATGCTGAGCATCGCCCG CGCCGGTGCCCGGCAGCCTCTCCAACTGTGTGGTCCCCGCGCGGGCAGAGAGGCACGGACTGCAGGCCGTGGG CAGCTCCATCTTCCCGCGTCCTCCTCCTCTGGCGCTGCCCGCTGTCTCCCGCCTTCCCTCTGCTCCCCGCTCG CCTCCGCCTCAGCGCCCCGCTGACCTCGCCTCCTCCCCTCTGCTCTTTGTCCCTGCACTCTCCCCTCCTCGGT CCTCTGACCCCCCCGCCCTCACCTCCTCCCCTCCTCTCTCCCCTGCCCGCCCCGCGCTCTCCCACCGCTCCCG CCGCCCCCGCCGCCGCGGCTGCCACTCCGCCCCCCGCGCCGCACGGAGCTTCAGTAATAACCCCGGCGCGGCG GCGGAGTCGCTGTGGGGAATCCTCCCGCGCTCTGCCTGGGTCGGGTCCTCCCTGCCCGCTCGCACGCTGCCGG CCGGGGACCCTCCGGTGGCCCCTAGCCCCTCGGAGCGCTCCTGGATGAAGCCCCGCGCGCGCGGATGGCGGGG CTTGGCGGCGCTGTGGATGCTGTTGGCGCAGGTGGCCGAGCAGGTGAGTCCCGGGCGCTCCCACCAGCGCGGA AACCGCGGGTCCGGACAGCTGGAGGCGAGTCCCCCGCGGCTCCTCTCCCGCGGACCCCGCCGTCTCACCGCGA TGTCGCCGCTGTTTTCCGCAGGCACCTGCGTGCGCCATGGGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCG TCCCGCGTCCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGGTAAGTCCGTGAGGTGGGGGCT TCTAATCCTTGCCATTTAGCAGCTCGTAATCTCCGTGCCG CGI: 21 range = chr5: 6790705-6791004 CGGATCGAAACTGTGGTGAAAGACCTTTGGCCGACGGCTGATGTGAGTATGTTCTTTGGAGTTCTGTGTCGCA CGTCACGTGCGAGTAAATTTAAATACCCTGTGATGATGATGTGTCGGCTAGATCCACACAGACCTTTTCTCGT TGGCCCGAGGCAGCAGTTCTCCAAGTGTGCTTTGAGAAGGCCTCCGTTGCCTGGAATGCATGGCCCCCGGCGC ACCTGCACCTGCTGTCTTAGACACCTGCGGTGGCCGCACATCTTCGTGATGCTGGCGCGCACTCAAGTGCGAA GACCATCG CGI: 54 range = chr5: 54554812-54555385 CGGGCTCGGCGGCGGTCTGCTCGCACTTACGTCGCCAGCCCAGTCTCGTACCCGAAAATTCAAGCCCCATCCG AGACAGGGAACCCAGCAGGCTTGCACTGCCACGGTGGGGAGCGGGACGCACGGAGCACGACACTGACTGGGGG AAGGGGGCAGCAGTTCGCGGCTCCTGCAGAGCAGCTGCGTGGCGGGAATGGGTCCTTCCACCGGCGGTGCGGC GGCCCTGCGCCGGCTCCGGGCAGCCGAGTAGCCCGCCACCCACCAACTAGCTAAGCAGCCGCCTCTGTGAAGC TCGGCGGTTCCCTGTGCGCCTGCGAAATTTTGACTCCGACTCACCAGCGACCGGCCACCGAGCCGCCGCTGTA GGAGCTGAGAGCACGTCTTGAACACCGGATCTTTCCACCCAAGACCCGACAGCGTGCAGGGGCCTCGAGCAGT AATTTGAGGCCGCGTTTCCCGCCAAGGTTTGGCCCCAGCTAACCGCCCCACCCATGCAACCGAGCGGGAAGAA AGCTGTGATTCGAGGGGCCAGGAGAATACGGGAAAAGCTTCTGTTCTGCGCACAGCCAGTGCG CGI: 129 range = chr5: 114542616-114544119 CGCGCACAGGGAGTCGAGTGCTCCTTTGTGCCATCACCTCTTCTCGAAGCTCCAGGCGCAGAGGGCAAACGCT GACGCCCTTTCCCGCCTTCTCTCCGTCTGCGAGTTCCGGAGGGCAGTGCACTGTGCAGCCTCCGTACTTCCCG ACACGTTCCGCCTGCAAACCACTTAGGAGCTTCTGCCGGCAATTTCTCGGATGCAGCGCGGAGCCCAGCCTCC CGCACTGACTCAGGCCCGGCACCACCCCGCCTGCTGAGGGCGTCGTCGCGGGCGCCACCGACGGCGCCAGCCT GCGTTCCTAAAGGCTCCAGGACAGGTGTGGGGCTGAAATCCCGCTCCTCCAGCATCTTCCCCTCCCTACCAAA AGAAGGCTGCTTTAAATATTCCCGGCCTGGAGCAGCAGCAGCTAAGGACCTGGAAAGAGGCCCGAAAAGGCCA GGGCAGGGCGAACGAACGTGCTGTCCCTATTTACCGGCCACACGCTCTGACTGCGGGCTGACCCTGATCGCAC ACTTCGAGCCTGTTCACTCGCTGGGCGGACCCTCCCTCCACGCTCCGCGCCCAGGCAGGCGAGGTCACCCACT CGAAGTCACCACGTTTGAGTAGCCCTGGTTGGTGGGGCAGCGCCCCCTTGGCCAACGCCCCGCCCTCCTCTCC ATCTTCCGACGCTGGGCTCTCGCCCTTCGGCGTCCGAGAGCCCCTATTGCTGCCCAGCTGGCCCCAAAAGCGT CCGAAAGTCCCCTCTTGGCTTATTTCAGAGATGCCACGCAATAAAGAAAAGGCGGCTACTTTGCATTCCGCAG CTGCTGGGACGCCCGGGCTGCGAGCGCGGCTCCTGGATTCCAGCCTCCCGCCCTTCCCAGGCGCTGGAATGGA CACGGACGCCCACAGTGGCGGGCCAGGTAGTGCCGGAGTCGGGGGCCCAGGCCGCGGCGCCCCGCGCCTCATC ACTTACCTTGCCTTTAGCTATCAATTCCATGATGTAGCCAAATTCACTCATCTCCCCAGACTCCGACATGTTT ACACCCCTTCACAAACTCTGGAGGACCGACGCGGGTGTATCGAATTTGTCCTTTCTTTTCTCTTTTTCTGTTT TTAGTCTGAGTTTTGCCGAGCTCCCCGCCCATAAGCTGTTAACCAGGAAAAGAGGGGAAGCGCCGGGGAAAGC AAGAAGCGGGCTTGGGTGAAATGAAGGCCATCGAGGGCTCCCGGGCAGCCTCGCCCGGCTTGCTAGGATCCGG GTGCAGCGGTCGGGGCTGCGCGATCTAACGGAACAAACGAGGGCGGCGGCGGCGGCAGCAGAGGCCGTGAAAC CCTCACCAGGCGGAGCCGGGCGCGCGGAGGCCCCGCCTCCTCGGGGGTCGCGGCAGCGGTTCGGACCGCAGCG GAGACAAACAAACGCGCACACAAAGCGGGTCCGCACTCGGCTCAGCGCGGCCCCAGCTAGACATTCCCCGGCC TTTATCGCATGCCGGCAGGTTGGCCGTCCCCGGCTCTCGGCGCG CGI: 21 range = chr5: 127899858-127900162 CGCGTCCCGATTATCAGTGCAATGTGATCACTTGATTTTAAACGCAACTATGCGTCCAAATGGCTGAGTGCAA GAGGTCGGCCGGAGATAGGGCCGAGTGCGCTGCCCCAAGCTGCGATCCCTGCCAAGCACTCACGGACAATGCA CTGGTTTCCTCCAGGGAGCGTCTTCCATCCAGGGCAGCAGTAGGAGTGGAATCTGGAGCCGCACACGTTGGGC CTGTGATGGACAAGCGCGGTCACGTAACAGATAGGTAGAGGGATGCAGCAACATATAAACGGTCTTCGTAAGC AATGCCCCGAGCG CGI: 56 range = chr5: 135720297-135720941 CGCCAGTCCTTTGTAGGCGTTCATGCGCGAGCGCGAGTGGCTGAAGGAGTCTTTCCGCTGTTTCTCGGTGCAC TCATTGCACTTGCAGAAGTAGTCGTGGGGCCGCTCGATGCGGGCGCCCTTGAGCAGCAGGATGTGCACGATCT CATACTCCTGGCAGTGCGCCGCCAGGATGATGGGCGTGATGTCGTGGGAGAAGCGCGTGCCGTCCTCGTCGTA GGCATAGAAGTCGTCGTCGCGCAGCTCCTGTTCCAGCGGGCTGAGCGTCAGGCGCTGGCCCTGCGCGAAGGCC GGGTGGTTGAGGATGGCCTCCACGATGCGCACATAGCCCTTGCTGATGGCCAGCAGCAGCGCGTCCCCCACCC GTGCCAGGTTCTCCTTCTTCAGCAGCAGCTCCGTGACCTCTAGGTGCTCGTTGCCCACGGCCAGCTGCAGAGC GTTCTGCCCCATGTAGTCCACACAGTTGAAGTTAAGGGTCTTGGACTCCTCCAGCATTTTCCGGACCACCGGG ATGTTGCCATACTCAGCCGAGTCCAGGAAGCGCTCCTCCTCGGGCGTCAGACTGGTGCCCTTCTCGTTGAACA TGTAGGCGGGACCCCGGATGGCCTGGCGACGGCCCTTCTCCCTCAGCGTTGTGTGCCGGCG CGI: 29 range = chr5: 140780945-140781256 CGAGAAACCGCGGAATATCGGCTTAGAGCCTGCCATGGCGAATCGGCTACAGCGCGGGGACCGCAGTCGGCTG CTGCTGCTGCTGTGCATTTTCCTGGGGACGCTGCGGGGGTTCCGGGCCAGGCAGATCCGATATTCGGTGCCAG AAGAGACCGAAAAGGGCTCCTTCGTGGGCAATATCTCCAAGGACCTGGGGCTGGAGCCCCGGGAGCTGGCGAA GCGCGGAGTCCGCATCGTCTCCAGAGGGAAGACACAGCTTTTCGCTGTGAATCCGCGAAGCGGCAGCTTGATC ACGGCAGGCAGGATAGACCG CGI: 182 range = chr5: 141235749-141238152 CGCGGCGTCTTCCTGCACGAAGCGACCCAAGCAGCCCCAGTCCGCACCGCCTTGGTCAGCGGGCGCTCCCAGC ACACACCCAGCGCGCGGAGCGACTCCTCCCAGAGGACGCCGAGTGTGTGTGTGTGTTGCGGAGATTAGGGGGT GGCGGGGGGGACGGCGGCAGTTTCTTGGGCTCTGGCGGCCCCACCCCCACCCCGGCAGCGCCCAGCCTCCAGG AACCCAAGGCAAGGCTAGGGCGCGGCGTGGTGAGAACGCGCTTCGGCTAGTGGGGGGAGCCCTTGCGCCCCCC GCACCCAGGCCACCGCGGGGAATCCCTCCTCCCCGGCATCTCCGGCCTCGGCCTAGGGTCCCCCGCAAGCCGG AGCCGGCGCGAGCGGCGCAGCGGGCGCCAGGAGGGGGCGGGGAGGGAGCCGGCGCCGGAATCACAAAGCCGCG AACCCGGCTAGGCGGGGACATTCTCATAAAACCGACCCTCTCGTGGCGAGCAGAGGGGGTTTTTTGCCCTACG CTCAATCCTCCAAGGCCTCAGTGCCGCCCCCAGTCTTTCCTGGCAGAAGAAATAGTAGCCGACCACTGTTGGG GAAACTGAGGCCAGAATTCTGACTTACAGAGGGTAGCTGGGGGGAAGGGGTGCGAGACCACCTCGCCTACAAA TTCTGCTCCTATGCCTGCCGCGATCTCCGTTCTGGCTCCAGGGCCTGCCCGCGCACACACTGGCCTACAGCGG GGACCAGGCGGAGGGGGCGCTCAGGTGTGAGACGAACCCAGGTGTGCGGGACCCACCAAGGTGTGTGGGACCC AGGTGTGCTGGAGACCCAGGTGGCTCAGAAAACTCAGCTAAATGGCTGGAAGAGGGTCGCAATCACCGTCCCA GGCTAGCACCCTCTACAAAGGAACCTGGGGCCCCAGAGCTCCGGGGAGGCGGGATGGCTTGGCCAGCCAGGTC CAGCTTGTTCCCGGAACACCAGCCGGTTCGGCCCGGGAGTGGGGGTTGGGGAGGCGCCGACTGGGAAGCCGGC AGGCCGGCCCAGCCTTCCCGCTGTGCCGATATTTACAATAATAATGTCGCGATTAACGTGGCGGGGCGCTTGG GGCTCGCCGAACGACCCCGGCGGCTTCTCCTGCCTGAATCTGGACTCCGAGAGAGAGGAACGGAGTGTGTGTG TTTGTGTGTATGCGCTGCAGGGTGTAATGTAATGTGACACTGTTGGTTTAAGGTGTGTGTGACACCCAGTGTT AAGATGGGTGAAGCAGTGGATTCTGTGTTTGTGACCGTGAGGCGCTGCTGTAGGTGCCAATTCCTGTGTTAGA GTGTGTGCCATCAAGCGTGTGCTGAGATACTGGGTTGTGTGTTTGTGTGGGTGCAGTAGAGGGGTGCAAGGAG ACCTGTGCTGTGTACCTATGTTCTGGCCAAGAAGTGGGTAAGATGATATATGCTAGGGTGTGTTCCTTAAAGG AATGTGGGGGGTGGCTAGGTTTTGAGGGTTCATCTAGTGAACTGTGGCTGTGACACTCGTACATGAGGGCACG AGATTGTGTTTGTGTGTCCACGTCGCGGGGTGTCACACCCGGTTGTGTTATTGCTCTGTAAAGCCACGGGTTG TGTGTCGGTGCTGCTGATCGTGCAGACACTGAAGCGGATTCTGAGCTGGCGACGGTGCCCCAGTGGGCGCTGG TGTGCGGGAGGTATGTCTGTGTGCACATATGCAGGGATGTATGTATGTGTGTATATATGTCCACGGTCTGGCC CTCTGGGTGCCCGCGAGAAGCTGGAAGCGGCTGAGTGAGCCGAGGTAGTTGCCCAACAAGTGTGTATGTATGT GTTGTGGACAACGGTCCTTGCTTGCTCCGTCCTCCGGGAGACCCCCACCAAACTGGGGGCCGCGCGCTTCCCC AAACCCATCCTCCACGCCGCGCGCTCCTGGAGTCTCCTTATCCCCGTCTCTCCGAGCGCGCCCAGGTTTGGGA CGCGGGGACTAGGGTTCTGCTCAGCACCCCCTCCCCTCCCTCGGCTTCTCGCCGCGGACCTGGGAGGACGGAA TCCCTCAGCCGCATCCCCTGCTATGGGCTCCCAGCAGCCCCCACCTCAGCCCCCTCGCGCCGAGCTCGTGTTG GGCCCCCGCGGCCTCGCTCCGCCGAGCGCCCCTCCCTCAGCTCCCGCCGGCCATGACCGCTTCGGGCCCCAAG CCGCTGCTGCCTCCACCGCCGCCGGATCCTTACCCGCCTCCGGGCAGCGCCGGCCGCCCGCCCCGCTGTCCAT GAGCCGCCGCCGGCCCCGGCCTGGGCTGCGGCTCCGCACGGCTGGGGCTGGAGCTGCAGTTCGGGCTCCGGCT CCGGCTCCGGCTGGCTCTGGGCGCAGCAGCCCGGCGGCTTTGCGTCCGCGCCGCGCTCCCGCTCCCCG CGI: 263 range = chr6: 1326743-1330210 CGCCGCGCAGAGTCGGCCGAATCCAGCTTCTCCAAGGGCGGGCGGGTGGGATGATTTGTTGATTTGCTTGTTT TCCACCAAACCGCAGGGCACCTCCAGGAGCTCCGGGACAACTTACAAATGAAGACACAGAGCCCCCGTCCCTT GCTTCAGAGAACCAAATAACGGAACTGAATGATCGTTTCTTCAGCAAAGCCTAAAGACGCTTGCGTCCCGCGG AGAGGTGCCCACGCGCGACTCGGCTGCCCCCTCTTCTTGCGGGTCCGGGTAGGGTAGGGCGGGAACGCGGGAC GTGCCCTAAGCGGGCCAGCCGAGCGCGAGACAGGCGATGCTGCAGAAGCCTGCCCGCCTGCGGGTCACACACC GGCCGGCCTCGGCTGCAGGGGTTGCGGGGCCACGGGTCGCGGGGCGCCGGGAGCCGCGAGCAGGTGACGGCCG CGCCGGGCAGCCCCGCGGGCCGCGATTCCCGAGAGCCTGGCGCCACCCCGCGGAAGCCGGAGGAACTGCGGCT TCTTCCCGCTCCCGCGCGGAGGGGAGAGGGAGGCGCAGCGCGGAGGGGAGAGGGAGGCGCAGCGCGGAGGGGA GAGGGAGGCGCAGCGCGGAGGGGAGAGGGAGGCGCAGCCCGCACCGCGCAATCCCGGGGCTCTGGCGGGAGGG AAGGTGACTTGCGTGGGACGACTCCAAGAGGCCAGGCCCGGCCTTCGCAGTTCACCCACGAGGATACCGCGAC CAAGCCACCAAAGCACTCTCTGGCCAGGCCGAGACCCCTTTTCCCCCGGGCCCCAAGAGAAAAAAGCACTTTC TCCTAAAACACGAACTCCCCGCGGAGGGGCCCGGGGCTGCCTGGCACGGGGCAGGGTGTGCGGCTGCCGTGCG GGCGCGGGCCAGAGTCACGTGGAGGCAGGCGGAGAGGGCGAGGGGGCCCCCGTAAATCATCCTGAGGGATTTT TGGCCCAAGTCCCTGTTTCCGAAAGGTTGCGGGACGGCTTTGACGTTGATTATGTAGCTGTTCTCTTTTCAAG TGCGCGCCCCTCCCCACCGCAGCCCGTCTGGTGTGCGAGGATTGTGTTTGAAAGGGAGGAAGCATCCTTGAAG TGGTGGGTGATGGATTGTCTAAACCCTTCTGGGACGTTCTGGGTGGGGGTTTTCGAGGCAGCTCATCAATAAA GACCCCCCTGGAGAGAAGGGGCGGCTGGAGACCAGCCCCCGCCGCGCAGCCCCGAGGCCCCAGGCCTGGAACA CAGTCCTCGGTGTGGGGCACAGGGCGTGAGGGGAGGATGAGCTCCCCCTGAGCAGATGGAGATTTCTCCTTGC CTGGGCCGTTTGACCCCCAAAGCCTTGCAGACTGGCCGCGTGGGTGCCATGGGGCGATTTCTTGGGAAAGGAG GGCAGCAGAAAGGCCCGTGGGCTCTCAGCGCCTTGGAGTCAGGGGAGCAGGAAGGGGAGTGGAGGTGCGGACA CGCCTCCAGCCACCGTGCTCCCCTAGGAGGATCTCCCTTCAGCCCCTGTAGAACCCTGCATCTCAACCACCCT CGTGCATGTGGTTTACCTTGGCATAGATTTCCAAGCCGCTACAGAAAACCTGTCCACCTCCCCCAAGGTGGAG GCGGGAGTTGGGAGGCAGGGGTGCTGGAAAGGGTCACCTGGCTCAAGCCGACCCCAGGTCTGACGGGCGGAGA GCCTCGAGGGCCACGCCCCAGGCCAGTGGTGTCCTCTGAGGCCGCAAAGCCGACTGGCTTCTGGAGGAGCAGC AGCCTCGGCCTCAGCCTCGGCTGGGAAAAGACGCAGTCGGGGCCCTCCGTGCTCCAAACTTGAACTACTCTGG GTCCCCACGAGGAGGAGGCTGCCCTGGGGTCAGAAACTCCGACGGAAATGAAGGGGAGGGGGCGTAGGTTCCC TGGCACAGCTCGGCCTGGAGAGGCAGCCTGGGGGCCCAAACTCATCTAGGGCGCGCCCGGAGCTTCCCCGGCC TCTCTTGGCCCATCGCGAACGAGCTCCCCTCCCCGACTGGGTCGGCCTCGGGCGCCTTTCGCCTTCGCAGGCC GCCGGGGTTCCGCGGAGGGCTTGTGTCCCTCCCTCCCGCCGCCGCAGCCCGCCCGAAGGTCAGGCCGCATCCG GGGCCCGGGGCCTTTGGCCAGGCTGCGGGGAGGGGTGGGGTTGGGGGGCTCCCCAAAGCAGCTTCTCGGAGGC GGCGTCGGGGCGCCCTGAGGTCCCTAGTCGGCCTCTGGGCGCCGAGCACGTTTTATTTATCCCCACAGAGGAT GCTGGAGGACAAAAGAAATATTTGGACGTCAGAGCTGATTTATATTTTTGGAAGAGCTACGTTTCCTTTTCTG AAGAGAAGCGAGCGCGCCCCATATCCTGAGCTCGGCGGGGAGGACGAGAGGGGAGTTTTGATGCGCCAGGAAG TTCATCTATCGCCCAGGCGCTCAGGACCCGGCGCCCCGCCGAGTTCGCCGCCCTCGGAAATATTTATTTATTT GGGGGAAGGGAGGGCAGCGGGGAGGAGACCAGCCAGACGGGAGAAGAAAGCCCTGCCCGGGCTGGGTTGGGAC CTCCAGGGCGCTTCCCCGCGCGGCCGCAGCCGGCCAGCCTCTGGTCTCGGTTGGAGGGCATCGCAGGCGCGGC CTGGCGACCTCCGGGCGCCTTTGGCTGGTGTCTTCCGTAGCCCTCGGCGCGCACCCTCCCGCGTGCAGTGCCC GGAGTGACCTCTTCAGGCCCCGCGGGCGCCTCCTGGGTGGGCCCCGCGGCCCCTCCAACCCTGCCCAGCGTGT GTGCGCGGCCTAGCCATCTTTCTCCCCAGCCTGGGAAGGCGGGCGGGAGGAGGGGATCCGAGGCCGGGGGCCG CGGAGCAAAAGGCACGCGGACCCCTAAACGACCCCCGAGCGTTGCCACAGCCGGGAGGGCGGAGGGAAGGTGT GCAGAGCTCGGGGGTCTCCCAGGACGCAGCTTGGCTCCTACCGGTTTCCAAGGCATCTGCAAGCTCTGTCCTG CGACCTAAAGCATGGGGACGTCCCTTCCAGCAGCATCAGTGGGCGAAAAGTTAACATGCTGAGGGCCACCGGC ACCCACACTTGCTTCCAGGAATACTTGCGGTACAGGCTTCCTGACTTATTTTCTTTAGCCGCTGGGTGCCCCC CCTTCTTCCCCCGTTGGGAGACGCAGACCGACTCTGTTCCAACCTAAGCCCCTTCTCTCTGCCTTTTGGACAA AGCGGGCCGCCTCTGCTCTCCACTCACTCCCCGCAACCCCGCAACTCGCCACCCCTAAACGCAGCGGGCTGTA GGCGAAGTCGAAGAGGTGCTCCGCCTGGTACCGCGGCCTGCGCACTGGGATCGGGGCCTGCAGGCCGCTGGGC TGGCTCCTGGGATCATCCCAAGGTTTTGGTCTCGCAACCGAGGGGACCCGCGCCCGGCAATTTGGGAAGTGCG GAAATGGGGTGAGGCCGGTCTTCGCTTGAGGGTCTCG CGI: 190 range = chr6: 5947471-5950124 CGATGCGGATTCGCGCTGGCGCTGAACGCTGAGCGCAGGCGGGGAGGCTCGGCACTCTCCGACCTCAGTAGCG CCCCCAAAACCGAAGTCCAGCCGGCCAGAGAGGACACTTACGTGCACACGGTCTTGATGTTCGTCTTGTCGTC CAGGCCCTGCGGGTAGTTGGCCATGCTGTCGCCCAGCTTGAGCAAACAGTCCGAAAAGCCCTTGAAGACCGCA TCGCACTTGCCCGCTGCTCTCACGGCCTGCACCAGATACGCTGCGGGGAGGAGGGAACACCGGTCAGCAGCGC CACGACCCCGCCCTGCCGCCCACTGCCCTTTCCTGCGAGACCCTGGCTCCGCGCGGCCTCATCGCATCGGGCG GCCTCTCCCAGCGCCCAGCCTCGGGGCTCGCCAGTGTTAAAGGTGAATGAAAGACGTGACCCAGGAATGCCCG ACCTGCAGCTAACGCTGCGTCTAGTGCAAATTGTCGGTGTGTGAGCAGGTGTGGGTGGGTGGGAGGTAGGTGA GTCCATTCCTTTCCTCCAGCTCCCTCCCGCATCTCGCTCCGTATCTTTTTCTGTTTCCATCGCCCCCTCTTCT CACCTCCCTCATCCCTTTTATTTCTCTTTCTCCTCGCTCCCTCCTTCGTCTCCCAACACTTCCCCAGCAAGCC CTGTCACAGCTCTCGCAATGCGATCTTCCATTTTGAGGTGACAGAAGGGGTCTCGGCTGCAGCGTGCGGGGGC GAGAACGGGGTGGGGAGACGACAGGGCGTGGGGTCACGCAGCTGAACCCAACGCCACATCACGAGAATAAGCC TCAGGCTTGGCGCTCTGTCCTTGGTGGGCGCTCAGCAAACACTGCTGAATGAATGAACGAATATAGTCCCTGG AAGCCACCAGCAGTTACCGAAATGGATTGTTTCATTATAAAACCGATTGCCTACCGTGGACTCTGTATTCCGA GTGAGACCCTCGGATGCACCCTCTCCCGCCCCGCTGGAAAGAGGGCAGCCTGGACGTCCTGAGACCTGGCGCG GATGATGAGTGGTCTGGAGAGGAGAAGGCCAGAGGCCGGGCGGGGTCACGGATGAGTCTGCCTGGGTCACCTC CGCAAAGGCCAAATCCACGAACCTCGGGCCTCTTTCTCTCCTCCTCCCCTGTCCGCCACTCGGCTCCCCAGAC ACCCTTAACAACCCACCCGCCCGCCAAAAAGCCCGCCTACACTCCGGACGGCAGCGGGGAGAGGCTGTTCTTC TCCAGGTGCCAGCCCTGCTGCTGAAAGTGAGCTCGCCGCGGCCCGGGGCTCCTGGCCCCAGCTCAGGACTCCC TGCAGAGAGCAGGCAGGGATAAAAGCTGAGCGGCGGGAGGAGGAGGAGGAGGAGGAAACACAGGCCGCACGAA GGTCCAAGCCCCAAGCCCCCAAGCCCCCGGCCTCTGGACGGCCAAACCCCGAGGCGCGGGACTGGAAGGACAG GTACCAGGCTGCGGGCGCGCGGCTGTGGCCATCTCTTTCCGCCCTGAGGCCGACGAACCCGGCTGGAAGCTGA GTGCCTAGCGGCCCAAAGCAGCCCGGGCGCCGGGAGGGCGCCAGAGAAGCACAGCGTTAGGGCGGGGAAGAAA GGGTGAATCTCAGAATCGAAATCCGCACTGGCGCCCACGACCCTGGGCGCCGGCCTGGTCCTCGGCAGCTTTC TGGCGGCTGCGCTTGTGTGTGAATGTGTCCCGGGAGGACCGGACACCTCAATCCCCCGGCCCCCAACGCGGGC GCCTGTCCGCGAGCGCCGGGCCAGACGCCGAAGAGGAAGGTGACCGAACCCGTAGCAGCTTCCGAGAGCGTAC CCGTTTGCAAATTGCTGCAGGAAGAGCGAGGCGGGCCTTGCGCTTTTTAATCCGGAACGGGAAGCACTGGGGA AGGGACCGAGGTTAACTTCGACCTCCGCTGGGGCAGATACGTAAACCTTCTCAAACCTCCGAGTTCACCTTAC AGCGAACATTAAATACCCTTGCGACTACAATACTAACAAATCGAACACTGACGTAAAATCTTAAGAATAAACG AATCTTTGTTCTGATAGAGCTCGTTCAAAATGGAAATACACTCCACACATCTTCCTCTATAACGCATGTCACA AATACAGCTTTGCAGAGAAGAAACGAAATAAAATAAAGTCCAATCTCCCCGTCCACGTCTCTCCCCACCCCTT GCCTACACCCCCAAAACTCAGTGGCGAAAGAAGCCCCTAAAATGCATTGACATTTTTTAAGGGGAATTGGGGC TCGCCGGGGGCGGGAGCGCTCTTGTCACGTTATCTTCCCAGGCGCTGCTGGAGAAGACCCTGCACACCGCGCA TGTGTGAGTGTGTGCTGTGTAAAATAAGTCGTGAACATTTCTGTCTTTTAAAACTGTGACTCCTTGGACTCTA GCCTTCTCTGGGAGGCCGGGAGGCTGCGCGCGGGACGGATTTTGCAGGCGCACGCGTCCCAGCAGGTCGCAGC CCGTGGGTCCCTCGCTGTCCTTCCTGAACCCCGCTTAGGCGAGACTCTAGCGGGTGACCCTGGCTCCTTCCCT GTCCTCTCTGCCGTCCCCTTCTTGTGCGGTTTCCATCCGTTCATTCATTCGTTCGACCTCTCATTCATTCCGA ACTTCCTCCTGCTGCGTCTTCTTTCG CGI: 40 range = chr6: 10498025-10498551 CGTTTCGGGTGCGGGGTGCTGATGCTGCTTTTTTGTTGTTCGTTTGCGCTCGCGCTCGCTCTCGCTCTCTCTC TGCATCCCCCTCACCCCCTTTCTCGGAGACTGAACTAAGTGAAAAGTTGTTTCAATAATCGCAGCTCTCTGCT CCGCCAGGGCCGAGGGAGGCGGGCGGAACACGGAGGGTGTTTTGTTAAATGCTCCCGTCGTTCGCAGGGGCTG GGACTTGATAAAAGGAGACAGTTTTCTGAAAAGATTTGATTGAAATGGCGTGTGCCAGGGCTGATGGGAGCCA GCGAGGGACAAAGCGCCGAGAATCCATGGACACTCGAGCAATTATGCCTCCACGCTGAAGGTGGATTAGCGCG CTGGAAAGAAGCATATGTTTGGCCCGGGGCGACACTTCCCCCCGGCTGAGCTTAGAGAATGGGAGCGCGGAGA GCGGCTGGACCCGGAATATCAACTATCTGCGAAGCCCCCCCTTCTAGCCCAACTCCGCCAGCCTCCCCGCCCC CGCCGGGGAAAAGTCG CGI: 100 range = chr6: 22677564-22678684 CGTCCGAGGGTGGGTCCAACGGGCTTCGAGTGTTCGGGAGATAATGCACACTTCGCAGTGGATCTTCTCGGGG CCCCGAGCGTTGCCCGCCCATTAGGTGGCGCCGGTCCCCTCGAACAGGTCGCTCAACAACTCCCGCCCAGCAG CCGCCCTTACTGCGCGCGCGCAGACTTCGGCGTCTACTTCCGGTGTGGCCCAGGCGGGGTCCGCAGAACCAGC TATGTCGGCCTACGGCATGCCCATGTACAAGAGCGGGGACCTGGTGTTTGCCAAGTTAAAGGGCTATGCCCAC TGGCCGGCGAGGATAGAGCACATGACCCAGCCCAACCGCTACCAGGTGTTTTTCTTCGGGACCCACGAGACGG CCTTCCTGAGTCCCAAACGCCTGTTCCCGTACAAGGAGTGCAAGGAGAAGTTCGGCAAGCCCAACAAGAGGCG CGGCTTCAGCGCGGGGCTGTGGGAAATCGAGAACAACCCCACGGTCCAGGCCTCCGACTGCCCATTAGCCTCA GAGAAGGGCAGCGGAGACGGGCCTTGGCCGGAGCCCGAGGCCGCAGAGGGCGACGAGGACAAGCCGACCCACG CTGGTGGCGGCGGCGACGAATTGGGGAAGCCGGACGACGACAAGCCCACTGAGGAGGAGAAGGGGCCGCTGAA GAGGAGCGCGGGGGACCCGCCGGAGGACGCCCCCAAACGACCCAAGGAGGCAGCCCCCGACCAAGAGGAGGAG GCGGAGGCGGAGAGGGCGGCGGAAGCGGAGAGGGCGGCGGCGGCGGCGGCGGCGACGGCCGTCGACGAGGAGA GTCCGTTCCTCGTGGCGGTGGAGAACGGCAGCGCCCCTAGCGAGCCGGGCCTGGTCTGCGAGCCGCCTCAGCC AGAGGAGGAGGAGCTCCGGGAGGAAGAAGTCGCGGACGAGGAGGCCTCCCAGGAGTGGCATGCCGAGGCACCG GGCGGCGGAGATCGCGACAGCCTGTAGTTACCAGCGTTTCCAGAAGAGCCCCTGCCCCGTTCCTGCTGCGGCC TGGCCGTTCTTGGGGAATCTGACCACGGCGTGCAAACTGGGACTGCCTTTCCCTCTCCTCAGCCCGTCCTCCT CCAACCCGCGCTCCTTTGCCCTGCCG CGI: 20 range = chr6: 25834434-25834701 CGCCGCCCAAAAGCTTATTGAGTTCCTCATCATTGCGGATCGCTAGCTGCAGGTGGCGGGGAATAATGCGAGT TTTTTTGTTATCGCGAGACGCATTGCCTGCCAGCTCAAGGATTTCTGCTGTGAGATACTCTAACACTGCCGCC AAATACACTGGTGCGCCTGCCCCTATCCGCTCTGCATAGTTTCCCTTACGAAGCAGACGATGGATCCGGCCTA CGGGAAACTGCAAACCCGCTCTAGAAGAGCGAGACTTAGACTTGGCGCG CGI: 71 range = chr6: 41176454-41177326 CGGCTTTATCGTAGGAGCGTCTTCGCCTCCCCCGTTTCCAGTAGAAAAGACAGCTTTGCTCCTTTGAAAGCGC AGACCGCCGCACCTCCAGCCCCTTCTCCCCGGGGAAGTAGGCCCCGCTAAGAATGTGGGAAGGTGGTGGGGCG GCGACTGAAGTCGCTTCCGATTGGCGTTGTCCCAAGGAAGCCTGCGCGGATTGATCGGCGGCAGGCCTCCAAT AGAGCCTGCTAGGCGGATTGGCTGCTACGCGGCTGGGCCCTGTTTCCGGTACCTAGGCGGGCAGCCATGGTGA CCGGCGAGCGGCATGCGACGCCGCCTCTGTGGCCTGTGGAGGCCCGCTTGGCGGCGCTGCTTCCCGACCTACT GGTCTTTCGGAAGCCTCGGGGATGGGAACCCGAGCTCGCCACGGCCCAGGGCGTCCTCCTAGGCGTCCATGTG ACGGGTGAGGGCGACGGCCGGCACTTGCACTTAAGTCTCCTGGCCTGCGGGAGAGGCGGCCGTTGGGTCTAAG CCCCTGGAGGCCTCGACGGTTACAGGCCTAGCCTCCCGCGAGCTAAGGCACAGTTTAACTTCGTGCTGCGGCT TCCTTAGGAAACTTTGAGTATCTTCGTTTTAGCGTGGGAGGACATCTTTTGGGATGAACCGGCTCAGTCCTTG AGCTCACCCCAAAGATGATGAAATTGAAACTCAGAGGAAAGGATTTTTACAGGACCACGCCCCGGGCTTTGAA CCCGTTTTTCCCAACCCCGAGCATTTTCTATTAAGCGTTCTGTTTCAATTATTTTATTCGTTCAGTTAATTCG TTCTTGGCGTCATAAGTATATGCCCGCCGTTGTTCTGGCCGTAGCTATCTAGCAGCCACTCCGCGAGTCG CGI: 68 range = chr6: 50895246-50896050 CGTCCGAACAGAAATCGCAGCCGCCTCCTGTGTGGGCATCTTTCACGGAAATTTCTGCCCACGTTCAATGCGT ACGGGTCTCTAGCACTGAGGCTAGCTCAACTCTTCGGGGCAGGAGAAGTTGCGCCCAGCCAGGAGGACGCCAG CCGCCTCCGGGGCCCGGACCGCGCTCGCCAAAGCCCTTTTCCGGCTCGGGCGAGGGCTGACGCGGCCAGACGG CTCCGCTACTCGCGGGCGAGGCGGACTAGGCGGACGAGGCGGCCGAGGCGGGCGAGGTGGGAGAGGCGGGCGA GGTGGGAGAGGCGGCCGAGGCGGGCGAGGCGCGGGGCGCGCGGCGGGCCAGGCTGGGGACCGGGAAGCCCGCG GAGCCTCGCTTTTAAGCGGAATGGTCTGGGACAGCCCCAGGTGGTTGCCAGGGGAAGGGAGGAAGGGAAGGTT CTGCTGAGACGTCGAGGTTGGAAATAAAAACTTCGGAAAGGCGAAGCGGATTTAGAAAAGGAGGGAAGTCGAG GCGGGCGAAGCGGGCCATGGAGATTGCTAAGAGGAAAAGTTGGAGAGAAAAGGAAGGAAGAGAAGCAGACTCC CGGGTGGCGGGCGCGGGCCGCTAGGTCAGACGAAAGGTGGAGGGATGCAGAGGCTCCCCAAAGAGCCGAGAAA GACACGCGACCCCTCCGGATCGGGACAGCTCCTGAAAGCCCGGCGCAGAGCCGCCTCGAAGATCCTAAGAGTG GGCGACTCACAGGCGCGGCCGGCAAGCTCCTGGGGGACTCGGGCTCGGACGAGCGCCCACAGGCAGCGCCTGG CG CGI: 43 range = chr6: 75968300-75968853 CGGCGCCGTTTTGGAAACCCATCTCGGAGCGCCCCACTGCCTCCGCGGGAAGGTCCGACGCACCCGGCTGTCC CTGAGGGAGGCAGGATGGAGCAAGGGCAGGACACTGGAGGTGGTGCCCAGCAACTCCGGCGCGCGCTTGCTTC CCAGGCTGGAAACCTTGGCCCAGGCTCAACCTGTCTGAGCTGGACCAGTCCAGGCCACGCGCCTTGGAGCCCT GCTAACCAACAGGGACAGCCGCGACCCTAGGTCGTGCGAACACCTGGGGTCCCGGATCTCCGCTTGCCTGCCA TCATCCCCCAGGCTGCTTGGCTGCTGGCTCATCTGCCCGCACCGTCCGCCCCGCCGACTGAGCTCCCCACAAA GCACACAGAGGCGCAGAGCCAGCGCTGTTGGAGTCTTTTATTGTGTTCTGTCACCGAGGTCGCAGCCCCGAGC CAGGTGGTTGGTTACCAGCCAAGCGAGCGAGTGCGCCCGCTCTTCGGGGCTCCTGGGTGCCACCCGGAGGTGT CCTGTTGGTTGCGCTGATTAGAGCCGTCGCCCCCTCTCGGGCG CGI: 27 range = chr6: 101953488-101953856 CGCCTTTTGTGCCGGGCTGTGGCTCGCTATCGACATCTCGTCCGTTACCAAGGCTGGGTTTCCTACTGATTTC CCTCCTCCTCTGCTTTCACAGGCTCGCGCGGCCGGACATTGTGGGTGTGCGTGCTGGATTTCTCCCGGATGCT CTCCGACTAACATGGATGTCCCACCATTCCTTGCAGTGGAAGGTTGTTCCTTGGCGCAGTGAGTGAAGAACAT GCAGCGATTGCTAATGGGTTTGGGAAGCGGAGACTCCTTCCTCTCTCTATGACCATGCCGTGATCGTGTCTGC GGTCACCACTCGACGCATCCTCATTTCTACCCGAACCCAGGAGCCGAACGCTAGATCGGGGAAGTGGGTGCCG TGCG CGI: 318 range = chr6: 108592365-108597232 CGCCGAGTTCGAGAAAGCGCTACGCCGCCGGTCGGGCTAGCTCCACAAGCGGCTGTACAAGTTGGCTGTCAAA AAACGCTGATTTCTCCTCCTGTCACCTAATAAACCCCTACGCGCTTATGGCCTCGTCCCACAATCCCCCAATC TCGTCCCAATTCGAAAAACCGAGGAGGAGGGAATAAACTGAGAGATAAAGATCCCCCCATCTTGCTCTTTCCC CGGGACCCCAGCCTTGGTCGCGGCGCCCCACTAAGGAGGACACAGGCTCTGGTGTGTGTGGTGTGCGAGACCC CGAGCTCGAGGCCGAGCCAAGGCTGGGCAGAAAGTTGCAATCACGTGCTGTCGGAGCCCACTGGAGCGCACAG CCCGCTCCCCCTGGGACGCCCAGGCGGAGGACCTGCTGCGCCCTCCCAGGGCTCGGGGGACTCCAGCATTCAC TTGCACGCACAGGCGAACTCTGATTGAAAGCCCGGGATGACACCGAGTCTGGAGAAAGAGGGACCGGGGGGTG GGCTGGCGGAATTGCAGAGCGCCGGCCACAGCTCCCCTCCCCGCGAACGTCGAGCGGAGGGCGGGAGGTGTAA CCTCTGACCTCTGGCCGGGTCCACGCCCTGAGGAGGGACTGGCAAGCTCTTGTTCGACAAGTTCAAGCTGCCG AGAGAGCTTAAATAGAATTAATCTCTTAGAGATCGGGGATCATCGCTCCCTCGGCATGCGCTCTCCCAGCGCC GCGCACAGAGCAAGGCGCGAGAGAGCTCAGGAATCGCGGGAAGGCAAGCGGAATGGGGAGGGGGTAGGGGATG AGGGCCTCTCTTCACTATTCCTCCGCCCGGAGAGCGGGAGCCCGCAACGCCCGCCGAGGACGAGCGGCGGGAG GGAACGCTCTGCCCTCCAGCCGCCCCGGTGCAGATAATGGAGGCGACAAGAGATTCGCTCAGCGTCGGATGGG CCAGCTCTGCTTGGGGAAGCTGGCGGCATCCTCCCCTCGGCTGGTGCCCAAACCCACTGCGCGAAGGCCGAAG GAACGCGGAACCTCCAGAAGACCCCATCCTCAGCCCTGACTTTCCGTAGATATGTGCAAAATGAGTAAATTAC TCACCTCGGGCCAGATCCAAGTTTTACCCAACAGAAGGGGCACCGGACCAAGAATGAACCAACTCACATGGCC ATGTCCGGCGCGCACAATCACACGCCAGCACACAGCCACCCAATTTCTTCCGCGAATCTATCTGGCACTCTGG AGAGAGGGGGAAAAGCGTTTTGAGAAAGCCCCGTCACCCCTCCCCTTCCTTCTTGCCGTGAAATATACGAATT CATTTTTATTACGAGCCGCACCGTCCTCACCATCACGCACGCACAGAGCCACACTCCCATATTCACACTTTCT AACTCGTAAGCTCCGACAGCGCCTGCATTTTCTTTGGGAGCCGCTTGGAGGTTCATTAATATCATTAGCATTT AACCCCCTCCCTCTTCCCATCCCCTCCCCGCACATGGCTGACGTCAGACCCCGCCAGGAGTTGGGGGAAAAGC TAAGTGGGCCAGGGACGCCCTATTCCCCTCCCCGCGGCTGCCTGTCAGAGCGCTTCTGGAGATATTACAGGGG ACCCAGCCCGCAGCGACAGGCACAAAGTCACGGGGTAATGAACTTCGGGGACCCTTCGCCGCTGCGTGCGCGG CTCTCCCCGGAAACCCGGACCTGGCCGCCTCTTCCCTCGGAAGATTTCCCAGCAATCTAGTTTTCCCACTCTG CGCTTGGGTTCCGGCAGCGCGGAGCCCGTCTGCCTCTGAGACTGCGGTAGTGTTTTCCTTCTTTCCTTGGGAG ACCAGCGGTCGGCAGAGATTGCCCACACTCTGCATGCCTATGTAGAGGGAGAGATCGAAGACTGAGTGACAGG AATGGGGAAAAAGAGGGATTTCGCTCCGTAGGAAGGCCATTTTCGTGTCTCCATCTCTGTCTTTCAACATCCC TCTCTTGCTGTTCTTCCTTCTTCCTCAGTCTTCCTGTCCATCTCTCCATCTGTCTGTCCATGTGTGTGTCCAT ATCAAGCAGCATTCCCAGCAGCTGCGGTTTTGCAAGAGCCGGGAAGAAACTTAAGGATGCTTAAATTTCCACT GTTGGACGAATTCTGAGCGCCCAGGGAGCAGCGCAGCGCGCGACTGACACCCACCTGTCCCGCCCAGGAGCCT TGCAGGCTGGAGGGCAGCTGGAGAGCGGCGGCGCCCGGCGGCGAGGCGGGCGCTGCCGGCCGGGACTCGGGCA GCGCCCACCAACCGCTCCGCCCCGGGACAGCCAGCATGAGCAAGCCAGCCGGATCAACAAGTGGGTACCTCTC GGGCCGCCGTGGGGCCTAGGCGCGCAGCCTGGGGCGAGCGAGCGGGGAGGCTGGGGGAGGTCCTGCCTGGAGC GCTGCGAATCTGAGCCCCTGAGAGGGATTCCAGCGGGCGTGTGCGTTCGGCCCAGACCTGTAGACCGTGAGTT GGAGCATTTCGTGGAGAGGGGAGAGCCGTTTCGTTGCCTCTGGATTGCTTGATCCCCCCTGTCTGGTGCGGTG AGAAGGTTACGACCCGCGCAGCCCACCAGTCGGATGAGTTGTCTCCATTTAGCCGCCAGGTGCTGGATGGGGG GGCCATGGGGGCGGGAACTGGGCCGCAGCTCCAGGCGGTAGCACAATAACACACTCGCTCAAAACTCCGAGCT CCAGCGCGCAAAAGCAACTCTGTGCAAAGCGGATTTTGAATGGAATGCTTTGCACCCCGTTTCTAGCTATTTC AAATAATCCTGCAAACTGGGAAGCAGAAACAATTTAAAAGTCACATTTTCCTTAATCCTAAATCCGCGTAGGT CATAACTGGGGAATTTAAAGTATGGCGAACCACTCTAGCAAAGAGAGGACCAAATCCCTAATCCCAAGGACTT TTCGAGCCGGAGCCCAGCAGAGGCAGGAGTGCGCGGCCTGCTCCCTCCGTGCGCTTCTCTCCTTCCTCGAACT TCCTTAGCTGCCGGCTCTCCGAACGCCAGGCCGCAGCTGACCTCTCACCACCCCGAGACTCACGAGCGCAGGG CTAAGTGTGTGTGCGAGGGCATTTGCTTGCACCCTGCCTGCGGAACCCAAGAATGTGCAGGCCCGAGCCAGCG TTGAGCAGGCGCGGTCACGGTGCTCAGATCTCCCGGGGGCATTTCAGTTCCCGCCATCCAGTGGCCCACGGCT GCGGGCTCCAGGGTCTGAGGCTGGGGACTACCGTTGCCGCCGCAGTCCCCATATCCCGAAGTTGCCTTGCTGC TTGTGTTGTTTTCGCAGATAGCATTTTTGGCGCTCTGTGCGTTCCTTCCCTCCCCCTCCCCCTTTCACTCGCC CTCATTGTCCTGAGTCTTTGAAAGTTGGGAGAATCGGAGATACTTCTGAGGACTGGTAATGAAGTCTCACTTA AGTGGGATGCAATTCCCGCCCTCCTACCCCCCTCCAAGAAGGAGGTTGTGTTTTCATTTTGTTTTGCTTTGGG TGCTGACCTTTAAAAAATTAGAGCAAAATGAACGTGAACAAAAAGAAAAGGAGAAATGTTTCGAGCTGGGGCA GAGGGAGCAGAGAAGGAGCCCTCACCGCGGCCGGAATGCAGAGCGGACCCTGGCCCAGGACTGGGTTTCCCTT TAGGCTCGGGCCTACCCTGGCCCTCGCTGTTGGAATCTCCAGGAGGTAAAGCGACCTCGATTTTTGTTGCCCG CATTCCCGGGCGTGAGTGTCCTTCCCAGGAGGCTCAGGAGGCCGTTTCTGTTGCATTCTGAGCCTCCGTTGCA AAAACTGAAGCCCGTGGGTCTCGGCAGGCCTCCTAGCTCGCTCGCCCCGGGACAGGCCCTCGCCTACACCCCT GGAAGTAAGGAGCCCCGGGCTCTTTCGTCCTTTTCGGGGTGTGGAGCCCCTGGGGCCCTTGAAAGGTGAGGCC TCAGAGGCGAGGGAGGGGTGAGCGGGGAGCTCTGCCCGCCTGCGGCTGCGCCCCCGCTGTGGACTAGGAGGCA GGCCAACCCTCCGGACTTTGGGGGAAAAACCACAGCGGGCTCCTTGCGGAAACTTTGGCCGTTCTAACTTGCC AAGAGCCTGAGTGAGGCCTTGGAAGCCTCCAGCCCCGGCTCAGGTCGGGACGCGGCTGCTGAGCTTTCTCAGG CCCGCAGGACAGCGGCCCCCGCCGGTGGCGCCGCTGCATTTAGGCCCTTTCCAGACCGGTGGCGGCAGCCAAC CCGAGACTTGCGTCCCTCGGGCCCGGGGCAGCTAGGAGGTCGGCGCGCAGCGGGCCGGGTCAGGACTGGGTCG AGCAGACAGAGCTGCAGCCCCCGCCTTGCCCGGCTTCTCGCGGCTGGAGAGCAGAGCGATGTCACCCGGAGCC CCGCCTGGGTGGTAACGAGACCCTGGCCAGTCACCCCTGCAGCCCAGACTAACTTCTTTCAACAGCCTCTGAT GGTAATTACAGTAATCGAAGCTGCCATATATCTTTAGGCAATTATGACACACAAAAAGCCCCGAGGGGACCCC CTGGCGAGGGAAGTTAAGAACGGTTTTCCAGCTTCAGGAAACTCCGGCTCGCCTCACGTCGGAGCTCGCTCGG CTTGCTAAATGAGAGGAGCTTTGCAACGGGGTCAACCAGCTTGTCTCGTGACCCCAAGTCACCTTAACGTGGC TGGGTGGCGGAGTCTGAGGCACAGGCCCGCTATGCCCCGGAATTTTCGCGTCCCTCCCTCCTGGGCCCCGCCC CAGCCCGGTTGCCTGTTTCTAATCTGCCCCGGGAGCCGCGGCTCAGAGGTCTGCTCAGAGGCAGGACTCGCAC TGGTGGTGGCCTAGAGGGCAACAGTCCGGAAGCTCGGGCGGGGGAATCCG CGI: 38 range = chr6: 126122028-126122524 CGCGGTACCTGAGCTCCGTGGAAGGCCTGGACTCCTCGGATCCGCTGCGGGTGCGGCTTGTGTCTCATCTCAG CACTTGCGCCACCCAGCGGGAGGCGGCGGCCATGACATCCTCCATGGCCCACCACCATCATCCGCTCCACCCG CATCACTGGGCCGCCGCCTTCCACCACCTGCCCGCAGCCCTGCTCCAGCCCAACGGCCTCCATGCCTCAGAGT CAACCCCTTGTCGCCTCTCCACAACTTCAGAAGTGCCTCCTGCCCACGGCTCTGCTCTCCTCACGGCCACGTT TGCCCATGCGGATTCAGCCCTCCGAATGCCATCCACGGGCAGCGTCGCCCCCTGCGTGCCACCTCTCTCCACC TCTCTCTTGTCCCTCTCTGCCACCGTCCACGCCGCAGCCGCAGCAGCCACCGCGGCTGCACACAGCTTCCCTC TGTCCTTCGCGGGGGCATTCCCCATGCTTCCCCCAAACGCAGCAGCAGCAGTGGCCGCG CGI: 270 range = chr6: 166499964-166503413 CGTCGCCTCCCGTTCAAGCAGCGTCCCTTCCCACAACCCCCGTGCAGAAGGCGCAGCGCGGCCCCCTCCTCGC TGGTCCCAGACCTGGCGGGCTCCTCACACCTACCTGGCCCCCTCCGTTGAGCTTGTTGGTGAGCTTGACTTTG CTGAAGGAGACGGGAGCCTTCATCCAGTGGGCCCCGAAGTTGGGCGAGTCGGGGTGGATGTAGACGCAGCTGG GCGCCTGCGGCTCCGGCTTGCCCCCCGGCACCCATTCCCCGTTCACGTACTTCCAGCGGTGGTTGTCCGCCGC CACGAAGTCCAGCAGGAAGGAGTACATGGCGTTGGGGTCCAGGCCAGACACGTTCACCTTCAGCACCGGAAAC ATCCTCCTGGAAAACACGGGGCGGGCGCAGGAGGACCCCGACACTGACCAGGTAGGCCGGAGGCAGAAGCTGG GCACAGAGGCCTCAGTTATTTCGGGGCACAGAGGAGCCCCCTGGGGAACGTCCGAGGGTGACTCCCAAGCTCC CCCTTCCCCGAGCCCTGCCAGGTCCAGGTGGCCTCCTCACCATCTCCACGGCCTCGGGAGGGAGGGGAGGAGA GGACCTGGCGAAGGGTTTCAGTGCAGGAGGCCACATCCCGCGGGGACAGGCGGGGACCAGGGCGCGCCTCGCG GGTCCCGGGATGCCTCCGAGGTCGGGACACCGAAGTGCGCGTTCCTCCTCCCCAAGCTTCCGCGGAGAAAGCC CCAGAAGAGGGGCTTGTAGAAATGCACTCGAGGGAGTTAACCAGAGCGGGAACAAACACAAAGCCCTCCTCCA GGAGAAAAAGGGTTCGACCTCCGGGAACTTGCCAGGTCCCCCAGGCTGCCCAGGCGCTGGAGAGCGCGGCGCG CGCGGGCTCCGGACGCGCACCCACCTGCCGTTCTTGGTCACGATCATCTCATTGGTGAGCTCCTTGAAGCGCA GCCACAGCTCGCTCTCCTCCAGGCCCACGCGCAGTTCGCGCTCTGTGGGGTCGCCCTTCTCGCTGCCCGCCTG CAGCTCATTCTCCACGGCGCTCAGCAGGTGGTCCACTCGGTACTGCAGGCTCTTTCCCGCGCTCTCGGTGCCA GGGGAGCTCATCCTCCCGTCCGGCTCCCCTCCCCGCCGTCCCCGAAGCCCAGACTCGCTACCTGAGATCCACC TTCCCTGCTCTTGGCCGCCGCCCTTCCGAGAAAAGGGGCCCCTTGGACCGAGACCTGCGACGGCTCCCGGGTC CCGGGTCCCGGCACAGACCCGGGAGGAGGGCGCGGACCAAGACTTGGGGGGAGGGGACGGGGGCAGAGGGGTG GGGAGAAGTTATTCCACTTGAACTCCCCAAGGCTCTACTAGTGTAGGTCTCTGGGGACCGAAATTCAGTGCCC TCCCCATAAATAGAGCCGCGGCGGCAGCGCTGGGGTGCTCGGCGGATTGGGCCGCGCACGCTTTGAAGTGCCG GGCAGCCTCCCATTGGCCGAGAGCGGCCATATCAGACCCAGCCGGGCGGGTCTGGGAGGCCGGGGGCCAACAA TGGGCTCCCGCACGCCTGTTTCATGTAAATCCGGGGCCCCAGCCCTGCGAGCCCCGGCCCAGCCCCTACACCC CCGCCCTTCTCCAAATGTTTGCACCTCCATCAAAGCGGCGGGGCAAGCCCCGGAGGAAGGTAAGCTGGACGCC CCGGCCTGCCCCAGCCCGCCCCAGCCCGCCCCAGCCCGCACTTCCGCGAGGGGCTGCCCGGCAGCCTGCGATG CTCCCTGATTCCCGCGCGGGGTCCTCCTCGCTTTCCCAGCGCGCCCGGATCCCGCAGCCGCGCCAGGCTGGAA CGTTCGCGCGGCCTCACCTGTCCCCGCTCCAGGCGCGCCTCCCTCCCCTCCCAGGGACGAGCGCATTTGGCCG GGCTTTGGGATGCGCCGCGCTCGTCTCGCCGCAGTAGTAGTGCTGTTCTCGCGCCTCCGATGCCTCAACTCTC CAGTCTGGCAGTTTCCGGTGCACCTGTCCCCACACGTCCCTCGCCCACGGAGCCCCAGGCGGCGTTACGCACA CCCAGGATCGTGGATCAGCCTGCCCCGGCGTCGGGTGTCCCCGCGGCTCTCACCATCTGGAAAAGGAAGGTCC GCGCGCAGAGAGGGAAATGGACGGAAATAAGCAAAAGCAAAACAACCCCTTCTGAGAAGTGTCCTCCTCGCTC TCTTATAAAAACAGGACTTGTTGCCGAGGTCAGCGCGCGCATCGAGTGTGCCAGGCGTGTGCGTGGTTTCTGC TGTGTCATTGCTTTCACGGAAGGTGGGAGAAGGTCGGGGCTGGCGGGGTGGTCCGGACTAGTGGGACTCGGGG CGCTTTCCCCGCCCGGCCCAGCGCCAAGCGGTGTCGGCAGCGGTTGTTTTATTACCTTTCGGTGAGAACTTAC GCGAGGAGAGCGAAGGAGAGGTGACAATGAGCAGGAAATAGTTCAGTGGGGTCTCTTTAAACAGTAACATTCC TCCTAAAACGGGAGCCCAGGAAGGGGGAAGGAGGCAGAAGCTCCCCCTTCCAAGGCCTGGCTTTGCGCTTCTG CACACCTCGCCCATTCGCTGGACGAGGGCCTGCCTCGGGTAGCAGCCTCTGTTTCCCGGTCTCCTGAGCGGGC ACCCCAGCCCCAACCCCTCTAGAGAAAGCCTGCGCATCGGGTGGGGCAGCGAGTTCAGAGGAGTCTTGCGCCC TAGCAAGGGGGCTTTCCCGCGGACATGGTATCTGCGCCCCGCGCTAAGTCTCCCCTGCCCCCTGCCCCCTGCC CCTCGCCCCTCGCCCAGCCGGGCTCGCTCCGGGGTCGGGAATTGCTGGGGAAGCCGAAGGAGGGATCCCCGCC CGGGACTCGAGGGATCGACCCGCCTCGCGGTATGCGGAGGGCTGCCAGGAGCCAGTCCCGGGGAAGGGTGCCT GCCGCCCGTGGGGGACAGGGCTCCTTCTCTCCCTTCTCCAACTTACACCGACGAGTCAGGAAGCCGGAGCGTC TAGTCCCTGTCCGCATTTCTCAGTGTCTTTTGATGTCTGGGATGCATGGATATTCCCAGGGGGCTGACCCGAG GTGGGGAAGTTTCCTTCTAGAAAGAGGCACCAAAAGGACCTCATTTGCTCCTGACGCCGGACCCTCCTGACAC GCCTTCACTGGCTCATCGGGTCCTGGGCTTTGGGGGAGAGCGTGGTGCGTGTTACTCTCCTTACTCCGGGTAT TAAAATGTCTAAGAGGTCATCGCTTTGGCCCAAGGCCTCCCGAGGATAAGATAAAAGGGAAAAGTGGAGGGGA GGTGAAGGAGGAACGAGGGTGGGTCCCAGGCAATTGAGGGCCTCGGAACCCTAGGCACGGGAGCGAAACCTCT CCTGCGGCTTCAGGGCAAAGGAGTCCCGAAGGCTGGATCCCTCCCCTGCGCTCGGACGGCGTCGCGGCCGCTT TTCCCACAGTCGGGAAGCG CGI: 25 range = chr6: 169801163-169801511 CGCGGCCGGGTTGATCTCCAACACGGCAATCTTCCCGCCAAAGAGGGAGGCCAGCAAGCACAGCACCTGCAGG GACGCGGTTTCAACATCGTTAGCGACACCACCCAGTAAAAGCAGACGAAACGTGCATCCGCACACGTATCCTA ACAGCTGCTTCATTCTCATAGCAGCGACATCGCCCTGTCACTCCTAAAACGTTTTTACACACAAAATCCCGTT TACTCAGCCAGTCGTTACAGGATCACTCTGAAGAAAGAAGAAATCAGAGGCACGTCTCATAGACAGGGAGGGC CGCGTCTCAGGACTGACCTTTTGATCCGCAGTGCGGTTCCTCAGGGCACACGATCCG CGI: 40 range = chr7: 1029023-1029492 CGCATACGAGTCCAGGGGCTGCTACAAAGCGCGGCGACGTCTCCGCGGCGAGCTGGCCACTCCATGGTCCCGG CGCAGACACTGGGGCAGGCGCCGGCTCTGTCGTCGAGGCGCTCACAGGCAGGCACACGTGAGCTCCTGGAGGA CAGGGAGAGCGGCCGCCCCGCCCCTGCGGAGCACAGGACGCTTCCTGCCACCCCTGCAGAGCATGGGACGCTT CCTGCCATGGTGCCGTGGCAATGGGTGGCACCTGCCTGTGGCCCCTTCTCAGAAGGACGTTTTAAACGCGTGA GGTCTGATGCACAGCCACAGGGAGACACAGACGAGCAGATGTGGGCATCCGAGTATTTACAAGGTCTGGTGGC TCCTGCAGCCGCGACACGGGCTGAGCGCAAGTGATGTGTGAGGTGTCCCCAACAGATGGCACGGGGAGCGCCC ACACCCGCCACCGCGGGGTCTGCGGAAGCTCG CGI: 26 range = chr7: 19113449-19113833 CGCTTCTAAACCCAATACGCTTTTCTGGAGTCCTCGGAACAGCTGGCCGGGGCTTTTAGCACACGGGACGGGA CCTTCGCCTTTGCCTGTTTTTTTTTCGACCAGGAGAAGCAGGTGCGAGAGTCTGGGGCTTAGGAGGTGGAAGG CGGGGAAAGAGAATCCACTAGGTCCTCGTGTAGAGAACAACAGTCGCTCCTTAGATATTACTCCAGGACGGAA ACCTGATTGCAAACCGCTGTTCCTTCGAAACTTGCAAAACCCGGAACAGAAAACTCCCGCCCAGCCAATTTTA GCTCTCGCTGAACTCTCCCGCCTGCGTTACGTTTGCACAGCAACTCTTTGTAAATGTCCGAGTCCTCTCGGAG GAAAGATCGTTAGGGCGACG CGI: 207 range = chr7: 27149139-27152087 CGAGAGCCGCGTCCCCGCGGTCGCGTGGATTTAGAAAAAGGCTGGCTTTACCATGACTTATGTGCAGCTTGCG CATCCAGGGGTAGATCTGGGGTTGGGCGGGCGGCGCCGGGCTCGGCTCGCTCTGCGCACTCGCCTGCTCGCTG CTGGCAGGGGCGTCCTCCTCGGCTCCGGACGCCGTGCCAACCCCCTCTCTGCTGCTGATGTGGGTGCTGCCGG CGTCGGCCGAGGCGCCGCTGGAGTTGCTTAGGGAGTTTTTCCCGCCGTGGTGGCTGTCGCTGCCGGGCGAGGG GGCCACGGCGGAGCAGGGCAGCGGATCGGGCTGAGGAGAGTGCGTGGACGTGGCCGGCTGGCTGTACCTGGGC TCGGCGGGCGCCGCGCTGGCGCTGGCAGCGTAGCTGCGGGCGCGCTCTCCGGAGCCAAAGTGGCCGGAGCCCG AGCGGCCGACGCTGAGATCCATGCCATTGTAGCCGTAGCCGTACCTGCCGGAGTGCATGCTCGCCGAGTCCCT GAATTGCTCGCTCACGGAACTATGATCTCCATAATTATGCAACTGGTAGTCCGGGCCATTTGGATAGCGACCG CAAAATGAGTTTACAAAATAAGAGCTCATTTGTTTTTTGATATGTGTGCTTGATTTGTGGCTCGCGGTCGTTT GTGCGTCTATAGCACCCTTGCACAATTTATGATGAATTATGGAAATGACTGGGACATGTACTTGGTTCCCTCC TACGTAGGCACCCAAATATGGGGTACGACTTCGAATCACGTGCTTTTGTTGTCCAGTCGTAAATCCTGCCTGA TGACCTCTAGAGGTAAACTCGTGCACTAATAGGGGAGTTGGGTGGAGGCGAGGGGGGTGGCGCGCGCGCCCCG GGCGCGTGCCCGCCGCCAGTTGCCGCCGTTCAGCCGGACTCGAGCGCCACCCGCTGGAGGCAGGGCTCATCGC CCAGCTTCCGACCGGGGGCTGCAAGGGCCGGGGTCGAATTGAGGTTACAGCCCATTATGGCAAAATTATTGCA TTTCCCTCGCAGTTCCATTAGGATGTACCAATTGTTAGGCCGTCAGCTGCCGATCGCGCGCCCGGCGAGGATG CAGAGGATTGGGGGGAGGTGGTGACTTGCATTTTATTTACAACAACTTTATTTCCCCCGTTTTGCAGCCCCTC TTATTTTTGTGTCGAGGTTGGGGTCGGTACTGACCGTCCTGCCAGCAGCTCTGAATTTTGAAAATACAGATAT CACCTTCGGGGAAGGGGGAAAGCCATTTAGCCAATTGGAGAAATAAATCCTGCCCGCAGCAGCAGCAGCTACA ATTACGGCTCTGTTTTTGCGAGCGCATGAGGGACAGTGTCCCTGCCGCTCTTAAATGACAGGCGTCTATTAAA GATAGCTTTTGTGTAGTGTTTCTCCAAGGCGAGGTCAAATTCCATACACTTTTATAACCGTAGTCGATTTTTC TTTCGTGTGAATATGGTTTTCGTGTCATTAGTTTGCGATTTGATTTGCTTACGTATCCAGCCTGGAAAATCTT CATCACAGGGTCCGGTTCCTCGAGCCAGCCGGGCCCCAAGTCGGAGGGTTCTCCTTGAACCCAGCGAGTGGGC CCAGGCTCCCTGCAGCCACAGAGGCTGCCTGGGGTCTGGGGATCCGTGGGGCGGGTTACTGGGGTCTTGCTTA GACCTCCAGGAGTAAAATGAGGGCGATAATGGAAGCATTCCTTGGCAGTGCCTAGTATCTCTGTAGTTATTTT CCACGGCTCCGAAAGACTCAAGTAAATCACAAATATAGCTGAGAGGCAAGTGGAGTCTCCCCGCTGGAGGCCC GGCGTTGCAGGCGCCCCTGGCACGTCTGGAAGCCAGGACTCTGGCGGCTCCCATGGCCCTGGGCCCCTCGTTG GGTCCTGAACGCTGCTGTGGCGGCGACGCGGGCGCTATCGGAGGCTGGGAGCGGGAATCCGGAGCCGGGAGCC TACCCCGGGCTGTAATGTTCCACCCGCGCCCAGGTTAACTCGCCTCGGCTGAGGCTGCTTCTCTTCCACTGAC GGTTGCACACGCGGGACCGAGAGACTGGGCTCTGTTGGGGCCCCCTTTGTTCCTCGAGCTTCCTTCCTGTTCT GGGAGGCGGCTTGGGAGGCCGCGACAAGGCCGGGCTCCAGCTCTTAGACCCCCTCTTTCCACTGGCCAGAGAT GATTTGATGATGCCCTTCGGGACTTACTGGCGAGGGACTTAGGCAGAGACGCCCAGACACGAAACGGGGCTCG GCCCAGGGCTCTTTCCTCCCCAGCAGCCCCGCGTCCCGAGGTCGGGGAGCTCAGAGACACTAGCACAGGAGCC CCAGACGCATTCAGGGCGCACCCCAGAACTCCGGAGCCGGTTTGGGCATCCTTGTGGAGCGGGACTGGGTGTG TGCAGTGCGCCCCGCTCCACCGCTGGTATTGGCTGTGTGTGAGGTTTTGTTTTGTTTTGTTTTGTTTTGTTTT GTTTTGTTTTGTTTTGTTTTGTAAGAAATAAATGCACAGACGCTTGCAAAGCTCCGGGCTCCCCTGAAGCTGC GGAAGCCCCCAGATGGGAGCAGGCGGGGAGAAAAGTTGGGGAACAGGCGAGGGCAAGGGGGCAAAGCCGAAGG AGGTTGCAGCGCTGGCCTGGTCCCTGCCCAGGCATCTACTCGCCCGCCTTTGCCTCTGAGTCCTCCCCGCTGG GCTGCGTGGAATTGATGAGCTTGTTTTCCTTTTTCCACTTCATGCGGCGGTTCTGGAACCAGATCTTGATCTG GCGCTCGGTGAGGCAGAGCGCGTTGGCGATCTCGATGCGGCGGCGCCGTGTCAGGTAGCGGTTGAAGTGGAAC TCCTTCTCCAGCTCCAGTGTCTGGTAGCGCGTGTAGGTCTGGCGGCCTCGGCGCCCATGGCTCCCATACACAG CACCTACGAGCAGAAACGGCCGGGCGCCG CGI: 201 range = chr7: 27170441-27172987 CGGAGCTGGGCAAGCCGTCAGGGCGCCCTAAGGCCGCTGATCACGTCTGTGGCTTATTTGAATAATCTGTCAT GGGGACCCTTGTGGCCCGGGTCGCCCGCAGCCTCATCTTGGCAGGATTTACGCCGCCACTGGCCGAAGGCAAG AAGTGGAAGGAATCGGCCGTCTCCCCCAGCGTCCCAGCTCCGGCTGCCCTGGCTGCCGCCGCTCACGGACAAT CTAGTTGTACAAAAGGCTCTCTGGGCTGCACTGCTTTCGAAGAACGGCCCAAAGTATCTCGGTCCTGGGCCTG GGCAGCCAAGGAGAGGGGCGGCCAGTCTTGGCTCGTCCCGAAGTGCCCGCCCCGCCCCCTCTCGCTGCAGCAG CCGCCTCCTCTCCCGTAGCCCTGCGGGCCGCTCTTCACTGCTCTCCAGACTTGGGGCCCTATCTGAGGCGTCC CAAACACCAACTTCTGGCTCCTGGCCCCAACTCGAGAGGCTTCCAGCGAGGACGAAGGCAGGCTCGAGAGAAA CCTGGCGGGCCAGCAGATCCGGGAGGCCGGCGTGGAGGCGGCGGCGGATTTGAAGGGAGGAGACACTTACTGG GATCGATGGGGGGCTTGTCTCCGCCGCTCTCATTCTCAGCATTGTTTTCAGAGAAGGCGCCTTCGCTGGGTTG TTTTTCTCTATCAACTGGAGGAGAACCACAAGCATAGTCAGTCAGGGACAAAGTGTGAGTGTCAAGCGTGGGA CAGTCACCCCTTCTGGCCGACAGCGGTTCAGGTTTAATGCCATAAGGCCGGCTGGAGGGCAAGCCCGCGAAGG AGAGCGCACCGGGCGTGGGCTCCAGCCAGGAGCGCATGTACCTGCCGTCCGGCGCCGCCGCCGCCACGGGCGC CTGGGGGTGCACGTAGGGGTGGTGGTGATGGTGGTGGTACACCGCAGCGGGTACAGCGTTGGCGCCCGCCGCG TGCACTGGGTTCCACGAGGCGCCAAACACCGTCGCCTTGGACTGGAAGCTGCACGGGCTGAAGTCGGGGTGCT CGGCCAGCGTCGCCGCCTGCCGGGGAGGCTGGCCCAGGGTCCCCGGCGCATAGCGGCCAACGCTCAGCTCATC CGCGGCGTCGGCGCCCAGCAGGAACGAGTCCACGTAGTAGTTGCCCAGGGCCCCAGTGGTGGCCATCACCGTG CCCAGCGCCTGGCCCGCCCGGCCCGACCCACGGAAATTATGAAACTGCAGATTTCATGTAACAACTTGGTGGC ACCGGGGGGGAAGTACAGTCACCTAATAAGTTGCCGGCGCCCGCGCCCCCATTGGCCGTGCGCGTCACGTGCC CGTCCAGCAGAACAATAACGCGTAAATCACTCCGCACGCTATTAATGGTCCGATGTTTTGCAGTCATAATTTT TATAGCAAAAGCCATATGTTTTTATGTAAAGGGATCGTGCCGCTCTACGATGGGGTTTGTTTTAATTGTGGCC AACGACGATTAAAAGATCAAATCTAGCCTTGTCTCTGTACTCTCCCGTCTCCCCCCCCATACACACACTTCTT AAGCGGACTATTTTATATCACAATTAATCACGCCATCAAGAAGGCGCGGGTCCCGCGTGCGAGTGCGGCCAGC GGAGCCCCTCACATAAAATTAGACAATAATTGAAGCCATAAAAAAGCAGCCAAATCGCATTGTCGCTCTACTG TATTTAAATCTATATTTATGATATTTCATAAGGAGTTATTGTTTCAGAAGCCACACAGGCTGGCGGGAAGTCG GAAACGACCAACAGATTCGTTTGCCTCGCCGTGGCTCCCAGCTGTAAAAATTTACGAGGACTTGGAAAGGTTA GACTGTTGTGTTTGGTTGGCGAGCTCCCTGTAAATAATCCCTGCGGTCCCCGGGAGAGGCGAGTTTACCCGCG GCCGCCCTCGAAAAGTCAAATTCAACGCAGGATCCGTCCCAAACGGAGCCGCCGCCGGCCCTACCAGGGCACT CCAGGCAGGGACCGGCCGCTCAGGGAGTACCGCGGGTGTAGGTCCCCACAGCTACCCGCCTGGAGCGAGGGGC GCCCGGGCAACCCTTAAATTCGCCTTTGCTACGAGGACCCCACGGAGGAGCTGGCCAGGAGGGAGCGGCCAGC CGCCACCAGGGCGAAGGTTTTGAGGGCCTGGTTGGTTGTGCGGCGCGCTCGGTCCCCGGCCCTCGACCCCACG CACACGCGCGCCCAGCCCGCCTTTCTCATCAGCTGGCAATCAGGATTCCCAGGCGCAGGCGGCTGGCGACCCA GCCCTGTGCTCCAGCCTCAGAGGCTCTAACCATGAGCGCTGCAAGCCTGGTTGCGCTCCGTGAATCCCAGCTG GGGAAAAAACTACAAGTGGCATGAATGGAAGGCAAGTTCGGTTTGGGAAAAGGCAGCCTCGCCTAAGAGACCC CGCAGCTCCGGAACCTGGGAGGCCCGCACCGATGTGGCCTGTCCCGGGGCCGCGTGAGCCTTTCAGGGCTCCT TCCTCCCTTTCCAGCTGCTACTCCGGGCCTCGCCTTGGTTACCTACGGGGCCCGGAGACTCGGCG CGI: 114 range = chr7: 27198331-27199622 CGGCGGCAGCGATCGGCCCTGACCATAGAGGCGGCCGTGGCGCGGAGGACTTGACCTTTACGGCACGAGAGGA GGGCGCTGGCTGAGCCGCAGGGAGGGGGACGCTGCTCTCTCCAGCCTCCTCCACCCAATAGCAGTCCGCTCGA CCCACGCCAGCTGCGCGCTCACCCCCTTTCCCCCTCCATTTTGTGCAGTGTCCGCAGACCCGCGGCCGGAAAC AAAGCCCCCAGCCCTGCTCTCACCACCCTTCTTGCAAGCTGCTGTCGCCAACCCCCCAGACCAGAGGCTCAGA GCTAACGCTAAGCCCCTTAAGGCCCTCTCCAGGGCCCTCTTCTCTCGCCAGCCGCCCTCAGCCAGCTCCTGAC CCCAGCCGCCCTCAGCCAGCTCCTGGGTACCACTCTGGGTGCCAACCGGGACCTGCCGGTGCCACGGTCCCGT GCGCCGGGTCCCGGCCTCGGGCTGCGGGCGGCTTCGGGGCCTACAGCCCAGCGGCGCGGAGCGTGGCAGAGGC GCGGGGCGCAGCGCAGCCCGAGGCTGCCTCCCGCCCGGGCGGACGGCGCGGCCGCTGGGGTGCACAGCGTAGC CCCGCGTGCCCGGCTCGCTCTCCGTTCCCTCGGATAGCTCCCACCGCTCGGCTCCGGGCTCAGAAAGCGGAAG TATTTGGTAGAGAAAAACACGGTTTCTTTTCAGCTCGTCTCAAAATCCCTTTTAGAGAAAATGCTCCTGTCAA GTTTTATTTCCCGTTGCAAACCACCTTCCACGCTGCCAAGAATTAAGACCGGGAGAGATTAAATACCCGATTA TTCTCCTGGGGAGGGCGGGGCGGGGCCGGGAAGTGGGCACCCACACCAAACATTCCTTGAAGTAGGCTTGTCC TGATCCAGCCGCGCCCGGGGAGCCCCACGAAGGCCCGCGCGGCCTGCGGTGACGTCAGCCTGCAGTTGCGGGG CCACTCACCCGCACAGACACGGCCCTTGCTGTTCCGCGCCGGGACCTCCGCCAGCCGTCCTGCCGCAGCCCCG ACTGGCCCGCGTGCCGTCAGAGGGAGGCCCGCTTTACACCGGCCTGAGCCTCCATTTTGAGTAGGGGGTTCTT GTAGAAGCGTGGAGGGTTTGGGGCCGCGCCTCTGTCCCCGAGGGGCGCGACATCAGGTAGCTCTCCGAGTTCA CACCCCAGTACCTGGGGGAGGACCTATGTCGCCGCATAACCGCCCGCAGAGGTTTGGAAATCTCTGAGACCCG TTGTAATTATTTCTGCCCAGTGGATCCGGCTCTTCAGCGTCACGAGAGCCG CGI: 111 range = chr7: 35263447-35264743 CGGTTTCCGGCTTTTGGACAATGGTCCCTCGCTTAACGAATGCTAACGAATGCTCCCTTAGCTGGGAGCTGCA GGGACCGGTCCCGGCAGGTCTAACCAACCGTCCGCAGGCGCCGTGGTCGAGAGCAGAGCCGAGACGGCGGGGC AGGGTGCCAAGCGGAGGGCACAGCCTGGCAGCCACCGTTGGCGGCAGGAGAGAATGGGAGAAGGGAGACCCGC TTCTCAGCACAAGGGCATCTGTCTACTCCCGAACATGGCCGGAGATTCCTGTCCACAGCCTCCCTCCAGCTCT TTCTGGTAGACACTTTAAAAGCGACATTAACGGGCTTCGGTGCCTTTGGATTCCTAAATTAGGTTTACGGAAA AGGAAAGACTTCCCAAGAACAGTGAGAAGAGGAACTGCAGCCCCTCCAAGGCCGCTGCGGCGCGTTCCCGGGG CGCGCCGAGAGCAGCGCGCGGCTCCGTGCCCCGTGGGGAGCGCGCGGCGCGGCCTTGGATTTCACCGCGAGTC GGGAGGGCGGGTCTGAGCCTTGCCTCCCAGGATCCTTCCGACGAACACCCCGCGGGTTTTAGTTTATCGAGCC AAAGTGGTCCCGGAGAAGCGCTCCCTCGCAGCCAAGCTGCAAGAAGTGGCCGGGAACCTACAGGCCTCGGGCC GACCCAGGAAGCCTCCGCACCAGAAAGCTCGAGGAGCCCTTACCCAAGTCTTGCTCGAAGGGCAAAGCAAAGA GCCAGCACCCCTGAGTGTCACTGAAGTTCCTGGATGGGGTGTGAGTGCGCGCGTTCCGTCCGAGACCTCAGTC TCGCCCAGCTATAGAGCCGATAAAGGGATGTCTTGTGGGCGTAAGGCGCTTCGCGCCCATCTCCAAGGCCGAT GTGGTCAGGAGGTGAGGGGAAATGTCCTTCTGGCAGAAGCCCGCGGTGCTGCGACGTTGACCCGCCTGGCCTC AGGCTCAGGGCGGCGGGCAGCCCAGGGCACATGTAGTTTCAGCAGCCGCGCTACGTGGGCGGGGGACCCCAGG CCACCCCACGTGTCCGCCCTGGGCCTCCTCCGGGTCCCAAGGCGCGGCGCCTCCAGGCCTTGTAGCGTCTTCC CCGGGTCCCCGCGCGCCAGGCCCCGCAGCCTGCTCACAGGACAGCCCTCGGGGCTGCGACCCTCTCGCTCCTC CCCGCGGCCACTCGCTCCCCGTTCATCCCCCACGAGCTCACTACCGCAGGGACCGGCCCTCAGAGCCCCGGGC CTCCTCCCGGCAGTGGAAGAATCAGCGTGCTAACATTGTGTGCAAAACTCGCAGCG CGI: 30 range = chr7: 96469320-96469736 CGAGGGCCTTGCCCGCCCTCCTCCTCCCACCCGCAAGGGTTGGCCCGCGTTCCCCTGCGGGCGAGACAAAGAA GCAGGAGCCAGGACCCGGCTGGCGCCTAACCCGGCGCCGGGGCCTTGAGCCCCTGAGGTGTGCGCCTTCCTGC AAGGCCCCAAAGAACCCGAGTTTTTGCCCCTTGCTGAAGGGTTGGAAGTGCGGGCTGGACTAGTGCAAACAAG AGTGACTCCAACCGCCTTACTTCAGCTCATTACCGTCACCCATGAAAACGGAATGAAGGACTGGGAAGCCAAT CTGCCGCGTTCAATTGGAGAGAAATGACTGTCGGAAGAGGCCCTGCGGTAAATAGCCTCTGAGCCGCGAACTC TATGCGCCGTGGCCGGTGGCAGAGGCCACACCTGGCAGCCACTCGTGGCGCG CGI: 32 range = chr7: 119702299-119702721 CGGAAATCATCGGCGACTGCTGTTATGAGGAGTACAAGGATCGCAGGCGAGAGAACGCCGAGCGCCTGCAGGA CGACGCGGATACCGACACCGCTGGGGAGAGCGCCTTGCCCACCATGACTGCAAGGCAGAGGGTCTGGAGGGCC TTCGAGAACCCCCACACCAGCACGATGGCCCTGGTGTTCTACTATGTCACGGGGTTTTTCATTGCCGTCTCTG TCATCGCGAATGTGGTGGAAACAGTGCCGTGCGGATCAAGCCCAGGTCACATTAAAGAACTGCCCTGTGGAGA GCGGTATGCTGTGGCCTTCTTCTGCTTGGACACGGCCTGCGTCATGATCTTCACAGTTGAGTATTTGCTTCGC CTGGCTGCAGCGCCTAGTCGTTACCGTTTTGTGCGTAGTGTCATGAGTATCATCGACG CGI: 42 range = chr7: 158509937-158510390 CGTCCTCCGACGCGAGATGGCTGTGTGCCACCGACTGTCCAAATGCCCTGCCAATGCCATCGTGAAGCATCCG TGTGAAGGAAAAAGTCCACCTTACCGTGCGCTGTGGCATCGATCAGGCGTGTGGACAGTCGCAGGCACGCAGC GGTCTCCCAACATCAGGGCACACCGCGATCAGGTGTGTGGACAGTCGCAGGCACGCAGCGGTCCTGCAGCAGC AGGGCGCACCGCGATCAGGTGTGTGGACAGTTGCAGGCACGCAGCGGTCTCCCAGCATCAGGGCACACCGCGA TCAGGTGTGTGGACAGTCGCAGGCACGAAGCGGTCCTGCAGCAGCAGGGCGCACCGCGATCAGGTGTGTGGAC AGTTGCAGGCACGCAGCGGTCTCCCAGCGTCAGGGCGCACCGCGATCAGGTGTGTGGACAGTCGGTGGGCACG CAGCGGTCTCCCAGCG CGI: 20 range = chr8: 10624024-10624296 CGCAGGAGGGCTCGGCCTGGGACCCCCTCTGCGGGCCTGCGGCTTTAGCCAGCAGAAAGAGGGGCGTCAGTCC TATCCCCAAAGTTCCGCCTCGGGAAAGAGCCCTGAGCTCTGAACTCCGACGAAAAAAGGAAGGGCTCTGTTCC GGACCGGGTGGGGTTTGGGAAGGGTAGAGCCGGCCTCGGGTGCCCTTCTTACAGGGCCTGTCTCCCGCTGCGT GCACCAAGTGCTTTGAAAGTTTTTCGCGGATTAAAACGAATAAAAACCTCGTCG CGI: 221 range = chr8: 11597006-11600365 CGAGGGTGAAGGATCGCCGCAAGGCACCGCACCTCCCGCTGCAGCCCATCCCGCACTACTAGGAGAAGCCGGC GTAGGAGCGCCGCCTGTGTCCTTGGCTGTGGGGAGGACGTCAGATGGCACCCCGCCAGACACTAAGCCCCAAG CCCCTGGCTTGTTGCTAAGAAAATTCACTGCCCGGTCCAGACTCAGCCCTTTTCGCCCTTTAAGGGTCGCGCG TGGGAGGCAGCTCTGAGACCCCGGGTAGCGCTGGAGCCACAGATTTCCTCCGAGAAAAGAAAGGCCGGGATAG CTTCCCGCTCGCCCAAGCCCAGATTTTCCACTCTCCAGGAAGGCCTTGCAGGTCCCTGCCGCAGGCCTTGGCT TCGCGCCTCTCTCGCTCGCCCCCCACGAAGATGATTGCCGGTTTCAAACCGGGAGCAGGGAGTCTGCTTCCTT CTCCGCTGAGTCCGAAGGATCGCAGATTGGAGCGTGCTCCGGAGACCGCTTTTCCGCAGCGCCGGCCTCCGAG ATCCCCAGCACCCCTTCAGCCTTAAGTTCCCACGTTTCGGGTCCGTGGCGCCAATTCTGCTAAGTAGCAGGCT AGGAATTGGGGGAAGTCGGAGAAGAAACCCTAAGTGTGTCGCCCCCAGCTTCCGGGATGCAGGCCCGCCGGGG TCTAGAGGGGCGGCTGCCGTGCGTCCAGCCTGTGCGCAGGCCTTTCGCCGCTCGGCGCCCCAGGCAGCCTCAG TTTCCTTTCCTCTGTTTGCGCCCCAGTGAACCTCCGCACCTCTCATTCAGGGAAGAGAATTCCCCGCGCAGCC GCGCTCGTTTCTTCCTCTGGGATTTTCCTGAGAATCCCCAGGAGTTGGCCACGATCCCATGGGGGGTTTCCTT CTACCCAGCCCCGCGTCCTGGCCTCGTCCTTAACCCCCGGGTTGCCTTCACTCAGGCTGGGAATCCACGATTG ATTTCCTACTACGGAAGCGGGTGGCGTTCCCAGCCTGCTTTCGGAGCAGCACGGGTTTCGTGCAGGGTGTTAT CCCGACCCCTTCCCCCATCCCTCTAATCTGGCTTGAGAAGCCCGTGCTGGAGAGAAAAACGCGGCCTTAAAAA AAAAAAAAAGTTTAACCGAAAGCGTGAGAGCCACCCGCCGGCTGTTATCTGGGGCTGAAGGCTGCGGTAATCG ATGGGTTATTTTTACGCGGTAATAGGGCCCTGTGATTGCTCTATTAACCTTTAGACCTGTCTGAGGGACTCTC CGGCTCGCAGCCCCGCTGCGCTGGGGCCTCCAGGCTCTGACGCCGACTCCCAACTCAGGCCTGACACATTCCC CTCCCCCATACCCTGGAAGAGCCCCCTCCATGAAGAAGCTCCCCTGGACCGCCTGGCTCCCCAGCCCTTGCCA CGTCCCTTGGATTGGTGCAGAGCCGCCGCAGGCTGCAGAAAAAAGGGGGAAAGATTAGAAGAGAGGAGGCCAC AGGAGATGGGAAGTGTCGCCAGGAAGGGATGCAGATTGCATAAATACATAAAATTGAGGCTGAGGCCTGGGCT CCCGACCATCTCCCTGGGATTTTGGGAAGGCAAAAGGGAGGCTTCGGTCTCTACGCTCTGATTTTAGGAGGCA GTCTGGGTGTCTCCTGAACCTCCAAGGAATCCGGGGCTGGGAGGATCCCCACTACCCCTGCCCAGGAACTAGC ATCCAGCCGGGCACCCCGGGTGACCCAGTGCCCCACACAAGATCGAGAGTTGAGCCCAAGAGGTCACCTTCTT CTCTACTGGCCCCGCCCCTCGCCCGCCGCTGCGGGATGAGGACCACAGGAAGGGGGGGCGGGGAGGGAGAAAG GGAACTCATTAATAAAGCTGACCCTGGGCACCACAGCGAACCCAATCGACCTCCGGCTGGGTTGCGGGTGATT CCCCGCTCCCTGGCGGTAGCACTTGGGCATTTTCCGCGGAGACCCCAGAGCCTGGACTTTGCCTGCTGGGGGA GCTTTCCGCACAGTCCCGCAGCCTGCGCCCAGCGGAGGTGTAGCCGGGGCCGCGCACCCCCGCCCCGCCCTTG CACGTGACTCCCACAGGCCAGTCAGCGCCCTAGGGCCGAGTTGCTGGGCCGGGGACCCGAGCCGCGAGCTGGG GACTTGGAGGCGGCCGGCGCAGGGGCCGCGAGAGGCTTCGTCGCCGCTGCAGCTCCGGGGGCTCCCAGGGGAG CGTGCGCGGAACCTCCAGGCCCAGCAGGTAGGGCTTTTTTCTTCCCTTTCTTTGCTCCTTCCCGCGGTCCCCC AAACTCGGAGCTTCTCCGCCTTTGCTTGTCTGGAGGTAGAGAGGTAGCTAGTGGGAGGAAAAGAGACGTGCGC TACTCACTTCACCGAAATTGCCCAACCCCTGCTCTGCTTTTGACTTTGCCTTAGCAACTTCTTTAAGTCAAAG TAAGACTTGGGGGCAAAACAGAGAAATATTGGAAGCGCCTTTGGATTCTTTCCGTGTGAACTTGAACGCTTTC AATCCCTGTCCCCGTGTGCACATTCTCCAACCCTTGTTTGCATATCGCAGGCCGGGGCCTGGGTGGTGATGGT GGCCGCGTGAAGTTACCGGGACTGACGGGCCCGGGACAGGCTGCACGGCAGCTCGCACATGGAGGGAAGTAGA CGGAGGCTTGTCGCCCACCAGCGACTCCGGGGACGCAGGGTGGCAGTGCCAGGCAGCTCCGCTGGGCCTCAGG GGCCCCCGGGAGCCGCTCTGAGGTGCGGAGAGGCTGCTGAGTGGCGGAACTATTCATGCCCTTTCTGGCCGGC CTCCTCGCCCTCGGGGCTGGGGTCCAGGGACTGAATGCTCCTCTGGAAGCTCACCACCCCACCTGCCCGCGCT GCTTCTACCTGAAACTGGCCAAGGGCCCGAGCCCGGACCGGAGCCGTGACTTCCCTCCGCCGGCCACGGGGCT GCCCGGATCCGCCGGGTTATGTCGCTTGGCTTTGGGCTCAGGGGTCACCGTGGGCAGAGGGGGGTGCCGGGGT CGCGGACTGCCACCAGGTTGAGGAAAGGAGGGGCCTTTTGGCTGGGGAAAGAGCGTGGTGGGGGACCCGCGGC CGATGGAATCCCTGGGGCAGCGCGGCCCGCACCGTGGAGGTTGGGGAAGCGCCTCGGGGAAGTGTTTCCTGTG TTCCCAGAAAAGGAAGACAACCGAGAGCAGGTTTCAGGCTTTTAAAGAAAGCCTGGGGTGTGGAGGTGATGCT CCGCACACGTCTGTGTCTCCTCCCCTGCTGCGGCCGGCTTGGTTGTGCCGGCTAGCGTGCGACCGTCCTCCTC GCTGCAGGCCGAGAGCGGAGGCGTAAACCCAGGCCAGCGAGGAGTGTCCTATAAAGGGACGGGGACTTTTCGG CG CGI: 25 range = chr8: 25955253-25955609 CGTTTGCTCCGCCGTCAGTCCATAACCAGGCGCTACTAAGGCCTCCAGGCTCGGTGCGCAGAGCCGGGAGCGC TCCTCCAGCTCCAGGTTGGGGGAGTCGGGGTGGGAGGAGGTTCGGGAAATCGACTGATTTAGAGGCTGGGGGT GAGTAGCCTCGATTTATCATCCCTGATGGTGAGAGTGGAAAAGTGTCGCGAGAGTGACAGATGGAATCTTTAG TGCTTCGCAAGAGGGAGTTATTAGGCCGCGGGGTTTGGGGGGTACTTTCCGCTTACTTTGTCATTCTCCACAA AGTCCACGAAGGCCGTCCGCTCGATCTCCACCGGCTGGCCCTGCCTGTCATAGAGCGCCAGGACG CGI: 233 range = chr8: 55532724-55535078 CGCTCGGTATGTTCATCTAAACGACCTTGGGCAAGTACGTCGATTCCAAGGTACAATCAGCCCTCCCAGACGG CTTTTCGAGTCTCCCTAACCCCGGTGGGAGAGGACGCGGCGCCAGAGCCCAGCTCCGGCTAGTTTTCCCGGGG GCAGGTGTAGCCTTGGGCGCGGGGCCGGGGGAGGGGCAAGGGGCGGGCGTGGGGTTGGACTGGGACGTGGGAC TCGGACCACGGCCTGGGCGTGGGCCTAACGACGCGGGACCGGCCCGCCCTCGCCGCTCCATTGGCCACATCTG TGCAGAAAAGGCCCCGCGGCCCAGGGGCGCCCGCAGTGTCACTAGGCCGGCTGGGGGCCCTGGGTACGCTGTA GACCAGACCGCGACAGGCCAGAACACGGGCGGCGGCTTCGGGCCGGGAGACCCGCGCAGCCCTCGGGGCATCT CAGTGCCTCACTCCCCACCCCCTCCCCCGGGTCGGGGGAGGCGGCGCGTCCGGCGGAGGGTTGAGGGGAGCGG GGCAGGCCTGGAGCGCCATGAGCAGCCCGGATGCGGGATACGCCAGTGACGACCAGAGCCAGACCCAGAGCGC GCTGCCCGCGGTGATGGCCGGGCTGGGCCCCTGCCCCTGGGCCGAGTCGCTGAGCCCCATCGGGGACATGAAG GTGAAGGGCGAGGCGCCGGCGAACAGCGGAGCACCGGCCGGGGCCGCGGGCCGAGCCAAGGGCGAGTCCCGTA TCCGGCGGCCGATGAACGCTTTCATGGTGTGGGCTAAGGACGAGCGCAAGCGGCTGGCGCAGCAGAATCCAGA CCTGCACAACGCCGAGTTGAGCAAGATGCTGGGTGAGTCCGAGTCGCAGACCCAGGCGGCCGGGCGCGCTGGC GCGAATCGCTAGGCCGATTTCTTAAACCCCAAACTGTTCTTTGCGAGCCTGACGCCCAAAACCAGGGGTGTGT AGCGGCCACGTCCTTTCTTAAGGCTCTGGGTTCCCTTCCCGCTTCCCGCCCTCCGACCCTCCAAAGCAGCTTT CCGCCTTGCTCTCCGGCTCCCGGATTCCCCAGGTGGCCGGGGGCGCGGGTCCAACGGCTCTGGGAAGGCGACT TCCCGGCACCTCCGGGCGGCGCGAGAGCACCCTTGGCCCTGAACTGGGCCGGTTGTGTCCATCCCTCGACCCC TTCCCTAGTTAGGTGTCCTTTTCTGTTTTTCGAACGACCGGGTGATGGGTGAGCGGAAAGCCGCTTCCAGGAG ACCAAAAGAAAGGGGTGCCTTTAGAGGACGGGTGTTCCCCAAGGGCTCGGACTCAGGAGTCCCAGATCTCCCT CTTTAACTTCACCCCGGTTGCGCAATTCAAAGTCTGAGGGGGGAGGTGCGTCCAGGTGGGGCCAGGTGGGGCC TGGAGCGGGAGCGCAGCCGATAAGCCCTGCGCCCCTCTCCCCCTTCCTTCCACTGTGCAGGCAAGTCGTGGAA GGCGCTGACGCTGGCGGAGAAGCGGCCCTTCGTGGAGGAGGCAGAGCGGCTGCGCGTGCAGCACATGCAGGAC CACCCCAACTACAAGTACCGGCCGCGGCGGCGCAAGCAGGTGAAGCGGCTGAAGCGGGTGGAGGGCGGCTTCC TGCACGGCCTGGCTGAGCCGCAGGCGGCCGCGCTGGGCCCCGAGGGCGGCCGCGTGGCCATGGACGGCCTGGG CCTCCAGTTCCCCGAGCAGGGCTTCCCCGCCGGCCCGCCGCTGCTGCCTCCGCACATGGGCGGCCACTACCGC GACTGCCAGAGTCTGGGCGCGCCTCCGCTCGACGGCTACCCGTTGCCCACGCCCGACACGTCCCCGCTGGACG GCGTGGACCCCGACCCGGCTTTCTTCGCCGCCCCGATGCCCGGGGACTGCCCGGCGGCCGGCACCTACAGCTA CGCGCAGGTCTCGGACTACGCTGGCCCCCCGGAGCCTCCCGCCGGTCCCATGCACCCCCGACTCGGCCCAGAG CCCGCGGGTCCCTCGATTCCGGGCCTCCTGGCGCCACCCAGCGCCCTTCACGTGTACTACGGCGCGATGGGCT CGCCCGGGGCGGGCGGCGGGCGCGGCTTCCAGATGCAGCCGCAACACCAGCACCAGCACCAGCACCAGCACCA CCCCCCGGGCCCCGGACAGCCGTCGCCCCCTCCGGAGGCACTGCCCTGCCGGGACGGCACGGACCCCAGTCAG CCCGCCGAGCTCCTCGGGGAGGTGGACCGCACGGAATTTGAACAGTATCTGCACTTCGTGTGCAAGCCTGAGA TGGGCCTCCCCTACCAGGGGCATGACTCCGGTGTGAATCTCCCCGACAGCCACGGGGCCATTTCCTCGGTGGT GTCCGACGCCAGCTCCGCG CGI: 74 range = chr8: 72916429-72917309 CGGGGCAAGGGCGCGTTCCCTATCGCAGGATCACTTGCTATGGTAAGCCGCCCACCCTGCGCGCTCCTCCGCG CGGGGAAGAACCTGCGCGGCAGGACGTGGTGTTGGAGTTGGGGCGCCCGGAGCGTGGAGTGGGGAGACCTGAT GCAGAGAGTCTGGAGTCGGAGCTGGGGGTGCTGCAGGTAGGAGCAGGAGCGGGGCGGAGAGGGAGGCCCGAAG AAGACCCCACACAGGTTGGCGCAGCGGGGCTTGGGGAGGCTTCAGCCCAGAAGTGGAGAGGGTTGACAGACGC CTGCCTGATTAGAAAAAGCCGGGAGCTTGGGAAGGAGACGGGATTGAAGAAGCCACCCGGCAGGGAGGCCGAA CGGCCCAGAGCTCTCCGGGTAAAACCCGCCTGCGGTGATCTGGGAAGTGTGTCTCCACCTAGCCCTGCGAGCA GCGGCCTTCCTCCCGCCCGTTAGAAGGGCGCTGTGCTGGAGTACGAACCCGGCCCAGAGAAGCCACTCGCCCT TCTTTGTCACTTAAAACCCTGTCCCGACGCGGATCTCACGTCTAGACCTCTGTCTTTAAAGCGGATGTAGAGC GCGTTCTAACCGTTCCCTAACCATTGTGTCACCGCGAAAGGCCGGGGCTGTGTGGAACCGTCCCGCACGTGTG CGATGAATCTGGCTCCGCTGAGAACGGATCCGTGGGCTGTCTGGCGCGGGCTGGGGCAGCAGCCGAGAGTTAG TCTACAGAGCTAGGGCCCGAGGGTGGACCTGCGTCCGCGTCTCGTCACGAAAGGAAGCTCTTTTTGGAGAGGC AAAACGTGGTCGCCCAGATCCGGCGCAGCTGTAGCCGTGGGCGCTGTGCAGTGACAGCCACACCCGCCACCTG TCACG CGI: 17 range = chr8: 140700279-140700514 CGGCCGCCCCGATGCACAGCGTCCCCATGCAGGAGAAGAAGCCCACAGTCACCATGTTCTCCATAGACACGTC AGTGTTGCGCATGCCACAGCACTTCTTAATGCGCTTCAGCAGGTAGCGCACGAAGGTGTTCATGCGCTCGCCC AGGCTCTGGAACATGACCAGTGTCAGCGGGATGCCCAGCACGGCGTAGAACATGCAGAAGGCCTTGCCCGCAT CGGTGCCAGGTGCAGCG CGI: 21 range = chr8: 145014900-145015187 CGCTGACCACCTGCCGCAGGGCCGCAGCCCTCCCAGACCGACAGAGTGCCACCAGCTCCCGCCGCTTGTCAGC GCCAACGTATTCGGAGAGCAGCAGGTCCCAGAGTGACACGCTACACCCCTTAAACCTCCCTGTGCTGACGGGC ACCTTCATGGCCCTCAGAGCCACCGCGGTGTGGTCGTCCACCTCAAGCACTGTGTCTGAGGGCAGTGGCAACA GCAACAATCCGGTCTCGGAGTCGCACACGCAGCGCTCCCTGAGCTGCTGGTAGGTCACCTGGTCCCGCG CGI: 260 range = chr9: 959530-963276 CGTGTGCCCTTCGGCGGGCGGCTGTAGCTGTAGCTGTTGTGACGGCTACGGCGGAGGCTGCGGCCGCGCGGGG AATGGAGCCGGACCGCGGAGTCGTCACCTCCAAGGTGTTTCTAGTGGCCTCCTGGAAGATGATCCCGCGCCCA CCTTGCCGGCGTGTTCGCGGGCCCCTGCCCACTGCCCCCCCTCTTTCTTTAGGTCTGGCTTTTGAGGATCCCG GAGTCTTGCAGCTCCCGCCATTCCGCAGATAACCTCCGCACACTTAATTGTGACCCGCGGGGTGGTCGGAGAA GCTCCGCACGCGTCCTCAGTGGGAAAGTGTCCCCTCTCAGCACTGCCCCCTTCAGTCCCCCTGCATTTCTGGA AAGTCAGGCAAGGCCCAGGTAGGCTGCCAGTGCACTCTCAGCCTTGACTGAGCACCTTTCGGGCCTCTGGTGA GCCCCGAGAGCCAGGTTTGGCTCGGCAGAGCGGGCTTGGGCTGCGCAAGCAATGCGCATCGTGGCCGCCTGCA CCCTGGGAACTAGGCCTGTCCAGTGGGCAGCATCCTCATTTTTGAAAAGGCCCTTCTAAACCCACCGGCCTCG CCTAACGCCGTTTGGTGCTGCATCCGAGCGGCCTCACGCGGTCCCCTGGAAGGGCCACTCCCAGCGGGAGGGC GGGGCCCGGGACCTGCGCTGGCCACGCAGGGTCTCAAGCTGACCGGAAGACCCGGCTTTTGGCCTGTGTCCAA TAGCCCCAGAAGAGAGGGGTCTGGAGCCTTCCTCCCACGCGTAGTGACGCTCAGGTGTCCTCGGGTTGTTAGT CTTGACCCAGGAGAGTGCAAGACAGGCCCAAGGCCTGGGGGGATTGCGTTATGAATGTCCAATTCTAAACACA AGGTAGAGCACAGACAGTACATCCTCACGGCTGGATTTTAACCGTATTTTAATAAACACATTCGAGGGGGTGT CAGTTTCCCCAAGCTCTGCCCCCTTCCGCGGGCGGGATCCATGGTGTGTGCAGTGTAAGAGTGCGCAGAACGC GTGTGTTCAAGTGTGGGCGTGGCAGGCGTCGTGTGCTCGCCCCGCGCACTGTGCGGATCGCCCAGACAGCCTT GACAGGTTTTTGCAGATGTTTGGGTGCTACGGTGTGGGGAAACCCAGGCAGGAGCGCCAGGCCTAATTCTCCT GGACTCTTGGTGAGCGGCCGCTACTCCACGAGGGGCTAGAAGCAAAGGGGGCACGCGCTTTTCCCCAGGCCGC CTCTTGCTGCCGCAGTGGCTGAGGGCGCTGATGACCCCTCCCCGCTTCCAGCGGACTTGACCCGCGGGCTGAC AACCCACCGCGACAAGCAGGCGGCTGGGTTCGCGCCGCCGCCCCGGGGCCCTTGGCTCAAATTTCACCTCGAG TCCTGCAGACCCTGCGCCACTGAATTGGGGCCCAGGACGCCCTTGGTGACACTCGCCTTCTTGCTGCCACAAC CACCGTCATACCCGCAGCCGGGGCTCCCTCCGCTAACCACGCTTGGAGACCCCAATCGGGGACAGAGGTGGGA GTCAGACCCCCCCTGGCCTGCACTGCCGTTTCCCTCGATTCTTGCGGAAACAAGACTCCCGCCCACACATAAA AATGCAGCTCCCGGCCACCGGGCGCCGGTGGCTCACGCCTGTAATCCCAACACCTTGGGAGGCCGAGGCGGGC GGATCACTTGAGGTCAGGAGTTCGAGAGCAGCCTGACCGACTACTAAAAATACAAAAATTAGCCAGGAGTAGT GGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCACAAGAATCGTCTGAACCCGGGAAGCGGAGGGA AGCAGCGAGTCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAATGAGATTCCGTCTCAACAAATAAAT AGAAATAAAAATATGCAGCCCCCTCCGCTCCACTTGAACTTTAATGCTGAACCGGTTTCCCACGTATACGTGT ATCGCACCGCATTTTGACGCTTTGCATCGAGTCGCATTAATGGCGCTTTTGAGAACGCGTCGTCGCGCTTTAC AGAGAAACCCTACGGGCAGCCTGTGGAGGGGTAGGGGATATTCATTGGCTTTCCCTGCTGGGCCCCGTCCGCC GGGCGGGTTAGGGTCGTGGCAGCCTGCCCGCGCGCCGCTGACTCTGGAATTTTGTCCGGGAAACTGGCGTAGG GCCCTGGCTCTCCCTTCGCCCTCCGCGCACACGCGGACGAGGCCTTAGATCCACAGCCTTTTCTAGGCCCTGC GCCTTTGAAGCTGGGCCACTGCCAACCGCTCGCGATTCTCACCTTCAACAGTCGCCCCCTTACCCCTCCCCCA CCCGCCTGCCCTCGGGAGCGGGTCGCCTCCACTCCACCACCTGTTTAAGTTCCTCCCCCTCGGCGCCCCTCCA GTCCCCACCCCGGCCCCGGTCCAAAAAACCAGCAAACGGAACTTTTCCACAGTTGAAAGCCGCGGCCCGCGAG GCCGGGCTGGGAGGGGAAAGCGGGGCGTGTCTGGGGGGCGGGGCCCCGAGCACTCCGGAAGTTGCCCCGCCCA GGAGGCTCCTGGGAAAGTGAGGAGAGGGCCCGGGCCTACTTTCGTCCTGGTGTGGCGCCCCTCAGCCTCCCCT CCTCCCAGTTCCCGCGCCTCCGCAGGGCGCCTCGGCCTGGCCTCCAGGCAAAGTTCGCGCCCCCTGTTCCTGG GGTGTCGGCCGCGCGGGCCGTTTCCCTTCATTACTCCCGGGCCCCTGAATCCGAACGCTTTCCCAGAAGCGCG CAAATCCGCTTGCTTTCCCCGCGGCTGGGCTTTGTTCAGGGACAGCAAAGGAGGAGGCGGGAGGCTGGTGAGG TTTTCTGGAAAAGGGGCTTGTCCCGAGGAGGAAGTGCCCCAGATCCCTGAGAGCCAACGCTCTGGGGAGAAGA AACTTTCCTTCTCCCTTGAATGTTGCTCAGATTACCTAAAATTATTTTTTCAGCCCTTGTGTTCTAAAGTCGC AGGGTAAAGGTTATCTTAAGACTTAACATCAGCGCTGCTCATTTGTACGTTGGTGGAGACGTGCCTTTTTTCC TTTGCACTTAAGGTGGACAGGGTCTGCGACGCTCCCTTCCAGGACGGTGTGGGGAAGCGGCCGACGTCCCCAG CCGGACTCACGCCCTCCTACTACTGGGCGTCGGCTCCGCCGCGGGCGCTCCCGACAGGGAGCTGGAGTCGGAC GAGCGGCTGCCCCCAGGGCCTCCAGGAACCGCGGCCCAGCGGGGAGCGCCCCAGGCTAGCGCTTTTCCAGTTC CCTTCGAAAGCGCGGGGCTGAGGTCGCGGCGCTGGGCCCTCGGATGAAGCCGTGCTGTAGCTACACCTGAACC CCGCGAAAGGCTGGCGCGGTCGTGTATCCAGGCTGGGTCTGAGGAATCCGCAAGCGGGAGAGCGCTAACTCCT AGGCGTGAGCCGCTGCTGGCTTCGAGAGTTCGAGAACATGAAGGACCTGGCTTCTCCCGCCCGGTCGGCTTAG GGCCAGCGAGGTCACAGGCCGTTCTGCTCTCCCTGTTTGTCCCCAAAGGCCTCGGCACGTGGGGATCTGGAGC AGGCCTCAGGCTGCGACCCGTCTCTTCCCCTACCAAAATTATGTGGGAACAGCGGTCCAGGACCTTCCCCTGT TCAGCGGTATCCCCGGGCCGGTGACCCCGGGGTTCAGTCGTCTCCCCGACCCCAAGCGGCCTCTGCTTTCCAC CCCTCGCCCCGGAGGGCGGCTTCG CGI: 25 range = chr9: 21979774-21980108 CGCGGCCAGTGAAATCCCAATCGTCTTCCACGTGGAACCCCAGGTCCGCAGTTATGATAACGGATCACATCGC TCCTGCGGAAAGTGCGCGCGGTGGAGTGATAATTGGACCTAGCGTCTAAATTCTTGTTGGAGGACCTCGTTCC AGCTGCCAGTTAAGCCTCTGGGATCCGCAGCGTCTCTAGGAATTGAGAGAGTGGGGAAGTTAGGATCCAGGAG GAGGATGGTGGGGGCTGAGGAGTGGAGGAGCAGCGTGCATCTCATCTCTTGTCGCCGGGCGGGCGCTCTTTCG GGTCCAGGGCCCTTGCACCCCCAGCGTGGCTCCGGAGGCGGCG CGI: 20 range = chr9: 23812413-23812667 CGACTATGCAAACGCTTGCCGCTAGCCGCATCCTTCTATCGCCCCCCAACTCAAGACCCGAAATGGCCAACTC TTCACCGAGGGGGCGTCCCATCGCTGCCTTGCCTTGGCCCGCCCCTTCGCCAAGCTCAATCCCTTTTCCCCAG AAAAACCTGTGCCTGTCCTCAGACCCGGCCCCACGGCTGGAAGTCAAAACCCACCCCGGAGCCACGCGGCTGG AGCACGTTTTTACACCTGCTCGGCCGCTTAATTACG CGI: 278 range = chr9: 37024136-37028341 CGCTCACAGGTCGGAATAATTCAAGCCTTCCGCTCCCCCGCCGAGCTGGGGTAGCTGATCACTGAGCTGAAAC TAAACGTTTTAGGTGGAAAAAAAGCGTCCGAAGGCACCGTGAAATGATTAAGGAACTAAAGAGCTTCTCGCCA TGTGAGATCATGTCCTGTTCTCGCCAACATCACAAGATGTCCCCAGACACGCCGCGCCCCCAGCGCGCCGCCC CACACTGCCGGCCCGGAGCGAGGAAAGGGTAGGCGCTGCGCGGCCGGGCCTGCTCAGCGCGCCAGACGTGGCG GACCCGGCCCGGCCGGAGTAGAGCGGGAAGCCGGGAGAGCAGCAGTGCTGCTGCCGCGCCGCCCCAGACTTTT ATAGGGGTTGGGGGGAGGGAAGGAAGGCTTCAGCCTGCGCCGGGCGCTAGCCAGCGCACCTACGGGAAGGGGC AGACCGAAGCGGAGCCCGGGAGCCCGGGTCTTCCAGCCGCACCTTCTATTAAGACATGCGCTTGGGGGTCGCG GCCCTCTGCGCTGTGCGCGGGGCCTGTGACATCTCCATGTGCAAACCCCGCTGCTTAGACGAGCGCAGGCCGG GTTTTTGTTTTTGAAGAAATTAACTGCTCGGCCAAGCAGGTGCTTTTGAAAGGGGTTGCAAAGGCTGGCAGTG TTGCCAGGCACCGAGGCGACGTTCCGGTTTACTCCGATTCACCCCTAGGGCGGCGCCCGACCCCAGGGTTCCC AGCCATCCAACCCCCACCCCAATTTGTTGGGGTCCTGACTATTGCTGGGCCCCTGACCCTAGGGCAGCGCCAG ATCCCTAAAGCCCCCAGGTCCCATCCAGTCTTCTAGTCCCAGAACCCCTCCCCACATCAAGTTCCATTCTGGC CCAGAGCATGGAGGTTAAGCTGTGAAATACTGGAGATGAAATCCGGGCTTCCGCTTTGGAGCACCCGGGCAGA GCAGAACATCTCAGTAGTTTCTGGAGATTGGCGGGAGTTCCAGACACCTTACCCCGGCCCATAAGTGGAATCG CATTGCCCTCGAGCCCTGAGACGTTGTGGAGTCCCAGAGCCCCAGGACTTGATTCCAGAGAGGAAATCAGATC CACAGAGACCGAGCAGAGGTGTGGCATGTCCAGCCCTCTCTCTTCGGGCCAGACTCAAGCCTCCCCTCCCTGT TCCCCTCCCCAGCCTTGAGTTAGTTCAGCTGCTGGGCCTAGCCACTGAAAGCCTGTGGGGCCCTGCAGCGGGG TGGTCGCAGGGGAAAGGTTCTCCAGGGCGGGGGAGCGCTCCGTAGGAGGACTCCTGGCCCGCCGGACAATGGC AGTTTTGGAGAGTGAATCGTCCTCAGCAAGAGTGTTGTTTGTTTTTTGGAGGGGGTGGTCACGAGGCTGGGTC GCAACCTAGGGGGAAGAGCCTAGAGCTCGAGGAAAGGGGGGCCCCCGGCGGCAACTGGACATCACATATCCAC TGAGCAGATTTCGCCACAATCGGAAATGTGGCTGTGGATTCCCGGGCGGCCCCCCCACCAAGTGGTCTGCGCA GTTCCCCAGCGCCGCCTCCTCCCTGCAGCCTGCGGGCCCGTGTCCCTACCCCGAGATTTGATTTTTGGCCATC TCCGAGTGCTCGACTCTTTCCCTCCGCAGCCCAGCCCCAGCCCAGGCTTCCCGCCCTCCCGCCTCGCCCGCGC CGGGAGGCAGCGCCTGGGAGGAGCGGCCTGTCCGCGCCTGGAGATCAAAAGCCCTCCCGGAATTGACATTTCA CCCCGGGCTGGGGGCGGGGGGTGTTGGTGTTTTGTTGTTGTTGTTGTTTCCATTTAGAGGGCTTGTTTTGTTT TTGTTTGTTTTCTGTGAGTTTTCATTTTTCCATGGGATATTCTTTTGTTTCGGGTGTTTTGCGTGTTGTTTTT TCGTGGGATTGATTTTAGCGGGTTTTGCTCTGTAAGTCCTGGTCTTTGGGGTGAGTTTTGATTTTGTGTAATT TTGTACTTTGTCCTTGTAGGCTGTCTTTTTGTGTGTCGTTTGTAAGGCTTTTCCTTCTCCGCGGTGTTTAGAT GTGTTTTGATTTGGTGTGAGTGGGTGTCGTCTGTGTGTGTGTTGCCTTAGGGAATTTCGTGTTGTGTGTGTTT TGTTTCCTTCGATTTGAATTTTATTTTTTTGAACTGTACGTTTTGGTGGGGGATCGGGTTATATTTTCATGTG TTGTCTTTAGTTTTTGTGTTTGTGAGATGCGCTGGTGAGAGTTTGCGTGTGTATTTTGGCTTTTGTGGGGCTT TGGGATTAGGGAGGGGACATCAGCCGCTACTCCGTTCCTGCCCGCACCCATGAAGGGCAGAGGATTAGGCCAA GCATCACGAATCGTAGGTTCGCCGTGCTCCGCCGCTTCGCGCTCTGGACGCTCGAGACCAGCGGGAAACAAAT GTGGTTCCCGAGGGGGCGCCCGCTGGTCGTCAAAACCTCGCGGGCCCGGAGGCGCCGCTGCTGGGTCAGAATC GCAGAGCCCCCCTCGCGGGGTACCGAGGCCCAGCCGCCGTCCCCTTGCCCACCCTCTCCCCTGTGAGTCGGTC TCCCCTTGCGCCTGGCCAGCATGCTTCGGACCGTCCGGACTCCCGCAGCGTTGGCCCAAGGGGCGGCTCCCCT CGGCGGAGCAGGTGACGAACCACTTCGGAGGACACGGAATTGACACTGCGGCCCTAGAGATACGGGACAAGGG GCCAGAACGCGGGGAGTCTAGGCTCAGATCGGAGTCGGGATCCCGGGAAAATCCCCCATCTCCCTTGCCCGCA GCCCTAGAATCCCAGAAACCCAACTCCGCGCAGCTTTCGGTTTGGAGAGCCCGCCCTGGTTTGCAAGCACAGA TACATGTGCCCACACCCGAACACACGCAGACACCGCCAGAGAGCGAGACAGCGAGCGGGCGCCTCCGTAGCAG CGGCCTGCGGGGCGGAACCGGAGCTGGCGCCGCCTCAAGGGGAAACCGAACTGTAGTGACCGGAAATGTCCCC AGGACAGAATAAGCCATTCCTTCTGTCCACGTTGCCAGGACTTCTCCAGCTCAACACACCTTGGTTTGTTTAA TGTTACACGAGGGAGAAGATTTAGAGGCAGAGACACATGCTGGCTCAATCGGCGAGGAAATACGAGCAGAGTC TAAACAGAAAGAAATATGGAACGGGGGGAGACTAGACTGTGGGGAAGGCAAATTGGAGGCCCAGAAAAGGGGC TGGTGCGGAAGCTCCTCCAGGCCCCTGGGCGCTCTGGCATTCTGTGAGAAGGAGAAAGCAGAAGCCGAGAACA GAGAGTGACAGGAAAAGAAAAGAGACGCAGAAGGGGTTGGCCTAGGCACGCTGCGAGCTGCCCTCCAGCTAAG ACGCTGCGGGCAAGGGAGGGGGAGGCCGACATCGCCAGGCGAGGGGCCAAGGTCGGGCTCTTTAACTCAGCCA GGAAACATCGTTGGGGGCTCCAGGGCTCGTGGAGCCCGAACTGGGGCTCATTTCCGGCCCGATGCCCCTCTTC CCCAGACCCCTAGCCCGGAATCCAGCAAAGGCTGGGCCATCGCCGTCCGCCACTGGGCCTCCCTCTGTGCGAG CCCTGGGAGAAGCCTCAGGGAACGACTCTGGCACTGGGGCTCGGCCCCGGAGCTAGCGCAGAGCGTGGGTGGG AGTCGACATCCAGGCAGGAGGCAAAGAAGAGGCCCCGCCCTAAAGCCGAGGGCCCAGTTCTTCGAAAGCCTGT GGCCGGAGCTGGACTCACAGGATTCGGGGTCCGTACAGCGCGCACGTGGTACCGCATCTTCGGCAGGCGGCGC CCCTAATGCCCAGCCCCGCCCTGCTTCGTTTGCCGGGCCTGAACTGTGTCAGCATTGAGGGTGGACGCCGAGT CGCGGCGAGTTGGTCCCTTGCGGTATAAACTTGGGGCTTCCCTAGGGGCGGTGCCGGGATGGATGGGGGCGCC TCTCCACCTGCAACTCCCCCAGCGCAGAGCGCAAAAAGTGCACATCGCGGGCCAGCCGTCGCCTCGGGGTTTC AGGCGGCGCCCGGGGCAAAAAGGAGCTGAGGATTGGTTTGGGTCAAAACACCCATTTCAGTTGGCAGTGGGGT CCTCTGCGCCTACAGGGCTTCGAGCTCCGGGTGCGGGCTCACTGGGGCACCATGTGCCAGCGACTCGCCACCC GGAAATACTTGGGTTGCGCTAGAATACGCAATGGGTCTGTGTTCG CGI: 392 range = chr9: 101621613-101627382 CGGGCCGCCACCGCCGCCTCGGCTCCTCCGTGACGTCCGGGAAGGGTATCCCCGGCACTCAGGAAGTGGTGGC CGCGGGCAGCTCCGCCCCCACGCGACTCGGGGCTGGCCGAGCTGCCGGGTGGTAGAACCGCCGGGCCTTCCGC AGGGCGGGCGGGGATCACCGTCTCCCCACCTCCGTGCGCACACACATGCACGGGCCTCGCGCCCCGCTGTCGC CCGCGCCTCGCCCTGCTCACTTCTCACAGCCCGCGCCGGACGAAGAGAGCCGCCAGCGCCCCCCCTCTCTCCC ACGGCTCGCACCCACTCACCCCGACCCCCGGCGCCGAGCCCGGCCCCTCGTCGCCGGTCACCAGACCTGGTCG AACCGAGTCCAAGATGGCGACTCCGCCCCCGCCCCCTCCGCACTCCCGGCGGGGTCAGGGCGCCCCCTCACGC GGCGGGCTCGCGCCCGAGACCCGGCTAAAAATAGCCAGGCCCGACTATATTTGGTTCGGCCGGATCCTGGCGC GGCCGCGCGCTCCCCGCCCCGCCCCGCCCCGCCCCGCGCGCCCTGCCCCGCCCCGCGCGGCGTTGAATGGAGA AGGGGCGGGGGTGACCGAGGGGAACCTACTCCGCTATCTGCGGCGCGCGCCGGCGGCGGGTCCCGGCCAACCG CCGAATTTAGTAACATCGCCTGCGTCAATCACGCGCCTCGCGTGCGTCAGCGCCGCGCGGCTCCAGGTCCTGC TCCCCCCCTTCAAGCCTTTGAATGGATACAATGTAGCAGCGCCCTCCTTCCTTCCGAGGCTGGATTGGAACCC GCCGCAGTGCAGAGACTCGGTTGCTCTCGGCTGGGTCAACTTTCGGGGCATTCTCCCACGATCCTCTCCGCAC CACCGTGTCTGAATTGGAAGTGGAGGCGAAGAAAGATATACATGCCATATTTACCTATATGTAGTTTGTTTTC AAGTTTCTGGTCCTAGCTCGAACCTTCTTCGATTCTGAAATGTGTGCTGTCTACAAAGGAATCTTGTATCTCC CCTCGGCGCAGCGCCCCCCGCCCCCGCCACACACACACAAATTGGGACAGGTCAAACATATAAAACGGTATTT GTGATTCAAGCGGACCACATGGGGACCACTCTATCTGCATTGTTTCACTCAAATATTTTCTCCTGTCCAAAAA TTCATTTCTGAAAGAGACTGCGTTCACTCAGCAGCAACCTTTGGGACTAGGGGTCTTTAACTCTGATAAATTT TGTTTTCATCAAGAAATTTACACTTAAATTTATCATTTCCAGGAAGAAATTGCTCTCCTTCATACAGTCACCC AGGCTTTCGGCACACCATTTCATGACAAATGTGTCCGAGGAGACCAAAGCAAATCCCCTAGCGAGGGACTGAC TAATAAGTCCTGTTGATTGATTTCGAAATGTTTAATTTGGGAGATGTGGGCGGAGGGCATCTACAACCATCAA AAAGTGAAAGTGCTAGTTGAGAGTTCCATTTCTGACCCGGTGCCGGGGAGGAGGAATGATTTGCAATAGTCAG ACCCGCTCAGCTGTTCAACACGTGTGTGTTTGTTTTACACACAGAGTAGTTTCTGCTGCAGCGCGCGTGTGCA TGATGGATGTGCACTTCGCTGGGTTATAACGTGTCCAGTTAAGAAACCCACGCCGTACGTGTAAAGAAATCAA ACCTTATCCCCGGAACCATCTGCATCCCTGTGTGAAACACGCACCCAGTAAATGATGCGGGGAGGGGGGATTA GCCTGGGCGCAGAGGACCGGAGCAACGTAAACAGCTTTAGAACCTATGCAAGAGGAAAGTGCAGCTGCACCTC AGGGCGTCTTCGGGCTGGTGCCAGACGCCTTCTGCACCGGCTGCCAGGTCACTGGAGCTGGTCAGAAGCTGGC TGGCGGAGCCTTCCCTTTCGGAAGAGCTGTCCTCTCCCTTACCCCCCTCGCCCTGGCTCCGTGCCTCGGGGCA GCCTCGGAGGCGCGCCAGCAGCACTCCTCCAACTCTACTCCACCCGAGCCTGACAGCTGGGCGGTCCCGCCTG ACCCGTGGGCAGGCCGCTGCACCCTCCCGCAGACGCACGCCCTGGCGAGCGGTTCCGCTGCAAAAAGAGAAGC CCCCAGGCCGGGGCCGGCCGTGCGGCGGAGTTTCCATTGTGCGGCCGTGCGACTGGCCGAGGAACGCGCGCGC GCGCGCGCGCACACGAACACACACACCCTCCCTCGCACACGCGGAACCGGCTGGGCCAGGGGAGGGAGGAGGA GGGTGACGTAGCGTCCCATGGCGTCACATTGACGTCTCGCATTCCAGGCACTCTATGGAGAGGCCGCTAGGGC TCCTGTGGCATAAATGACGTGCCGAGAGAGCGAGCGAACGCGCAGCCGGGAGAGCGGAGTCTCCTGCCTCCCG CCCCCCACCCCTCCAGCTCCTGCTCCTCCTCCGCTCCCCATACACAGACGCGCTCACACCCGCTCCCTCACTC GCACACACAGACACAAGCGCGCACACAGGCTCCGCACACACACTTCGCTCTCCCGCGCGCTCACACCCCTCTT GCCCTGAGCCCTTGCCGGTGCAGCGCGGCGCCGCAGCTGGACGCCCCTCCCGGGCTCACTTTGCAACGCTGAC GGTGCCGGCAGTGGCCGTGGAGGTGGGAACAGCGGCGGCATCCTCCCCCCTGGTCACAGCCCAAGCCAGGACG CCCGCGGAACCTCTCGGCTGTGCTCTCCCATGAGTCGGGATCGCAGCATCCCCCACCAGCCGCTCACCGCCTC CGGGAGCCGCTGGGCTTGTACACCGCAGCCCTTCCGGGACAGCAGCTGTGACTCCCCCCCAGTGCAGATTTCG GGACAGCTCTCTAGAAACTCGCTCTAAAGACGGAACCGCCACAGCACTCAAGTACGTATGAGATTCGCCCAGT TAATAAGGGGACTTGCTAAAAAAGTTGGCTTGCTGGGAAGCGTCGCTCCTGAAATTGACAACTTTGAGTGTGG GGTTCCCTCCCCTGACCTTGCCGCCCGGCTCCGGCTTTGCTAGCCCAGCGGCCCGTAGGTTCTGATCTGAAAC TTTTCCCCTGTAGTGGGCCCGCGGGGATCTCTGGAGCTCGTGGGATTCCTCCCCCCACTCGAAGAGGCGAAAA GCCTCTAACAAAGAGGAGGACCGGGATTTGTGCTATAGCGGCTCCAGCGATGTAATTCAGGGTATTTCGGCTC TAGTTGTCATGGTAATGATGCTCTCGGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGGGAGTTGCAGCTC CGGTGATGAACGGCAGTAATTTTCCTGCCTTTTAAGTAGGATTGAAAATAGGAGCTCTGGTGGGTCCAAGTAA ATGTTGCTAATGGTGGCACCGAGCTGGTTCTCTGGAAGGAAGCTTAGGAGGGAAGGGCCTAGGCAGCGACGGC CAGAGTTTGCAGACGCACTCGGAGGACCTCAGGAAAGAGGGCGTAATTGTAGGAATGTGGCTTATTGTATTGA AATGAGCCTGGGGTTCCACTAGGCACGTCTGCCTGTCGTCGCTGACATGCCGGTTTACACTTTTCCCTTAGGA GGTAAATCGGGTGTAATTGGCGACTCCCGCACACTGACACGTGTGGGGACGGTGTCCCTCTCCTCTGGACGTT GGCTCGGTGTGGGAAAGGCATGCTTTTTCACGGACAGAACTCGCGCTTTTGGAGAAGTTGCTCCGAGTGTTTT ACTCTTAGTAGAAATGAAAGTTCTCGGTGGTGAGACGAGAGCGGTCATGCGAGCGCAGCCTGCGGAGACTGAC TTCCAAAGGCACCTCTCCAACCTGTTGGAAGCCTCGGGGCAGTGGTGAGGAAGAACGCATTTGTCCCTTGATT TCCAAAAACGTTCTTGGAGATTGCCTTTTATTTATTTATGCGTCCGGATTCTCCAGAGGGAAGAGCTGCGAGG AGTTAGTAATCAGAAATGTCGGGCTGTGATCCCAGGGCCTTGTGGTGCTGGGAGAGAAGAACAGGGAGCCGTC ATTCCATCGCGAGTCCAGTGCCGGATCTCCTTTTCCCACGACCGGGAAATATTTTATAGAATCAAGTTAGGGA AAGAAAAAGCTGCCTAACGTGGCTGATGGGCACAATGAATGAAGTTACTTTATTCGAGTTATTTTCGCTGAAC AAGATGCTCGCAGAGTTAGTATCAAAGCCTCCTTAGGCCACAGCAACCTCCACGTCCGCTCCGCCCCCCACCC CCCGGCACCCATCCACCCCTTTGCCTGGGACCGTGCGCTCACAGAAATTCTTCCCCGCGGTTTGTCTAGTCTC CCTCGGTCTTTCTGAGAATCTCAGTCTTTCCCTTTCTGTCAGTCTCTCCCTCGCTCCTCTTGCCCCCGCCCAA CCTCCGCCCCCGCTCCCCAGGGTTGGAAACTCCGCAGAGGAGCCCCGGTCACAATGGTGCGTTTCACGGTTTC CTCCACACACTTCACCACCGGGAGGGGAACACGGGGGTGTTCCTTTCGTCTGCCCACGAGAAAGAAAGGGGCT TTGACAGAGGTAGTTATTTCTTCCTAATTTACAACCCCAAGGCTCTGTGCTCCCGGCCCCGGCGGCCGCAAGC AGGAGCGGCGGAACGTGTTTCCAGGCACTGAGGCTTTGCCTAGGTAACCGGCCGCTTGTGGGGTGGAGAGAGC GGCGGGGCGCTGGGCTGGGCTGGAGGAAAGGCTGTGTGGGTCCCTCCCGCGAACGCTGGGCGCTCGAGGGGAA CTCCTTCGTTGGGGAGAGGCGGTCCCCGCCCACCCGAGTTCTGAGGCCTCCTCTCAGAGAACGACTCCGCTTG AAAGGCCCTCAGGGAATGCGGGACGGGAATGCGGGCACCCACTGAAGGGGCGGGTGGGGGATTGCTGGAGACC CCCATTGAAGATGCGGGGAGACGGGAAGCACGTGCTACAGCCGTGGGAAGATCCGCTTCTACCCGCGCTACAT CGAGCGCAAGCTTTCCGTCCGAGCAGCTCCAGCTGGGGCTGGGGGTGGCAAGGGAATCCCCCATTTCCTGGTC GTCGAGGGTTTCCTGGACCTGGGAGCCCCGAGTCCCTTTCTCTCTTCCTGCAGGCAAGCCCCGGGCTCAGGGG CGCCAGGAGATGACCCTCGTGGCCCCGCGCACCTCGGAGGTTTTTGGTTTGGTTTGATTTGGGGTTTTTCGGT CCCTGTTCCCACTCTTCGAGCTGCGCCCACCCCGGGCAAAGGGGGCGCTATAGGCCGGAGTTTGGGCACCCAG TTCCTTCCCTGAGGCCTGCTGAGCTGCGCTTTCAGCTACAAAGTTTCGCTGAGGCTGTGGGCTGAGACGCTGG TCCCGGAGCTGCGCTCGGCGCCCTCAGGAATGTGCCCCCGCTAGGCCGCTGGGTGGCCAGGAGCCTCCAAGCC GCCCACCCTCGAAGACACCGCCCTCTGGGTGCAGGGGACCTGCCTCCGCTCGTCCCATCAGCCGCTAACGCCG TCCGCTTCGTCCCCTTGCTTCCAGCGCCAGCCTTCTCATCGCTGTGCCCTTTTGTTTGCTTGACCCCTGGCCC TCGAAACTCGCGGCTAATAGAAGCGAAGCTCCATTAGCATTTAGAATGAAAAGCGCAGACTTTCTTAATTCCT CGGGGCATTCATGCATTCGTTCCGGACCTTGTGCATTTCCTATGCAACGTGTAAAATTTGTATTTGAGGGGTG GGGGCGGGCGGAGCTGGAAAATGGCTTTTTTCCGCTGGTGAACACTCACTGACCCCCCGTATTCGGGCGGAGC TCG CGI: 56 range = chr10: 13556172-13556753 CGCTGTTAGATTTCGGGTCAATATCCATCATCGCTGTTAGACTCGGGGCCGACATCCGTCATCGCTGTTAGAC TCGGGGTCGACACCCATCATCGCCGTTGGACTCGGGGCTGATACCCGTCATCGCTGTTAGATGCGGGGTCGAT ATCCATCATCGCTGTTAAATTTGGGGTCGATATCCGTCATGACTGTTAGATTTGGGGTCGATATTCCTCATGA CTGTTAGACTCGGGGCTGATATCTGTCATGACTGTTAGACTCGGGGCCGATATCTGTCATCACTGTTAGACTC GGGTCAATACCCGTCATCACTGTTACACTCGGGGCCGATACCCGTCACCGCTGTTGGACTCGGGTCGATACCC GTCACCGCTGTTGGACTCGGGTTGATACCCGTCACCGCTGTTGGACTCGGGTCGATACCCGTCACCGCTGTTG GACTCGGGTCGATACCCGTCATCGCTGTTGGACTCGGGTCGATACCCGTCATCGCTGTTGGACTCCGGTCGAT ATCCGTCATCAGTGTTGGGCTCAGGTCGATACCCGTCATCAGTGTTGGACTCGGGTCGATACCCATCATCG CGI: 22 range = chr10: 15294605-15294858 CGTTAGAGCATAGCGACATCACGTGCGGTTTCTTAATGTCCCTGGTGGCGGATACGCCGAGTCCTCGGAAGGA CATCTGGACACCACTTTCAGCCACCTCCTTGCAGGGGCGACATCCGCCAAAGTCATCCTTTATTCCGAGTAAT AACTTTAATTCCTTTCTAACATTTACACGGCAAACAGGAATGCAGTAAACGTCCACGTCCGTCCCACGGCTGG GCTGCCGTTCCGTTTCCTCCACGAACGGGTACGCG CGI: 987 range = chr10: 76825135-76839606 CGCTCCCAAAGCCACGCGAAAGTGGAAGCGCGGGGCCTCGGGATGCCCATCCAGCCGGCTGCCCGCGCGCTGG CCGGGGTTCCAGGACTCCTTCCTGCTCCGCCGGGCTCTGCAGCGCCGCCTGGTGGACACGCGGCGCTCCGCCC GGGCTCCAGCCGCCAGCCGGCGCGCCGGGGATCCCGCGGCTGTTCGGGAAAAAGCTGGAGAGAGTCGGGGGGC GCGCCTTGGGGAGGGGCATTTGTCCCTCCGAGGAGGCTCGCACCTCGGCCTGGACACGCAGCAGATACTGGCA CCCACCCTTCACTTACCGCGCGCCCGGGGTGACTCGGATCCGTCCAACACGTCGGGGAATCCTTTCTGTCCTC ACCCCCGGGCGCCCCAGCGCCGGAACGCTGCTGCCTCTGTGTAGCTGCTCCCGGAAGGAGTTTCATCAAACTT TTAAGGGGCTTTGGTTTTGGGTTGTGTTGATAAAATACCAAGAAGGGGCATGAAGGCACGAACGTCCCGGGTT CGTCTCCCTGCTGGTCCCAAGCCTGAATCCCAGGGCGGGGGAATGTCTAGGTCCTTCCGGGCCGGCAAGGTGT GGTCGCTCAGGGACCCCTGTCCGAAGACGCTAGGGAAAAGAGGCACAGCCTGTGGGTCGCAGTGGCCAGGAGC GCGTGGCCGCTGCTGGTGAGAGAGTGGTAGACGCCTGGCTTTCAGGTCCTGAGCTGCGGGCACCGGAGCGTGG GACCCCGGCTGCAGCACCGCCACGCGCTCCCGCCCTCCCACCTGCAGGGCGGGGGATGTCTGTCCAAGAGGCC GGGGCGACAAGCCCGCCGGCCAGGATTCTCAAGGAACCAGGCCCAGCTCAGCCTCTCTCGGCGGGACCAGAGT GGGACCGGGGCCGCGGCGTCCGAAGACGCTGCGGGCCAGGGGTCCTCCTCGGCGCCAGCTCCGTTTCCTGGGG TCTCGCGACGTCCGGACATCAGGGTCGGGGGTGTGGAGACGGCGGCGGAGCCAGAGTCCCCACCAAGTCAGTT CCAGGAGGCGGCCCGCGCGCTTCCCGCAGTGTCCGGGAGGTCGCTGGGGGTGGCTTTGCGTGCAACCCGGGTA AAGGCCCTGCAGCCGTGAGGCTGGCGCTGGGAGGAGGGTGGAAAATCTCAAAGTCACCAATCCCGGTGCAAAT GGCGGCAGGGGCCGCGGGCTGTCGGACGCAGGCGAGAGGCCAAAGGCTGACTTCGCGCGGCCGTGAGTCCCCA GAGGCAACAGGGGTACCTGAGCGCCGAGGGGATCCCGAGACTCGGAGAAACCGGAAGAGCCTGACCCCAGGGA GCGGAGAGTTTGGGGTGCGCTCTCAGAGCTGTGACTCCACGGTCCCGGAATCCTTGGAAAGGGCGCTCTGGGC TCAGAGCTCCCAACTAGCCGGAGGACCTGGGCTAGCGCCCAGGCCTGGAGCGTCTGGGAGGGGGCGCTGGGTC TCGGCCCCCCTCCCCCCAAAAGGGACTGAGACTTTTTTCTGCGTGCTTCCTTCGGCGCTTCGGGCAGCTCTGT CCTGCGGCCCAAGCTGGGGAGAAGACAGCGGCCCGCGCCACAGGGAGCTGCGCCCGGACCCAGACTCCCGCCG CGCTTCTGCAGAGCGGAGCCCTAGGTGCCCACCTGGTAGCCCCAGAAAGGCCGGACCTGGGCGCCGGGACGCT CGCGGGGCCGCACTTGGAGGGGCTTTCCGGGTCCTGGCCGGGCGGGCTCTCCTGCGGCGCGGAATGGAATAGA GCGCCGGCTGCAGAGCCACCCGGACGGGGAAAAGCAGCGGTGGCGCCGGCCAGCCCCGGGTCCCGACTCTGGA GGGAGGAAGGAGCGGGCGGGTGGGGGTGGGGGTGAGGGCGAGGGTTGCGGGGAGCGTTTAGAAGGCCCTGGGC AGCCAGAAGAAGAAAAGAGGACGCACTCTCCCCTAGGGACCAGAGGGTCCCTGCGTACTCCCCCCAGGCCCGG GACACAGGTTCCCCCAGCGCCCCTCCGCCTCCCAGTCTATTCGGCTTGCCCCAGCGCGCTGCCCCACGTCCCC GAGGCCCCGGCCCAGGCCCAGCCGGCGAGTCCCGGCCTGCTCCACTCTGCACAAAACGAAACCCAAATGCCCA AAAAGCTCAGGAGGGAAATTTAACAAAAACCCTGTCCCCCGCCCCACACCCCCTTTCACTTTTAACAAGCCAG CTGCCAAGAGAAAATTGAAATAAAAACGAAATGATAGATAGCGGAGGACACTATTTTCCAAATGGTGAAATAT CCTCTAAAAATATGTTCCCCAAGGCCAACTTCGCGGCTGGTAGCCCCTTCCGACGCCTTTGCCTCCCAGAAAA TCACAACAAAGCGATCGGAAATTCAGCCACGGTCCCGGGAAGAAGGAGTAGCAGTGAGGCCCCGGAACCCACT GCGGCCGAAACTGCCATGCTCTCTTTAACCAAAATAAAAAAGATAAGAAGAAGAAGTAAAACCCTTTAATACA TCAAATATACGGAATTTTAATCTTTAAAGCGATACATTGTCTATTATTTTAGTACATGACGTAAACCTTGTCC CCTTCTCAGCGGGTGGACTTAAAAATTAAAAATAGTTAAGTGTTCCTTTTAAAGAACAAAATAAGGCAAATGA GGTTTTGGAATAGAATTTTTTCTTTTTCTTTTTTTTTTTGTTGTTTTCTTCCAGAATACATACAAAAAAATAC CCATTCTCTTCGATGGTATACACCTTAAAAATAATTGCAATTTGAAATCAGAGCTGACAAATTGTGACTTTTT TTTTCATTTTTTTTGTAACAAACATGCATGTAAATTTGTGTTTCAATCAGACATTAAATAACGTACAATACAA TCATAGCAATTTTAAAGTAACATTAAAGAGAAGACCTCTAGTTCTGTGGCGGTTTTGCTTTTATTTATAATCT ACAAGGGATGGGAGGGTTTGTTTTCCACATTTTTACCCTCAAGTTTTAAAATTTTTCCCACCTCCTTTTTACC TACAGAGCTCAAACTAAATAATGCACTTTTGAACCACCGGTCCGCTTGGAGCTAACATAAATAAATACCAGTG TCCACCGATGCAGTCCTCAGATGAACACTTTCTCAATTATTTTTTCCTTTTTTTTTCTATAAAAAGTCAAATG ATATTTTTTCAACTTTTATAAAGTTTGGGTGGGGAGGTGAAAGTGGGGAGAAGGGGAGTGTCCCACCGGGTCT CGGTCGCTGCTGTCGGGTAGATAGATACGGTATACATTTCTTTCCTTTCGTGGCCCGAGTCCTCCCCACGCGC GGGTGTCAGCAGCCTGGGCCGTGATCCCGCCTCTCCCTGGACTCCTCCCCTCCCCCTCTCCCTCCTCTCCCTC GCTCGCCCTCCCGGCCGCCCTCACTGATACCCCAGCGCCGAGGCGGTGGTCAGTCTCTGTCCGTAGAGGGCGT AGGGGGAGTAGTACGGTCCGGTGGCGGCGGGCACCGGCACGGGGGCGCCAGGCGTGGGAAGCGGGCTCTTGGA GTAGGGGTGGTAGCGGCTGCTGAGTCCCAGCGCGTGGTGGGGGCTGCGCAGCGCCAGCGTCCCAGGGCTGCCC GGTGCGCCCGAGGTGGGGATGTGCATGTGGCAAGCCATGGCGGCCGCGGCAGCGCTGGCCAGAGACGACGAGC TGGGGTAGCCCGACAGCAGTTTGTCTGTCCCGGGAAATGCCGTATGGGTCCGCAAGTGGCTCAGCAGCTCTTC GGACGTGGCGAAGCGCTTGTCGCACGGCCCGTTGGCCGACACCCAGTTGCAGATGTGGGGGAGTGGGTCGTTA GGGAGCATAAAGCCGTAGGGGTAGAGGGGGTGGCCGGCCAGGGAGGGCGGTGTGGCGCCAGCAGCCGCGGCGG CCGTTAGCGAGGAGTGCACACCGTGCAGCGGGTGCGTGGGGTACACCAGCGGGTATCCGGACTTCAGCGCCGC AGCCGCAGCAGCCGGATCATGTGCGCAAGAAGCGCTGGCGGCCGCCGCCCCTGCCAGGTGGCTAGCGCAGTGG TAGCTGAGGCAGTAAGGGTCCCGGCACAAACTGGCTGTCATCACGGACGGCGGAGACGCTCCGGCCAAAGGGC TGGAGCCGGCCGGCTTACTGCAGCCCAGAGACCCGGCCGCGGCCGCCGCCAGCTGCGCCCCCACCAGGCTGCC CGGCTTGGTGGGGTCAAGTGCCACGCCGTGTGGCAGGAACTGGGGCGGGTAGCCGGCGTAGGCCCCGGCCAGG CTGCCTGGGTAGGTCATACCCGCGGGAGGCAGAGGGAACACTGTCTGGCCCGGCTTGTAGGGTGACACGGGAG CCACCAGCCCAGAGCCCAACACTGAGGAGGAGGTGGGCGCGCTGGGGCCGGAGCCGGAGCTGGAGCCCGATGA ACCGCCGCAGTCCGAGCCCAGAGCCTTGCCTCCCGGGCCCCCATCCGGATGCTGGTTCACATCCACATTAATC CCGCCGCCGCAGCTAATCCGGCCGTGTGCCAGCCCCGTGGGTCCCCCTTCGGCCGAGGCGCCCCCGGTGCCCT TGCCACCGCCGCCCACGTCGGTGTCTTTCTTGTCGTCCTTGCCCTCCGGGGCACCCCCGGCCGAGGACAGCAT ACCTCCCGGCGAGCAGGCCGAGGCGCTGGAGCTCGGGCTGCCTGTCCTGGGCGTGAATGGCTGGCAGGTGGCG CTCGGTACCCGGAATCCCGACTTCTCCGACGAAACACCCCCGCCGCCGCCCCCGCCACCGCCACCGCCTCCAC CGCCGCCTCCCGGCTCCTTCTTATCCGAGCCGGGTTTGGAGTACGGCTTGAAACTCGACTTGTCCTCCACGCC GATGTCGCTCAGCTTCAGGGGGCCCGATTTGGTGTCCTTGTCGCCCGCAGCACCGCCGCCGGCACCGCCCGCG CCGCCCCCGTTGGAGGCAACCGAGGAGAGTTTGGAGGAGGGCGAGGGGTCGGGCTTCCCGATCTGCGAACATG TTTGCGCCAACAGCGCCAGCGGGCTCTTCTTGGCATCGAGCTGCGGGGTCAGACGATGGGGGGGGAGCGTCAC ACAGAGAAAGAAGTGGAAACCCTTTAGAATCCTGGCTTCTGGGGTTCAAATGCCTCTCCGCAACAGCCCACGA AGATCCTCCCAGCCCCAAGGCGCAATTCTAGGCGGCACCCCCTCTTCAACACCCACTCACAAACATTCTCGCC GTTGGGAAAGGCAGCAGATTGCTCCCCCCGCCCAACCACCACCCCCAGCAGCATCTTTCCTGCCCTCTCTGAG CGCTAACTAGATTTTTAAAGAGCAAAATGTTTTGGTTTTCGGTTCCTAGACCCAGAACTGTACCCCCTCCCCA CAAACACTCCTTAATTCTTCAGAGTAAGGGCTCGGGCGGCTGGCGCCTCAGAGGCTGTGTGCACACACTGGCT TCTGCGGATACGAAGGACGGCGACTTTGGAACCGTATTTCAGACCTCCGCCTGCCTTCGGTGCCGAGTGAAGG GGCCTGGGTCGGGGTAGGGGCTTTCATATCGAAAGGAGAAACAAGTATTGGCAGCCTTGCTCCCTAGCATGCA CGCCCCATTCCACTTCCTCCCCCTTTTCCGCCCTAGTTTTGAGGTACGGAAGCAGTAGCCTCTTCCCCCATTC GGGAGCTGAATCACTCCGACCCCCCCACCTCCGCCCAGATCCCGAGAAAAAGAAAGCCCTAGGGTGGCAGCCA GGGTAGTGGTCCCAGTGCGATCCAGAGAGAGGGTCCTTACCTCGATGGGGCTGACCGGCGTGGAAGGCAGGGG CTGCAGGTACTCGGGGTGCAAAATGTGGCCAGTTCGTGCCGTCAGCATCTTCAGCACCTTGATTGGCAGGCGG TTGGCCTGGCGCAGGGGGTCAGAGGGGGGCACGGCGTGCACAAAAGGCTTGGTGCTGCCGGCCGGGGACGAGC CTGGGCCGGGGCCGGAGCTATTTCCAGAGAGCGCGCTGGTCCAGGCAGGGTCTGCACCGCCGCCTCCGCCTCC GCCGCCGCCGCCGCCGCTGTGCTTACTGCTTCTTAGGGCAGAAAGCGAGGGCGCTGTGCTCATGACCCACCCG CGCGCATGGGAGCAGCGGGGGGGAGGGCTCCGGGAGGCGCGGGGCGGGCTCGGGGCTGCGCGCTCGCCCCGGG AGCAGGAGCAGCGGGAGGAGGAGGAGCTGGCGCGGCGGCCACGGGCGCCCAGCGCGCCTTCTCGGCGCCTGGA GCCAGACGCGAGTAATCCTGGGTGGCCCGCAGCGGAGCCGTGGCCGGGCTAGAGGAGCCGGCTGGACTGCGGG AGTGCCGGGCGGCTCGCGGTGTCCGCCTCGGGCTGCTCCCCTGCGCTGCGTTCTCGCGGCCCCGCGCCGGCGC TGCGCTCTGCGATGCGAGCCGCTGCGTGTCCAGCCGGGGCTCTGGCGAGGAAACTCACTTCAAAAGCAGCTGC ACCAAGGGGGAGATTAAAGCCTTTGCCGCCTTCCAATCAAATGGGAGCCCGAGGTGATTGGAGGGTCAAGGGG ATGTGACGCGTCCCGCGCCGCCGCCGCCGCCGCTGCCAGGACTCTCAGTGCCGGTTTTAATGGGCAGCTCCCT CTTCGCCGCCCCCCTGTGTGTCCCCTCCCTCGATTTCGCTGGGAGGACGAGATGGACATTTATTCTACGTTTG CCATCCGCCGCCTCCCTCTTTTTTCCTCCTCGTCGTTCTTCCTTTCCCCAGCTCGAAAATAAACTGAAACCTT CTTTTGAAGGGGGGTGCGCGTGAGGAACAGACTGCGGGGGGTGTCCAGAAGGAGCACCGGTGGGAGTGTGGAC ACCGGCCGGACTGTCAACTCCAGGGGCGAAGGGAACCTGCACACCCAGTGTTTTTTCCTTCGCAGTAATCGAG ATCCCGCGCGGCGCAGCGCAGCCACCAGGGTAAGAAGGCAAGGTGGGGAGCCGGAGCTGGAAGAAGCCCGCCC GCCCGCTCTAATTTCCTCAGATTCCGCGGCGGAGAAACCAGAAGCTAGATGGGCAGTCGCAGCGGCGGCGGCT CAACACCGCGAGGAGCGCTGGGCTCTCCGCCCTTCCCGGCCACGTGACGCCCGGGGACGCGTAGATTGGGGCA GCAGCGGGGGTCACATGTTTCCTCTGTTTCACCCTCAGTCTGTCCCCCAACCCCCCATTCTTACTCTCCCACC CTGTTTTCCTCCCTCCCCCCCTTCTTTGGGCATCTCCACCCCTCCATCAATTGTCAATGTTCCTCGACCGCAA TCAATCAGTTATTTGTCAGCTCTTGTCAATCCTCCCGTGATTTATGTCAGCTTTTGTTGCTGATTACAAGGCG GGTGCGACTTGAAGGGAAAAAGAGAGAGGGAGAGAGAGACGGAGAGGAAGGAGGAGATTGAGAGGGAACTGGA GGAGGGGAAAAGAGGAGCGGCCTCCTGGGATGGGGGTGGGGTGGGGGCTCTAAGAAAAAGAATGAAAGAGGCG CACGGTGTCAGGAAAATGAATAGCGAGAGTAAAGTGCGCAGGTGCGCCCAGGGCGCCGAGAGGGGCGCGCAGG CCTGGAGTGTGCGCCTGCCCTCTCGGTGTCGGAGAGACGCCCTTCCACCTCTGGGAGCCTCGGTCTGTTGGGG TCGCGGAGTTCGGGCGCGGCTCCGGGTACCCGAGACCAGCGGCGGCAACTTCTAACACGGGAGATTTCCCGCC ACCCCACCCCGCCGCCGCGAGTCCTCGCGGGGCGTGTTGCGTGCGGAGGTCAGGCTGCCACCCTCTGTAGTTC CCTAACCCCAAACTCGGAGACTTCTAAGAGCCACACCACCAAGGAACTTCTAGTCCTGGAGGTCAATGGTGGG GCAAACCTCGCCTCAATTCTTTGACCCCCTCGGGTCGTAAGCAGGGCTAAGAGGCTGCGAAGAAGAGGCCTGG CCATGGGTGTATGGGGGAAGAAACATCTCAGGCTCACTCATGCCCCCTCCCCGACCTTCTCCCACCTGCCGCC ATCCCCGCAGGCTGGGGAGCCAGGGTAACTCGGGGCTGCTCTCTCGAATTTATTGGAACGCCGAGTCGGAATG AGCTGCGCTAGGAGAGCCGAGGGAAGGAGCGAGAGAGGGAGGGGGCGGCTGCCTGTGGGAACGCGGGTTCTTC CAGGGAAGCGGAGCGGGACTGCCGCGTTCCCCTCGATTTGCACCGTCACTCGGGTTGTTTGGGAAGAAAAGGG GAGGCGCTGTGCGTGCCACCGGGTACCTGGACCTGGATGCCCAGTGTGTATGCATGCCTGTGGCGCTGCGTGA GTTATCGGGGCTCTGATAGCGTCCGGAGCGGGTTCGAGGGTCTCCTCCAGGAACTCGCAGAAATTAGAGGGGG TGGGGAGGAGGACACACCCCCTTCCTCGGAACGACTTAGAAGACTTTGAATCTCCCCTCCTCCGCTTTTCCGC CCCGGCTCTTCTTTTGTTGTCAAGTCCTTTTGATAAATGGTGGGGCTGGGAGCTCTGGGAGTCGGGAGCCAGT CTGTGCCCGCGTGGGGGGCGGGGGCCGAGCCTGGAGACCCGGTTTCGACCGGCGCGCACCTGGGGCTGAGCCG GGTGCGCGCGGGGGTCGGGTCTGGAACTGCCCTTGGTATGCTCGCCCTCTCCTCTTGGCCCATCTCACTCCCC TCCCCCACCTGACTCCCCTCCCCGGCTTCTTTCTCTGTCTCCCACTCCGCACGGGTACCGAGAACTTTCCGGG GTGAGTTTTAGAATTTGCTCCTAGGCATTCTTTTTCTGCGTTTGGATTTTATCCCTTGATTCTTTGGGTTGGT AAACTTTATGAAATGGTAACTTGACTGAAGCTCATTTGGAGAGAAGAGGGGAGTGAGGCGGTGTGTGCTTGGG GCTGGTGTTTGTCAGTGTGAGCGTGTAAGAGCACACCTGCATTCAAGGGGGTTTGTAGTGTCCGTGCGACATC TGAGGGAGGTGAGTCGGCGAGCGGGTGGCGAGGCCCCACGCTGAGGGAGGCGGTTGTCTGGTCTCCGGGGAGC AAGTCCCAGGTGCGCGTTTCGGAGGGCGGGACAGTCCTACGCTGTCTCTGCGGGGCAGCGCGTCTGTGAAGCA CTCTTATCCTTCGGGTGTGTCCATGTGTGCCTGGTTACTGAGTGCGCGGCCGTCTAGGTGTCGACCCAACCAA TGGTAGTGCTCCTAACGCCGCGAGCCCACCTTTGGGCCGCTATCGCCGCGGCCTCCCCGCGAGGCCCGGGCAC TGAAATTCTGGGGCCTGCGACAGGGCCGGGGGGGACGCAGCCAAGGGCGTCCCTCCCCAGCCTCCAGACTCAG CTCTTCCCCCTCTCCTCTAATTCCAGCAGCTTATTACGCCGGCGGCTCAGGGGAGGCAGCCTCAGCACCTGAA GCCTGGGGGGGCCGTGGAGTGGCTCCTGCGTCCCCCGGTGTGGCCACACACGCTCGTGGGGCTGCGCTGTGCT GCGTGGGTGCGGGTCGTGGTCAGCGTGCGTTCGCTTTTCTCAAAACTCCACTCCGAGGGTCCGAGCGCATGGG GGCGCCTGGGGGCCTGCGCGCCCGGGGCTTTTGGGAGGCGCCAGCGTCCGAGCCTGCGCACCTCGCGCAGGAG GCCAAACCCCCGAAGGCCGGCGCGGGCCCGGGAGTGGGGGCCATTAATTACTCTGCGCCAGGCCTAAAGCCTC CAACCCCCAGCAGCAGTTGGCGTGGATGTCCTGCGGATTTTATTTGCAAACAATGGAAATGATTTGTTTTCTC TAAAAAAGGAGTGGGCAAGGCAGATATTGGAGGAGGGGGTGGGAGGAGGAGAAGGAAGGGGAAAGAGCTGAGG AAAAAAGTTTGAAAATGCCTTGAACTATTCACTGTCGAGATGGCTAATCAGTATTGAGGCCGGAGGGCAGGCG GGCCGCCTTTCACCGCCGCTTCCCTTTCATCTCGGGCTCGGCGGAGGCGCTCAATTAAAAGCCTATCAGTTTG TAAGTAAATCAACGCCTATCAGAGTTGTCACATCAAACAAAACGATTATTATTGCAGCCCGCCTCCCCTATTA ATCTCCCTCGAAGATAATCCGCCTGACAGGTCAGGCCCGGCGAGCTGGAAAGCCTGGCCCAGAGCACCCAAAC AGTCCCGGACTGGCGCGCGCCCCCGGGGGCCTCCCCACCCCTGTCCTGCCCCGCCTCGCGGTCCCTGGGAGCG GGGAGAGAAAGCGCGCGCGGAGGCCTCTGCACCCAGGTCCGCCCCACCTGACTGGGAGCAAGGCCCAGATTCG CGGGGCCAGTAGGGGACAGTCCCGCGCGGCCCTCGCCGCTGCTCGGGGCAGGGGAGAAGCCTGGCGTGCAGGA GCCGCGGCCCGGCCCGGGGTCTCGCCACGGCCTGCGCTCTCCTCGGCTCTCATTTATTTTCTTCCTCCCTTCT TTTTGTTTTCTCTCCCGCGTCTTTCTGGGCTCCCCCATCTTTTTCCTTCATTTCCTTTTCCTTTTCCCTTTTT TTTACTTGCCAGGGAGTATTTCCCATTCTGGCTCTCTCTTCTTGGTGTGCCGTATAAACCTTTCTTGCGCAGC CACACTGCCTGGAGTAGGATGTTCTCAGGGCCCGGGTTATTTCTCCCGGGTTGCCCCAGGAGTGTGCAGTTCC CAGAAACTCATGGCAAAGTCCTCTATAATCTCTTTCCGAGCAGGGGCTCTGAGAAGCTCTGCGCCTGTTTAAG GGTTGGGTGGGTTTGGAGGGGTGAAGAGGAAAAAGAGGGAGAGAGACTGGTGGACAGTTGTCCTATTCTGGAA TTAGTATTTTGCCTTGGAATTTCATAGCTGTAACGTTGCCGACCTCGCTGTTGGCGTTGCCCGGGCTTTTCAA ATATGTAGATAAGACTCAAGGGGGCATCCAGGCCTCAGTAGTGACTATGTGTGTGTGGGTGGGTGCCTGATAC AAGTAAATACACCCAGATAACTGCCTCTGTGGCCTCAAGTTAGTGTCCCAAGAGTTTGGGTGGGGCCTCGCTT CTAGAAGGCGCAAAAATCGTGGCCTTCTTCCCAGTGGCCTCCGGCTTCCTGCTTTGGGATGCCTCGGAATCGA GCCGGACCCGCCTTTTTCTGCGCTCTTCCTCCACATCTGTAGGCCCAAACGGCCACTGCCGGAGCCAGGTGGA GCCAGGATTGAGGGGTAGCTGAAGTGTCTGTGACGAAAGGGCTGCCCGAGGGAGCCCAGGCCTGCCACCTCAT ATGTCGGGTTCAGTGCGCCGCGAAGGCTCTCCGCGCCTGTATCTCGGAGGACCCCCAGAGCGCTGCAGTATTG GGCGTCAGGGCCGAGCCTCTCGCAGCAGTCACGCCGCAGTCCGAGGCCACGGACATCCAATAGAGCCCACTTC AACTTGCATGGTGCATGGGGTCCAGGACCGGTGGCCCCCACACAGGGTTTCCCAAAGCCTCTCCATTTGTCTG CACTCTCCACTGCCGACCTTGTAGGAAATTTATTTCCATGCCCAGAAATATTGTTTGGACACAGTGGCTCGGT TATCTTCGCGCCTGCTTTTCTTAAATACATTTATTTCACCTCTGCCACGCTGCAGATATTTAAAGATCTGTAG ATACCGTAACCCTCAGCGATGCGGGACTCACTCTGGTTATAGATAATATTCTCTGGGTGGTTATTTGAACATA AGTTCTATCTCCAGCCCAGATGACACCCAAGCAGGGGCTGTAAAGGACACTTGCTCTAGAATGTTTTCAACTG AAATATATGTCCACACACGGAGAATTTAAGAGTATTTTTATATTTCTCTCTAGATCTAAATATTCAGATGTGT TAATTACATGCCCTAGAAGCTGGAAGCGATCAGTGGTGTTCACACTGGACGTGGAGCTGTTTGTATAATTTTC ATCTCCCTGCACTTAAACATGACTCTCAGTCTAATAAATTCAACCTTGTCATTTTTAGAATCGACGGGATTTC TCTGGCTGTCGTTTGCGCTGCATTTATCCGAATACATCCAGCTCGCAGGCATCCTGCAAGAAACGGCTCCCGG CTCGCGTGTACGCCGACACCTCGGCCCAACGCAGGACTCGAGGTGGTTTCTAGTGCCCGGGTGGCTGCAAGTC TGCCCTCCGAGGGAGGCTGGACAAGCGGCGCCCCCAGGTCGAGCGGCCTCTCGCTGCCTGGCAGTGCCTGGCA GCCCCCACCTCTGCCAGTGCTTCGGAAACCCGCCTGGCCAGGTTCGCCCGCGGTGAAAAATGAAAGCAAATTC CCCAACAGAGGTAGCCGGAACTTTCCTCGACGAAGGCTCCCTCCTGCGCCTGTGTCTGGAGAACCCCCAGAGC GCTGCAAGTTAGCAAGAGAGATTCGATGGCGGCTCTGGAAGGCGCACGAAGGGTGGGGCGGGGGAGCAAAGAG GCCACTGGGTGACCCAGCCTGGTCCGGGGTGAAACGCTAGAGAAGGCGCCTCGCCTTCCTTATTTCAATGCAA CTCCTCGGCCCCAGACGGTAAAAATAGTTTCCAAGCTGCCGCGGACGCCCAGGATGTGTTTGCAGAGATCAAA CTGGGGAGGAGGCAGCTTTGTAAAAGTTGCAGAAAGATTAGCCGAGAAGCGTCCGCCCGGCGGGGCTCAAGAA AGCTTGGGGACAGCTCCATGTTCCTTGGGGCGGAATGGCCCAAGAATTGGCCTGGGTAACCCCCTGCCCAGTT CTCTGTCCTCACTTCGAGCCAGTGCTTAAATAACTTCCCGCCGCCTGCCCTGCAAACTTCCCGGCGCGGCGCC GTTGAGGCCAGGACACAGCAAAGGCTAGCAAAACCCCGCCGCGGCGCGCTCGGCCCCGGCCCTGAGAGGCTGC GCGGGTGGGAGGACCAGTGTGGTTTCTGCTCCCACTCGGCTGCCCAGACCCTCAAGACCGATCCCCCAACTCC TGGGAGCGGGTGCTTCCCTCTGGGAGCCGAGATCTTGCGGGGCCAGCGAGGGCGCAAAGTGCGCGCGCTGGCC CGCGCGGGGGCGGCCGCGCGTCTCTCCGCGGGGCCTGTCGCCAGGCCGGCCGCGGCGCGTGAGTGATGAGGGC AGAGAAGGGCGCCCATAAATCGCGGGTGTCAGGGCGAAAAACTCTCTTTATTGTCTGCGTGATGGATGGGCCC GGGGACGAGACACCAAATACTTCGTATCGCCTTTAAATGGGAACACATTTTCCGCGGCCATAATTCATGTTTT TTAAATAGAAAGTTTGAAATGTTGCCTATATTTCACCAGCCCTGACATATTTATGAATCGCTCCCTGCATGCA AATATCATTACTTAAAGCGCCGGGGAGAGCGCGGGGGAGGGGAGGAGGCGCGGTTCCCGGGGCGTGGGGGTGG TGAACCGGGGAAATATCGGTGGAGGGGGGCCATCTCCCTAAAGGGCAGAGGGTGAGGTGCGGTGAATAGCCGT ATCCGGAAACCGAGCGTGCCCCGGGCTTCTTTCCCGCCGCCAGACCCCGCACAGCCGCCCTGGGACGTTTTTC GAGGCTTGGGACCTAAGACGGGTCCCCGGACCCTGCTGGGAAACCAGGGGGCGTTTTTCGTCCCTCTCTGAGG CCATTATCCAAGCTGAAACCACCTTTTATAAGAAAAAAGTTTAAAGAAAAAAAATTTAACAAACACAAATAAT AATAATAACCCAACATGTTTCGCGTTCTTTGCCACTGCATCGATTTTATTGATTTTCATTCTGCAAACCTGGG AATGTGCGCGCTCGGGAGGGGAGGCTGTCAAAACCCAGTCATCGCGGGGACTGGATGGGGGACAATTCTCCGA CGCCGCGGCCTGGACCCGCCCCCACCCAACCGGCGCACCACCTCCCAGGCACCACGGAGCCTGCGCAAGCTGC GGGGCCGTAAAGGAACCGGCCCCCAATCTCCGGGGCTTCAGTCCCGCCCCTCTCTCCCCCCAGTGCCCTGCAG CGCTCCCAGGGTCCGTGTCTGCCCTCCCCAAGCCCCCACTGTCAATACAATCCCTGTTAAAAAAAAAAAATCT TTTTAGAGCCAGGCACGTGCCGTCGGCCTCTCCCCTGCCCGCCTGGCCCAGGAGGCGCCCACACCTGCGCCCT CACTTGCCGAGACTTTTACCTGTGCAGTCCCCGGCGGCGCCTGCAGCCGCGCAGGTAACCGAGAAATGGAAGG GAGGGCTGGGGAGTGAGAAGGACAGAGAGCACCGCCCGACACAACCAGACGCGCGGACCCGGGGCCTCCTCTC TGGACCGGTGCTGGGGCCCTGGTAGAACCAGCTCCGGGAGCCGAAATTGAGCCATGAAGAGTGGGCCGAGGGA GGGGCGAGGGGAACGGGCCTCAGGAGGGAGGGGCGGGCCCGGCGGCACTTCCGTTGGGGGTGGGGCTGCGGGC TGCCGCGCCGGTCCCGCCCCTCCGCCGCGCGGGCCCGCCCGCTCCAGGCCAGGCTCCGCCCCCACCGACTCGG AGCTGGATCTCAGGCCACGGCGCCCCCCCAGTCGCGCCCCCAACCCCGGAGGCCTCGGGCTGAACCGGGTTTC GCAGGAGGGCACAGGGCG CGI: 356 range = chr10: 88112905-88117344 CGTGAACGCCCTCGCCTCGCACCTGTGGCGCCTGCCGCGGGGCCCGACCGGAGGCAGTGGCTGTGGACAAGGG CGGCCCCGGCGTAGGCCAGGATTTCCCCGCAGCCGGACCGGCCCAGCTCCGCTCCTTTCCTGGGCGAACAGCG CCCACCTCCGGCCCAGGCGGCGGCGCCTCCGCCCGCGGCGCGGACAGCGAGAGAGAAACCGGCTCCTCCAAAC CTGGTGGAGGAGCGCTGCAGAGAAGCGCCGGGCTGAGGCTCTGGGGGCCGCGGGGCGCGAAACGCCGCGCCTA CCAGGTTATGCCCGGGAGAAGGAGACAGGTCGGGCTCCAGCCGCTGGGCGCTCCTCACCTCGAAGCGAGGAAA ACACCGGGCCACTGAGATCAGGGGAGGTGCGCCCGATACAGGTACCCGGCACGCAGACACGCCCACCCCCAAA CACCGAGAAACAAAGACTGCCCCGAGCCACGCACGCCTGCGCGGCCAGCGCTGGGCGCACACCCGCGCCCACA CAGCCCGAAGGGCGCCACGCAACCCGCAAGAACACCAGCTCCCCGCGCTCGCAGGCTCTCCGTGCCGGCCCGC AGCGCAGAGCAGTCCCGGCGCCGCTGCCTAGGTGGGCCGGGGAAGGCGCGCCACCGCGCATGGCACCGCGGCT GCCGAGGAACAGAGGGTGCCCTGCGCAGCCCAGCTCGTCCCAACCCCTCCGGTGCCCACTGCTGCGACGCCTC GCAGGCCGTGTCCCAGTGGGCCCTGGGCACAGCGGTCACTCACCTTCCTGCACAGCCTGGAATGGGTTGTTGG CCTCGATGACCTTGATGGAGTAGGTGATCTTCTCGCTCTGCAGGATGTCATCGTTGAGGCTCAGGTCGGATAC CGCCAACTGGAACACCCTGTCGTCCTTGGCCGCGTTCTCCTCGAAGATGGCACCTGGAGGAGAGAAGGGATCA AGACCGGACCTGGACAAGAACCCTCTCCCCGCTTCCCTTGGCCCGAGGGTCAAGGCACTCGCAGACCGATGAT TGCCGGGTGGTGGGAAGTCTGAACTGGGATTTCAGCTTGGCGGGGTAGATTAAGGCTCTCCGATCTCCACCTG CACAGGAATATGTTCCCCTCCCCCCACCAGCCCTCAGCGCACACGTGCACACAGTTGACATGAGTTACACATG CACATCCCACAGGCTGCCACCAGGTCACACACGTGTCTCACAACCAAGGCACCACATGTCCTAGCCATGCTCC ACACAAGGGACTAAGCCAAGCTGGGGTGGCCCCAGGCAGCGCCCAAATGCCTTGACATGGTTCCATAAATCCC ATCCCAGGAGCCAGGAAGTTCCCCGGGAGGGTGGTGTCCCCCACCCAAATCCCAGGACAGAATGATGGGTCCT TCTCCATGCACGTCCCCTGCTGAGTGGAGCTGAGCGAAGCAGGTCTACAGTTGGCTTTCCTGCGCAGAGGGGT CTTCCTTAGGCAGGGGCTTCGGATGGCCTGCAGCTTGGATGACTGTGACGCTGCCCGGCCTGGCGCCCTGAGC TCAGCCTCCTACTCTCCATCCTTCCCCACTCCCATTTCCTGTACGTCTGTCGAGGGGAGTGGGGGAAGGGGAC TTGTGTCCTAGGCGCCTCCACGTTCAGATCTAGCGGAGCTGGGGGTCCCAGAAGGAGCTGCTCTTGAAGGGCT TTCTAGAACCGCGGACAGCTCCTCCAGGGCGCCCTCCGGCTGGCGCTTTGTGCGCCTAGCACAGCTTCCACGG ACCCTGCGCTTCCAGCCGAGATCAGTGCGACCAGCCCGAGCCTAGTCCTGCAACCTGGACAGCTCTGGAGTCA GCCACCCACATCCCGCCTCACCAAGCCTCGAGGGTCCCTGAGGTCCCGGAGCTAGGCCCAGTGATCCCTCGAG CTGGGGGCTGGGTAGGAGGAGGGAGGCCCGGATTCCTCACTACACCCGGAGCCGGCGCCGCAATGCTGACCGC GAGACCCGCACCCCTCCAGGGCGGGAAGCAGGTTTGGTCACGGGCCCCTGAGGAGGAATCGTAGCTCTCCGAG CCCAGGCCTAGTCCTCACCACCCCACTCCACCACCCACCCTCCCGCCTTGTCCCGTCCTCCTCGCCTTCAACA CCTCCCAACCCCCAGTTTCCCTGTGCTCGCTGGTCTTTCCCAACTTCCGGAAAGACGACTGCGGAGGGACTCC CCCAAAGCGACCGCTGTCAGCCCCCCAACTCGGCCCAACTTCCCGAGATTCCTCCCGTGTTGCTCCCAACTCC CACCCACTCCCCCTCGGCGCGCCCACTCCCCCTCGGCGCGCCCCCTCCTCCTCTGCGCTTTCATCTTCTCTCC CGGTTCTCTCTCTCTATCCATCTCTTCCCGCTCAGCATCCCCCTACCCCCCGCTGCCCACGCTTCTTCCCTCG GCTCCCACCACCCAGACCGTCTGGGCCCCCAAGACTTGGACCACGCAAAACTCTAGGACTGTCCAGGATGGGG ATGCAGTCGCCACAACCAGATACACACGCACTCACACATACACCAAGGGCTACACAGACACACACCGGAGAAG CAGGCAGACACTGTGTCCACTCTAACAGGCTGACAGACAGTCGTGCACGCACCAACACACGCTCAGATGGCCC CACACACCCCAACACCCTCTCACAGTAACACCGACACCGTGCCAGGCGCACACAGCGACACACGCTGACAACA CGCACCCACACACATTCACACACGGTTCCGGTCCGGCCTCTTTGATCTTGCCCTGCCAACTTGGCGAGCCCCC CGCTGTACCTCCCCCTGCCCCCCGCTGCTCTGAGCTGCGCAGAAGGGCCCTCCCGACCCGCCGACGGCCCCGC TAAGGGCGCGGGTCTCGACGCGCGTCCATCCCGGTGTTCCCCGAAGCGTCGGCCCTAAGTGTCGGTAGAGGCC GCGGGGCCCCGCGCGGAGATCGGAGCCCCGGGGAGCGGCAAGCAGCCAGCGGGAGCGCGGCGCGGCCGGTGCA CAGCTCCTCCGCCGGGCGGCGCGGCGCGGCCCTTCGGGGGAGCACCGCCCGCCGAGCCCCTCGGCCCAGGGAA ACGCCAAGTTTGGACGCCGCGCACCCCCTGCCCCGTTGGGGCCCCCGCCCAGCCTCGGCCCGGCCTCCAGCCG CGCTTACCGATGTGGATGATGGAGTCGGCCCGCACCGACACGCACTGGCATATCCAGGGGAGAAGCCACAGCG TCAGCGCTTCCATGTCCCCCGGGCGCGCGGCTCATCCACCCGGGCCCGGGGCGAGGCCGAGGGCAGCGCGAAG CGGGGAGGCGCTGGTCCCGGTGCAGTCCCGGGCCGCTCCCCGGGAGAGCCGAGCCCGCCCGTGCGTCTTCCCC CGCGCGCCCGCCCCTGCGCCCTGCGCCCGCCCCAGCCCAGCCCAGCCCAGCCCAGCGCGGTCGGGCTCCCGCT CCGGCTCCGGTGGCGGCTGCGGCGGTGCTGGCAGCTTGAGCCCAGGCCGGCGCGGCGGGGGCGGCCCGCGGCT GTGGCAGCGGCGCTTCCCGCGGCTAGAGCGGCTTCGGGGGAGGCTGAGGCGGTGGCGGCGGCGGCCGGGCCGG CGTGGCGGCTCTGGGCTGGCTGTGTGTCTGAGCCCCGGCGAGGAGCGAACTGCGGAGGACGCCCCCTCCCCTC CCCCTCCCCCTCAGCTCCGCTCCCCCTCCCCTCCCTGCCCGCCTCCCTCCCCTCCGCCCGCCTCTCTACCACG TGACTGCGGAGCCTCAGCCTCGCCGCGCGGCTCTCGCCCGCTCGCGGCTCGGAGGGGGCGCCGGGTGCTCCAC GCTCCCGGCTCGGGGGACGCTCGGAGACCGGCACAGCGGCGGGGACCGGCCTGGGCTGCGGCGCGCCGAGCTC TGACGGTTCGGGCCTCCTTCTCCGGTTCGCCAGGGGCGGGAGAATGGAGGAGGGCCGGCCGCTAACTGCCCTC GAGGGGCTCCCGAAGCGCCCTGGCGACCTCAGCAGCCGCGCGTCTCGGGTCATGTCCCCGGCCGAAACAGACC GTTCCTCGTGGAGTGGGACCTGGGGAGCAAGAAGAGAGACCGGGGCGGGGCGCCGGGCCAGGCCCCAGGACAG CTGGGGAGCCAGAGGGGGCCGGCCGCCGCAAGCATCTCAGAGTAGAGCCCGGGCCGTGGGCTCGAACCCTGGC TGGCCGCGCGGACCTCGGCGGGCGCCCATCCCCCGCTCCATGGGCAGCGCGCTCAGCCGGGAGTCGGGCAAGA GGCTCGGACTCTGAAGCCCAATTCATGGCCGGAAACCAGCGCAGCCGTGACCGCGGCGCCTGGACGTGAGGAG CCTTCCAAGCGGCCGGCGGGCTCAGACTCCGACCCTGCACGGAGCTTTCATGTGCGAGCCCGGGCGAAGAGCC CGCTCCTCGCGGCCACAGCGGAACAGGGCTCCCTCCGCCTCCGGTGCCTGCCTCGGGCCG CGI: 34 range = chr10: 94441310-94441717 CGAGGGTTTGATGATGCGGCCCGAGCCTGGCTGTGGTCGCCTGTCGGGGCTGGAGCGGGACCCTCAGCCGGGC CGGGCCTGGGGGCTAACGTTTTCACAGTGCGCCCTGAGTTTCCTTGGGTTACTGCTGGGACCGCGCAGGAGGA AGCAAAGAGTTTTTCGAGCTAGACCAACAGGAAACACATTGACGGAAATGTTGCCATAGCCCATGGGGTGGCT TTAACTGGCCGCCCCCGCGGGCTGGGTGTGAAATCAGAGGAGGCCGCGGCTCCCCCGGCCAGGATTGGAGGCT CCTCGCGCAACCTAATGCGGGTGTCCGGGCCCGAGCGCTTCCCGCGCAGCCAGGCCTTGTCGGTGCAGCAGCC CCGCTCCTCCCCAACACGCACACACCCGGTGTTCGCAAGTGCG CGI: 182 range = chr10: 99068802-99071038 CGCGCCCGACTGCGGGAGCCAGGATCAGGTCCCCAGGGCGCCCTTGCAGACAGCACCCTGAGCGAAGGAGCTC AGAAGGCAGTCCGGCTTCACCCAGACCCCCAATCCCACAGAAGCGCCGTCCCCCAGCGGCACAGCACCCCCTC CCCGGCGCGGTGGTAGGGCCCGACGTGACGTCACCCATTGTTTACAAATCAACCCGAGCCGGCAGGATTCCGG CTCCCGCGGCTGCAGGCGCGCGGCTAGAGTGCCTGGCGGGCTCCGGCTTCCGCGTCCGCCCCGGCCCCGGTCC AGACTTAGTCTTCAGCTCCGCGCCCGCTCCGCCGCGGCCCACCGCGCCCGCCGGCAGCCGAGCCCCCAGCGAC GCCCGCACAGCTCCGGGTGCCCAGACAGGGGGCCATGCCGTGCCGGAGGGAGGAGGAAGAGGAAGCCGGCGAG GAGGCGGAGGGGGAGGAAGAGGAGGAGGACAGCTTCCTCCTACTGCAGCAGTCAGTGGCGCTGGGCAGCTCGG GCGAGGTGGACCGGCTGGTGGCCCAGATCGGCGAGACGCTGCAGCTGGACGCGGCGCAGCACAGCCCGGCCTC GCCGTGCGGGCCCCCGGGGGCGCCGCTGCGGGCCCCGGGGCCCCTGGCTGCGGCGGTGCCGGCGGACAAGGCC AGGTCCCCGGCGGTGCCGCTGCTGCTGCCGCCCGCGTTGGCGGAGACTGTGGGCCCGGCGCCCCCTGGGGTCC TGCGCTGCGCCCTGGGGGACCGCGGCCGCGTGCGGGGCCGCGCTGCGCCCTACTGCGTGGCCGAGCTCGCCAC AGGCCCCAGCGCGCTGTCCCCACTGCCCCCTCAGGCCGACCTTGATGGGCCTCCGGGAGCTGGCAAGCAGGGC ATCCCGCAGCCGCTGTCGGGTCCGTGCCGGCGAGGATGGCTCCGGGGCGCCGCCGCCTCCCGCCGCCTGCAGC AGCGACGCGGGTCCCAACCAGAAACCCGCACAGGCGACGACGACCCGCACCGGCTTCTGCAGCAGCTAGTGCT CTCTGGAAACCTCATCAAGGAGGCCGTGCGAAGGCTTCATTCGCGACGGCTGCAGTTACGTGCAAAGCTTCCC CAACGCCCGCTCCTGGGACCTCTGTCGGCCCCGGTGCATGAACCCCCTTCGCCTCGCAGCCCTCGCGCGGCCT GCAGTGACCCTGGCGCCTCCGGGAGGGCGCAGCTCAGAACTGGCGACGGCGTTCTTGTGCCTGGCAGCTAACA CGCCCGGGGTGGCCACAGCGCCAGCCTCAGACTGGAGGGCAAGGGGTTCCCTTGAGGGCTGCAGTTCTACTCA GGCTGGTGGAGAACTCTGGCTTTTGGAAGCGAGAGTAAAAAGCTAATGACGAGGAACCGAAAAATCGCGAGTG TTTCGCGGGTAACTGGGGTTGAGGGCCAAAATATTTGGAATGAAGGACTTTGGCCCTATTTAAGGCAGATTTT ACAGAGCGCACCTCAAACGTACAAGTCAGTAGGACTCCTTATTTGGCGTGACCCGACCTGGCCGCGGAGCCTG CATTTCCTCGCAGCCTCTCAGTGCCCTCCAGCCCCGCGACCATGTGGCCACAATCCACGCTTCTCCGGATCGC GGTGCGCCGGAACCACGGAGGATGATGCCAGTTACTTGCTTTACCTTTTCAGGGCTGGCTCCTGATCCACTTT GGGGGAGGAGAACATGAGTAGATAATTTCAGGGTGCAGCCCAATCTGCCAGACTTAAAAAAACCATCTTGTGT CTTTGGAGGTGCTGCTTAATACCAAACATGCGGTGCCATGAAGGGACCCTTTGGGGGTTGAATAGGAGTTAAC CCCTGCGCTCTCTTTGCAACTGTCTCTCTTCTCAGAGTGGTGGGGGAAGGCTGTACGACACGGGTGGGGAAAG GAGGTGGGGGCGGGGAGTATTGAATGGTGGTGGAAGGGTAGAGAGGCGCGGAGTGAACCCCACGCCCTGTCTA AAGTGTATTTTCAGAGCCGGCCCGCCTCTCCTCGGTTCAAGGTCACTGTTTCCTGGGCACGCACTGGGTTGCG GGACAGAGTAGCCAGGTTCTGCCGGTGCTCGGAGAAGAGCGCAGTGTTTTGCAAGTGCTGGAGTCTCCTGAGG ACACGCGCGTCGCCGCCACCGCGGGTGTGGGAAAGCGCGGACGTGCTGGGCGGCTGTGCTTCGGTAGGCGACC ACCGCCCCTGGCCGCGCTCCGGGCTTTCACGGAAACTCCCGAGACCG CGI: 56 range = chr10: 101277153-101277910 CGTGCACGGGCTTGGAGACGGGGCGCCAGTACCAGGCAGGGCACAATGAGGCTTGGGGCCCTTACAGTCGCTG CAACCTGGAGGTACCGAACCGGGGACTCCGACCTGACATGCAGGCGAGGCTGCGAGGTCCAGAGCCTGGACCT GGTTCCTAGGGAGCGCCACTCCTTCTGACCCCTGTGGCGTGCGTCCTGGCGCGCCGCACCCGCCTGGTGCCTC GGCCCTCTCTGCTGTTCCCTGGCTGATTCTGAGCAAGGCCAGCAGCCCACGGCCCCACCCGACCCCCACATCT CCGCAGGGTCAGGCGAGCCGAGCAGGAACTGCGCCGGGGCAGTGGTGATGGCTGGGCGTCCCTGCAGCTTCAG GGGCCAAGGGCAATCGGGGGGCTAGGCCCGCAGACCTGGCCGTCCGCTGACGCAGCGAAGGTCTAGCGGAACC TTGGGGATCGCTCTCCCAGTGCCGACCGAAGGCCCGGACCTCCAGGCTGGACGCGGCGAAGGCCGCATAAGAC GTTACTTAAACATGTTACTTAAACAAGACTGCAGTAAACGTTTCTTTCCAAGTGAGAAAGGTCTTTTTCGTTC TCAGACGGTTTGAAGGTGTTTGTGCCAACGTGACCCCCGGGGAGATTTGGAGGAAGCTTTCTACGTCCTAGGA GGCTGAGATCCCACGGAGCCGGTTTACGGTTGAGAGCAGACAGTTTCGAGTAGATAGCGCTGGAAGAGACACG AAGAATCTCTCTTGCTTCTTGGAACGCG CGI: 403 range = chr10: 102974173-102980053 CGCTTTAACTAGACGGGCGGATAAATGGCCCCGTTTCTCCTCAGCCCCGACGCGCCTGCTTAGCTGCGCGCCC CGCGGGCGCCGCAGCTCGGGTGGGCTCAGCCCTGGGGCCGCCGCCCCCAGCCCAAAGGGACCCAGCGGGGCCA GGCCCAGGGCCGCGAAGCAGAGAGCGGCCGGAGGTGCCAGGGCCGCTTCATTGGGATTCATGAGCGTGTTGGG CGGGCGGCCTGGGGCTTCGGGCGCGGGGCGGGGGCCGAGTGGGGGGGTGCGCACGGCGGGCGCAGATGCCCGG GTGACCGACCCGCCGTGGTCCCTGCGCCGCCTTTGTGCCGAGGAGGCGCGCGCGGGGACCTAATCCATCAAAT TGTCTACAAATTGTGAAGAAAATTCAAAAACCATATGGTCGCCAGCGCCGGCGCGCTCTGGGCTGCGGAGGGC CGCGGCCGTGCCCGCACCGGGAGCCGCGGGGGGCTGGGCCCGGCTATTGTCGCCTGTCAGCGGCCGCCCAGGC CCATTCGTCCCGGCCTTCATGGTCCGCGCTCCGAATTACAGACCCATCCATCCTAAGAGAGGGCAATTTTTGT CGCCCGGGAGGAACCAGCCGCACGCCTGCCCCGCTGCCCTGCCGTCTCCTTCCTTCTCTGCTCCTTCTCTCTC TTCTCCTCTCTTCCCATTCTTTTTTTCTCCCTCTGTCTCTGTCTCCCTTTCTCCGTTTCTCTGTTTCTCTCTC TTTTTCCTCTTTTTCTCCGTCCTGTCTCTGTGGCTCTCCGCTTTCTCTCTCTGCTTTTGGAGTGTCTTTCTGT GCTCCTATTTTTTTTTCCTGTTTCTCTCTGTCTCTTCGTTTCCTCCTGGACACGCACGTTCCTGGCTCGGGCC CGGGGGCCCCATCGCCGCCCGAGACCAGATGCGCATTTCTCACATCAATTTTGCGGAGAAAGAGAGCCCAGCG GCCCGGAGGCGGGACCCCACTCCGGTGACAGCGGCTACTCGCCAGCCCAGCGACAACAAAAGCCCGGAGAGAA ACCCGCTCTGTCCAGGAAAGTGAAAGCGGCCTCAGCCCCCGCCCCAGCCGGCCTTGGGGCGCCGCAGACCCGA GAGAGTCCTTGCAAGATCCATACCTCTGCCCCCAGCGGTGTGCCGGGGTGTGGAGGCAGAATTGGTTAATGTT GCCAGAAATTCACACCAGCTCCCAGACGCTTGGGCTTACAGTTCCAGGTGCCCACATTGAAATTCAGCCTGGC CTTGATGCCTTTAGCCTTTGGCCCCCGACTCCCCAAGGATGAGGCCCTCGGGGCTAGAATCGAAACTTGGGAA CCCAAGGCTCCACCCCGCGTCTGACTGAGTGATACCTGCAGCGCTCCCGGGGCTCAGCCCTGTTTTCGGGGAG TGCAGGGAGAATGCCCTTGGGTCTGGGGTGGGATGCAGGAAATGCAGGGCAAGACCCCCTCCCACCCTTTGTT CAACACAAATTAATGTTGTACTGTGGTGTGCCCCCACATACACAGGCATTTTCTCCCAGCATTTCACGGCTCG TTTTTTACCCCGACCTGGCGAAGCCCGCTTCTCTCCCGATTTAGCAGCTGCCTCAGGTTTATGGGCAAGAGGC GCCTCCTCCTGCTGCTTCCCCCTCGCCCTTCACTCTTAAGCCTGTCCTGAAAATCCCCCCCAAATCTCCAAGG CTAGGGCGACCGGCACGAAGAGCGGCAAGAAGCCCAGCCTGCCGCTGCTTCTCGGAAACGGGCCCACCACTCA GACACGGTCGCCGCCGGTTCTAGTAAAATGGCAAAGACTTTATTTATTGGAGAAAGAGGCCTTGGGTACAGTC TAGGGAGGAGAGGGGAAGGGAGGAGCAGGGAAGGGGCACTCGCAGCCCACTCACATCCAGCCACCCTCCTCTG GCCAAGTCGGGTAGGAGTGGGGTGTTCGAAGTGGCAAGAGAGACCCAGAGCTGTGGAGGAGGTGAGGTGAGGG CTTGGGTCGGCCTCCTCTCTGTCTCTGTCACATGCAAAAAAATTCTAAAAAGAGTACAAAATAATTATAGGGC TTTGGGTTCTGTTTTCGATAGTTGGTTGGTTGGATTTCCCCCTGCATTGTCCCTAAGAGCCGGACTCCAACAG TCAGTCCGAGGAAATGCGGGAGGGAGGGAGGAATCTTAAAAACAGCATTAGTGGGCATTAGGAGGCAGAAATG GCATCGAAAACAGACTTTTCTCTCAGAGGGTGGGGAGGAAAGATCGATTTTGAAACTTGCAAGTCAGGACCTG ACTGCCCACCTCTTCCCCTCCCACATGAGGAAAAAAGGCCCGAGGAAATAGAAGTCAACTGCAATAAGGCCGA GGGAGGCGAGGAAGGAGCGGGCCGGTGCATTCGCCACATGCAGAGAAAAATCAAAACAGCCGGAGCTGCCACT CCCCTAGACCGCAGGGTTAGTGTTCCCCGCCCTGGTTTCTGTCTCGCCCTCAGCAAACCCGGCAGCCCGAGAG CTTTGAAAACATCGAAATCTCCGAGATTTAAAAAATAATAATAAAAGAAAGGAAAAATCAGGCTGCGGTGGGA AGAACCCGCTATATAGGTTTAAATATTTATATAGAAGCCATACAGAATTGCACGGCGAGGGCTTCCGGGGCGG CGGAGGCCGCTGGTGGCGGCCGGCCCGGCCGGCCAGCCTGGGTTTATTGCTTCGAGAGGGAAGAGGCGGCTGC CAGGAGCCGAGTCCGGGGCCGGGGACAGGGGAGGAGGCGGGAGTTGGCAGAGGAGGTCCCAGCTCCCCTCGGC GGTCCGGTCCGGGAGGCGTTGGGCTTTCGAGCGCTAGGAGCCCAGGGCGGCGGAAGACCCGGGGCGCCGCTCA ATCGTCCACGTCGATCTCTTCGTCTTCCTCGTCCTCCGAGCAGTCCTGGCTGCTGGCCGGCTGGTCCGTGAGC GGAGAGGCAGGCGAGAGCTGCAGGGCGCCAGCGCCCGGGGCCTTCGGGGCGCCTGGGGGGAGGACCGGAGAGC CGGGCCTCGACTTGGCCCTGCCGCAGCCGCCGCCACCGCCGGCTGTGGCCTCCGAGTTCTGCTCGAGTTCGGC CAGCGCCACGATGTCCATCTGCCCGCTGGGGCCCAGTTTCTTGGCGGACTCTACGTCGGCCTTCATCTCCTCC AGGTCCCGCTTGAGCTTAGCGCGCCGATTCTGGAACCAGGTGATGACTTGCGCGTTGGTGAGGCCCAGCTGCT GCGCGATTTGGTCGCGATCGGCGGGGGACAGGTACTTCTGGTATAGAAAGCGCTTTTCCAATTCATAGATCTG GTGGTTGGTGAAGGCCGTGCGCGACTTTCGCCGCTTCTTAGGGGTCTGCCGCTGCCCAAAGATGGTCATACCG TCGCGGCCTGGGAGGAAAGGACAGTGTAGGCTCGCGTTGGGAGAGAGGAAGCCCACCCTGGCTCTCGCCCCCG TAACTCCGTAACCCACCCAGGCCTGTCCGGCCTGCAGTCTACCAATGTTCCCTTCTCAGATTTAATTCAGCCT CCAGGACCAGGGCAAGTCTTGGCTATGGCAAACCATCTCCTGTCTTTGGTCTCCCAGAAGTCCCTAGGAAAAA TTGTTTTGGTCTCTGCCCCCTACCTAAGAGTTGGTTTGAAAGACCCAAAGTCTCTAAGGGTATGAGAAAGCCA GACAGAGACACCCTAATTGCGGTGTGAATGTTGGTTCTCCATCCCTTCCCAATCACTTCAACTCTACCCTACC CATAAGGTCCCCGGCAAAAGACTCTCGATTCCCCACGCCGAGTAGCCGGGCTAAGAGCGCCCAGGACACTGGG AACGCAAGGGAGCCCGGCAAAGCAAGCAGACTGCGGAAAGAGCTTGGCCACCCTTCTCCTGCCACCCCCCAGC TCTGGCCTACCCAGAGGTCCCTGGGAAATAAGGATTGGGTCCCGTCCCACATATCTTCACTCCCATAAGCAGC TGCTCAGGCTGGAAGGCCCTGGCGGCCGGAGAGGGCAGAGGCGAGCAGAGGCATAGGGGACGAAGCGCGCAGG GCACAGGGCGCGAGGCGCTGGGTGCAGGGGAACCCAGCAGCTGCGCCTACCTTCGGCTGCCTGCAGAACGCTG ACCTCCAGCCCCTTAAACGTCTTGCTGGCGAGCTCCTCCAGCGCGCACAGCGGCGAGGTCTGCGAGAGCAGCG CGCGGCCCGCCAGGGGCAAGCCGCCCTGCGCGTGCTTGTCCGCGGCGGCCAGCAGGTGCGCCGCCCCGCACAG CGAGTAACTTCTCCGCACAGACGGCTTGTTGAGGATGTCCTCGATGCTGAACGGCGTCAGTGGCTTGTTGGAG TTGGCAGGCGGAGGCAGGTGGTCCAGCGGGCTGCGCCGCCGCTCCTCCCCCGGCGCCGCCTTGCCGTCCTCCT TGGAAGTCATCTCGGCCTTGTTCGGGGTCCCGGCCGGGGCGGCTCGGGCCGCGGGGACCCAGCCCGCGGGCAG CTCGGGCGCCGGACGGCGCGGGCAGGCAGCGGCGGGTGGAAAGGAGGCCGCACTGGGCAGGGCGCGGGCCGGG CGCGGGGCCGATTAGCGCGGCGGCTGAGGAGGGGAGAACAGCGCGGGGCCCCGGGAAGAGGGCGCTGACGCGG GCGCCGCTGCTGCTGGGGCTTCCAGCAATCCGGGGCCGGAGCCGGGGCGCGCTGCGCGGGGCTCCAGTTTCGC CAACCCCGGTGCTATTTAAAGGTGTCAGGTGGCTCGGCAGTGGCTCCTGGCCCCGGGTCCTGGCGGCCGCAGT TGGAAGAGCCGAGGCGAGGGCGCCGATCCCGGACTGCGAGGGAGGCGGAGAGACGGGGCAATTGACTATTGCT AACAAGTTAGCCTTGATCGCGGTGTAATCAATTATCTGCAGCGGCACTTCTTTCTCTTTCTCTCTCCTTTCTC CCTTTTTCCTCTCTTCTTTGCCTCTGTTCTCTCCTCCTGTTCTCGCTCTCCCTCCCTCCCTCTCTCTTCTCTC TTCTCTGCTCCCCCCTTCTCTCTCCTTCTCTCCCTCTCCCTCGCCCTCTCTTTCACTCTCTGTCTGTCCAATG CAGGCGGCTGTAAGTTGGGAAGCTCATTAATTAGCGGGCCGGGGGTAGGAGGAGCCGGCTGGAATTAGCCTGC CTAATGCGCCTGTCAGTCCGGGCGCTGCGCTGCGTTCGGCCCGAGCTGTTTGTAAATTACATTAGCTGCTCCT TTATTGCACCCGAACCTCGGGCGACTGAAAAGCCACCGCCCCCACCCCAAACTGCGAGCCGCGCTCCTGGCGC ACCCGCCTCCCGCCGGCCTAGCTGCAATGACCGCACCGGCCCGAAGGTCTCGGTCTCTCCGACCCGGGATGTG GAGCCCGAAAGAGTGGTGGGAACCCCAGCCCGGGAGGGACGCGGCCGCCGCTCGGGCCAGGTAGGACCAGGAG CCCGGGTGGGCCCCGCTGCCACCCAGAGTGGACTTTGCGGAGCTGAGATCAAGAGCCCAGCGCCTCTACCTCT GACCCTCTTGCCCCTCACCCCACTGCCTGGGCGACGCGCCTGGGGAGAGGGAATCTGAAGCCCTCCTGCGCTG GCCCGCAGGAGGTCAGAGCCGGCTGCGCAGCCTTGGGTGGGCGACGCGGGAAGGGGGTGGAGGACCCCAGGGG TTGGGGGAGGGGGCTAGTCGGAGAGCTCAGCCTTCTCCACGCGGAGAGGCGGAGGAGGGAATTGTTGGCGGCT CTGGACGCCTCTCCCCGGCCTGATTCCGAAGCGGCCGCCCTACCTCCTCCGGCAATCTTGCTCACTTTCCTCC GGCAGCCGCTCCCCAGGCTGGCTGGGGCCACCAACGGCCTGATGATGGGCGTCTGAAGAGTAGCCAGGCCAGG TGCCGGGGCTAACGGGGCCGGCTCCGTGCCTCCCTGCTGCG CGI: 295 range = chr10: 106389558-106392802 CGGTCACGAAGGATCTCAGCTGCACCAAGCGCGCAGGCTACACTCCTGCAGTAGCGGATTGGGGACCAGATAA GCCCACGCGGCTCCCGCCTGAGTACCCTCTTAACTGGCGGCCGACACTTTGAAACAATTGAGTCCGTTCAGAA ACGGACTGGGGAGAGTGAGGGCACGACCTCAAAATCCTAGGCAGCAAAATGAGGTCTGGATCCTCCCTGGAAG AACAGACATCTCGACTACTCTCTCGCCCCACCTCTGGCCGGGAGGTCGGGGCAAGGAGAATCCCTCAACCGAG AAGATCTGGCAAGTCCCCGATCCCACCGGGGCCTTCCGCCTCTTTTCCCTCATCCCCTAGGAGGCTTTATCAG GTTCTAACCGCTTGTAGTGGGGGCCGTGGGTGCTCGGGGCGCCAAGAGGAGGGGGCTGCCGAGAGCGGCCTGC CTAGTTCTCAGCATTGCCTCTTTGACCACTCGCAGGCTCCTGGAAATGCAAACACAGCCCGTGCGTGATCCGC ACGCGACCAAAAGCCGAGCGCACACCTCCCGCCCCCGCCCCACTTGCCATCGCTCACACTAACGTGCACACAT GCTCGTGCAAACGCGCACGCACGGAACCGCGCGCCCCCTCACACCCAGCCGCGCTCCCGGCCCGGCTCAGCCA GGTGCCCCCACGCGGCAGCGCCCGGTCTGCCCGCCGGCCCCCTGCGAACCCCTCGCCTCACGCCCGCCTGCCT GCGCGCACGCACGCGCACGCACGCATTCCCCACGCCCCCGCGCGGGGGCGCAGGCCTTGGGTGGCGGGGTTTG GCCGGGAGCCGGCCGGGCCAGGGAGCGGCGAGCAGAGTCCAGGGTGCATCCCGCGCTTGGCTTCCGTGCGCAG CCTCCCCGCGCGGAGGCACCTGGCTCCCTCTCGGCTCTAGAACGCGAACAGTTGGCGTTGAGCACACAACTCC TCCTCCTTCTCCCCCGAGACCCCTGTACCCTCCCCGCGCGCCATCTCCCGCCCCTCATAACAGGCCCGAAGAG TAAACCCCCAAACGCGTCCAGAAGCGGCTCCCAACTCTTCGCCGGGAGCACGTTGGAGGCTGGATTTCGGAGA GACTCGGGATTGGGGTCTATTGCCGGCCCCTCCTGGATCCGGCTTGATTTTCATATTTTAAGAAGATTTTCTT ATTACCTTTGATTACTCCTTTTTACCAAATTTCTGGAGGAGCTCAGTGGGGAGGATTGGGGGGAATCTGATTT TAAGAAAGAAAGCACCGAAGGGGCAATTATTAATTTTCCTCGGGTTTGGAATCACCCTCTGGACAAGAGAACG GGCGAGCGGGAGCTAGGAGGGAAGAGTGGAGAGGACCGGCGAGGCGCGCCAGCCGGAGCCACCTCCTTCCCGG CCGCCCCCTCCCCACTCCCCCTACACACACACGCTCGCTCGCTCGCCGGCGCGCGCACACCCCCCGCGCCGGA CCCGCACCTCGGCGGGCGCCACACACTCGGCAGCCCGAGCCGCGGTAGCCGCAGCGGGATGGAGGCGGCGCGC ACGGAGCGCCCCGCAGGCAGGCCGGGGGCGCCGCTTGTCCGGACGGGGCTCCTACTCTTGTCGACGTGGGTCC TGGCCGGCGCCGAGATCACTTGGGACGCGACAGGCGGTCCCGGACGCCCGGCGGCCCCGGCTTCGCGGCCACC GGCGTTGTCTCCACTCTCGCCGCGGGCAGTGGCCAGCCAGTGGCCGGAGGAGCTGGCGTCGGCGCGGAGAGCC GCCGTGCTGGGGCGCCGGGCCGGACCAGAGCTGCTGCCCCAGCAGGGCGGCGGCAGAGGCGGTGAGATGCAGG TGGAAGCCGGAGGGACATCACCGGCAGGCGAGCGGCGGGGCCGGGGCATCCCAGCTCCTGCCAAGCTTGGCGG CGCGAGGAGGAGTCGCCGGGCGCAGCCCCCAATCACCCAGGAACGCGGGGACGCCTGGGCCACTGCTCCGGCC GATGGTTCCAGAGGAAGCCGTCCCCTTGCTAAGGGTTCCCGGGAGGAGGTGAAGGCGCCGCGGGCTGGGGGGT CGGCGGCTGAAGACCTCCGGCTGCCCAGCACCTCCTTCGCGCTGACCGGGGACTCGGCCCACAACCAAGCCAT GGTGCACTGGTCGGGACACAACAGCAGCGTGAGTACCCACCCGGCGGCGGGTCCGCCTGTTTCCTGACACCGA AGGGGAATGGGGGGGTGGGTGGGAGCGAGGGACAGATAGTTGCTCGGGGGTCGAGGCGGGGGACGCCTCGACT TTTCGAGATAACAGGTTTGTCCGATTCCCCCCACGCCCCCAACAGGTTAACGGAGTTTGTTGTTAGACGCTGT GTGTGTTTGTTTACTGGAGACCCTAGGCTTCGGCCGCCGGGAGGGGAGTGGAGGAAGGGGCTTCTTAAAGATG AGTGGGGGAGGGATCTGTGCTCACTTTCTCCAATACTTGGCTTGGAGGGTCAGTTTTCCTGTTTGCGGGGTGC TTGAATTCTTGGATGAGAAAAAGGGCTGACTTGGGGCGGGAGCCGCTGAACAGACCGATTCCTGCGGCTGCCG GGCTCCCCCTACCCCCACCCCACCCCCACCCCCCCTCCCGTCACGCGAAAGGGAACCCGGAAGGCCATTCGGA CTCCCAGCCTCCTGCTCGCCTCGGGGTCGCTGCTATCCGCTCCAGGCGCGCAGTCCTCCAGCCCAAGAGGGAG GCTCGGCCAAGTCGGCCCCCAGCCTTGGCCTTCAGGTAACCCCGGTTCCTCCTTCAAAGTCCAGGGAGCGGCC CTGGAAAGCCGTAGCAGAGGCCGTAAAAAAAAGTTTAAAGCGTGAAGCGAAATTCCACACCCATCCAGCGCTC ATGCCACACCGCTCGCCCTCACGCACGCACAGGCACACGGAAGTCGCTCAGCAGAAAACTCTCGACTTCACCA TTGCGTCCTGCGCCACAAACGGCTCCCTGAGCGGAGTTGGGTGCCTGAGCTTCCTGCACACCTCTCCACCCGC TTTTCCCCGCCACCGGGTTCTCCTGGACAAGGATGTACCGAGAGGTGGCGTCGTTGAGCCCGGTCTGGCCTAC TCCGGCATTCCGAACTGGGCGCCCGACTGAGCATCGCGCCTGCCTGGCAGCTGCAGCGGCCCGCAGCGCGTGC CCGGAGGGGCTCCCCCTACCTCGCCGGCACCCAGCGCTGTGCAGCCAAGCAAAGAAAAGGCGGGGGACAGGTT CCCACCATCTCCCCGACTTCCCTCCCTCCCGCG CGI: 56 range = chr10: 124891898-124892607 CGGGCGCTCATTCTGAGCCGCGACGCCCCCTCAACAGGCTCCCGGCACCGCAGAGCCAGAGGCCACGCGGTGA GAACCCCAGTGCGTGCGCTCTTCTTGTGTGAGAGGCCGGAGGTAGAGTTGGGAGAAAGAGGAGCCGGCGAAAA GGTTAGTGGGATCTGCTTTCCCTTCTGCGGCCTTCTGGGCCAGCTAGGGCCTGGGAGATGGGGACCAGGGTCG GAGGCTTGGGGGCGGGAGGGCGGTGCTGCCGGCTGCTTCCTGCAAGCGGTTTGAAGAGGCATCGCGTTGTCCG GCCGCCTGCGCAAGGGCCACGCGCTGCTGCTTTCACCCCCTTGCGCCCGCGGGGCACCTGGACTCCCCTTAAG AGTCCCCGTGGGGCCTGAGCTTCTGCTGGGCGCTACGCTGCCCTCCACGATTCCATTTTGCCCCATTTACTCG GGTCGTCCACTTCCCGCGGCTCAGTGACCCAGCCAGGGGGCGTCTTCCGCTAGCGGTCCAAATGTAGACTCCG CAAAGAGGCTAAGAAGACCTGTCTACCCGGGTGCGCGCGATGGGGTCAGGGTGTAAGAACCAGGAGCCTCATA GAAACCTCTGCTTGGGGTCCAAAGCCCAGCCGGGCACTCCCAGAGGACAACATCCGCCCCCGCATGTACACGT GGCCCCGCAGGACCCAGCCGCAGGGCTCCCACGCTCGGCTCCCCGCCCTCTCG CGI: 32 range = chr10: 128863581-128864054 CGACCACTTCCGTATGAGGCACGATTCGTTGGCATTCTTCACCTGCAGCAACCGCTGTGGGACTAGGCTGGTT CCCCAGCCCCGGCGGGGTGTGAGTCTGCGACGGCTGCTCACTACATTCGGGGGACAGGCACTGCATCGGGGGT GAGCAGGCCAGGGCAGTTTCCGAGGGCGCCTGGAGCCCGTTGAGATGTGTGGCTCTCCTCCGCTCGTCATCTG CCGGGCAGAGTGACCACTGGCTGGCGGCTGCAGAGTCTGACAAACCAGGCTCGGGGGCCCTGGCACTGAGGGC AGGTGCGTAAACGGTGGCAACCTCCGTTTTAAACACCCTCCTGAGGGCAGGTGGAGCGGGCTCCTCGGAGTTT GGCCTCCCCCGGTCCTGCTTGGCCCTCCCGAGCAGCTGGTAATCGGGCTCTTCGGATGGAGGCCGAGTGGAGT TTTGGAGCGCAGCTTCTCCATAGCTGAGCGGCTCCG CGI: 38 range = chr11: 22319439-22319953 CGCCGCCGCCGCGGCCAAGGGCACCTGCAGAATGTGAGAGAGCCTGGGAGGTCTTGCAGCTTGGTGTCACCCC ACCACCCTAATCCCCGAGGGTGGGGGGAGGTCGACGGCCCTCCTCCCAACCCCGACGGGTCCTGAAAAATGGG AATGGGTCAGCATCGGGGGTACCTAAGCCGCCAAGTCCTTGACTCGCCCCTGCTCTGCCGCGCAGGGTGCTGG AGAAGAAGCAAGACACCGGGGAGACAATCGAGCTGACGGAGGATGGGAAGCCCCTAGAGGTGCCCGAGAGGAA GGCGCCGCTGTGCGACTGCACGTGCTTCGGCCTGCCCCGCCGCTACATTATCGCCATCATGAGCGGCCTGGGC TTCTGCATCTCCTTCGGTATCCGCTGCAACCTGGGCGTGGCCATTGTGGACATGGTCAACAACAGCACCATCC ACCGCGGGGGCAAGGTCATCAAGGAGGTGGGCAACGTCTGGCCGCCCTGGCTCCTGCCCTTCGGCCATGCGGC CTCG CGI: 98 range = chr11: 31776637-31777992 CGGGAACGTGAAGCGAAGCTCACCACCGGTGCCCGCTACCCCCACGCCGGCAACTCTGTGCTTCGTTTGGCCC ACGTGTCCTCCCCACGCAACTAGGGGCGACGGTCCTGTGCCTGAGGTGACAATCACCCCCCAAAAACCTCACT TGCGGGTGGGGGGGTGGTGATTGCCAGTTGACCCAGAATTTTCTAGCAACTAGGCGCGTTAAAGTGAAAAGCC CCTGGACTAGCTCCACCTCCGGCCCCAACCATCACAGGCGGACCCTAGCTGATTTGACTCTCACTTCCCGCCC TCAGACTGCCGGCGACGAAAATCCGCCCGAATCGGGCGCCACCTCTGGTGGAAGCTGCTGTCCTCGGCTTCTG CCCAACTCCAAGAAGCGGAAGGGGGGTGTATCCTGCGCCCCAAGCTCATGGGAGCCCACGCACCGGGGAGAGC CCGGAGTGGAGGCTCTGGGCTCAGCCCTCCCAGGCCTAGGCCACCGTGCCCTGAGTCCCTCCCCAAGACTTCT CGGACTAAGTGGGCCAGACTCTTGTCAGGGGAGGGATCACCAGGACCTCAGATTGCTGGGGGCGGAGGGGTGG ACGCTCGTGAGTGCGAAGTTCGGGTGTCACTTGGGTGTGTCCAGTGTCTACAAGTGGGAATCCTACGGTTTCA AAAGTCAGGCAGGGATGGGGTTGCCTACACTCGGTGGGGTCAATCGCTAGTCTCACCAGAGGCGGGAGCGGGC CTGGGGGCCCTCTGAGCTCGCGGAGGCGGCGGGTTCGGGGCCCGTGCGGGCGGGGTCGCCCAGGGGAGCCCGG GCCCCGCGCGTCAGGAGGCCTCCGCCGGCCGAGCGGCCGCGCTGGGAAACAAGAAGCGAGCGCTTTGCTCCCT ATCTTCCCAGTGTCCGTCCTATATTGTTTTCTGCTCTTAAAACTGACATGTCTAATTGGCAATTGGTGCCGAA TCGTGTCCAGAGGTCTCTTGTGGAACATTTCTACAGCTGTCTCCTTCAACTAGACGCTTATTCATGTCGCCTT AATGAGAAACAAAACGTTCTCTAATGAGCAATTACAGAGCGACAGGATTGTTCCCATAACAAATTCTTGCGAG TGACAGAAGCATCCTTTGTACCAGATATTTCGCATACTGTTACCGATTTTCCCTTCCCTCGCCCGACTCCATG GAGGCGCCGGGCATCCGGAGCCGGTCCGAGAGCTCACGGATGCGCCGGCAGCCTCCTCGCAGTCCCGCGCGCC GCCCCTGGCCCCGAGCCCCTCGGCTCCGTTGTGCTCCTGGGAGTGAGACGCCACGTCCCATTATCCCGCATAT TATCTCCTTGTCACGAGGACAACAAATACCGATTAATCTTCG CGI: 61 range = chr11: 68274244-68274755 CGGACGCCCGGGTGGGAGGCTCCTTCCAGGACCCAGGCGCCCAGGGGCAACACCGCCGGGCTGCGGTGCGCGG GTAGCAGCGAGGACAGGAAGTGCACGTTGCAGGCGGGCGGCTGCGGGGCCTGCAGGAGCGCGACGTCCTCCAG CGCGCTGAGCTCTGGGATCCCGGGGTACTCCCCGAGGAGCTCCCCGCCGTCGCTGTCGCCCCCCGCGAGCTTC GCCTTGACCTGGCCCTTGCAGTCGGCGCCCAGCGCGGGGTTGAACGCGTGCAGGACGGGTTCCTTGGGGTCCG CCGGGCCCAGGTACGCTTCTTTGAAGACGTGGAACTCGTCCTCCTCGTACTTCACGGGGGCCTTCAGGCCGAT GTTCTCCGAAGCGAACGGACCCTCGGGGCTTAAGAGCTCCGTCACCATCGCATCCTCGGGGCTGGGCAGCCCG CCCGGCAGAGGGCCCTCCTCCATGGCGCAGGGCGGCGGGGCGGGATGGCGGGGGCCGCGCACCTGCAACACGC G CGI: 269 range = chr11: 117983446-117987106 CGGACGGGACGGGGGACGGGGGCGGGGACTGGCGGGAGGGGGGCGGGACAGGCTCGCTCTCCTCCTACTTAGC GAGCTCCCGGGGAAAAGCAACGGTGTCCTCCTAAGCCTGAGGCCACCGCGACCGAGCCGAGCCAGGCTAAGGG ACCAGTGTCTCCCTGCCCCCCCCCCACCTCTAGGTAAGAGCGCCCCGTCCCACTACACTTGCGGGTCCCATTC GCTGCGGTGCTAGGACTGGATAAGGGGAAGTCCCCGGGGCCTGGCGAGAGCCCTGAGATCAGCTCTAGGCTAG GGAGCTCGGCAGAAACCCGTGGGGGAGAGAGGGCACCCCAGGTGAGTGCGTGGGGGCGAAAGGAGCGTTATGG GGAGTTTTCCTGTGAGCCTCTTGCTTTTGCCTTCCTCGGCCGCTGCCAACGCCACCGCCAGAGGGGGCCGTGA CGCTCTCCCCCCCTTGGAGAAACTCTGATCCTGGCCCTATCCAGACTCTCCCGCCGGCACCCAGGCGGCCGGG CGGACACTCGCGGGGTATCGGGCGGCGAGCGCGCGCGCGGGTTTTCGTCCTCCAGCGCCCCACACCTCCCCCT CTCCGCCCACAGCAGGACCTTGGGGCGGGGGTATCTCCTGTGACGTCTCCCCGCCTGTCCCCAGGCCGGCCGC CTTGATGGACCAGGAAGGGATTCGGAGTCCGGCTCAGAGTCTTGAGCGTCTAGGAGGGCTGCCTGGGGGTGTC CAGGAGATGGGAAGCCCGCCTGGGGCCTCCCAGGCACTCCCCAAGGCCCCACGTCCTCGGGGGCCGGGGAGGC CGCCTGGGGCGCCTTGCCACGCCCGCGCGGTCCCTATTGGAATCCCTAGCGGAGTTCCCCGAGCGGAGGCTGA CCCAAGTCATCCGGGCTCCCCCGGGATAGGGAAGTGCGGGCGGGCGGCTGGGTAGGGGCGCCGGCGCAGGGTG GCCGAGTCGCCCGCTAGCGCTTCCGCCGAGGCAGGCTCGAGTGGGGACTTGGCCGGGCGACCGCACAGCCCTG CCGGGGACCCACGGCTCTGGGGCGGGGCTGCATTCTGGGCCGTTAGCTCAGCGGTCCTGGAGCCTCCCGAGGC TGACTCATCGGGCGGCGGGCTCACCCCCCAGCCGTCAAACGCAAACGCAGGCGCCCCACCACGCCGGGCTCCC ACGCGGCACACACGCACGCCTCCGCGACACTTCGCACACCTACGTCCCTGCGTCACGCCACCCAGACACACCC GGACCCGCCCACACGCCGAGGCCTTCCCACGCACTCCATGCCTTACGCCTCACAGGAAAGCGCCCCGCGCTCA CGCAGCCCCTCACACCCGCAGCCCCGCTTACACGCGCCCCAGCTCACACATGCACCCCAGTCACACAGCCTAC CTCACACACGCACCCCAGTCACACACACAACCCAGCTCACACACGTACCCGTCACACATGAGGCCCCAGCTCA CACACGAAGCCCAGCTCACACACGCAGTCCCAGCTCTCACACACACACCCCAGTCAAACACGAGGCCCCAGCT CACACACGAAGCCCAGCTCACACACACTGCCCCAGTTACACAGCCCAGCTCATGCAAGCAGCCCGTCACACAC ACAGCCCAGCTCACACACACAGCCCAGCTCACACAAGCAGCCCGTCACACACACAGCCCAGCTCACACACACA GCCCCAGTTATACACACACAGCCCAGCTCACACACGCAGCCCGTCACACACACAGCTCAGCTCAATACACAGC CCAGCTCACACACACAGCCCCAGTTACACACACAGCCCAGCTTACACACACAGCCCAGCTCACACACACAGCC CATCACACACACAGCCTATCACACACACAGCTCAGCTCAATACACAGCCCAGCTGACACACGCAGCCCAGCTC ACACATACACTCCAGCTCACACACGCAGCCCGTCACACAGCCCCAGCCACACACACAGCCCAGCTCACACACG CAGCCCAGCTCACACATGCAGCCCCCTCACACATGCAGCCCCAGTCACACACACAGCCCAGCTCACACCGCAG CCCCAGCTCACACACGCGGCCCCTCACACACATTCAGCCGCCCTTCCCGCAGCTGCCAGGCTCGGAACGGGCG GTGTCTGTGGGGGCCGCCCCGTTTCCCGGCCGCGCAAACAAGCGGCTCCTTCTCTCTGCCCCGCCAAAGAAAG GCCGCTTGTCAGGGGCGGGCGGGCAGGCGGCAGCGGCAGGCGCCCAACACTGCGGCCTTGTCCCACGCGGGCA GCCTGGGCAGGAGCAGGCCGAGGGGTGCAAGGGGCCGCTACCTTGCGGAAACCTCCCTCCCTCGGCCCTGCGG ACCGCGGAGAGGCACCTTTCCACCACCGGACACCCAAGCAACAGCCCTCGCTCCATCCGCGCTCTCCCGGCTC CCCCTCTCCTCGGGCCGCCCATCTCTCCTCTCTTCCGCCTTTGGGGTCCCGGTGGGCCCCAGCCTCCCTCTCC TTCGCCCCATCTCCCCGCCCGTCAGCCTCCCCTCCGCTGCCCTCGCGCATCCCCAGTGTTCCCGTCTGTCGTC GCCTCCACTTGAGGACCCGCCTGTCCTTTCTTCCCCCGACCCCTCCACCTCTGTGTTCTTCAGTCTCCCCGCA TCCTCTGCCCTCGGTCTTCCCCTCCCCAGCTTGCATTTTTTCCCATCTCTTAGTCTGCCTTTCATTTTCCCCT TCACATCCCGGTGGCTCCCCTTCCCCGCCCCGTCCCTCTGCACACCCCCATTCATCTCTGTCAGGTTTTTCTC ATCCTTAAGTTCTCTCGTCCCCCTCCCCACTCGGGCGTCCCCCGCTGGGCTCCCCGCCTCAGTTTCCTTCCCT TCCTGACTCCTTCCTCTGACGGCGGCCCTTTCTCGAGGGCGGATGTGCGCCTGGAGGGCGAAGGCGGCGGCCG AGAGGACCCCAGCTCGGCCTGGCGGGCCTCTGGCCACAGCCATGCACCGCTTGGGCCGAGGCCGAGGCCGACC CCCAGGGACACAGGTGAGGCCGGGCGACCCGCGGGGCTCCGGGGAGCGCCCGAGCAGTGGCCCCGCGAAGGGC CGGGTCTGGTGCTCTGGGGCTGGCTTTGGACCTCTCGTCCTGGGACTCCGTGGGAGCCCGGGAGCTGTGTCAG TGCCCGTTGGTGCTGGAGCCAGTCGGCCCTTCCTTGGCCTCCTTCAGGCGGGGGCCAAGACCCCCGAGAGTTC ACTCTGGGTGCTCCACTCGGCGGAGAGGGCTTCAGACTGGTGTCCCGCGTGGCTGGGGTGTCGGCGCATTCCC GCGGGGGAGGAGGCCGAGGGCCCGGGCCGGGGTCACCTGCCGGCGCCCCGGCCTTGCGCACAGAGGGCCTTGC CTGTCGCTCGTCAAATCCAGACACCTGGGCCTCCGCCACTCGGCTGCCGGGGCGGCACTGGGGCGTCTGTACC CAGCGTGCGGGAGGGCACCCAGGGCCGGACGCGCACCGCAGGGGTCTTTTTTTGGCCGCGGGGCCGGGCGGGC GGGTAATGACAGCCGGGTTGCTGGGGAGCCGCGGGCCAGATGGAAGCGGGGCCGCAGGTGAGGGACGTCCCTC GCGTAGCGCCACTCAGCCGCCGGGGCCAGAGCGGGAGTCAAGGTGAGGGCGCCCCCAGGTGGCCGCTCTCGGC CGCGGCGATCG CGI: 97 range = chr12: 1844001-1845219 CGTGCGGGTGACTCCTCTTCCTGCCGACAAGGTGGGCGATGAGAACGAGGAGGCCCAGTCCCACCAGGGCGCC GCCGACGGCGATGGGGATCGGCGTGTTGTTCTCGCCCAGCAGACGCTCCTCCGCAGATCCGAACTGGTTGCCT TCCACCTTGAAAGCCTGGCCCCACACTGGGAATATGTTGATTGAAAACGCCTTCGTGCCGCGGACACGCTCCG CTCCGGCTGTAGAATTGCCGATGGCTGCCCGCAATGCTCGCAGGGAGTCGTTGGCAGCTTTAAAAGTGGGGTC TCTGGGGTCAGGAAGAGTCGTATTCAGCTGGATTCCTCGTAGGAAAATCCGGCTAGAACCTGCATTCATCCCC AACCGGAAGCCCAGGACCGTGGTGCCCTCGCCGCGCCGCTCCCGGGTCTCCAGGTGGGCGCCGCGCTCCCGCT GGCTGAGGTCATGCCCAGGTCACCGTCGCGTGGTCCCTCCTCTCTGGGTGAGGTTCAGCTGCAGTCCCGCGCT GGCCGGCAGGCAGGCCCCGTGGGTGCCGCTCACGCTGTACCTGGCCACGGAGGGGAGAAGGGGCTCTCGGCGC CGTGGCGGGGAAGGCGCGTCTTGCTCGTGGCGCGTCTCTCCCTTGCTGAAGCTGCTGTTGGAAATCTAGGCCT GGATCGGGGCACCGCGGAGCCTGATGGTCTCGCTGTTCGTGCGGACCTGGGGGCCTTGATATCTGGTAGAGAT TCCACAGTCCTGATTTCCTTGGAGCTTGCACTGAGGAAAATGTGTGTGTCTGACAAGTTGTAAACAAAACTCA TGAGCTGGACGCTGTCACGTGTCGCACTTCTTGTGAAATGGAAGGTCAGTGTCTGTCTTCCTCCAAAGCACAA TCGCGTGCCTGGGGTCGGAAGTGTTCTCTTTACTGCAAGAGCCACTGTCAAGCACTTCCGCATTGGATGGCAG GTCAAAGGTCACATTCTTAGAGCCACTCTTAGAGTCGTAGTTCATCGAGAAGGCAGCGAAGCTGGCCATTACG CAGGCTGTCCCGTTGCCCTTTTTCACCGCATCCGCTGCGGCTGCACCACGCACGAGGCCCAGCAGCAGCAGCA GCACCAGGGGCAGCCGGGGGCTCCACCAGATGCAGCCCGGGCGGCAGGCGCGAGGGGAGCCGGTGTGTGGGGA ACCGGGGCGCGGGGAGGCGGTTGCGGGGCGCTGGCCTGAAGGACGGTGGCG CGI: 16 range = chr12: 40253533-40253742 CGACGGGACACGGTACATCACAAAGAGACCCGTGCGAGACCGAATCCTGAAGGAACGTGCCTTAAAGATCAAG GAAGAGCGGAGTGGCATGACCACAGACGATGACACCATGAGCGAGATGAAAATGGGGCGCTACTGGAGCAAAG AGGAGAGAAAGCAGCACCTGGTTAGGGCCAAAGAGCAGCGCCGTCGCCGTGAGTTCATGATGCG CGI: 79 range = chr12: 52726910-52727810 CGTGTTCCCGGGCGGAGGTGCGCGCAGCCACCCCAGGCTGCTGCCAGGTGCCCGCTGGGGCTGCCAGGGCGAG GAGGCCTCTGGGCTGTGGAGCGAAAGTCAGATCCACCGCCTACTGCGGGGTAGGGGCCGCAGTGGGGACCGCC AGCCCTGTGGTCCCTCTCGCGCTGACTGGCGTAAAGTTGTGGCCGAATTCGCATCTCTTCTGGTGCTTCTCGC CCGCCAGCGCAGGGCCCAGGTGTTTGAGGCGAAGGGGCTCTAGCTCCCCGCAAGCCTGGAGCCAGGCGTCGCG CTTCCTCCGGGCTTAATCCAGACCTTTCAACACACACCTCATTCGGGGGAGGAGAAAAGCACAGGACCGCGGA GAGCCCAGCTTTGAGGCCAGGCCTGAAGGGATAACCCACACAGGGAACGTTTTCCTATCAGAGAATAATGGAG CACAAAATAATTCAGAAAGCGAATGGGCAGGACCACAGCCTGAGAGTCCCGCGCCGCGGGGCCGCTGCAGAGC CGGTCTCCCGAGCACCGCGGCAGGACCATTTCGTTGGAATGTAGGGCGAGGCCGAAGCCCGCCCCGGACCCAG GCCGCGAGGTGCGCGCCGGCCGCCGAGGGGCCGCCTGTAAATTACAGCCCGCCGGGAGGACTCGGAAATACAC AAAAGGAGCCGAAAGATTTAAACAGTCGGAGGCAGAGGCGTCCCGAGGCGGCCAAAGCGGAAATCAATCACGT AATTAAAACAGGGAGGGGACGAAGCCCAAGGCTGGGGGTCCCGGGTTCGGAGGAGGCGGCCAAGGTGCAGGCC GAGGCTGGCGAGCGGCTTAGGGACGTGGCTCGCCCGCCAGGACCAGAGCGCGCGGAGGGGCTTCGGGGAAGTT TATAACACATCGCTATTGATTCCCG CGI: 32 range = chr12: 79634857-79635257 CGGAGCGACAGACTAGGGAGCTCCGCCCGGGATTTGCCCATCGGCGGAGGCGCCAGGCTCCCGTTTCTCCCCA TCCCTCTCGCTGCCGTCCAGGTGCACCGCCTGCCTCTCAGCAGGATGGACGTGATGGATGGCTGCCAGTTCTC ACCTTCTGAGTACTTCTACGACGGCTCCTGCATACCGTCCCCCGAGGGTGAATTTGGGGACGAGTTTGTGCCG CGAGTGGCTGCCTTCGGAGCGCACAAAGCAGAGCTGCAGGGCTCAGATGAGGACGAGCACGTGCGAGCGCCTA CCGGCCACCACCAGGCTGGTCACTGCCTCATGTGGGCCTGCAAAGCCTGCAAGAGGAAGTCCACCACCATGGA TCGGCGGAAGGCAGCCACTATGCGCGAGCGGAGGCG CGI: 30 range = chr12: 95164929-95165298 CGCGGTGGAGATCAGCCGGGAGAGCCTTCTGCTGCAGGACAGCGACTGCAAGGCGTCTCCGGAGGGCCGCGAG GCCCACAAACACGGCCTGGCCGCCCTCAGAAGCACGAGCCGCAACGAATACATCCACTCAGGCCTGTACTCGT CCTTCACCATTAATTCCCTGCAGAACCCACCAGACGCCTTCAAGGCCATCAAGACGGAGAAGCTGGAGGAGCC GCCCGAAGACAGCCCCCCCGTGGAAGAAGTCAGGACTGTGATCAGGTTTGTGACCAATAAAACCGACAAGCAC GTCACCAGGCCGGTGGTGTCCCTGCCTTCCACGTCAGAGGCTGCGGCGGCGTCCGCCTTCCTGGCCTCGTCCG TCTCG CGI: 35 range = chr12: 113609113-113609535 CGCGCGAAGCAGAGAACGAGAGGAAAGTTTGCGGGGTTCGAATCGAAAATGTCGACATCTTGCTAATGGTCTG CAAACTTCCGCCAATTATGACTGACCTCCCAGACTCGGCCCCAGGAGGCTCGTATTAGGCAGGGAGGCCGCCG TAATTCTGGGATCAAAAGCGGGAAGGTGCGAACTCCTCTTTGTCTCTGCGTGCCCGGCGCGCCCCCCTCCCGG TGGGTGATAAACCCACTCTGGCGCCGGCCATGCGCTGGGTGATTAATTTGCGAACAAACAAAAGCGGCCTGGT GGCCACTGCATTCGGGTTAAACATTGGCCAGCGTGTTCCGAAGGCTTGTGCTGGGCCTGGCCTCCAGGAGAAC CCACGAGGCCAGCGCTCCCCGGACCCCGGCATTAGGCGCCAGCTGCCGGCTATCTGCG CGI: 121 range = chr13: 35817738-35819004 CGCAATAATGCTGCGTCACGAAACTGCGCATTCCAAGAGAAACTTTTCTCAGGCCCAGAATTAAGTCGGAGGG ATCCGCCGCGCAGCTCAATCCCTAGGAAGCATGAAAGAATGTATTGTAAAGAGTAAAATCACGCGCAATCCAT CCCAATATAACCGCAGTTGTTCGTGGGCCTTCTTGCAGAGAAAGGCTGCCCAACCTTGACGGGGCCATGGGCG CTGCGGGAGGGCAAAAGACCACAGAGATCTGCGAAGCCAAAGTAAACAACGGGGTTGGGGCGGCGAGAATGAT CAATAGCGATGCTCCGAAAGGACTCCGCGATAGGAATCGAGCGGGAAGGATTCCCTCCATCCTAACAGTCCAT GGGTTAAGAGGCCGAAGCTTCCCTAAATACCACACTCCCGCGAGAGAAGGGACTGAGAACAACTTCTCAAACT ATTCTCTCTCGAAATCGCTCCCTTCCTCGAAAATTCCATCTCTGAGACTCGGATGAGGTCCCCACCCCCTCCA CCCTTGTCCCGTGACCGTCGCCCGCTCAGCCTCCCAGCCGAGTCCGCGGGGCCTGGGGCGCCCACCCCGCCCA CCCAAGGGACCGCGCAGGGGTGAACTCCCCCGCGCCCCACCTGCGCCTTCCAGACCTCGGGCGCCCCGGCGTT GCCTCGAGAGCTCCCTGCGCGGCCGCCGCGGCACGGACCAGCTCCCACTCCCTTACACTGGGCGCCGCTGCGC TCGCCGGGGGCCGGTCCCGAGGTTCCCAAGGCCTCGCGCGCGCGCTTGCCGTGGCAACCAAGACGTTCCACGA CGCGCGCTCTCGAACGCTTCGCGTCACGCGGCCGCGCGGCCCCGCCCGTCGGCCTCGCTCCCGCCACAGAGCC CGCAGCACGCCGCCGCCGCAGCCTAGGTCACGTGAGTACCCACGCGCGCGTCTTGCCAGCGGATTCATCACCG GCCTGCTCAGACTAGGTTCTGCCCACTCTGACCTTCTAAATGGTACGTGGGAGGACGTCCGTCCCCTTCGGAC CCAAGAGTCACCGTAACACTCTAGAAGGGGAGAAAAGGAGCGAGGGCGGCAGGCGACAGAGAACCTCGCGAGT CAGCGGCCCCGCGCAGACCCCCCCAGGCACGGTCCCCTGCGGCCACGTCGGCTGCTCGGCGCCTGCGCAATCT CTTTCTCTCCAGCGAAACCGAGGCCTCCGGAGAGCCTAGTAGAGAGTGTGGGCAGTGAGCGCTTGTAGCCGCT AGAGGGAGCGCTGGGCACAGTGCACG CGI: 58 range = chr13: 57101588-57102323 CGCGGCATGTTCGTACCAGCGCGGGCAGAAACGGGCTCACGAGCGCCCTCGAATTCACACACACTCACCGAAA TACACATCTCAGCCCGTGGAAGCGCATTCACACACACCCACGTACACTCCTCCGCACCTCATTCAGATGGGTC CACGCGGAGTCAGGGCTGCGCTTCCCTTGGCATGGGCGTGTGTGCGGCGAGGGCGTGTGTGCGTGCGTGTGTG AGAGTGTGTGTAGAGAAACCCTTTAGGCAGACCGCAGCTACGTTATTCTGCAAGCATACTGCGATTCCCGATT CCGTGTATGTAGGACCACAAAAAAATTAAATCGCTGTTAAACTTTTTTTTGTAAATTCTCTTTTCCGAAGGAA GGCGCTGGAAGAGCTACTCCCGGTGGTTAAAGGCCCGGGAGACCTGGTGGCGAATCCTGGGGCGCGTCCGCTT TGGCGGAGCGCTGGGCTCCGCTAGCCGGACTGGTTCCCCATCTAACTGATCTAATCAATGACTCCGAAGAGCC GGGGCTCCTGGCCCCGCCCCCGCCATCCTCTTCTCCGCCTCCCATTGGACGCGGGCCGAGAAGGCAGGGCCTT GCTCCTCGCTCGGATTGGCTGACAGGGAATCAGTATCAATGTTTAAGCGGCGGCGTGAGGTGAATAGAGTCAG TCAGCAAGAGACGCTGGGGAGAGAGCAGGGATCGCGAGCCCGGCGGATGCGGCAGCGGCGGAAGGCGGCTGGG GAGACG CGI: 30 range = chr13: 105943410-105943788 CGCCGGGCTCTGCGGGGGCATCTCCTGGACGATGTACACCGGGTGCCCGTAGTCGCCGCTGACCTTCTCGTAG TGAGGGCAGAAGACGCTGTCCGCAGTCCTTAGCGGGATGATAATGTCACTGGGCTCTGAGCCGTTGTTGTTGC CGCTGCGCTTGGGTGTGGCCAGTGTGCTGAGCGACAGCGTGGTCGTGTGCTGCGGCGAGTGCTTCCTGTGTCT CCTCCGGTACTTCAGCAAGAGGACCACCAGCGTGATGATGATGACGATGAAGATGATGCATCCTGAAGCAATC CCTGCAAATAAGGCCACTTCGGAACCGAGGATGTTGTTCCCCGAATGTCCGGCGCTGTTGCCGTCTGTGCTAG AACCTGCAGACGCG CGI: 74 range = chr13: 111763361-111764235 CGCTCCCAGCCGGCAGCCGCTCTGGGCGTGCACCCGCCACGCGAAGCCAGAGGTTGGACGACGCAGCCGGCCA GGCGCGGCTCCCGGGGGACCCCGAAACCGCCTGTGGCTCAGGCCCTACTTGGCAAGAAGAGACTGGGGAGTGA GAGGAGGGGTCACTCTTGCTCTCTCGCACAATAGACTTCCCGCAGGCGAGTGCGAACGGCCTTTTGCTTCCTC CTTCTTTTCCAGGACCCTTAGCGACAGGAGAGGAAGAGAAGCGGCCCGGCGGTTTAATTGCCAATTTCCTGAT GCAGCCACAGGGCCCAGCAGCGGCTCAGCCTAGGCCACCGGGTCCAGGCCTCTAGGCAATAGGCCCGGCGCCC CCTCCAAGCACCGTTTCCCGCCGACCCCGCAGTCATCACTGTGAGCTCGAGAGTATGGGCAGCCTGTGGTGCC CTGAGGCGCCGGGCGCTCGGCGCATCCGCCGTGCCCACAGCGCTGAGGACCAACTAGGGCTGCCCTCGGCCAG GGGCACTGTGCCCGTTTGAGTGGCACTCGGACCTGGCGAGGGGTGGAAGCCCAGGTAGAGCTCGCGTCTTTAA GAGCCACCCGACAGAACTGCGCGCTACATCTGCGCCAGCTGGGCTGGGTGGGAACAGCGCAGAAATACTCCCG TGCCGGGGCGTACAGGGCAGGTAGGCCCAGCAGAGAGTCTTCTCGGAAAGTTTCCCACAAAAGAAGGGCCGGG CAGGCCGAGCGGCAGGAAAAGCCGGTGCTCAGCGGCGAGGCCCGAGAGGTCTGGCATCCGGCGGCCTCCCAGC TTTGCTCGGGTCTCCCGCCGCCTCTCTCCAGAGCCGCCCGTAGCTCCGTGGGGCGGAGGGCGCAATGCCCCG CGI: 28 range = chr13: 112249708-112249928 CGATTCCTATCGAATCAACACGGCCATTAAGGACAAAAACGGGCAGGACACAAAAGCAAGCCTGGATGGCGCA CCCTACAAACGAGTTCTGAAACAAAGCGAGTGCCAGACGCGCGTGGGAAAGACGCGCGTGGGAAAGACGTGCA TGGGAAAGTCGCGCGTGGGAAAGTCGCGCGTGGGAAAGTCGCGCGTGGGAAAGACGTGCGTGGGAAAGACGCG CG CGI: 87 range = chr14: 19992581-19993863 CGTGACGTAAGTCCGCCGCGGGTTCGCCAGCACCTTGCCATCCCGCACCACGCCCACGCCAATCTTATTGGCG CTGCCTTCAAAACCCAGCACCGCCGGCATGGCGGAGGCTGGGAGAAAACGCCGACAGGACTCCTGGCAATGTC AGGAGCTGTGGAGGTCCTCACTAGTCCGCGCTGGGCCGCAGCTTTCCGGAGCGCAGAGGAAGCTGGCCAGCCT GCAGATAGCACTGGGAAAGACACCGCGGAACTCCCGCGAGCGGAGACCCGCCAAGGCCCCTCCAGGGACCTGT CTTCCTAACTGCCAGGGACGCCGAGCCAACTCTGTGCCTTACATTCGTATCCGTTTTCCTATCTCTTTCCCGT GGTCCAGCCCAGCCTTCTCCACTGTTTTTTTCCCTCTTGCACATAGTTAGAATCTTAAGTCAGTGTCACACAA TGTGCTGTGCATCTGGCACAACGATAAACAGCCCGAGGGAGGGTTGGGGACCTAAGTGTCCTAGAGAATTAGA GGAGGGAGGCGAGGCTAAGCGTCTCCGTCACGTGGTGTCAGACAGACCAATCACGCGCATTCTTCGGCCACGA CAAGCGCGCCTCTGATCACGTGACCAGGTCCGCTACCCACGTGGGGGCTCAGCGTGCACCCTTCTTTGTGCTC GGGTTAGGAGGAGCTAGGCTGCCATCGGGCCGGTGCAGATACGGGGTTGCTCTTTTGCTCATAAGAGGGGCTT CGCTGGCAGTCTGAACGGCAAGCTTGAGTCAGGACCCTTAATTAAGATCCTCAATTGGCTGGAGGGCAGATCT CGCGAGTAGGGTACAAGGCACTATGAAATGATCTAGTTTCGTGGGTGAGGGGCTGAAGGGCCTATGATGCACG GAGGCGGGGAAAGGATTTAGAGATAACGTGGTTTGAAAGGCGGGACCTGGTGCGGGGACGCTCTTGGGAGGAG TCTTCTCCCCAGCCTTAGCTGGTTTCATGATTTCTTTGCGTCTGTAGGCAACGCGGTAAAAATATTGCTTCGG TGGGTGACGCGGTACAGCTGCCCAAGGGCGTTCGTAACGGGAATGCCGAAGCGTGGGAAAAAGGGAGCGGTGG CGGAAGACGGGGATGAGCTCAGGACAGGTAAGGGAATGAAATCAGCCCTTCTTCCTAGAAGCTGCGGCGGGGG TGTTTGTCATTCCCTTGATGTACGGTAAGTACGGGCCGACTCATTTTTGCAGGGGTTTGTGAAGAAGTCGCAG GAACCGTAGGCTTTCGTTGGGTCTATAGTTAACGCCGGATCG CGI: 79 range = chr14: 23710894-23712060 CGCCTGTTACTAGAGGCGAGAACCGGAGCCCATTGGTCGGAACACCTCACAATGGACCCCAGCGGCGCGCAAA ATCCTTATGATTGGTTTGCTGGCTGCCTCGGGAGACCCTGTTGCCAGGATACTTGGCGTTCCCGACCCGACCC CCGTTCCCCATTGGCTGTCAGGGCAAAAGCCGCCATCTAATGAGGAGCGAGGTGCGGTGCCCCGAAGCGCTCG CTTCCCGCGGTGCGATCTAGTCCTGCAGTAGGCGGCCCGGGGCCACACCGCGGCCGCCCAAGCCAGTGCAAGG CCCAGGGGCCTGACATCGCTCCCAGCGCTCGAGGACCGAGGCCTGCTGTGGAGGACACCGTGCTCCCTCGGGA CCTGCTCTGGATTCCGGCCCGGACGTCCCCTTGGAGCTCTGCATCTCCAACCTGGAACCCAACCCAGAAGTCT CAAGTTTGACGCATCACGTGGCGTGCGGATCCACTGAGGGTCCACAGAGAGGGGCGCCCATCTCCTGCGTCTC AGTTATCCTGGTAATTGTGTATCTGCCCATTGTTCGTTGCCTCATTAACTTGGCTTTCTAGGTGCACCCACCT TGCCACCAGAGAAGTCCAAATCCTGACTTCTCTCCAAGGTGTTGGGAATTCTGTGCCCTAAAGAATTCCGACT CAGATCCGAACGGGGATCTGGTGGAATCGAGGGTGAAAGACCAGAGGGACAATGTTCTACTATCCCAACGTGC TTCAGCGCCACACCGGCTGCTTTGCCACCATCTGGTAAGGGCGGGGCCCGTTGGCGCGCGATGGCGGACGCTG CCCGGGATCCCAGCCTGACAGCTCCCCCTCCATCCCCATTCTCCCACCTTCCCCACCCACTTCAGGCTGGCGG CGACTCGCGGCAGCCGGTTGGTGAAGCGCGAATACCTGAGGGTGAATGTGGTGAAAACCTGGTAAGGCCCAGA AAAGGGAAGGAGGGCCTGGTGCGGGGGGTGAGTTAGGGGATGGGGTGGCCAAGACTGTGGGCCCACTCCTGGA CGCAGCGGTAATCAGGGCGCATTGTTCCCCAGCGAGGAAATCCTCAATTACGTGCTGGTACGAGTGCAACCCC CGCAGCCCGGCCTGCCGCGGCCCCGCTTCTCCCTCTATCTCTCAGCCCAACTTCAGATCGGTGTGATCCGCG CGI: 23 range = chr14: 28317076-28317375 CGTAGCGACGACGTGGTCCTTGTAGGACCAAGCATTCTTGGCATTCTGTCGAGATTGAGATTCCAGAGCATCG GATGAACGGGACTTATAGCTAAGGCGTACTCACCCACCCCTCCCTTCGTCTTTTTACGCACGCAGCAACTCGT CCTCACGTGCATAGGGGTAGTGGACAGTGTTGACTTGAATTGCTGTCCCTCGTTCCAAGCCTTTCCTGTGAAT GAACCCGAAAACACTCGACAGGTCGTGAATAATCGTTTTAATGAGTGTGCAAAGCGTGCGACGGGGTGCACCG AGCTGTCG CGI: 147 range = chr14: 33338698-33340189 CGAGAACTCCAAGTCCGACGAGAAGGGGAACCAGTCCGAGAACAGCGAAGACCCGGAGCCCGACCGGAAGAAG TCGGGCAACGCGTGTGACAACGACATGAACTGCAACGACGACGGCCACAGCTCCAGTAACCCGGACAGCCGCG ACAGCGACGACAGCTTCGAGCACTCGGACTTTGAGAACCCCAAGGCGGGCGAGGACGGCTTCGGTGCTCTGGG CGCGATGCAGATCAAGGTGGAGCGCTACGTGGAGAGCGAGTCGGACCTGCGGCTGCAGAACTGCGAGTCACTC ACGTCCGACAGCGCCAAGGACTCGGACAGCGCAGGCGAGGCGGGCGCGCAGGCCTCCAGCAAGCACCAGAAGC GCAAGAAAAGGCGGAAACGGCAAAAGGGCGGCAGCGCCAGCCGCCGGCGCCTGTCCAGCGCGTCGAGCCCAGG CGGCCTGGACGCGGGCCTGGTGGAGCCCCCGCGGCTGCTGTCCTCCCCCAACAGTGCCTCGGTGCTCAAGATC AAGACGGAGATCTCAGAACCCATCAATTTCGACAATGACAGCAGCATCTGGAACTACCCGCCCAACCGGGAGA TCTCCAGGAACGAGTCCCCCTACAGCATGACCAAGCCCCCCAGCTCTGAGCACTTCCCGTCCCCGCAGGGCGG CGGCGGTGGGGGTGGCGGTGGCGGGGGGCTGCACGTGGCCATTCCCGACTCGGTCCTCACCCCGCCCGGCGCC GACGGCGCGGCCGCCCGCAAGACTCAGTTCGGCGCCTCGGCCACCGCGGCCCTGGCCCCCGTCGCCTCCGACC CGCTGTCACCCCCGCTCTCGGCGTCCCCGCGGGACAAGCACCCCGGGAACGGCGGCGGGGGCGGGGGCGGGGG CGGCGGCGCGGGGGGCGGCGGCCCCAGCGCGTCCAACTCCTTGCTGTACACTGGGGACCTGGAGGCGCTGCAG AGGTTGCAGGCGGGCAACGTCGTGCTCCCGCTGGTGCACAGGGTGACCGGGACCCTGGCCGCCACCAGCACGG CCGCGCAGAGGGTCTACACCACGGGCACCATCCGCTACGCGCCCGCCGAGGTGACCCTGGCCATGCAGAGCAA CCTGCTGCCCAACGCGCACGCTGTTAACTTCGTGGACGTTAACAGCCCCGGCTTTGGCCTCGACCCCAAGACG CCCATGGAGATGCTCTACCACCACGTGCACCGGCTCAACATGTCAGGACCGTTCGGCGGCGCAGTGAGCGCAG CTAGCCTGACGCAGATGCCCGCCGGCAACGTGTTCACCACGGCCGAGGGACTCTTCTCCACGCTGCCCTTCCC CGTCTACAGCAACGGCATCCACGCGGCACAGACTCTGGAGCGCAAGGAGGACTGAGGCGCCGCCCGTCCTGGG CCCGGCCAGGCCCCGCTTGGAGGAGGCATCGTCGGCATTTTCGTTTAGACCTTTAATTCTAGCACTTTGAATT CGAGCAGGTCAGCGTCTTCTCTCGCCACGACG CGI: 22 range = chr14: 36122289-36122589 CGCCCGGCCGCTGCCGATCTCGGAGCTCGGAGGCCGAGCTCCACAAATTTGGGTCCAGGCCCGCTTTAGAGCC CCTGGGCGGGGGCGCTTCTCAGGGCATCCTGTGAGGGCTTTGAGGCCTCCTTGGAGTCGCCAGATGAACTGGT GCCGCCTGTGCGCCTTGGCCCCATAGCCTCAACGGCACTCTCACTGCCTGGGCTTTGGTCTTTGCCCAGGAGC CTGCCCATGGCCTACGCTCCCCGCTCGCAGCATGGCAGACCCTGACGAGGCTGCCCGCCTTGGTCCGGGAATG GACCGATCG CGI: 123 range = chr14: 37137198-37138958 CGGGGCAGGGTACCCGCGAGGGCAGGCACGTGGCGGCTCCTGCGGTGTCCCGGGTTAAACTTGCCTGTGTTTA AGACGGGTCTGCGACAGCTTGGGGCGGTCCAGGTCGCGGGGAGGGCGGGCTCCTCAAGTGGGGGATCCGCGGC AGTGAGGACTGTAGGGTGCGCGGGTACTCCGGGTAGCCGCCAGCGGAGGAAGCGGCTCCGCCCTTCCCGGAAG CTGCCCTTGCTACACCCGTGGGGCCTGCTCCCGGCGCAGTCCCGCAGTACCTGAGCGGCACTCGGTCCTTTGA CCACGCTTGGCTGCCTCAGCTTACACTTCCCAGCAGGATCTGGCTGGGAGCCCCTTCCTCAGATATTCACCAG GCAGGTAGAAGCAGAGGGAGACGACGGCGAAAGGTGGAAGGAGAGGCCGCGGCCTCGGGCCTCGGGCCCCGGG CCCAGACGGCGGCCTCTCGCGGCGACAGGGTCCTTCCTATTTAGCAGGACCGCAGGGTTGGCAGACAGCAGGG CCTGGGCCGGCGGGGCTCTGCGGTGCCCATTCGAGTCTCTCCAGGGCTTCCCTCTGTGGCTGTCCCTCGCCTG CCCCCTTTCCTTGCCTACCCTTCCCTGGACGGGGTTGTTGTCAGGTGACGGCTTCAGCAACCCAGCCATGCTT GGTGTGGAGTGGTTCGAGTTCCTCCGCGGGCCCCCACCCCCCACCCAGATAAGAAGCTTAAGTCCTCCTTCTG CAGGGGAGAATCGGATGCAATGAAACTAAGACCTGTGGTCGTTAACGCGGTTCAAAGCCGACCCCAACTGGGA CACGGCTCAGCTTAGAAGTGAGGAAGGCCTGGGACGCTGGAAACAAGGGGTCACACGTGCGTGTGCCTGGCCT TCGCAGGTGGATGTGTGCGCCGAGCTGGGGAAGGGGCCAGGGAGCCGCGAGACTGCGGTCCCCCGCGAGAGAG AAGTATGGGCCTGGCCAGGGTTCGAACTCCGTTCCTTCGCTGCCTTCCTTTTATTTTTCTTCCTCATCTTCCT TCCTCTCTCCCTTGGTTCCATCATTAAATCTTTAAGGGATTAATTCACAACTCTGTAGTAGGTAGGGGCCCTG GGACCACTTGACGGGCCTTTGCAGGCAGTTCTGTACAGAGTCCTAACCCGTAACGGGCCTCAACCCCGGCTGT GTGTGCGTGTGCTTGTGTCTGTGTGTCTTTGTGTGTAAAAGCAACGCATAAACATACCCAGGGCTTTCACTTA TTTTATTGAAGCAAACAAACAAAAACAGCCACTGGGTTTGTCTTTTCCCCTACTCCTGCCTGAGCGCCGCCGG GTTTCTGAGCTGCTCCGGGCGCGGACCTAGCTCACCCGCAGCCGGATGTCGGAGCCGGAGCTGCTCCCCACCC GGCCTCGCCCGCGGGCGACAAAACCGTCCCTCTGGCCACGGGAGAGCATCGCCTTGCCAAAATCAACTCGCAT TTTCATGTATTCAAATGAGAAAGACTGAGAAGGGCGATTTCCCCTGCTGGGCAGTCGACAGCGTTGGAAGGAA GAAGTGCCCCCTAGGGCCTCGCGGAAACGGGAACAAACCTCCCTCGAGGCCCCCGGAACCGATATGGCGACCC CGCCCAGACCTGGGTCCCCGCGGCCGCGCGCGTCTCCCGCCGTTGTGGCCCCCGAGTTACTGACTTTTGTTCA CACCGGTCAGCGCCTGTTGGAGGACGTGCTCAGCCCCAGCCGGTCCCTCCTCATCCAGCCGATCCCCCTCCTG GGGAGCGCG CGI: 20 range = chr14: 56347822-56348040 CGGGCCTCGAGGATGCGAGTGTGAGGTCGACAAGATATCGTGGAAGAGAGCGAACGAGGGAGGCCCCCGTTGG AAACAGTTTCTGTGTTAGAACAAACGCCACCAAACGACCGACACTGCGAGGCCTGGAGCTACCTGGGCTGGCG CCGCCCGAGCCCCGGGCTGCGAGCCCAGAGGCTGGGAAGTGATGGGACCTGGGGGCCCGAGCCGGAGAGTGCG CGI: 178 range = chr14: 60045486-60047933 CGGCGGGCGCTGTCGAGCACGGGGAGGTGCTGAAATAGTCCTGGCGTGCTGATTCAAGCTTTGATTGGCAGAG CCACCCGGTGACTGACAGGGGGTCTCCATGGCGCCCGCGCCGCCAATCCGCCCACCCCAATAGCGGAGCCAGC TCGCCTGCCGGCGTGCCTGAGCCGAGCCGAGCCCGAACCCCAAGCCGCGGAGCCAGCACCTCCTCCAGTCGGG GTCGTCCGCTCCCGGCCGTTGAGCCACCGCCGCCACCCGGTAGTGTGTCCCGCTGCCCCAATCCGCCTCATCA ACAAGCGCCTGGCACACTCAGCCAGGCCCGCGGGCATCTGCTGCGTGTCCCGCTCCGGGCTCAGTGCCCTCGC CGCCGCCGGCACTGCCTCGATGTTCCAGCTGCCCATCTTGAATTTCAGCCCCCAGCAAGTGGCCGGGGTATGT GAGACCCTGGAAGAGAGCGGCGATGTGGAGCGCCTGGGTCGCTTCCTCTGGTCGCTGCCCGTGGCCCCTGCGG CCTGCGAGGCCCTCAACAAGAATGAGTCGGTGCTACGCGCACGAGCCATCGTGGCCTTTCACGGTGGCAACTA CCGCGAGCTCTATCATATCCTGGAAAACCACAAGTTCACCAAGGAGTCGCACGCCAAGCTGCAGGCGCTGTGG CTTGAAGCACACTACCAGGAGGCTGAGAAGCTGCGTGGAAGACCCCTGGGACCTGTGGACAAGTACCGAGTAA GGAAGAAGTTCCCGCTGCCGCGCACCATTTGGGACGGCGAACAGAAGACACACTGCTTCAAGGAGCGCACGCG GCACCTGCTACGCGAGTGGTACCTGCAGGATCCATACCCTAACCCCAGCAAAAAACGTGAGCTCGCCCAGGCA ACCGGACTGACCCCTACGCAGGTGGGCAACTGGTTCAAAAACCGCCGACAAAGGGACCGAGCGGCTGCAGCCA AGAACAGGTCGGTACCTAGAGGCCTCCGCGCTTTGAGCGCACCGGGGAGGAGGCGGGTGGAGGCACCTCTGGC GCCCTTACCCAGTCCCTGGCGACTCCAATTCAGCAGGAGTTGGGAGCGCGGTCTGTCTTGGGTTAAGAGCCCT GCGTTCTGGGCTCCTGGCCGGGAGTTCCCTTGCCGGCTCTGCTTCCCCACCCGCTGGCTCCCCACGCCTGCGG GCAGCTGCAGCAGCTGGTCCCGGTCACCAAACCAAGGCTTCACTGGGACGGAGAGGGGAAGAGAAATAAAAAA TTAAAATCCTACAAACAGTTAGGGACCCCAAGACCCAAAGCTAATTCTTGTCAGCCTGGGCACAGGCTCCTAC TATTAATCGAAGCCTGGCTTATTAGCAATGTGTCGGTTTCATGTTAATTATCATTTTCAAAGCCCAGGTATAT CCCTCCCTAATGCTTTGAAAACAGTTTTCAATGGACTTTTGAGAAATGGGAAGTCGAGTTTTCCTCTTCCCAT GCGCTGCCTGCCACTCTTGTCTCAAAACAGCAAACTAGTCCGTGGGCCGAGGCTTTTCGTTTCCCGGAGTGTG GATCTCGATTAGCCAAACATTTTGCGGAAGAGCCCGGCCTCATCCCCCAGGCCCAAATGCTCCTTACAATCCT TTTTGCCTTTAGGTCGGGCCGACCCGATCCAACGCGATCGCGGGAGCACTTGCTCAGGCGTAAGCCCCAGGCA GACGCACCGTTAGAAATGGTATCCCATGTCCCTGGGACCGATCTGTCCTTGTCACCCACACTTCGTTTATTTC CTGACAGTCCTGTAAATCTCCCAAAAGTGCACAACAAACAGGGAGGACACTGCAAGCCCAGTATATAAAAGAC CTGGGAGCTGCGGCGCTGAGAAAGGGCGCGAATCATGGTGGGGCACAACAGTAGGGACCCGCGGAGGGGCGGC CGCGGACTCCTGCCCGACCTCTGTCGCCTTGCCGAGTAATCCTCGCCTTAACTGCTGGGGTCTTCGGAAGAAC CTCTAGCCGCCGGGCTGGAGGGACGCAGGAGGTGGTGGGGGCGGGCGACGGGCGGCTGTGTTACGAGCTGTGA CCCGTGTTCCCTTTCTTCCCCGTAGACTCCAGCAGCAGGTCCTGTCACAGGGTTCCGGGCGGGCACTACGGGC GGAGGGCGACGGCACGCCAGAGGTGCTGGGCGTCGCCACCAGCCCGGCCGCCAGTCTATCCAGCAAGGCGGCC ACTTCAGCCATCTCCATCACGTCCAGCGACAGCGAGTGCGACATCTGAGTTGCCCATCCAGGATGCTCAGAAG CAGATTCCAGTGTAAAAACGAGAAAAACAAAATGAAAGAGGGGAAGAAGATGAGAGACCTGCAAATCCAGCGC CACAGAAGCCAGGTGACCAGGGACCCGCGGGCTCGGGTTGCCGTTTCCCGCCCCACCCCGCGGCCGGCCTGGC TTCACTGGCGCCCTTTGGCCGCGACCACGGGAACCAGCG CGI: 54 range = chr14: 60173732-60174416 CGGCTAGGCTGCGCCTGCATCAGGCGTGGTGATTGGCAGGCGCCTACGGCCCACGCAGAGATGGCCGCGTGGG GGTCGGAGCGCCAACTTCTCAGCTCCCCTTCTCCCATGACCCTCACCCCCCACACCATCTTCAGCCGCCCACT GGGAGCTTCCTCCACCCCTACCCCCCAGTGCCGGCGAGGCCCCCTGGCAGATGGAAGCTGCTGACTGATGGGG GCTGCCGAGCGCGAGGGAGCTGAGTGAGGCCCTTGCGCCCTAGGCGGTTGCACCCCGGACCCCTGCAGCTGTG GACGCCGGAGCTGTGCGCAGTCATCCTGAGCCAGCCCGCGGGGCCCGATCGGAAGGGACGCCTCTCCTAAGAG CTGGCCTGGAGTCCTGGAGCCTCCAAGCGGGCAAGTAGGGGCCGCAAAGGCTGGGCTGGGCCTCCGCTGAGGC CCTCGGGGGCCTCTGGGCCCTCATGGCCTGGAGGCCGCGCGGCCCAAGCCCCTAGAGCAGAGGCCGCGCTAGC CTGCAGGGGTCGACGCAGGGCCGGAGGCAGCGGCTTTTCCTTCCCACTCCGGGTTGACCCTAAAGACACGATT TAACGTGGCGGCGGCAGCTGCCCACGCTGTCTGGAGGAGCAGGGCGCCTGGGATGCGGCGGCGAAACTGGCCC GGAGGGGGGCCCAGGCCTCACGCGCCCG CGI: 133 range = chr14: 98781593-98783184 CGGAGGCTCCTTCCGTCCCGGCCTCACCTGGATCCCGGGAACCGCCCGCTCTGTCCCGCCAAGGTGGGCTGAG GAAGACGGCGCCACTCATCAGGGCAATGGCGGCGGGCGGAAGAGGGATCCCCGTGCGCCCCCAGCACCCGGGA CGAATGCCACCCCGGCGAAGCGACCCGACCGGCGCGCACGGTTTCGGGGAGGGGACCACTTCCACATTCCCCA TGCCCGAGAAGGTCACCCACCCGGGAGAGCGCCCAAGGGCCAGAGAGGAGGCGACTGGTGGAGGAGGGGCGGC CCCGTGCGCACAAAGGGGCCCGGGGCCGGCAGGCTCCCCGCCCTTGACCTTGGGTCTCCGCCTCCATCCATCT CCGCCGGCTGCCAGGGAAGGGGGCTGGCCCGGGGCCAGAGGCGTGCTCGCTGGGCTGCTGCTGGGCTGGGGAC CGACGGGGGCGGGGGGGAAAGGAGCCGGGAAAAAAGACTCCAGGGCTGCAGAGTGCTCCGAGGAAGCCTGCAT TCCACCACCTTCAGGAGCCGGTCCCGAGGCGGCTCCGATTCACTGCATGCCCCCCGCCCCCCAAAGCAAAAGT TGCACGGATGCACGAGGGAAACCCCTTCCCAAAGCTAGCCCTTCGACTCGCCCACCCCCCGCCTTCCTCGGAC CCAGGCCGAGTGGGGGAGGGGAGTGTCAGGGGAGGAAGAAAGGAGCGCGCCTTCCCAGCGAGGCCAGACGCGG GCTGGGTCAGCTGCGCCTCCGCCCGCCCCTCGCCGCCCGGCTCAGGCAGCTGCTCCATTAAGCCCCCGAATTA TGCATGGACCTTGAGCCCTCTCGGCCCTCCCGCCCCACCAAGGCACAATCAACGTGCGCAGCGGGCGCGGGTC AAAGAGAGAGGGAAGGAGGTGGACGATGGGCGCAAGGCCGTGGGCGAATCAGAGGCCGGCGGCCAGGCGGGGG CCAGGCGCGCCCGCAGGCCTGGGAACAGTGCCGAGGAGCCTCCCGACCCGGCCAGGGCCAGCCGGGAAAGGGG CACCGCTCGCAGGGGAGGCCCCCGCGCAGTTTTGAAGTTGCCAAAGTGTCCGCGCCGTGCCGGGTGCGGGGTC CGGGAGATGCAGCCGCCCCCGCGGAGCTCTGCGCCCCTGGCCTCGGGGAAGGCCATTGTGTTCTCCTGTGTGG CAATGAAGGGGGCTATGGACCCCAACCATTGAGCCCTTGGAGGGAGGGGCCTGAAGACCCCTCGGGCAGGGCG GGGGAGGCTGTCTTGCGGGCGGCGGAGAGGATGGGTATGATTTGCTCGGGATAGGCACCGTCGCGGGGAGGGG AGGAGGCCAAGCTTGAGGAGGGGCTGCTGGAGATGGAAGGAAGTGAGAGGAGACTTGCAAGTTGCAAACGTCG GGGAAACCGGAAAATTGCAGTAGCGGGGAGGCAGGTGGCGCCCAGAGGTTCGAAAGCAGAATTGGGAGGACTT CGATGTCCACCTCGCAGACAGTGACCCAGGCCCCAGAGGGCTCCGCAGCCTGGAGCCTCGCGTCCCGCCTCCC CGCAACACGCTGTTTTCAGCGTTCCAGACCACAGCGCTGCAGTCTACGCTGCCCTGACG CGI: 248 range = chr15: 50867751-50870991 CGCCAAAAGAATGAGCGCGGGAGGGGGTCACAGCAGCCAGTTCGGCCAAACATCGACGCTGCTCCGGCACGCT CCAGCCCAGCGCCTGGGATGTGTCAGAGGTACCTGCGAGGAACATTTGCGTGCGATTCCACGCACGCGTTGCA TCCCTCTTCCCAAACCCGGATCGCTGAACTGAGAGGTGGCGCAGAGTGTCTCACCAGGTGCGGGGATTTCTCT CCGCCTCAGGCCGTACGAGCTTCCCTCGCTGTCCCTGAGCGCAAATGAGCCTCTTCAGTCGCCGAGGCCCGGC CGCTTAGCTCTCGGAGCCTTCCACAGCCCAACACCCTGAGCCCTGGAGTAGGCAATTTGCTCCCACAGCCCTG TGCTGGCCCTTCCAGGCACAGGGAGTCCCCCTTCTAGGGGTAGGGGCGGGCGGGATGAAGCGCACCCAGCCCT CTCTCCTACCCTTCCTCCTTTGGTCCCTTCGGCTTTCGTGTACCTTATCTCCCGCGCGCCCAGCTCCTTGGCC GGCTCACCTGCTAAGCGGAGCGCGGACATGCGCTGGAACTCCGGCTCCTGCAGCCACTTCCACATCCTCCGGA AGGTCTCCCGGCCGGATTTGAGTTTGCTCCAGGGTTTGGGGTTGCGCAGCAGGTCCGAGAGGGTCCCCTGGGA GCGGCAGAGCACCCTCTGCGCGAAGATGGCCTGTGGGATGCTGTAGCGCTTGAGCTCGGTGGTGATACGCTGC GCCACCTCTTTGGTATTGATCTCTTCCATCTGCCCTGAATTACTTCCATTGCTGACCTGCGCGCCGGTCACCG AAGGGTTGGGCTCCCGGGCTGTGCCCAGGAGTTGCCCGTGGCCCTGGGCGTTCAGGTGGGCGTGGGGATGGTG CGGAGGAAGGCCGTTGATGGGCACCATGCCGGCCGAGGTGGGCGTGAGGTGCTGCTCCCCGTGGCGGCCGAGC ATGGCCGGGTGGTGGGCTTCGAAGCCGTTGGGGGTGAGCATCTTGTCGGTGGGCATGGCGGCCCCCGGGTGGG CATAGTGGGGGAGCCCTTGCTGGGAGTTGTGGATGCTGCCCAGACCGGAGCTGGAGAGGGGCGAGAGGCTCTG GCCCATGCCGGCCACGTCCTTGTGGTAGGGGGTATAGAGGTTATTCATGGAGGCCAGCCCGCGCTCATCCCGC ATGAGCGTGAAGCTACCGCTCACGTTGCCCGCCAGGCGCTGGTGGTGGTGCGGGTGGTGGTGGTGATGGTGGT GGTGGTGATGGTGGGGGAACTTGTCCGAGACTGTGGAGATGGGAGGCAGCGGCTGCAGAGGGGTCAAGGTGGT GTAGGTGGTGGGCATGCTCATACCTGGGGGAGTCTCGCAGGCCATGGTCATGGTGGGATGCAGGGGGCCGGCC AGGCTGTGCTCAGGGGCCCGGTGGTGGTGGTGGTAATCTCCGCCGCCGCTGCCGCCGTCCAGCAGGGACGCCA TGCCCATGGAGCGCGGGTGCGCGGGGGGCAGGTGGCTGCCGCGGTGCGCCACGGAGCTGCGCGCGTGGGGGCT GCCGCCCAGCAGGTCGGCAGGGGCGGGCACCGGCTCATGGCTCACCCCGTGCAGCTCGCCGATCGCTTCCATG GTCAGCTGCGCGTTCATCGTGATCCGGGCGAGCAGGCGGCGGACACAACATCGATGTGGCCAGGCAGAGGCGG CGAGGGGCGCACGGAGTCCGGTCTTCACATCGGCTGCTGGCGACTGTTGCCTTCCTTCCTCTCACTGTGGGGC TCTGTCTCTCTCTCTCTCTCTCTCCGTGTGTGTGTGTCCGTGTGTGCGTGTGCGTGTGTGTGTGTGTGTGTGT CTCGCCTTCCCTCTTACCCCCCACCTTCCCCTCTGCGTCCTCGGCTTTTTTTTTTTTAATATTAATTTCCAAA GAGGATCCGCGCCGTTGGGAGAGCGCAGTGCCCCAGCCCGCCCGCCTCGGCCACCTCTCGCCCCTCTCTTTCT TAAAATTCTGAGGTCTCCGGCTCCCCTGCCGCGGCCCGCGCGCCTGCCGCGTCTGCTGCCTGCCCGCCCCGCT GGCCAGCTTGAGCCATGGCTCTGTTACTGTTACAGACTCTGTGGCCGCGGTTCGGTAGCCGCCGCCGCCGCCG CCGCAGCGGCCCGCCCTCACGCCCGCCAGGCGCAGCGCGCATGCGCGAGGCCCGCCCCCGCCCCCTAGGTCGC GGCGCGCCAGGCCCTTGGCGTCCCGGTACAAATGAAGGAGGGGGCCCAGCGCCTTCCCTGCGGCGCTGGATGG CCAGGGAGCTGCGGGCACGTGCGAAAGATTGGCGCAGAGCGCGACCTGGGGCCGCCGCTGCAATCCCAGGAGA CTCGCGCCTGGCTCGCTCGCCTCCCTTGCTTGAGTGGGCTCTGTCCTCCCAGCCCGGGGACGCTCGTGTCGGG CTTCTAGCGGCTGGAGTGCTGTGCTTGGAGACATCGCCCCTCTCTCTCCAGTTGCTGCTTCCCGGTGCAGCTT GCCCGGGGAGCTGGGGACTGTGTCATCACCCCTTCGGCTCTAGCCCACTAAGCTTTATTTCCCGGGGGGCTGC TGGGAGTGCGCTTTCCCACCCTTGAATTCACGGCCTATTGGGGGATGGGGGTTGGGGTGGGGTGGGGTGCAGA TTGCTTAAAGGGCTGGGTCCGTTTGGCGGCCGTTGACCCGGCACCCTTCGTCCTCCCAGATACATACTTGCCC ACCCTTTCTCATCCATGCCCTGGGGAGAGGAGTAATCAGTGCCAAGAATCCCAGTTCGGGCCATACCTCACTG TCCCCCGCCGCCTGGCTCCTTCTCCCGCTCAGCTCATAATTAAGGCTGTGCGTCCGCTTCGCCGATGACTCGG CCTGTGGAGGGGGGCGAGGGAGAGCGGAGGGAGTGCCCTGGAGGGTACCCATGTTAACTTCCGGGTGCTGGTG GGGCCGTGGAGGCTCGGGCCGTCCCTGCGGTTACTCCCAAGGCCCTCCTGCTAAAGCACCCGGAGGCGGTTGC TTTCCAGAAGTACTGACGCAGACAGGGTGGACGCCGGCGCGCGGGTCTCCGCTTGGCCCCTAGGGACGCCCTT TTCCCGGCGTCCCCGAGAGACGCCTCCAGATTTGAAAATCAATTCAGCTTCGGGAGTAATTTCGCCCTTCCCA CAGTCACGCTCCAATCTGGAATCGAACCTGGTCTTTGGGCCTGGTGGGGACGTGTGCGGAGGCCCCCAGTTTG AGACGTACACCCGGCCGCCACATGCCGCG CGI: 226 range = chr15: 58083428-58085812 CGCGCGGCTGCTCCATCTGTGAACGTGAGTGGTCGCCTGGCTCCCTCTTCCGCGGCGGCCGCTTCCTCATACC TTCACACGGCGCACACCGGCCGGCGCGTCCAGCTGCCTGCCCAGTGGCCGAGGCTCTTCCCCCTCGCCCAGTC TTGAGCTGGAAGTGATTCCTATTGGCCAAGGTGTCCATGTAAATAGGTGTGAAAGAAACCAGAGCTGGCCGGG CTCTCCCTTCTCGCTCAGTCCCCTCCCTCTGCAGCCCCCGCTCCCCCTCCTCTTCCTCCTCCTCCCAAGGCGA TTGTCATATGATAGCTAAGAAGTGGCACATTAATGAAGCGCCGCTACAGGGGTCTTTTCTGCTCCTGTCACCG CTTAAAACTATCAGATGGTTCGAGGGAGGACATGGAGGCAGCCACCTAGCTCAGCGGAGACGCGGAGCCCACA GCAGCGCCCTCCGGAGCCCTAACACGTCGCTGCCACCATCCGCGCCGGGACTCCGCAGCCGAGCTCGGCCGCC CGCAGGACGCTCCAGGAGCGTCGCGGACCGGGCGGCACGGGACGCTGCGGGGCTGAGCTCAAGAGCCCAGGTT CGCGCCGAGTCCAACCGGACCCGGACGCTGCGCGCGGAGTGCGCGTCGAGTGCGCGCCGAGAGAGAAGCGGCG CGCAGCGGCGTCCTCCCGGATGCGGACGCGCAACTTGAAGCAACTTTAAGGTGAGCAGCTCTCTGTTCCGTCC CTGCCCCCTATTCTGGCCCCAGTACCGACTTACTTCCCGGCTATCCTCGCGCCGTTCGCCGGCTTCCCCTCCC GCGCCCACTAAGCCCGCAAAGTTGCTGGCGAAAGAGTCCGGGCGCTGGCTGATCGAGCGCCGCAGGCCCCACC CCCGACCCCCGAAGTCTGTTACTCGGTCTGGCTGACCCCGCCGGTGTCTCTGTGCATCCATGCTACCTTTCCC TATTACCCACCCCCTTCCCAGATCCGAGCAGTCCGCCGGCCCGCGCGGACCCAGAGCAAGAAGAGGGCGAGGA AGAAGATGCCTCGGCCCGGCCGCAACACGTACAGCGACCAGAAGCCGCCCTACTCGTACATCTCGCTGACCGC TATGGCCATCCAGAGCTCTCCCGAGAAGATGCTGCCGCTGAGCGAGATCTACAAGTTCATCATGGACCGCTTC CCCTACTACAGGGAGAACACGCAGCGCTGGCAGAACAGTCTGCGCCACAACCTCTCCTTCAACGACTGCTTCA TCAAGATCCCGCGGCGGCCGGACCAGCCAGGCAAGGGCAGCTTCTGGGCGCTGCACCCAAGCTGCGGGGACAT GTTCGAGAACGGCAGCTTCCTGCGGCGCCGCAAGCGCTTCAAGGTGCTTAAGTCCGACCACCTGGCGCCCAGC AAGCCAGCCGACGCGGCGCAGTACCTGCAGCAGCAGGCCAAGCTGCGGCTCAGCGCGCTGGCGGCCTCGGGCA CGCACCTGCCACAGATGCCCGCCGCCGCCTACAACTTGGGCGGCGTGGCGCAGCCCTCGGGCTTCAAGCACCC CTTCGCCATCGAGAACATCATCGCGCGGGAATACAAGATGCCTGGGGGGCTGGCCTTCTCCGCCATGCAGCCG GTGCCCGCTGCCTACCCGCTCCCCAACCAGTTGACTACCATGGGCAGCTCGCTGGGCACCGGCTGGCCACACG TGTATGGCTCCGCCGGCATGATCGACTCGGCCACCCCCATCTCCATGGCGAGTGGCGACTACAGCGCCTACGG CGTGCCGTTGAAGCCGCTGTGCCACGCGGCGGGCCAAACGCTGCCCGCCATCCCCGTGCCCATTAAGCCCACG CCGGCCGCCGTGCCCGCGCTGCCTGCGCTGCCAGCGCCCATCCCCACCTTGCTCTCGAACTCGCCGCCCTCGC TCAGCCCCACGTCCTCGCAAACAGCCACCAGCCAAAGCAGCCCCGCCACCCCCAGCGAAACGCTCACCAGCCC GGCCTCCGCCTTGCACTCGGTGGCGGTGCACTGACCCGCAGGAGCCCACGCCCCCTCTCGTTCTCCTCCCCAC CACCTCACTCGCCTTCCCTGGCTCCCAGTCCTGCCGGCCCCCACCTGGGACCGCCACCCTAACTTGTTCATTT CACCTTCGGCCAACCCGCCTTGCCCCAAGAGAACTTTGTTTTGGACCCAGGAGACCAAACACAAACTTGCAGA TGGGCCGAGAGGCGCGTGGGAGTTGTCCTCGCCCCCACATCAAGGAAGGCCGGGGCCACCTGAGCCGAACCAT CCCCTCCCTGAGGCCCCGAAACCCCCTCCTATTTGACCGGCGGGGGAAACCCTGTCACCCCCTCTTCGCCGAG AAAAGCGCGTCTTCCCTCCGCCCAGATCGGCGGAGCCCCGAACTCTGCG CGI: 22 range = chr15: 62984853-62985116 CGCGCCCCTCTGGCCTCCATCACTGTCGTGCCGGTCGTGGGGACAGATGGGAGGGAATTACGGTATTTACAGC TGCTCTTCGCCGGCTCTTGCTCCCCCGCGTGTCGACAACCGAAACTGCAGCGAGGCCCAGAGGCCTCTGCCCA CTCCCCTCGGAGTTCCAGGAGGACGCTAAGCGCGAGAAGCCAGGCTCAGGGAAACTGAACGCCCATACGCTCC TAGTCCCTCTCACCTGGATCCTCTGCGTCAGGTTACGTGCTTGCG CGI: 541 range = chr15: 65902540-65909629 CGGGACGCAGGTGCAGGGTGCTGGACGCAGGTGTGCGGCCGCTTACCTGGGGCGTGCAGGCCTTGGGCTGCGG GGAGGCGGCGGGCGCCGCGCGTGGCCCGCGGGCGGGCGGACCCGGGGAGGGCGCTAGCGACTGCGCGGGCGGT GGGTGTGGCGCCCCGGCTCTCAGCTGTCAGGCGCGCCTGCCCCGCCACTCGGGCTGTGACCGCGCCGTCCCCG CCGCCGCGCCATGCGCTCCAGGCTTCGGCCTCTTCTTCCGGCCAGTCCCCGGCCTCGGGGTCAACGGCTCAGG GTTCGCATCTCCGCGCCCGGGGTCCCGGCGCCCCGTGCCCGCTGAGAGCGGGAGGGGCCGCGGGTGGGAGCGC GGAGAACCAGGGAGCACGGCTGTGCGCGCGCGCGGGGAGGGGCCGCGCCGTCACCCGGAGAGCCCGGCGGATC CCGGACTCCCGCCCGCCGCTCCTCCCGCCGCGCACCTCCGCTCACCGCTCGCCCGGCTCCAGCCGCCGCCGCA CTGTGAGTACCCACGTCCGGTAGCCCGCCGCCCCCGCGCTCTGCTCCTGCAGCTTTTTTTTCGTTTAGTTCTG ATTTGGGCTCCTGTGGCTGTTGTTTTTATGATTATACCTAAAGACACCACCGCCTCGCTCCCACCACTGCCAG TCTCCCGCTTCGCTGCCCTCCCCAAGCTCGTCCATCTAGCTCCGGGAGCCGACGGGGGTTCCTCAAGCTGCTC TGGCTGCTGCTCCTTGTCGCTGCATATGGCTCTTCGCCTGTGCTTTCCGCTTTGGCCCCCGAAATTCCGTTCC TTTCCTAGGGACCCCCTTCTTCTGACTCCGGGCCCGGACCCCCCTCCTCTCACTCAGGGAAAACCGCGCAGGG ACCCAGGACCCTCAACTGGGGTACGCTCTCGGCTCGGGCGCTGTCTTCACTGTATGCGGGCCAGGCATAGTTG CCGATTTCGAGAAACCGAGAAGCTGTCATTTCCCAGCGCTGCGCGCCCTCCAGCCACCTCCAGGAGGGCGCGA GGCTTGTCAGCCGGGGAGTTAGGACAGTGTTTTTGCCTCCTACAATGATATAAAGGACTTCAACGCGAAATAA GGGTCAACTTATTTTAGTTCGATCCTCGGAGATAAAGATGAAACAGACAGATAATACATAAATAGCTTGATAC TTGAAGAAGGTACAAAACAGATGAGAGAAAGAGGAACGAGCCGGCAGAGACAGCTCAGGGACAGATAAGATCG ACAAATGAGGGTCTCCTAGACAAATAGAGAAGAAGGGAGAGAGACAGATAAACAGAAGATTCCAGTCTCCTTG CTGAAGGCTTTTGAACTGGGATCCCCTGTCTGGAGCTGCCCCTCTGAAAACGGAGTTACATTCAGGGCCGACT GCAGGGGAGGAGCCCTCAGGGTTGGGCTGCCCTGGCCGCAGGAGCGCCTGCAGCCTTGGGCCGGATGGGAGCC TGGCTTGTCTGAGGACATGTGGCTGGGTCAGGCGACCTAGAGGGCCCCAAACATCAGTCCCCAAGTACCCCCG CTGCTGAGGTCTGCCTGCACAGCTCCCTCCCTGCCTCAGCCAGAAAGCAAAGTGCAAGGACCAGCAGCAACTT GTGTGCCTGGAGCCTTGCAATGGCTACGAAGATGGCTGAGATTCCTTCTAGCCCATATGAGCCGGGACAGCGA GGCATGAAGGATACTCAGAGAGGTGATGCCCCTCAAAGAGGAAGCCCAGAGCCCCGAATCCTGCAGTTGGCCC GAGTGGGAAACGTATATCTGAAGGAGGAAAGCTCAAGGAGTGGGCGACTGGAAGCTAAGAAGTGGATCCCAAC AAAGTTCCTTGAGAACCTCTCTGTCCCACACGTTGACCTCGGTGGAAACCAGCTTTGGTCTGGAATACAGCTA AAAATGCAGAAAATGTGGTTAGAACTGCAGGATCCTGGTCTCACTAATAGCTGGAAAGAAAACGGTTTATATA TCCAGCCGAAATCTTTCTGCTCAACGAACGCGGGCGCCAGCCGTGAGAGGAGAAGCTCGGGTTTGTGGAAACT GGCAATGTTGTCCCCTGAAGCCGGCTCGGGCACCAAGCTGGGTGCGGTGGGGGCCGCGCTAGGTCCGGGTGCG CACCGAGCGCTTTGGAGAGGGTCAGGTTCAGCACCGCGAACAGCGGTAGCCTCCGCCTCTCTCCTTCCCTGGC AGACACGGTTCCCTCCTCCTTCTCCTCACCCCCCTCCTTCTCTTCACCCCCCTCTACCCCCTGCTGTCTGGAG ATGGGCAGTGACCGCCCCTCCCCCCTCCCCACCCCTCCTTGCACTGCCCCCGCCCGCCCGCGTGCATGCGCGA CTGAGCAGAGGGGCGGCCGATCCCCGAAGTCCGGGCTTCAGGACCCGGGCCGGCAGCACCGGCTGCGAGGGTT GCCGAAGGCGCACGGATCTGGGCGCTGAAAAAGCCAGGATTTGGCAATGGCTTTGCTGTGTGGCCTTGGGCAA GTCACTCTGCGTATCTGGGTTTCACTTCCTTCCCAATCCGAAAACGGGATTGGGTTCCTTGCAGCCCGGGCAT TCCTGAGGTCTCCTTTACCCCTTCTCCTCCCCCAAGCCCCGGGGGCTGTTGTTAACGGCGCCAACATGGGTCT GAGTAACAAAAGACGCCTGTCCAGGGGGTGAATGAGTTTGGACTCCCCACTGCCAAGTATCCCCCGCGCGCCC AACTCGGAGCGCCCTGCTGGGCGGGCCCGAGCCTCGGCGGCGGCGCTGAAAATGGCTCATCTGCTCTCTGCTT TCTCTATTTCGCAGGAGCGGCGGCATGGAGGCTCTCACCACTCAGCTGGGGCCGGGGCGCGAGGGCAGTTCCT CGCCCAACTCCAAGCAGGAGCTGCAGCCGTACTCGGGCTCCAGCGCTCTCAAACCCAACCAGGTGGGCGAGAC GTCGCTGTACGGGGTGCCCATTGTGTCGCTGGTCATCGACGGCCAGGAGCGCCTATGCCTGGCGCAGATCTCC AACACCCTCCTCAAGAACTACAGCTATAATGAGATCCACAACCGCCGCGTGGCCCTGGGCATCACGTGCGTGC AGTGCACGCCGGTACAGCTGGAGATTCTGCGTCGGGCCGGGGCCATGCCCATCTCGTCGCGCCGCTGCGGCAT GATCACTAAGCGAGAGGCCGAACGCCTGTGCAAGTCGTTCCTGGGCGAGCACAAACCACCCAAGCTGCCCGAG AACTTCGCCTTCGATGTGGTGCACGAGTGCGCGTGGGGCTCGCGTGGTAGCTTCATCCCTGCGCGTTACAACA GCTCTCGTGCCAAGTGCATCAAGTGCGGCTACTGCAGCATGTACTTCTCGCCCAACAAGTTCATCTTCCACTC GCACCGAACACCCGACGCCAAGTACACGCAGCCCGATGCCGCCAACTTCAACTCCTGGCGTCGTCACCTCAAA CTCAGTGACAAGTCGGCCACAGACGAACTGAGCCATGCTTGGGAGGACGTCAAGGCCATGTTTAATGGCGGCA CGCGCAAGCGGACCTTCTCCCTACAAGGAGGCGGCGGAGGCGGTGCCAATGGCGGGTCGGGTGGGCAGGGGAA GGGTGGTGCTGGCGGCGGTGGCGGCGGTGGCCCAGGGTGCGGTGCAGAGATGGCCCCAGGCCCGCCGCCCCAC AAAAGCCTGCGCTGTGGCGAAGATGAGGCTGCCGGGCCTCCGGGGCCACCTCCACCCCACCCGCAGCGCGGAC TTGGCCTGGCGACTGGAGCTAGTGGCCCGGCGGGCCCAGGAGGGCCCGGTGGCGGCGCCGGCGTACGAAGCTA CCCGGTGATCCCGGTGCCCAGCAAAGGCTTTGGGCTCCTGCAAAAGCTGCCCCCACCACTTTTCCCCCATCCT TACGGCTTCCCTACGGCCTTCGGCCTATGCCCCAAAAAGGACGACCCGGTTTTAGGCGCGGGCGAGCCAAAGG GCGGTCCTGGCACTGGGAGCGGCGGCGGCGGCGCGGGGACAGGCGGGGGTGCGGGGGGCCCGGGAGCCAGCCA CTTGCCCCCGGGGGCAGGGGCGGGCCCGGGCGGCGGCGCCATGTTCTGGGGGCATCAACCCTCCGGGGCAGCC AAGGACGCAGCGGCAGTGGCTGCAGCGGCCGCCGCCGCCACTGTGTACCCGACGTTTCCCATGTTCTGGCCAG CAGCAGGCAGCCTCCCGGTACCGTCCTACCCCGCTGCTCAGAGCCAAGCCAAGGCCGTGGCGGCAGCCGTGGC GGCGGCAGCGGCGGCGGCAGCGGCAGCTGCTGGCAGCGGTGCCCCAGAGCCCCTGGACGGTGCCGAGCCAGCC AAAGAGAGTGGCCTCGGCGCGGAGGAGCGCTGCCCGAGCGCTCTGTCCCGCGGGCCCCTGGACGAAGACGGCA CGGACGAGGCGCTGCCACCGCCCCTGGCCCCGTTGCCCCCGCCGCCCCCGCCGCCCGCACGCAAAGGCTCCTA CGTGTCGGCCTTCCGGCCGGTGGTCAAGGACACCGAGAGCATCGCTAAGCTCTACGGGAGCGCCCGGGAGGCG TACGGCGCGGGGCCTGCTCGGGGGCCGGGACCCGGCGCTGGGAGCGGCGGCTACGTGAGCCCGGACTTTCTGA GCGAGGGCAGCTCCAGCTACAATTCCGCCTCGCCCGACGTGGACACCGCGGACGAGCCCGAGGTGGACGTGGA ATCCAACCGCTTCCCCGACGACGAGGACGCCCAAGAGGAGACCGAGCCCAGCGCACCCAGCGCAGGGGGCGGC CCAGACGGTGAACAGCCCACTGGACCCCCTTCCGCCACCTCCTCTGGCGCGGACGGTCCCGCAAACTCTCCCG ACGGCGGCAGCCCCCGCCCCCGGCGCCGCCTCGGGCCACCCCCAGCTGGCCGGCCCGCATTTGGGGACTTGGC AGCCGAAGACTTGGTGCGGAGACCTGAGAGGAGCCCGCCAAGCGGCGGCGGCGGCTACGAGCTGCGAGAGCCT TGCGGGCCCCTAGGAGGCCCCGCGCCGGCCAAGGTGAGCCCCGCGCCCGCCCCGCCAGTGGCGCCTTCCCACC TACCCTGTGCGCGGCAGGGCTGCGGGGCCGGGCGGAGAACGGGAATTTTGTTCCGCGCAGGCGTGGGAGCAGC AGGCCTCGGCCACTCTCCGCAGGCCCAGCCTTGGGCGCGCTGCGAAACTGGGCCCACCCGCACCCTCCAGTGA GGGTTTCGAAGGGAAGGGAAGCTGGGGGCGGCGGGAGGACTGGGGAACTTGTGTGCTTTGTTTTTGTTGATGG GAATGGGGAGGAGACCGGCTGAGACTGCCAGACACAGAGACAGAAAAGGGGTGTGGAGAAAGAAAGAGGAGGT AAGAAAGGAACCCAGAGCCAGAGAAAAGCGCTCGCCCGGGTGGGCATCAGAGCCCCAAGGAAGAGGAGAAGAG AGGACAGTGTGGCCTCTCCCTGAGTCGGGCCCCAGCAGTACCGGGTCCCCGGAATCTCCCACCACCCCAACTC GCAGTTTTCCGAGTCTCTTCGCACTCCCGCCTTGGGAACCACAGGGTTCGTTGCTGGGAAGCTGTCTCGGGAC CGCGTGCGGAGCGGGAGGGGGGCTCTCAAGCTGGCAGGGCCGGGGCTTGAGGGGCAGGATGCAGCCAGGCTGG AGTCGTTGGCCATTTTGAAAGTGAGTGCGCATACCTGTACATTCGGTTCATTAAAACACGAATCATTAACCGG ATGCGAAAGGCGTCATTTATGCCGCGGACGGGGCACTGGCGGGAGGGAAAATGCCTAAAAGGAGGCGGGTGCA GAGGGTGGAGGACACTTTGAACGCCCCTCGGCTTGGGAGCCGCTTTGTGTTTAGAGTAATTTTCCCGAGGGCG CTAACAATTACCCTGAATCTACAAGGGGGCAAGGGTGCGCCGCGTGCGTCACTGTGCCCGCTCAAGTCCAGCG GGCGCACCAACCTTTGCCACTCCGTCGGCTTTCCCTCTTGGCCGCGGGGTAGGGCTGGGCGTCTTTGGGCCGC CGCAGGGCGCCACCCTAATCGCCTGTCATTTCTCGGCCGTCGCAGGTGTTCGCGCCCGAGAGGGATGAGCACG TGAAGAGCGCGGCGGTGGCGCTGGGGCCCGCGGCCTCCTACGTCTGCACCCCCGAGGCCCACGGTAACGCCTG TCGCGGCCGCTGGCCACTGTAATGGGGGAACCGCAGACAGAGGGCCGGGGTCAAGGAAGGCCTGCGAAGGAAG ACAAGGAGAGAGACGCAGAGAAAGAGGGAGAGGGAAAGAAAAATAATGAAAACAAGGAAGCTAAGCTAGTACT CCCAACAACTTCCAATCTTTAGTTACTTAAAAACAACAGTGACAACGCCCTCTCCACCACACGCACACACATG CTGCAGTACACCCAGACACGGCGTTAAACCCTTAACAAAATCACGCCCGACACGGCCTTCAAATCCTCTCATT TATTCAGCAAGTGTGTTTGGCCGCGGGGTCCCCTTTGGCTAGGCCGGATCGGGGCGGAGGATGGGGGCACATG GCCGCGCGCTTGGGTACCCCAGAAGCGCCAGGGTAGCTGAGGCCCATCGCGGGGTGGTGGGGGCCGCCCTGCA CTTGCGCGCCTTACCAGGTTCCTCACAGAGGAGGGGTTGGGGGCAGCGGAAAATCGGGCAGGTCGAGGCAGCC GAACCCCGGACGATGTCCCCCCACCCACCCCGAAGGTCGCAGCCTGGGCCGCGTTCTCAGCAGGAGTCGGGCG GACAGACCCGGCGGCCACGCGCGCTCGCGGTGCCCCAGTATCTGCGCGCGATGTAGGTCGCTCGTCCCTGGTG GGCTCGGCTGCTCGCCTAGCTCTTTTCCAAGGGGCTGGGGCGGGGGCCTGAAGCCCGGAGATGAGCAGACCAG GCGCGGGGGTGGGGGGTGCCCGGCCCAAAGCCTCAGGGCGCGCTCCTGGGCGCACAGCCGGGAACCAGAGGCG GCCACGACGCTTTTAATTAGGGCTGGGGCGCCCCGACCGCGGCAGCTCCGGCAGTATCCGGGTCACGGTTTCT TTGCCTCTCTTGAAATTCGGTTTGTTGCCTTCAAGAGCCAGATAAGGAAGACAATCACTCGCCCGCCGATGAT TTGGAAACG CGI: 216 range = chr15: 72206924-72210097 CGGGAAGTAAAGCCTCGGGACTTTGGTTAAGCGCGCCCCACTGGCGTATCGCGCCGCGGGACTGCAGAGCCGT GAGCAGCGGTCGCCTTGGTGCAGGGTTCCAGCCACATCTTCCTCGCCCAGCCAGCACCCTCTGCCGTTGACCC GCCTCTGCGCCCGGCAAGCGGCTTCCAGCAGGGGGCGCGCGCGGACCAGGCTTGGGCCCTAGAACAGCGCGGA TGGAGTCGCTGGAGCAAGTCCCCAGATCCAACCGGTTTCAACCCTCCCCACCCTCCCGACGCTCCGGGTTCGC GACGTTGAAGTTAAGGGTCGATCCGCAGAAAGCGGCCAGGGGCTCCAGCTCTCCATTCCTGGGTCTGTCTGGG GTCGGCTCCAGCCTGGTTAGAAGCCTTAGTCTGGATTCGGCAGATTCTGAATCTGGGACCCTCTGCGCTAGCG GCTTGGAACCTTGTCACCCTCCCCTCCCCCACCCCTACTTCCACACACCTGATTAGTTGTCTGTTTCTTTAAT GATCAAAGACGTGGGCGGCGGCGGGATGAGGTCTTGGTTCCCGGCTCCACAGCCCTCCCTAACTGTCATTATT AACGTTATAAACATTAGACCCGCTTCTGCGCGCCGGACGGCGCCGGACGAGGTGCGCGCAGTCTTCTAGCTGA GCTCGGAGGCAGATCCAGAAGTCGCGGCTCCCACCCCAGGCCTCGGCGGACTCTGCCTGGGGCGACTCGGGCT CCAGCCCTGCCCGGGCGGGCACTGGGCTCTCCAGGGTCGAAGGCAGGGGTAAGGGGCGTCTTTCCCCCAGGGC AGCCTCCGGGAACAAAAGCATTTGCTGTAGAGTGAGCTAGAGCCTCCGGGCCCGCGGGAGTCAGCTCCCGCCC AGGGGTGGTCACCGCGTCCTTAACCACCCCAGGAGCCCCGTCTCCCTGCCGAACTCCTTGGCTTCTGCAACCC TGTCAAGACAGCAAGGAAAGGGGGTCTTCCCTGGTCCTCGGGCCCCGAAGTTTCGGGGTTGCTTATAGGACGG GTTCCTGCAGTCCAGGGAAGCTCTGGGCAGATAGCGAGCCCATTCTCCCTTCCATTACCCAGATTCTGCCTCC CTGCGGAAGGCAAAAAAGAAAGAAAGAAAATAGGTAAAAACCGGCGGAGGGCCTTGAGCCTCCCCGCCTGGCG CCCCTCACTCAGTCCCGAAAAGTCCCCTGGACACGCCATGCCGGACCGGACTCAGCTCCCGCTGCTGGGCCCC TGCCTCCAAATATCCTTCCCAGGCACAGGCTCCCAAGACCGCCCCCTCAGGGTTCCCAACACCCGGACAACTG CCCAAGACGCCGCTCCCCGCCCCCACCCCCACCTTGTTCGGCAGACAAAGAAGGGTGTGCTGGCCCCGCCGTC TGCCTCCTTCTCCCGACCCCACAAGGCCTAGAAACCTCAGGGACTCACCCCGGGCTAGGGACCCAATCCTGGC TGTCCCACCACAGGATCCCCGGCAGGGACGGGTCACAGTGCTCTCACCCCTCGACCATTTTCGAAGACACCTT CCCTGAAAGGCGCCTTGCGCCCTCCCCATGGGTCGGCGGGGGGGGACTCCAGGCCCGAGCAGGCGGTGTGAAG TTCTGTGTTCTGAACTGGGGCTGAGCAAGATGCGATGGTCTCAGCCCGCTGGGCCGCCCGTAGCGACGGCAGG AGTAGGGGAGAGGGAGGGACGCTTGGAGTGTGAGCGCACCAGTCTGTTCATATTTAATTTACAAAGCAGCCTC GGAACCCCGGGCCGGGTGGTCTCTTTAGACGCTGCGCTCTTAGCCTGTCTCTCTTCCCCACCCCCTCCCCTAG CTCATTAAGATGCTCAACACTCAAATCGGGGTATTGATCTCCACGGAAGCCCCAAACCCTCGCCATCGAGAGA CCCCCATGGCCCGGGGTGATGGCTGTGGGGCTTGGTGCTCCCAGAGAGCTCAGTGGCTACAGAATGGGTGGGG ATTCTGCGTGTCTCCCGGAGCCTGAACCCCTTTCCTGGTTATGGCCGGTAGCTGTCTCCAGGGCTAACGTGGG CAGCGCAGGGGGGCGGAAACCGGGTTTTAGCCAAATGCCTCGACATCGCCGCGCCTCCGCCTCCTCGTCGCTG AAAGAAATGTCGGGGTTTCATCAGAGCTAGGGAGCGACAGTCGGGAACAGCGAGTCTGCCGAAGCCGGCTGTT GTGTGAGGGTGTGAGACGGCGGGGCGGTGAGGGGCCACCGCGGCTTGGGGGATAGTGCGTGTGGGGTTGACCG TGTGTCTGCTTGAGAGGCTGTGAAGATATGGGGGGCAGATATGGGAGAAATGCTCGGGCCTGAAGTCCCCAGC CCACCGTGCTCAAGAGTAGCGGACGTTTTGCCACCATCCTTGTCTGTGCTACTGTCTGCTGCAGCTTCCGTGC CCCGTTCTCCTGGAGCAGGCAAGACCTGGAGTGAGGTGCTTGGGTGCGCTCGAGAGAGCTTCCCCCTGCTCCA CCTGTCCCGCGGTGCGCGCAGGCCAACGCGTCGGGCAGTGGGCTTCAAGCGCTGGTTTAGCCACAAAAGACCA GAAGTAAAGAGTTCCGGCTTAAGAGGCTGGGCAGGGCTGCGGTGGGCTGGGGAGGGGGGTGTCCCTTCCCAGC ACGCCCTGCAGGGCTGTGCGTTCTGGTGTCGGGTTAGACTAGCAGGCGGGGCGGGGGGGTTGGGGCGGCGGGG CGGGGGAGACTAGGGCTTATATCAGCCCAGATCCAGGCAAAAATGGTAGGGAGGGTGCGGCGCTCTGCTAACA CTATCAATTATGCATCATGTTGAACGTGGCTTCGGGGAGGAGGCGGCTAGCAGCGGGGGGTGCGGGAGGGAAG GGTCCGCGCGAGCTCGGCTGCGCGCAGCTCAGCGGGTCCCGCTCGAAGTCTGTCGGTGCCACCGCCTGCATTT GCAAAAAGAGTTTAAAGGCAAAGACACGCCTTCCCCCCCCACTTCAGCCGCGCGCCTTTCCTTCCCCCAAATT CCTCAAAGATGGTTTGTCTCACGTGTTGCAGGGCGTAAAAGCGGCTTGCATTCAATTAGCAGCGAAGCTCGCG GGCGCTGGCGGGACAGGCGCGTGAGGGTGAGTTCGCGTGAATGTGTGTATGCGTGTGCGAGAGGAGAACGGTA AGTGTCCCGGGTGCAGGTGTGCCCGTGAAAATGCG CGI: 32 range = chr15: 74414579-74414893 CGGAGCTCAAAAGCCGGACGCTACTGGACGAGGCTTAAAGCGCTCGCCCCAGCGCGGGGCCGGTGAGGAACGT TCACCGTGGACCATGGTCGAATAATGTTAGCGTGCACTCGGGGCCTCGCCCTAGCCTTCTGCAAAGCCTCGGC CTGCGCCCTCGGCTGCATCCGTTTCGACGCCAACCAACCTCATGCTCTTAGTAGAACGGCAGTAGCGACCGCG CCCTCAGGCCCACAAGCCCGAAGGTCTGGGCAGGGTCTGGAATGGCGGTGGAGACACTTTATCCGCAGGCGTT TCACCTCGCGCCCCACCCAGGCG CGI: 109 range = chr15: 88158407-88159577 CGGCATCTTGGCCGGGTTGTAGGAGCGAGGGAGAACGCGACTGTAACGCGGGCGTTGAGCACCTAGAGTTCCC CTTCCTCTTCACTGAGAGCTGCGGCGGAGGCTTTAGACCGAGGAGCGAGATCTAAGGTTAAAGAAAGGGCCTC TGAGCCCAGTGTTGGCCAGAGACCCCACAGGCGGGCCGGGTTCGCCCTTTGCCTTCGGCCGCGCCCCACCCAC CAGGGACAGAGTGGCCGCGGCCGAGCCGGGTCCACCCGCCGCAGCTTAGCTCCGCTCCGCCGCCCTCCCCGTC CGTCCTCCCCAGGCTCCCGTCGCCCTCGCCCACCCTGGGGCCCCCTCCCCAGATGGGAGCCCCTCCGACCCCT GCGAGGCCCGCTGGGGACCCACTTGACCGCGAGATCGTAGTGGGAGCTCGGCCAAAAGAATTCTTCGCTTTCC CTGGCCCTCAGTTTACCCATCTGGGAAGAGGGGCGTCGCGGCCGCAGAAGTCCAGCTCCGCACGCGCCAAGCG CTGGGTCTGCAGCTCCCTCGGTTCCCGCGCACCCAACTGCCCCACGACCCCTACCCGCGCCCGCAGCCCCCGC CCTCCCGCCCCACTTGCCTGGGCCGCCGGGCGCTGGAACCTGGACCCTGGACCCTGGCGGGTTCCGAGCTGCG CCGCCGCCGTCCCTGCCCCTCCAGCACTGGACTCCTCCTTTCCCGTCTTTTTAAAGGGAAGTAACCGGACCCG ACCACTACTCCACCCGATTCACCCCTAGCGGGCCGCCCGCCCGCAGCTCCGCCCGGGCTCCTCCCCCGTCCGC CCGCGGCTTCCCGGGAGCCCCCCAGGGCTCCTCCGCTCCTCCGACGGCCCGGCCTTCCCCCCGGGGCCTGGGA TGCACCAGGGCTCCTGCTGCCCCCGACGGGGTCCCTGTCGCCGCAGCCCGCGGGACCCGCCGGCCACATCTGG ACGGCATCTGCCGCGGGGGAGGGGCTCAGAGCCTCGCCCTGAGTGTCCCGCAGGGAGCCTTGTGCATCCGGGG CAGGAAGCCAGCGCATCCCGTGCAGACGGGTGGTGCAGATAACGGACCCGCCACAGCACGCAATTCAACTTTC TTGGTACCTGGGACTCGTAGTTCAGAAGGCGCAGTAGCACGACCTTGCGAAAAAGCACCGGAGTCGGGAACAC GCG CGI: 21 range = chr16: 727072-727328 CGCCACCCGCACGACGGACGTCGGCACCACACGAGCTGCCCTTGGCAAAACGCGTTGTCGGCTGCTGGGATGG ATTTCAGGTTAAAGCAGAGTCACCAGGCCGACCACTGCTTACCTTGTTAGCATCTAGAACCTTCTTCAGCTCC TCGTGGCTCTGCTGGGTGATAAGCACGGTCTCTGCGGAGGTGATGCAGCCGCTGCACGCCAGGCAGTCGTTTA GCGAGACCTTGGCCTTCTCCAGCCTCCGGGTCCCGCCG CGI: 61 range = chr16: 47868915-47869809 CGGGTCCACTCCTCACTCGCGAAGTCCCTATCTATCTCTGTGGGTCCCGGAGGCACAGGGCTGCAAGGGCGCC CGCTAGAGCTGCTCCACGGCTTACCGGATTGCATGCGGAGAAGAAACGGGCCCGGGTTTCAACAGAGGCCCCG TGCTCCGTGAATTTCTAACTCGAACCAGCCGCTGGGATAAATCCGAGAAACGTTGTTTATTGTGCTATTATTA ACTTTCCCTTCTCCCCACGCCCCTAGAGGAAATAAAATTCATTCCTGAATATTGGGCCAGGAAAACGTTTCTC TGAAAGGAACCACAACTGCAGGGGACCACCCGGCTGCAGCTCCCAGCTCCCGGCCCTTCGCCCTAGGCTGCCC ACTCGCTCCGGCTCCCGACCTCCCCGCTGCCGAAGCAACTGGGTCAGCCTTTCAGACTTAAAACGAAGTCGTT TATTTCATTTTTGCTTTCACATTATGTTCCGATACAATCAAAACTCCTGGACGAACCTCTTGAATAAAGTCCT GTGAATGAGCGGAATCATAGGTCCTGGGCGCCCGAGTATGCGGCGGGTGGACTCCGGATTCAGAGGCGGTGTA TAAAACATACGCTGCTTCGGGAACTGCGAGGGGGACGCGGTGGGAGACATCCGGGGACAGAAGGCCTGAGGAG TCTGCCGCTCCAGGCAGGGTCGTTTGGGTCCTCAAACTGGGACTATTCCTGATGCATTTGGAATGCAAAGAAA AAAATCAAACTTCGCTCCTGGGCCGGCGGCCGCGCCTGGCCTAGCAAGATTTCGGCCACATTTCTTACGTTTC CGCCAAAGCTGTGAACACAGGCGAATGCAGTGCTGGTCCCCGGCCTGGCGCAGGAAGGAGCGCAAGGCCGGCT TTGCAAGGAAGCCCTCGCG CGI: 179 range = chr16: 53527803-53530347 CGCGAAGGCTCGGGGCTGCGAGCCGAATGCCCGCCGAGCTGCCTGGGAACGGGAACCGCGCACCCGGGAACGC CAGGCGTTTCTCTTCATCCAGGAACGGCGCGGAGAGCCTCCGGCTGGGGAGCTAAACCGCTGGGGACTCCGCG GCTGCTGCCTGAGTCGCTGTCCGCTGCCCGCATCCCTTCCGCCCTGGGCCTCTGCACGGTCTGCGGTTTTCTG TGCGCACTTGGTCTTCAGTACTAGCACCCAATTACGTCTGGGTTTTTCTTCTTTACAGAGCTGGGTTTCGGTG GCCACCAGCTTTTCTGGTGTTTAGTGACTCTGAGTTTGGAGGTGGCCTACCAGGCAAACGGGGATTCAGGGCA TTTAGGAAACGTCTTCCGCGCTTAATCCCAGAAGTGGTTGCGTGTCCGTACGATCCCAAGTTCCTCCCGGAGC CTCTTCTTTGCTGCGTCTCGGGCCCTCCAGCAGGCGAAGCCTCTTAGACGCGCTGGGGAAACTTCCGGCGTGT TCGGGGCTCAGGGTTTCTTCTCAGGCATGGATTGGGGCGCAGAAGTTGCGCGAGGCAGCGCCTAAGGTCCCGA GGTGCTGAGACTGTGCTGGCGTTTGCCACCTGCCCCTGGCTAGGCCGTTTCTGGGCCCCAAGAAACGCCTACC TTGGCACTTAGGGACCAGAAGCCTCTGGATGTCTAGCAACAGGGGTCACGGGATCACTGCGTGGGGTCTCTGT AAGCAGTCCCCTGAGGCAGTGCAAAACCGGAAACCTGCTCTGTGCGGGGCCGAATCAGTTCATGGGATTTGGG AGTCAGGAGAGACGTCTTTCTCCTCCCAGCTCCTACACTCCGGGTACCAAGGCCCGAAATGCCGTTCCCCCAG CCCGGGTGCGGGGTCTGCAGCAAGGCCTCCTGATTTGCAAACCCCTCCGGGCTGCTTATTCCTGGTGCCATGC GCAGCCCTTGGGACCTAGAAGATTGTGGGGGAGGGAAGGTCGCACGTGCGGTTTTGGCACCGACCGTGCCTCC TAGTCCACCTGTCCCCCACAGCTAGCTGCCAACTCGGACGGAAGCGCGGAACAGCGCAATGCAAACCGCCCAA AGTGAAAGGAATGTAATTGCGCTCCCATGACAGAGCCAGACGCGGATGCAGTTTAGGAAGGGCGCCGCCTACC GGCCCCTGGGAGCCATGCGATTCGAAGGGAGGGGGACCTAGAGGAGACCCCCGCTATCCCCCCACCCACCGTG GGGCCTTAGCTTTGAACTCCGGCCCGGACAAACTTAAACTGCTTCGCCACCCCAACGCGCCACAGCCCTGGAC CTAAGACCCAGTTAGCATTGGGAATTTGGGGAGCAGGGCCCACGACTAGAACAAAGTTAACCCTACCGGTTCC CGCCACGGCTTCGGCACATTTCAAAAAACCAGGCGCAGGCAATTGAGAAATACGCTGCCGGCTGAAACAGCCT GCGGGTGGGGGCTGCAGCCGTGCGCGCCCGGCAGTTCCCGTCCCGCATCAGGTGTACGCACTTCCACTCCTGC GGGCCCTTCCACGCTCCAACTCTGGACCCCGCGCAGTTTTAATCTGCGGTTTGGGAAATGGGGGTGCTACCGT GCAACCGCGCCCTGAAAGACCGTTTTGGTCTTAAGAGCTTTTGGCCTGTGGGGTGGACATCTGTAGAAAAAGG AAAAACAAAACAAAAGTAACCTCCCATTGCGTCGAACCCTCCTATTCCGAAAAGAACTTTAATGAGGTTGGCT TGGCAAGGCCTGCGGTGCTTACCTCGGCTTCGCCCTACCCCGCCAGAAGCCCTCATAGGTTGTATCCACTGGT CTCCCCCAGGTGCAGGGTTATTAGGGGAAAGGGGGGCGCGCCCTCGGGCTGGATCTTTGTTTCCCTCGTCGCC CGGTCATCAAACAGGAGGGAAATCGGGCCCGACTGGGACCTTGCTGCCCGCCTTCCCCTTAAACTGGCTAAAG CTTCAGGACTGTCCCTAGACCCACCCCGCGGGTCTTCCTTTGTGTCCAGGGCATAGCCGATCTCCTTTTCGTT TTCACGAGAACTGCGACTTGGGCCTCGGGCACTAGGCGAGCCCAGGTTGTGGCCTAACAGCAGATCGCCTCGG GAGCTTGGCTGCAGCTCTGCCCGCACCTCCAGCGCTGGGCGGCCTCTCGGGGCCAGTGGGGATCTCTGGCCTC GTGTAGGCCACGGGCCCCAGCCCTGGGTCCCCAAGGCCGCTCGCCGGGCAGCGCTCGTTTCCGGCACCGGGAC GAGCCCAGCGCGCTCAGACACCACTTTCCCGGTGAAATCTGCTTTTATTTGCTCCGAGCAAACCTCGGGCTCT CAGCGCTCCCGCCTGATGGATGCAAATGTAAATGTGCACTTATTTAATTGGATCAGGCCCCAAGATAAAAGAG ATAAACGGCTCCCCGCTTGCTAACTTATTTTCCTAGGCATGCAGCGCCGCGTGGAGGGGAAGCTAATGAAGGA GCAGCGCGGTGCTGGGCACTCGAGCTCTCCGCAGCCGTGGCACGCTGGCCGGCCGGCCCCGCG CGI: 78 range = chr16: 66071900-66072846 CGCAGGCCAACGCGAAGACACGATGATCCCAAAGACCTTAGTGTCTTGGCGGGGGGAGGGGGAAGAGGTGGGG GACTTTTCCGCTTAGCTTCCCTAAGGGTTGCTACGCGACAGCTCTCGGGCTACGTCAGGGTAAAGAGGTTTGT ATGGCCACACCTCGCACCGACCAACTACCCCCGAAACACCCCCTCCTCCCAAACTGCAGGGTGAGCACAGCGA GAGAAAAGGTGGCCCAAGCAGAGGCGAACAACTGCGGTTCTTAAAGCCTTGTTTGAGTTTGGGCCCGCGCCGA GCCACAGCTAGAGGTAGATCCCGCTCCTGCGCGTCCGCTATCAGCCCCAGGATTCCCAGAGAGGCCTCTCAGG CCCTTCAAGACCCCCCCTTCCGGCTTCCCGGCCTACACCTCTGAACCCTCAGGCCCCGGACAGCCTCTATCCC CGCCTTTCGCGGCCCCGGCTCACCCTCTAGCGTCTCGCACTGCACCAGGTTGAGGTAGTCGGCCTGGCTGAGC ACCCCGGCCTTCAGGCCGCGCACCAGTCCCTCCAAGTAGCCATTGTCCACGTTAAAGTAAAGCTCCGGGAAGA ACGACATGGCTGCTGCGGGAGCGGCGGGACCGGAGAACCAGGACCGGCCGGCACGAATCGCGACTCCCCAGGT CAGCTGACGCTGCGTCCTCAGCGGGCTGTCAAGTGCGTCAGGTGACGCGCAAGCGCCTCACGTGACCATAAGG GGGCGTGGCTCTGAGCGGTGCCCGGCTTCCGGGTGGCTGCGCGGAAGCGCGGTGCAGGCGTGGGCTGGCCCTG CGGCGCCTGCGCGCTAAAAAGAGGAAGTTTGAGGCCGGCCGCTTGGTGGCGCCTGTGGCCGCAGGGATTTGAC TGGGCCTTCTCTAGCTTTCCCCGGTTTGCTGCACTTGACGCTGCAGGGCGGGCGGGGTAAAGAAGGGAGCG CGI: 39 range = chr17: 38089258-38089793 CGGGGGTTGGGGGCACGGAAGGGGAAGCTTCGGTCGCTAAGTGGGCCGGCCTTTGGAAGGGTCTGGGAGGGGC CAGCGCTGACTAACAGTCGGTTTCCCTACCCTAGACGGCTGCGACGAGGAGCTGGTGGGTCCCCTGTATGCAC GCTCCCTGGGCGCCTCCTCCTACTACAGTCTCCTTACTGCGCCGAGATTCGCCAGGCTGCACGGTGAGCTCCG CGGAACATCAGCTGCCAACTGGCAGCGCACCGCGGAAGGGTGGGGGCCTCCGGAGGACTTCGGGGAGAGGGAT AGCCGGTTAAAGCTCCTGTCCTTTCTATAGGCATAAGCGGGTGGTCACCACGGATTGGGGATCCGAATCCCTG GCTCCAGATAGACTTAATGAAGAAGCACCGGATCCGGGCCGTGGCCACACAGGGCTCCTTTAATTCTTGGGAC TGGGTCACACGTTACATGCTACTCTACGGCGACCGAGTGGACAGCTGGACACCGTTCTACCAGCGAGGGCACA ACTCGGTACTCTGGGCGCCAAGGCG CGI: 69 range = chr17: 44074360-44075233 CGGCGCTGGCGCAGGCGGCCAGGAGAGAGCAGATGAACCGTTCGTTAGGAGCAGCGAGGTAGTCGTGAGCGCT GAGATCCAGAGACTAGGACCCACTCCCTCTCTGAGCAGCAAATTGGGAAGAAGATGCTCACTCGGTAAGGGCG AGGGAGCCCGGCATGGCGCCCCACCACGGGCTCGGTCTATCTGCGCGCCAAGATCCCGCTTGGGGCGAGGCGT TGGGTCAGCGTTTAGAGCCACTCCCTGCGCTGGTGGCTGGACATAGCCTCCCTATCCCACCTCATCTTCCCCC ATCCCCGACAGAGGAGGTTGTGAATCTACAGGCCCTTGACGTTGAGGCGTCGGAGGGCGCACCTTTGTAATTG CGGCCTCCCTTCGCCCCTTAAGTGCCGCTTCTGGGCGCCTAGGCTGGATATGAAAGCCCCGTTCCTAATCCTC TGCTCTGGTCCCCTCCTCTGGACTGCTGGGACTCTAAGCTAGGCCCTCCCCAGGTTCCATCACTGCGGCGCCA ACCCGCGGCTGGGCTGTCCGCAAGAGGGAGTTGAAGGCGCGCGGAATCCCGAGGTGCAGCTGACCCTCCTCTC AACGCCGACTCTGCCGCTCCCGCCCGGCCACCTCCCTGTCGGGCAGACTTCCTGTTCTCCTGCTCACAGCAGG GAGGCAGTCGCCGAGCCGGTCAGCAGCGTGCACGGAGATCTTCACTCTGCGCCCAGCCCCGGGACACAGGTGC AGATCTCCAGCGGAGCACTGCGGAGTGCGCGCCGTCGAGCACTAGGGAATCCTAGACGGAGGACTTGGTCCAT TCCACGCAGTCCCAGGCAGGTCCGCAGCGGAGGGACGCAGCGGTCTCCAACTCCTGGTCACGACTTCGGCG CGI: 269 range = chr17: 67627870-67631593 CGACTCGGCTGACGTTTTTGACCCGGCCAGGAGGCAAAGACCAAAACGTCAGAGCAGTAGCCCTGTTACTGAG GAGCGTCGGCAGGGTCGCGGGTAGAGGGGGCTGGAGAATGACTTGTCAGAGCTCAAGGTCGATGTGGCGCGGG GCGGCCTCGAGAGCGCCGGGCTCCTGCGTGGCCACGGCCGCCGCTGCCAACCTTCGCGGGGACTTAGCTTTGC TTTCCATTGACTCCCTTTGCAAAAGCGCAGCAGAATCCTGACCAGCCGCACCAGCCCCGGCGAACCCGAGCAT GTTAATCTATTTATATGGATTATTACGGAGGAACAGCGGGCGTTGAGTCACCAAAACATTTGCTTCAAAAGAC TATTTCTAAGCACTTTTGCAGGCAGGCAGGCTCGCTCCAGGCGCGTAAACTCGGCTACGCATTAAGAAGCGGC TGCTTTTCGAATACTGCAAACTCCAGCTAAGTCCCCGGTGCCGCGGAGAGAGCAGTGAAAAGAAATGTCGGAG GTGGGGGTAGATCCTAGTCTAGACACACACACTTGCGCGCACACACACACACACACACACAAGATTCGCGCGG AGAAGGCACTAAAATTCTGGCATTCCGAGAGTACGACAAACTTACACACTTGGAAGTCCCGGGTCCCCCGCCT TCCCCGCAGCACCCCCCGCCCCCCCACCCTACCGTCCGCCCTTTGGCTGCGATCCCCTCCCCTCTCCTCCCCT CCCGCCTCGTCACCCAGCCCAGTGCCACAATCCTCCTCCCTCCCCAAAATCGGGTCCAATCAGCTGCCTGCCA ACCCTGGGACTGCTGTGCTGTGATTGGCGGGTGGCTCTAAGGTGAGGCGGAGTATTTATTAAAGAGACCCTGG GCTGGGAGTTGGAGAGCCGAAAGCGGAGCTCGAAACTGACTGGAAACTTCAGTGGCGCGGAGACTCGCCAGTT TCAACCCCGGAAACTTTTCTTTGCAGGAGGAGAAGAGAAGGGGTGCAAGCGCCCCCACTTTTGCTCTTTTTCC TCCCCTCCTCCTCCTCTCCAATTCGCCTCCCCCCACTTGGAGCGGGCAGCTGTGAACTGGCCACCCCGCGCCT TCCTAAGTGCTCGCCGCGGTAGCCGGCCGACGCGCCAGCTTCCCCGGGAGCCGCTTGCTCCGCATCCGGGCAG CCGAGGGGAGAGGAGCCCGCGCCTCGAGTCCCCGAGCCGCCGCGGCTTCTCGCCTTTCCCGGCCACCAGCCCC CTGCCCCGGGCCCGCGTATGAATCTCCTGGACCCCTTCATGAAGATGACCGACGAGCAGGAGAAGGGCCTGTC CGGCGCCCCCAGCCCCACCATGTCCGAGGACTCCGCGGGCTCGCCCTGCCCGTCGGGCTCCGGCTCGGACACC GAGAACACGCGGCCCCAGGAGAACACGTTCCCCAAGGGCGAGCCCGATCTGAAGAAGGAGAGCGAGGAGGACA AGTTCCCCGTGTGCATCCGCGAGGCGGTCAGCCAGGTGCTCAAAGGCTACGACTGGACGCTGGTGCCCATGCC GGTGCGCGTCAACGGCTCCAGCAAGAACAAGCCGCACGTCAAGCGGCCCATGAACGCCTTCATGGTGTGGGCG CAGGCGGCGCGCAGGAAGCTCGCGGACCAGTACCCGCACTTGCACAACGCCGAGCTCAGCAAGACGCTGGGCA AGCTCTGGAGGTAGGACCCGGCGGGGGCGGCGCGGCAGGGTGGGCATCGCGGCGGCTGGGGGCGCTGGTCAGG GCTGATTTGCCCCGCCCCGCCTCCCATCGCCCGGGAGTTGCCGTTCCGGGAGCCGGCGGGATGGGGTTGGGAG TGGGAATGGGGTGTAACTGTGGCTCAGAGTTTGACAAAGTTCTTGGGCTGCTCGCGGGGACGCGGAGGAGGGG GGTGGTAAGTGGAAGAGGTGAGGGAGGTAGCTGGAGGATGGACGAAGACTGGTGGGAGACGGAAGGAGGGGGC TGCCAGCCTGCTCTCCAGTCGCCTGGAAGCTCAATCGGGGCGGGGAAGTGAAACTTGCCTCCCTCCTACCCGG CCTCTTAAAACTGCACTCTCTCGTGCAGCCCCACTGTCCACGGAGATGGGGCAAGGGAGAAACCGAGGTTGGA GGAGACCCTTGGCAGGAACTGGGAGGCGGGAGGAGGGAGGCTACTGGAAATAGGTGGGAGTGTATGGTGGGGG GTGAGAATTGGGGACCTTCTTGCAGCTTAAGTAATTTGGGGGAAAGTTTTCAAAGGGGGTTGGGGTTGGGGGC GGTAAGTCGAGCAGCAAAGGCGTTTAGGGGGCAGCACCGGGAGTCGTTTTCATCTCCAGCGTTTCCAAAATAG AAATAGAAGGGGAGGGGAGGGAGGGGGCGGGGAGTGACCGCTCAGGTCAGACTGCAATAACTTATTTATTTAT TTATTTTTAAGAAAAGTTATGAGCTGTGGTTGCAGGCAGGAGGGAAGATGGAGTTGTGTGCAGAGGAAGCCGA GTGGTCTGGGTCGCCGCCTCCTCCCCGCCGACCTGACAGTTTGGCGGATTTCACTGACCCCTCTCCCTCTTTT TCTCTGTGCCCCCCGCCCCGCCCCGAGCAGACTTCTGAACGAGAGCGAGAAGCGGCCCTTCGTGGAGGAGGCG GAGCGGCTGCGCGTGCAGCACAAGAAGGACCACCCGGATTACAAGTACCAGCCGCGGCGGAGGAAGTCGGTGA AGAACGGGCAGGCGGAGGCAGAGGAGGCCACGGAGCAGACGCACATCTCCCCCAACGCCATCTTCAAGGCGCT GCAGGCCGACTCGCCACACTCCTCCTCCGGCATGAGCGAGGTGCACTCCCCCGGCGAGCACTCGGGTGAGTCG CCCCTCGACCCCACCGGACAAGCTATCTCCGTCCCGCCTGGCACACCCCCTGCCCTCCGCCTGGGAGATTCTT CGTGGGGACTTTATGCTTCCCGGGAGGGACACACTGCCCTTTGCGCCCGTCCCGCTCCCCTCTCTACCCAGAG CCTAAGAGGCATCCAAACAACACACACACAAACACACACACCCCAACTCAATCCCAGCATCCGAAGAGATTAA CTTTTTTATTGGGAGGTAAAATGCCCTTAACAGCCTTACAAGACCTCTCCCTTCTTCTCTGCTCCCCCACCCC AAAAGCACACACAGGGCTCTTACACAAGTAGCAATTAGGTCTTCCGGACCCTCCGGGCCCCAGACCCTCCCCT GATAAAAGGGGGCTGTCCAGTGTGTACCGGCGGGTTAATCATTGGGCGACTTATCTCCGGTGCAGCGCGCCTC TTGCGCGGGTGCGGGCCCTTATTACACTTTAGCAGCGAGGGAGGGTCCCCGGAGGGTGCCTAAGACTAGGGCG TCTGCACAGCCCTTGTTGATTTTCTCGTGCTTGTTCTTTTATTGTCCACAGGGCAATCCCAGGGCCCACCGAC CCCACCCACCACCCCCAAAACCGACGTGCAGCCGGGCAAGGCTGACCTGAAGCGAGAGGGGCGCCCCTTGCCA GAGGGGGGCAGACAGCCCCCTATCGACTTCCGCGACGTGGACATCGGCGAGCTGAGCAGCGACGTCATCTCCA ACATCGAGACCTTCGATGTCAACGAGTTTGACCAGTACCTGCCGCCCAACGGCCACCCGGGGGTGCCGGCCAC GCACGGCCAGGTCACCTACACGGGCAGCTACGGCATCAGCAGCACCGCGGCCACCCCGGCGAGCGCGGGCCAC G CGI: 260 range = chr17: 71582000-71585125 CGCCTCCGCCCCGCGTTTCCTCCCCCCGATCTCCCAGGGGTCCTCTTTTGAGGGCACCCCAGCCCCTCGACGG TCCCGGGATATCCTGCACCCCTGCCAGGCTGCAGGGAAGCGCCGAGGCGCGCGGAGTGCGAGGTCCGTGCTCC CTGCGGCGCGGCGCACACGCAGGGTCCGGGGTCGACCCCTCCACCGCTCCGGCGTCTGCCGGGGAAGTCAGTC CGCCTGGTCAGCCCAGAACCCCCGACTGCGGGGGCTGGAGCTCGGAAGCAGGTACAAGCGCCACTCTCCGCCT GCGCCGTGGAATGCGCGCCGGGACCACTCCGCAGCCCTTCCCCCAGCGCCGCCGGCCGCTGCTGGGGACAACC TCGCCCTCCTGTCTCTTGCTCCTCCTCCTGACCCCAGCGCACCCCCATCCCCGCCCCAGATGAGGCAAGGCTC CCTCCGCCTTCAGCCCGGCAGAGTCGCACTAGGAGTTGCAGCGGCCGCAGCCCCGGGAGCTTCCCGCTCGCGG AGACCCAGACGGCTGCAGGAGCCCGGGCAGCCTCGGGGTCAGCGGCACCATGAACGTCTCGGGCTGCCCAGGG GCCGGGAACGCGAGCCAGGCGGGCGGCGGGGGAGGCTGGCACCCCGAGGCGGTCATCGTGCCCCTGCTCTTCG CGCTCATCTTCCTCGTGGGCACCGTGGGCAACACGCTGGTGCTGGCGGTGCTGCTGCGCGGCGGCCAGGCGGT CAGCACTACCAACCTGTTCATCCTTAACCTGGGCGTGGCCGACCTGTGTTTCATCCTGTGCTGCGTGCCCTTC CAGGCCACCATCTACACCCTGGACGGCTGGGTGTTCGGCTCGCTGCTGTGCAAGGCGGTGCACTTCCTCATCT TCCTCACCATGCACGCCAGCAGCTTCACGCTGGCCGCCGTCTCCCTGGACAGGTGAGCCAGCGCCTTGGCCTC CCTGGGAGATGGGCATCCACGCGGGGGATGGAGCGGGAGGCGGGACTGGGGACCAAGAAGGGACGCGCAGAGT GGGACAGGACACTAAGAAGGCAGTGGAAGACAAGCGGGCGCGGAGGAGGAAAAAGAGGAATAAGAATGGGGGA CCGTGGTGTCCCTCGGTTAGATGCGTCCTGGGGCCTGGAAGCCTGGAGAATGTGGCTCTCCAGCGCCGCCCGT GCCTGACAACGCGCAGCGTTTCCCAGTACGACGCGTTTGTGCGCGTTCATCTCGCTTGAGCTTAATGCCCTCC GTGAGGGTGGGATAGGACAAAGTGCCCAATATACAGAAGAGTTGAGTTCCTAAGTAACTCGCTCAGAGTCGCC AGCCAGGGATCGGGTGCGTGAAGTGACCGTCTGTCTCCTGCAGCCAACTTCAGGCGCCTCCACTGCGCTCGCC TCCAAGCCACGGTTTGGTTGGTTGGTGCAGCTGGCTCAGGTCCAGGCTGTGGATCTTGGGTCCTTTGCAAGGA TCCACTCCGGAGTCCCAGCGAGCGTGCCTAAAGGTCCCTAGCTCAGTCCCAGCCCACTCTGCCTCTCGCCTCC AAACAAAACAAAACAAAATAAAATCCAAAACAAGTCGGGGCCGGGAGAGGAGCGTGCCCTGGGGTTCTTCCTC CCCAGCCAGAGGAGAGCGAGAGACGCACATTCGGGAGAGCGCGGGACTCAGGTGGAGCTTGAAAGGACACTGG GATGGTTCCTGGGGAGGAAATCCGGGTATTTCCCCTCTCCATCCTCTGGAAAAACAGAGAGGCGAGGCCAGAC TGCCCCCACACCTCCTGTAGCCACTGAGCGCGAAGTGCGTTGGTTCCGAGCGCGCTGGTGGGATCCACAAAGC TCGCATTCTCTCAGGAATCCCCTGAGAAATTAACTGTCCCTTGCCCAACATGTCTTCTCCAGGCTGTCTGCTA GAGCCTCAGGCGCCTCCGCCCTCCCTCCCGCGGCACCGTCACCAGTGGGTAGTCACAGCCTCCCGGAGCCCAT AGCCGGTTCTCCAACCTTTAGTCTTCAGTGGCTTTGGGGTGCCCTCTCAGTGGAGACTGTGGTTGCAGTCCCC GGGGGCAGCGGGAGAATGGCTTGAAGGCACACCTTTCCTGCTGCCGGGCCCGCCCCATTTCCAGGCTCCGCTG AGTGTCTGGGACACGCTGGGAGGCCCCCACCTCCGCCCTCACGCCGAGCCTCACCCCCACCTCCTCTGTGTGC GGTGTAACCATGCGCTAAGGACCTTCCTCGAGAGCAGCCTTGGGACCGAGGTGCAGGGGTCGCGGCCCTCCAG CATGAATGTGCCCGCTCAGCCGACGTCTCCCTTCCCGGTCTGACCGCAGGTATCTGGCCATCCGCTACCCGCT GCACTCCCGCGAGCTGCGCACGCCTCGAAACGCGCTGGCAGCCATCGGGCTCATCTGGGGGCTGTCGCTGCTC TTCTCCGGGCCCTACCTGAGCTACTACCGCCAGTCGCAGCTGGCCAACCTGACCGTGTGCCATCCCGCGTGGA GCGCCCCTCGCCGCCGCGCCATGGACATCTGCACCTTCGTCTTCAGCTACCTGCTTCCTGTGCTGGTTCTCGG CCTGACCTACGCGCGCACCTTGCGCTACCTCTGGCGCGCCGTCGACCCGGTGGCCGCGGGCTCGGGTGCCCGG CGCGCCAAGCGCAAGGTGACACGCATGATCCTCATCGTGGCCGCGCTCTTCTGCCTCTGCTGGATGCCCCACC ACGCGCTCATCCTCTGCGTGTGGTTCGGCCAGTTCCCGCTCACGCGCGCCACTTATGCGCTTCGCATCCTCTC GCACCTGGTCTCCTACGCCAACTCCTGCGTCAACCCCATCGTTTACGCGCTGGTCTCCAAGCACTTCCGCAAA GGCTTCCGCACGATCTGCGCGGGCCTGCTGGGCCGTGCCCCAGGCCGAGCCTCGGGCCGTGTGTGCGCTGCCG CGCGGGGCACCCACAGTGGCAGCGTGTTGGAGCGCGAGTCCAGCGACCTGTTGCACATGAGCGAGGCGGCGGG GGCCCTTCGTCCCTGCCCCGGCGCTTCCCAGCCATGCATCCTCGAGCCCTGTCCTGGCCCGTCCTGGCAGGGC CCAAAGGCAGGCGACAGCATCCTGACGGTTGATGTGGCCTGAAAGCACTTAGCGGGCGCG CGI: 38 range = chr17: 75936057-75936582 CGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTCTG GGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGT ACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAA ATGGCAGAAGAGCATCGTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTC CAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGC TGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGGAGGCCAA ATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCA GCGGAGTGGCTGTCG CGI: 22 range = chr17: 76404186-76404427 CGTCACGTGCAGAGCATCCTCCCGACTGGCGAGGTGGCTTCCACGTGCCCCGTCAATCAGGGCTGGACAGTCC GTCACGTGCAGAGCATCCTCCCGACTGGCGAGGTGGCTTCCACGTGCCCCGTCAATCAGGGCTGGACAGTCCA TCACGTGCAGAGCATCCTCCCGACTGGCGAGGTGGCTTCCACGGAGCGATTCTCGAGACCCGAGGGGCGTGGA CACAGCTTCTACGCAGGCAGTCG CGI: 53 range = chr17: 77537903-77538626 CGCGCGTCGGGCGCTGGGAAGGTGACTGTGCGTTGGGCGCGCTTGGTGGCCCCAGGGCTGGGCCTGCTCCCGT CTGACAGTAGTGCCGCGCTGCATGGCACGGGTGTTGCGTTCGTGGGTGAGAGCGCTGAGGTCTGCACGTCGGG TCTCAGTGGTCATGGGGATGGAAGCCACCCCAGTGGCTGTCGGGGTGAATGGAGGCCCCTGGAGATGGCAGCG GGTTAAGCACGAGCACGGAATTCTCCCTCCCAAAACGGAACTCAGACAACAGTGACGGAGCCTAAGAGCAAAG CCAAAGCCACGGGCAGGGGTGAGCGGGACCCGAGGCAGGAGATGACGGAGCCTAAGAGCAAAGCGAAGCCACG GGCAGGGGTGAGCGGGACCCGAGGCAGGAGGTGACAGAGCCTAAGAGCAAAGCGAAGCCACGGGCAGGGGTGA GCGGGACCCGAGGCAGGAGATGACGGAGCCTGAGAGCAAAGCGAAGCCACGGGCAGGGGTGAGCGGGACCCGA GCCAGGAGTGGCGCCGGGCAGGGAGGCAGGCAGCCCCAGGCGCTGTGTGGGCACTGGGTGAGAAGCAGGGATC CCGGCGCCCTGGCTCTGTGCTGCTTCCTGAGACGAGAGTGGCAGAGGGCAAGAAGAAAACCAAACAGCGCGGG GAACAGAAGTCAGGAAAGATGAACGTCTGGAAGGAAATGCCCCTGGGCCGGGCGGTGCCCCCGGGCG CGI: 330 range = chr18: 894579-899574 CGGAGAGACCTCGGAGCAGAGAAGGCGCCGCCGACCCTCGCGGCTGCCTGGCCCGCGGCTCCTACAAAGGCGG GCTAGCCGCCCGCCCTCTCCCTTGCCTTCCTCCCCTTCTTTTCTGACTTTCCCTCTTTCCCTTAATCGCCTGC TTCTTCCTCCGGGTGGACTTACGGCCACCTTGCTCCTCCGCGCTTCACCTCATCGCCCCCTCTTTCTTTCTTC TGCCTCTCTCTCTGCGCCCCCTTCTCTCCGTGTCACGCTCCCTCCTGGTTCTGCGCGTCTACAAACTTTTGAG CAGAACACGAGCCTCGGCAAACGAGTCCCGCAGCTCCTCCTGCTGCTCCCGCTGGTTCCTGCGGCTTCTGCTC AGACACCAACGCCAGACGGCGATGCCTCTCGGGTGGTGACTCCAGCGCAGGAACTTGAAGAAGCGCTTTGCCC GCCGTCCTACCTGGCAGCTCTCCTGGCAGCGGGAGGAGTTGAAGGGTAAGGGAGGGAAAATCTTACCAAAGCG ACCGGCTCACTCGACTGCTGATTCTTTCGCTTGGCATCGCGTCAGGGGAGTTAGCTTTCCTTCAGCCGGGTCT GGCTAGTTATTGGGCGCCGGGTAGATGCATATATATATATTTTTTTCTAACTATAGCAAGCAAGAAGTGGCAG GGCGCGCACCGGCTGTCGCCAAGTGCTGTTCAACTCAGGGAGCCGGGGCTTCGCTCCGTCCCTCCCCCGGCTT CCAGAGCTTTTTGGGGTTGGAGGGTGGGAGGCCAGGGGCGTTCTCACAGCTGTGTGTCCTCTTTCCCATCCTG CGCAGAATGACCATGTGTAGCGGAGCGAGGCTGGCCCTGCTGGTCTATGGGATAATCATGCACAGCAGCGTCT ACAGCTCACCTGCCGCCGCCGGACTCCGGTTCCCCGGGATCAGGTAGGTGCTGGCTGCCTGGCCCAAGCAGGA GCTGGGGCTTCCCAGGCACAGACGCTTCCTCACGGTCTCCTTCCTGCAGTCCTTTGGGTCCAGACTACTAGCA TCGCCCTCTGCGCCCCCGGTGCGCCTCCGCCAGCCTCGGCTGGACAGCGGGTCCCCATTCTAGCCGAGGGTCT GGCAGGCTCCGCGACTGCTCGGACGCCTCCCCCAGCCCTAGGCAGCTCAGGGTCCCGGGTAGAGCCAGTGAGC TTCTGGCCGCTGGAGAACCCCCCCTCCCCCAACCCGGCCCACAGGATGGGGGCAGGGCACGGCCCCTAGCTTG GTTTCTTTTACCTATTCTTGGGACGAGTTAGGAGAACTTCAGCTCTGGAGCCTGGCCGGGGGTTGAGCGTGAA GCTCCCTCGGACTTTGCTTTGTTACTGCTTGTTCTGGACTATCCGGGTGGGGTCTCTCTCTCTCCTCCACCCT TTCTTTTCATTTCATTCCAATTCTTTCCCCTGAAGAGCTTTCTTTCAAGTGATCCGTGTTCCAACTGCATTTT GAATCCCAGGCTGTCTTGGGGGGCGTGCGGTGGGGAGGGTGTTGGCCCGGTGTGATTGAGGAAAAGCGACTTA AGAGAGGGAAGAACAAGGACGAGACTGCGAAGGAGGGGGAAAAACAGGCGCAAAGGAGGAGGAAGGGAAAGCC AGCAGGCAGGCAGGACCGGGAGAGCAGCCCTGCCTGGCCCGGGATGGAGGAACCTTGGCTTTTTTCTTAACCC CGGGTTTCTAACCGGCAGGCGCGGCCCAGGTTCCCGGAGGCAGCCCCAGAGTCGCGGACCGATGTGCCAGGCT GTGGATGAGCCCTGGGTAGGGGAGGGTTCGTACCAGCGGCGCCTGGGGCAGCGAGGAGCGCGCGTTCTGCCTG CGAAGCTGCCTTCTCCGAGCCCCGCCCAGGAACATTAGCTCTGGGGGGCCGCTGATCATTGATTTGGACGGAG AGATGGGTTCTGGGTTCTGTATTAGGATTCCAGCATCTGGGCTCGAGGCAGGGCAATATCCAGAAAGACCCCA GGGTTCGGGGTACCCGGGCCAGGGCTGAGGCGCATCGCCGAGCAAAGGCTGGGTGCGAGGCGTGCGGAATGAT GCGCTTGCCTTGCCCGGGCCTCTCCAAGGATGGAGAAAAGGCGAGTGAAGCAGCGAAGTACGACTCCAACCCC GCCCAGAGAGTGCTACTAGCGCTGGCTGCACGCCAAGTCTCTCCAGGGGTCCAAAGCGAGAGGGATTTGTTTT AACCCATCTCTACCCGTCCTGTGTCAAGAACGGAGGCTGTAGAGGGCGACTGCGAAGTCGCCAGGCACTCGCT GGATCTCGGTCCCCCTCCTCGTGCTCTGGGGTTGAGATGGGGCACCGCCATCGATAACAGATCAGCGCGAACT ATTCGTTTAGTGGCCTTAAAACACCCTGGTTTCACCCTCAGCTATTTTCAAGTTCCCGTGTGCCTGGCACTTT CTCCGTGCGAGAAGCACCGGAGGGTGCGGACGCGCCACAGTCTGAGCCGCCGCCGAACTGGCTAAGTTTAGGG GCATTTATTATTCATGTTCCTGCCAGATCCTCGCCTGCCCAAAATAGAAACCGAGGTTCTCCGTGACCTACAT CTGCTCGGAGAAGGGCTCCCCTGGGCTCGGAGGCTGGGGTGGGGGTGGCTGAGGAGTTGGCCCCCGCACGCCC CACGCATCCTCTCCTTTGCTTTCTGGGCCTCCCCATTCGGGTCTTCGCGTGGGTCAGCGCCCGGTCTCCCAGG GCCTTTCTCGTCCCCGCCCGTTGCTGCTTTGGGGAGGCTCGGGAGCCAGGCGGGGAGGGGGGCGGTCCTTTTC CGTAGACAGGTGTGCGCGATCGGCGGAGACGCCTCGGTTTCCCAGCGCTTGTTGAGGCCGTGGCCCGCAGGAC GACCCTTTACCCGCGAAGGGGGGGTGGGCGGGCCGCCCGGCGGGGTAGGAGTGGTTGGGTGTCGTTGCCTCCT CCTTACCTCTGCTCCCACCCCCAGTCCTGGGAGAAGAGACAATTCTCAGCGGAGGACTTTTATCACCTGTGAA AATCCGCGCGAGCCCCTTACTTTGGATCCTCGCCGAGCTGGGGAGGAACTTGCACTGACCACACCTTCTGTCC CCGGCCACCCCGCAGGCCAGAGGAAGAGGCGTACGGCGAGGACGGAAACCCGCTGCCAGACTTCGATGGCTCG GAGCCGCCGGGCGCAGGGAGCCCCGCCTCCGCGCCGCGCGCCGCCGCCGCCTGGTACCGCCCGGCCGGGAGAA GGTGAGATTCGCGCGGCCTCGCGCACACCCGCGGCTGGGAGCTCGGGACTGCGGTGACGGGAGGGGCAGTGTG GTGACCCACCCAGGATTTTTTTTTTTTTCCCGTGAAAGTCCTCAAGCCTGTCCTCTCCCTGGCCCGATCCTAT TGCAGCGACAGAAAATCAGCAGCGGGCGGGTCTGTGTGGACCTGAGGGCCGCGTGGGGACCGAGGGGGGCTGT GGCCCAAAGAGTGGCAGTGAGTGGCGTCAAGGAACCCACACTCCGCATCTGCCACTCCTAGAGCCGGGACTAG CTCCCGATCCTAGCAGTTGCTCTCGAGATCATCCCGGGAGTTATTGGCGAGTTCTGGGCCTCTGGAGGTTTCC CTGTCAGCCTCCCCGGCCGCCGAGGGGGCGCGCGCCCAACAAGGGGGTCTCTAGCGGCCACCTGGGGACAGAA ACAGTGACCCTGGGCGCGCACTTTGCCTCCCCGTTAGAGATGTCGCCCACGGGATCCTTAACGAGGCCTACCG CAAAGTGCTGGACCAGCTGTCCGCCGGGAAGCACCTGCAGTCGCTCGTGGCCCGGGGCGTGGGGTAAGAGTTT GTGGAAGGATTAACCTGCGCGCGCCGGGGTGGGTGCCTGTGCGGGGCGCGCGGGGCGGGCGGCGGTGGGTGCC CGTGGGGGCCAGGGTGAGTCTGCGCCCCTGGGTCTGGGGTGGGCATCCGCCACGGGTCGCAGTTGGAGATTTT GAAGTGGCACTTTAAATTTGCCCAGAGAGCTCTGGAAGAGGCAAAAAGGGAACGCGAGCCAGGGAGTTTGATC CGTTTTGAATGAAAAGAAAGAGAAACCAAACCAAACCTCTCAGTCATCCAAAACCTTCAGGCTTCCAGGGAGG TTTTGCTATAATTTTCTCTAAGCATGACTGTTTCTGGGGGAGGGGAAAGGGGTGGTTGTATTTACTGAAAATT CAAATCGAAATAATAAATGGCCAAATGTGGACACTTATGGACCCAAACAGTTTTGCTCACGCCAGAGAAACTG AGAGCACAGGGCTTGTGTGAAGCCTATCTCGGCAGAAGGCAACATTCTAATAAAGCCCGTGGGAAAACAGATT ACATTTTCGCCATGAATAAGTCATGCAGTGAAAAATATTGCCTACAGCCTGTCGACTTATATTATTATCACGT TTTTCAACTCGGCGTGAGGAGGGAGAGGAGTGTTCATATTTGACTAGGAATTGCAGGATCGATGCAAACTCCA GGGCAGCAGCCAGACTGGCATATGTAGGGCTCTCCGGTTACTTTCTCTGTATGTCGCGGGTGAGAGGAACAGC GAGGACAATTTAGCGCAAACACACGAAGGGTCGGATCTCAAGGGGGCAGCGCTGGGAGAAAGGTTAGGCTTGA AGCGCGCGTCGCCTGCCCGGATCTTATCCCGGGCCCCCTCCGCAGGGTTTGGTGCCAGGAGATCCTGCGTGGG GAGGGGGGCATCGAGGGGCTGCCGTCTCGGCCCTCCCCACGGCTGCTTCCAGGCAGAGGCGGGCGACGCGGTG GGCAGTGCGAGCCCCGGGCCCTCCCCGAAGGCTCCCGCGTGGGGTGGGGCCCGCCTGCTCCCCGCGGCGATTG AACCTGTGTCTCCCGCCCCGCCACCCTCTTCCCGACCCCTTTGCTTGCAGTGGGAGCCTCGGCGGCGGCGCGG GGGACGACGCGGAGCCGCTCTCCAAGCGCCACTCGGACGGGATCTTCACGGACAGCTACAGCCGCTACCGGAA ACAAATGGCTGTCAAGAAATACTTGGCGGCCG CGI: 338 range = chr18: 74837994-74842232 CGCAGAAATTACTCGTGCGCACCATTTCCGCTGTGGGGGCATTCGTACAAGTTTCCGCTGCACACACAGCCTC CCGGGCCCTCTCCTCCAAGGCTCTGCCGGATCTTCCAACGAAATCCCAGAGCAGCCTGCGCTGGGGAGCCCGC AAGTCTCTCCAGATCTCTGCACCCCGCACCGCCCGGAATCTGGGACGGCGCCCACGCAGGGCTGGGCCAAGGG CAGAGCTCGCACCCTGCCTTCACGCCCGGTTCACTTGCGTCCACGAAAGCAGCGTGCCGGCCTCCTCCATCTT CCCACTCGCGCAACGCACGGCGACCCGCGCGACACTTCTGCAATCTGAAGGCTTGCTTCTTACAAATAAAGGG CCAGAGTCTCACACTTGCCTTCGTTGGAGGGACTTAGAAGATCCTCCCCACGTCCACACCTTGTAGGAAATGC AAAACAGATCGATGAAATTAAACAGTTGCATTTGGAAGCCCCAGAAAGACCTAAAGACATCGTGCCGGTTTGT TGGAGAGAGGGTTGCGGGACAGGGGGAGCGGGCCTTACGCAACAGAAAAGGTGGGCACAGCGCGCTCAAAATG ACCCAGTGAGGAGTTGGTGCCGCCGGGCCAGAGGCTGCGAGTCCAGCTGGCTCTGGACTTGCTCCGCAGGCGT CAGACGCCGTGGGAACCTGTGTCTGCTTCTTCTCTCCAAAGTGTATCGGTTAAAAAAAAATAAAAGTAGTAGT AGTAGTAGTGGTAAGGAAAAAAATAAAAATAAAAAGGAGACACAATTAACCAGGTCATAAAAGCTAGGGCACC TTCGACCAGGGCTCTGGCCCTCCAGCGATCGTTTTGCGTTGTTTCTCTTCTCAAAAGTAGTCTCAGACCCCTG CCTTTCCGCTGCAGCTCTGCGACTTCCCCAAACTCCTTAATCCTGTAAATTCTGCAAGAAACTCCCATCCTGC AAGCTGCTTTTCCCCCTCCCCCCTGCGTTCCTTTTTTCTCTCCCCACCCGCGCCGCCTCTCTATGCCCCTCTC TTCTCAGAAAAATTCCTGCCCCCCGCGCGCCCCAAAGCCCGGGCTGCAAACTTTTCCCCGCCGGGCGCCTCTG CGCCAGATGCCGGAGCGTCTCCACAAAGCCTGAGCATCTGCACAAGTTCGCAGCCTAACTGCGGGATAAAGAC GTTTCCCCCGTAGCTTAACTAGAAAAGCGCCATCGATGGGTGTGTTAAACGGGATAACTAGAGATTTCAAACA CCTTTTATTTGCCTGTCTTGAAAAAAAAATCTAAATGAATACGCCCGCTACCAAAAGGCAAAATAAAACCAAC CTTAAGGGTTTTTGTTGTTTTTTTTTTTTTTCAAAAGTGGCGATAGGGACTGTTTGGACCTGACTCCAACCTG CGCCCTCCCTTCCTCTATGACCCTCCTGCGCTTTTCCTGGAACCCAAAGCTCTGACTTCGTCAAACTTACACA ATTAAAGGCAGGCGGAAGAACGCGGGCTGGGAAGCAAGCGGGAAGATTCTAGAATGGAAGGGAGCCCGCCGAG CGCCGCGAGCCGCGCCAGGCCGGGTCCGATGGAGCAGGCGGGGATTCCTCCCCCAGGCGGACCCCCGCCACCA GCCCTGCCGGGAGCTCGCGGCCTGCGGAGCGCCCGGGCTGGCCGCTCACCGCCCGCTTCCCCCAGCGAACGAC TCGGGGAAGCTCCAGGAGGCCATCTGTGCTGACGGTTCACACCAGACAGGACCACTTGCAAGGACAAAAATAA GAAATTTAGGAAACGAAAAAAGACGTACTGGGGCGAGGGGCGCGGGCGCGGCGACGACGGGGCCGGGGGCACA TCCTGGCGGCCGCTCGGGGAGAGAGGACACGCGCGGGAAGGAGCGCGGCGGGTGCACGGCCGCGGGTGGGAGT ACGCGCCTGTGCGCGCGGGGCGAGGGCGAGGGCGCGTGCGTGTGACCGCGGGGAGGGGGCGGGCGCGTGTGCG GGGAGCGCGCCGCGCCAGGGGCCGAGTGTGTGGGGCCGATCCAGAAGTGCGCAGCCCCCTCACCTGGCCCCCG TGTCATCCCCGAAATCCCGGGAAAGGGTGGGCCGCGCGCGGGAGTTTGGTGGAGTTGGAACTTTCGGTCGCGC TCGCTGCCCACTCCGCTGGCGCCCGGTGGCCCGTGGTGAAGGGGGACTAGGGTGGGGAACACCGGGGCCCTGC GGTCCCCTCCCTTTCCTGTATTTAAGAAGCCGCCGGCGGCGCAGAGGCCCAGGCGGGCTGGCGCGGGGGCGAG GCGGCCCGGTGGCAGCAGCGGGCGGGGCGGGCGCTCCGGAGTCGGTGGGGCCCGCGGGTTGGGGGGCGGGGAG AGGGGGGAGTGGAAGGGAGGGGGAACGCAGGGGAGGGAGAGGAGGGGAGGAGCCGCGCGGCCCGCGCCGCTTC CGAACCGGAAAGTTGGTCTTGCCGAAGTCCTGCCACCCCGGCGTGCGCACTCCGCTCCGCTCCGGCCGCGAGC CTCCGAGCCCGGCCGGCCGCCGGGGGAAGCCCGCGGAGGGGACGCGGGGCCGGGCGAGAAGGTCCGGAGAGCG GGGGGCACCTGAGCCCGGGCGGGCCCGCCGCGCTGAGCGGCGCTGAGAGCCGCGGCGGAGCAGCGAAGGCGGC CGGCCGACCCCGCGCGCCCGGAACAGGAGGCGCGGCGCCCGAGCGGCCCGGGCGAGACAAAGGCGCCGGGTCG GAGCCCTGCCCGCGGCCGCTCGCTCCGGGAGGGGCCGCCCGGCGGCGGCGGCGGGGGGGGCGCGGGCGGCGGC GCAGACACTCTATAAAGGGGCGAGCCCGGCGCGCCGGCGGAGACGGCGCCGCGCGGACGCCGCCAAAGTTTGC TGCCTGCGCCCTGCGGAGGGACGGCCACCGCGGCCCGCGCCGCACCCGGGCCCCGCCACAGCCGCACCCGGGG CGGCCGAGGAGCGCGGCGCCGGAGCCCGCGATGTGAGGCGGCGCCGGGCAGCGCGCGCCCCGGTCCCGAGGCG CCGCGGCCCCCTCCTCGTCGGCGCGGCCGCTAATTGCGAGCGCGGCCTCATTTGCATAGGCCGCCGGAGTCCG CTGGAGCCCGGCCAATCGGCGCGGCCCTCCGCTAATGGCCATGCATTATTCACCAGCCTAATTGCTCAGCCCC ATGCGCGGCCCGCGCAGCCGCCGCCGCCCCGCGCCCCGCGCCGCGCGCCCGCCAGGCCGCCCCGCGCCGTCCC CGCCGGCCGCCCCGCTGATGCCGCTGCCCCGCGCGGGGCCCGAGCGCCGCTAGCAGCATGTCTCGGCGCAAGC AGGCCAAGCCCCAGCACCTCAAGTCGGACGAGGAGCTGCTGCCGCCTGACGGGGCTCCCGAGCACGGTGAGGG CCGGGGCTGCGGGGTGGCCGGGGGGTCTGGGGCTGCCCGTCCGGGCTGGGGAAGCGCGTGCGGCGGGAGCGGA TGCGCGCGTCCGGGAGCGGGAGAAAGTTCCCTGCTTCCTGCGGGCAAGCGTCCGCCCCGCGCCAGGCCGGCCG CGGGGCCCCGGGTACTTCGCCGGAGCGCGCGCGGCCGCCGAGAGAGTTGTGGGCGAAGTAAACTTGGCTCCTC TCCTCGGAGTCGGGGAGCTGCCCGCGAAGGGCGCCGAGGCCGCGGCCGGCTCGAGGACGGCTCGGAGGCCGGG GCGGGAGGGAGTCCACGGTGCCTCCGCCGCCGCGCCGCCCCCCAGGGTCTCTGCGCCAGGACGCTGAGGCCGG CGGCGGCGGGGAAGGCGACCGCAGCCCACCTACCGCTGGACGCGGGTTGGGGACCCCGCCGCCCGGCCAGCTT TGTTCGGGGGCCCGCGGCCCCTCCCGGGCCCCCGCACCGCCTCGGGTGACCCGCGGTGTCCCAGCGCGTTGAC GCAGCCTGTGATCCCTCGCGAGGCGAGGAGAAGGTCGGGGGCTTGGCTCTGCCTAATGGCCGCCCGGGGAATT AAGCTGGGGGTGAGCGCAGCGGCGGCGGCCTGGGCCTGGCCCCTGCTCGCGGCGTGTTTCCGGGGCGTTCGTT GCAGCGTCTGCGCGGGCCTTTTCTCTCCCGTCTTTTTGGATCCGCCGAGGCCGGGCGCTGGAGACCTCGGCTT TGCAGTCATTTCGCTGGTAGGAGCGTCCTCTTCGAAACATCCAAGAGCAAAGGGCAGGCGCCGCGAAAGTTAA GAGACTGGCAAAGGGCTGGACTTCCCAGAGTGGCGCCTTAGCCCCGCAAAGTTTGGGGCGCCCCCACCCCCTT CGTCG CGI: 43 range = chr18: 75565313-75565933 CGGGTGCAAACGCATCCTCTGTCCCACGTGGAGTGGTGTGTCCACACGCATGTCCTCTGTCCCATGCCCACGT GGAGGGGCGTGTACACACGCATGTCCTCTGTCCCGTGTGGAGGGGCGTGTACACGCACACGTGTCCTCTGTCC CGTGTGGAGGGGCGTGTACATGCTCACATGTGTCCTCTGTCCCGTGTGGAGGGGCGTGTACATGCAAACGTGT ATCCTCTGTCCCATGTGGAGGGATGGGCACATGTGTGTCTTCAGGACGCCTGTCTCAGGCACCCGTGTGTCTT CAGGACGCCTGTCGGGCACACGCGTGTCTTCAGAACGCTTGTCTGGGGCACACGTGTGTTCTCAGGATGCCTG TCTCGGGCACACAGGTTGCGGGGGCGGCCGGGGCTCCTCAGGCCTTTTCTCCCGACTGTTGCTACTATTCTTT TTAGGGCATCTTTCACTTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAG GACTTCCTGGAGAAGATCGCCAAGCTGTACGAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACA CCATCGCAGGTCAGTCAAGCCGCAGCCGAAGAGGCCG CGI: 33 range = chr19: 898548-898981 CGGGACCGTTTCACAGATGAGAAGACCGAGGTGCCAGGGTGGCGATCGCACGAAGGGCCCGTCACGGGAGAAT GAGGAGGGTCTGGCGTCAGCAAGCTCCCCCGGAATCTCGTGATCTGGAAATCCACAGAGAAGCACCTTCACCA CGCCAGCTTCCCGGGCCGCGCTTCATTGTCATTTCTGGAGAGTGTTATTAATATCCGCCCCGTGGGTGCGGCG CTGTGTATTTCCAGAGAGGGGACTCGGGGCCCATCAGGGCCGGGGGAGTGGAGCCGGCAGATGTTCGGCCCTG CCCAGAATCACTTCCCCAATTTCCCCACGCCCGGCGGGGCTCTCAGCATCTGCATCCGCCGAGGCCTGGCTGT GCTGACGGGAATTGAAAGGACCTCGTGGCTTAGGCAGGCGGGGGAGCCCCCCGGCTGGTCAGGTGCACG CGI: 70 range = chr19: 9131907-9132918 CGCCGCGACTATGGGGTAGCGTTCAAGGGCAGGCCGCACCTCACTCAGCACATGAGCATGTACGACGGGAGAA AAATGCATGAATGTCATCAGTGCCAAAAAGCCTTCACCACGAGCGCGTCCCTCACACGGCACAGGAGAATCCA CACCGGGGAGAAGCCTTACGAGTGCAGCGACTGCGGGAAAGCCTTCAACGACCCTTCAGCCCTTAGGAGCCAC GCAAGAACTCACCTCAAAGAGAAGCCCTTTGACTGCAGTCAGTGTGGAAATGCATTCCGGACCCTCTCGGCCC TGAAAATCCACATGCGAGTTCACACTGGCGAGAGGCCTTACAAGTGTGATCAGTGCGGGAAGGCTTACGGCCG GAGCTGCCACCTCATCGCACACAAGAGAACGCACACCGGAGAGAGGCCCTACGAGTGTCACGACTGTGGGAAA GCTTTCCAGCACCCCTCCCACCTCAAAGAGCACGTGAGGAATCACACGGGGGAGAAGCCCTACGCGTGCACGC AGTGCGGCAAAGCCTTCCGCTGGAAGTCCAACTTTAATTTGCACAAGAAGAACCACATGGTGGAGAAGACCTA CGAATGTAAAGAATGCGGGAAATCCTTTGGCGATCTCGTGTCCCGGAGGAAACACATGAGGATTCACATCGTC AAGAAACCCGTGGAATGTCGGCAGTGCGGGAAGACCTTCCGAAACCAGTCCATCCTTAAGACTCACATGAACT CTCACACTGGAGAGAAACCATACGGGTGCGATCTCTGCGGGAAAGCTTTCAGCGCGAGTTCAAACCTCACCGC ACACAGGAAGATACACACGCAAGAGAGACGCTACGAATGCGCCGCCTGCGGGAAAGTCTTCGGTGACTATTTA TCCCGGCGGAGGCACATGAGCGTTCACCTTGTAAAGAAACGAGTTGAGTGTAGGCAGTGTGGCAAGGCCTTCA GGAACCAGTCAACGCTGAAGACGCACATGCGAAGCCACACGGGGGAGAAACCGTACGAATGCG CGI: 25 range = chr19: 12985960-12986259 CGGAAAGCGCGCTTTTCGGCAGAGCTGGTTAGTTTTTAATGCGGGCTTTTTTTTTCTCACCCGCCGTTCCCTC CGCTCCGGTCTGATTCGCAAATCCCCAAACTGGCACAAACCGGGAAACTTGCGGCCGGCCGTTCTTCTCCCCG AGTTGGAGACAGCCCTCTCCTCTTCCCTCCCCCGCCTCTGGGCCCTGACCCACTGCCTGGTTTGCGCTAGAGC CGTTTAAAAAAGAAAGAAAGGAAGAAAGGAGCCGGGCTCTGGTACCCCGATGCCAGCCGAGGGCGCGTTTCCC AGGCGGCG CGI: 35 range = chr19: 55553586-55553895 CGCGACCACCCGCTGCGCATGCGCTTCACTTGGGCGTCACCCGGGGAACTGCGCCTGCGCAGTCTCTCCCCAT CCGAGGTCCGCTCCGCGAGTGCGAGCGCGCGCCAGGCCCACCCGGGCGCTGCTCTTCATGTCCCCGCGGTCGA AGACGGCCACATACGTCCCCAAGAAGACGTCACCGAGGATCCAGAAGGGCCCTGCAGGCGGAGGGACATCCAG GGCCTGGAAACCGGACAAGCAGAGGCGGACGCCATTTCGAGTAGTCTGCAAGGCAACAAGACGACAACTGGGT GTCGCGGCCACAAGGACG CGI: 47 range = chr19: 57082654-57083180 CGATTCGCTTCCCCACCACGACGCCCTAGCGCTACTGTGCAACGAAGACCTCCCAAGCACTGGTTCCAATGCG GAGACCATGGGCTCCCAGACTCTGGGAACTCCAACACGACTGCGAAACGAACTCCGAGCGAGGACTCCCCGAG AGCTCCCCGCAACACGGACCTCACGCGCTAGCGAACAACAGAAAAAAAAAAGCGCGCTCTCCCTGCCCCTGAA ACATTCCCAGAAGCCCACGCAGACCAGACCGATGACCTGTCTCCACTGCTGGAGGCGAGTCAGGGACCCGAAG TCTCTAAACACTCGCCTCTACCCGCCGCCCCGCGAACCCCACACACTGCAGACGCGACACTCGCAAGTTTCGG GGATGGCGGCCGGCGAGGGCCATACTGCGTCTTTCCGGAGACACGGAATACGGCACCAGCCGTCCCTTTATGA TGCAATATGTCTGCGCCCAGGGGACGCTTGCTGGGAGCAGCCATTTTCAACCCTACTGCCGTAGAGCAGGCGG AGTCCCTCTTTTCGCG CGI: 159 range = chr19: 60283718-60285792 CGAGGTGGGGGCGAGGAACCACCCGGACTGGGTCTCCATGGGCGGGGTCGTGGCTTAGGGCAGGGACAGGTGT AGGGCGAGGGGTGAGTTCGGGGCGTGGACGTGCGTGGGTTCACAGGTGTGAACGGTAGCCGCACGTGGGCTGG GACTGAGCTGAAAAATCGGCCAGGGGCGAGGCCCGGGTAGGAAGTGGGTGCGGCGTGGGGAGGCGTGGCCTGA CGGTGTGATTGGCAGGCGGAGCTGATCCGAGAGGACATCCAGGGGGCTCTGCACAATTACCGCTCGGGCCGCG GGGAGCGCAGGGCGGCGGCGCTCAGGTGAGAGGGAAGAAGTTGGCAGGGTCTCTGGGAAGCCGGTTTCCCCTC CTTGTGCCTCAGTCTACAACACCAGCCTGGAACAGAACAAGAGTTTTGCATGGAGTCAAGCACACCCTAGTCG AGTCTTGTCTGTACCTCCCAGACGAGCTGACCCCTTCTCCAGAACTCTGCTTCTTTTCTCTGTTCCCTGTCCA GGCCCTCAGTTTCACTCTAGAGAGGTGCTATCCCTCCGTATATCGGATTTCTCCCTACCTCGTTGAACTTGTT CACTCCCTTTGAGCCTTTTGAGCCTGTGTGTCTCGTTCTGCGCCCTGGATTTCCCCCTCCCTGGACCCCTCAG TGGACCCAGTCTTGGTGTCCCCGTCGCCCTCCGCAGGGCCACGCAGGAGGAGTTGCAGCGCGACCGCTCGCCC GCCGCTGAGACCCCGCCCCTGCAGCGCCGCCCGTCAGTCCGCGCAGTGATCAGCACCGTAGAGCGGGGCGCGG GCCGCGGACGACCCCAGGCGAAGCCCATTCCCGAGGCAGAGGAGGCGCAGAGGCCTGAGCCGGTGGGGACCTC GAGCAACGCTGACTCGGCCTCCCCGGACCTGGGTCCCCGGGGTCCTGACCTGGCGGTTCTGCAGGCGGAGCGG GAAGTGGTGAGCCGCTAAGGAAGGGGTCTGGGGGCAGGGCCAGGCGACTGGAGGCGGGGCTAGGGCGTGGAAG GGCGGGGCCGGCTGCGGGACGGGCGTTCTCTGGTCAGACTTCTGCGTTATGGAAGAGGGGCTGGGTCGGGGGC GGGGCTTGGTTGTGGGGCGTGGCCAGGTGTTTGGGGCGTGGCCTGATCTGGGGAAGTGTATAGGTGCTCAGGT TCAGGGCTTCGACGGGGATGGTTTTGGAACTCGGGAGCCCTGAGCGTCCCCCTCCTCTGTCCCCTAGGACATC CTGAACCACGTGTTCGACGACGTAGAGAGCTTTGTATCGAGGCTGCAGAAGTCGGCGGAGGCGGCCAGGGTGC TGGAGCACCGGGAACGCGGCCGCAGGAGCCGGCGCCGGGCGGCTGGGGGTAAGGGGCACCCTGGCGTGGGATC TGAACCCCCTCCCGATCTCTTCCAAATGTCCCCGCTCTCCCCAGGCTCTCCCCTCCCGCCACTTGCCAGGGCT GACCTCACCGCCATCTTAACCGGGTGTCCACCTCTCTCTGCCTGCCTGGTGCTGGCCCCGCGTCCCCATCGCC GCGCCCGTCTGCTCCCCTCAGAGGGCTTGCTGACGCTGCGGGCCAAGCCGCCCTCGGAGGCCGAGTACACCGA CGTGCTGCAGAAGATCAAGTACGCCTTCAGCCTGCTGGTGAGGACGCGCCCGCCCCTGGGCCGGGGCGCGGGC ACGACGAACCTGTCCCGTCCCCGCACCCACGCCAACCACCTCCCTCCCCACGCCCCAGGCCCGGCTGCGCGGC AACATCGCCGACCCCTCCTCTCCGGAGCTGTTGCACTTCCTTTTCGGGCCTCTGCAGATGGTGAGACCCGCCC CAGGCCCTCGGGCCCCCCTGCAGCGGGAGGAATCGGGTTCGACTTGTAGAAGGTGTGGCGGCACAGCCTGCCC CTCCTGCTCCCCTGACAGATTGTGAACACGTCGGGGGGGCCGGAGTTCGCGAGCAGTGTGCGGCGGCCGCATC TGACATCGGATGCCGTGGCGCTGCTGCGGGACAACGTCACTCCACGTGAAAACGAGCTCTGGACCTCGCTGGG GGACTCGTGGACCCGCCCCGGGTGAGGGGCG CGI: 34 range = chr19: 60907042-60907388 CGCTCCCCTGCGTTTCGGCTGCTGGCCCAGCAGAGGGCGCCGGAGAGCGGACGGAGCCGCAGGCGGGGTTGTG GGAAGACGCTGGGATCCCGTGCGCGCTTGTGCTCCTTCCTTCTGGGCCAGCGCGCAGACTATCAACCGAGGTA TTCAGTCCCTCGGAAACCCAGTTCCTCCGTTTCCAGGCTTCTCGCCCACACGGAGACAGTCGCTCTCACACGT ACCTCTCGCGGGCTCTTACTCGTGGTCCCGGTCTCCTCCTGGTCCCCACCTTCCAGCCCAGCGCGCACACTAG ACGGCACGTGCTCTCCACGCTCTTTCTCCAGCGCCCCTTGCTCACCCGCCCCCCG CGI: 61 range = chr19: 62043096-62043807 CGCAGCAAGCCTCAGCCGCCCTTATTTAAGATACCGCCCGAGAGGGCGGGGAAAGAAAACCCCTACAGGCAGG ACAGCCCTTCGCCCCTCCCACCACCACTGCGGCAAACAAGCCCCGCCCCCAGAGGGTAGCCGGGCACGCCGGC GCCGCGAGGCCGATGGCACCCCGCAGGAAGGGGCATTTTCGCAGCCCCCAGACCCAGCCCAGGAGGCCCAGGG CTCCCGAGAGCCGCATTCCGCCGTGGCAACAGGGATAGCATTGGTGTCGACCTTGCTGGACTTGCCGTGGCAG AGCCCCCGGCTGTCTGCCCTAATGCCCCCGGTTTGCTGCGGTGGCCCCCGGCCAGTCAGAAAGGCGCGGAGAC CCTGCAGCAGCCCCTCAGACCCCGGACTGCAAGATGGCGGCACCAACGCAGCAGCCCGGGCTGCGCCCACCCC TGCCCCAAAAAGGCACCAACCATCCACAGCCTGGCCGCCACTGTGCCCACTCTCGGACTGGGCAGCGGGCGGC CAAGTACCATGTCCGCCAGCCCGCCCTGCCACAAGGGTCGCTGGCTTGCCGCGGGGTCTTGGGCTTGCGGCAA GACGGCCACTCTGGCCCAGAGCCGTCGCGACACCAAGGTCCCGCGGGCAGGAGGCGCGCGGGGCGGCCGAAGG CGCACTCACCTCACCTCAGTGCTGCGCAGCCTCGGGCACGAACAGCCGCCTAGCG CGI: 94 range = chr19: 63321122-63322053 CGCCCAACGAAGAGGAGGGAGTAGGGGTCCGCGCCCCACCACGAAAGGAGAGTAGAGGGCTCGCGCCCTGCGG GGAGAGGCGTTAGGGGGTCCGCGCCCGGCGAGGAGATGCGCGTACCAGCCCCGCACGCCAAGGGGAGAAGACA CGCGGGACGGTCCGCGCCTGGCGGAGAGAGTTCCTCACGCCCGCCCCGCCGGGAACCACAAGCCAGCGCCCCT AACAAGCCCCTGCCCAGAGCAGGGCTGCCGCGTACCCTCACAGACAGAAAGAGCGACCACGCAGCCACCGCCC AGCCCCAGCCGCTCTGGAGTCCTTGACCCCACCCTCACTAGGCCTTGGCTCCGCGACCGGTGGGCGGGAACGG AGGAAACAGACCCGAGAGGCCGCGAGAGGACGGAACTCACTTCCCGCCGCCGTAGCGTCCTCGTCAGCTCGCC CTCCGACTCTCCGCATGGGCGCGCAGAGTTCCCGGATGCGATATTCCGGTGACACCGGACGCTGGGGGCGGGG CCTAGTGCGACGAGGGCGGGGCCGGGGCCGGCCCGGGGCGGGGCCGTGGCCGCAGCTGCCTGGCAGCCAGAAC CTGGGAGCGCTCGCAGTGCTGCCTTTCGGGGTTCTTTGTCCTTCGCTTCTGCTGGTAGGTGAGGTTTAACAGA CGGAAAGACGCCGGGAGCGCACGTGGGCTGCCTTGAGCCGCTGCGGACGAGCACCTTGTCTCTCAGGTTGACC AGCCGTATATCCGCTTGCGAGCCTGCACCACCCTGGGCGCGCGTGGTCTCGGCAGAATCTCGTTCACACGGGT CCCACTCGTAGGCTGCTGTGTCTCCTTCCTCTCACGGCGTCGGGGACTGGGGCCTGGAGTCACTCCTCTACAG GGGTGTGGAACGCGCCAATGGACGCTGACACCTTCATGCGGTCGTTTAACGCTCCG CGI: 35 range = chr20: 9444472-9444893 CGCTTCCCTATCGGGGCTGCACGTAGAGCATCTAACCGCATGTTCCCGGAACCTGGGATGCGCGCGCGCAAAG GAGCGCCCAAGCGTGCAACCCAGAGTTTGGACGCGCCGCCCTTTACAGCCCCCGCCCCGGGGCCGGGCGAGCT GAGGGGGCGCGGGGCGTCTGTGTTCCCAGCTGATCACAGAACAGGCCGATATCGCATTGACCCGGGGAGCTGA GGTGAAGGGCCGCTGTGGCCACAGCCAGTCGGAGCTGCAAGTGTTCTGGGTGGATCGCGCATATGCACTCAAA ATGCTCTTTGTAAAGGTAACTCCGAGCCCAGCGGGCAGAGGGGCCGCAGGCTCCGCGTGGGTGTGGGAAGTGG CGGCCCCTAGGTTTAAGAACCCAGACGCTGCGGGGACGATTGAAGCGCACCTCCCCG CGI: 671 range = chr20: 21433933-21444714 CGCGGAGACATCTCGAGTCCCGCAGGTGTCTGAGCTGCGCTGCGCGCCCCAGCCGGGAAGCCTTTTCTTATCC AACCGCGCCGCCCCGCGGAAAGCCTGGGTACTGCAGACGCCCTCACCGGCCCACCGACAGCTGGTTTTGAAGC GGGGGCTTAGAAAAGTAAAGGGGACAGTGTTTGGAGCCACGATGCCTTTGATGTGAGGCGGTTCCACCCAACA ATCAACGAATCAAGCTGGAACTGCAGGCCCTACTTTTGTTGGGGGGAGGACCTTAAGGAATGTCACCCCCTTG TCCCCTACCCTCTGCCCCACGCCCAGCCTCTCAGAAGGCACCAGGCGTGAGTAGAGTGCGAGGCGTCCACACC CTCGTGTCCCTTCCATTCCCGGACACCTTTGCACCCTAGCCGAGGCCTCAGCACGGAGTGAGGGTTGCCTGGG GTGCCCTGCTGTGTGTGGGGCGTTCTTGCCTCCCGGGCCCTGACCCCACGGTCTGGGTCGGCGAGGCGTCTCT CCCTGGCGTCTGGACTGTGCGCCTGCCCCGCTTCCAGGCGACGAACGGCAGGAGCCGGGGGTCCGGCGGGACC CGGATCCAGGGCGGGCGGAAGGCGAGGGTCTCTCCTTCCCGGAACCCCCGCCCCGGAAACCTGCAACCAAACC GGGTCCCTCCTCCGCATCGCTCCCGCGCTCCCGGGCCGCCTCCCCACGCGGGCACCCACTCTCCGGGCCCTCG CAGCACCGCCCTCTCCGCGTCCACCCGCGCGGCCGACGCCGCCAGGGGCCCTGAGATCGCGGAGACAGCGCGC CCTGGCGCCTGGTGGGGCCCTCCCAGTGGCCAGAGCGCTCCTGGACCAGTCGGCTGTGGTCTGTGCCCAAACA CGATGGAAACCGGGGCTGGGACGGGCGGTGGTACGCACGTGGAGGAGAAGAGGCATGGCGGGAAAACCACAGC CGAACACAGGTCGACTCGCACCTCCCAGGCACCCGCCGCCGTCTGACTCGCGGCTCTCCCCAAGGTTCCGACT CGCCGCCACCTCTTGGCACCACTCACCGGGCTCCGACCCGGGCCGCGAGTCCGCTGATGCGCAGCTGCCTCCG GCGGCTCCCGGGCTCTGCCCGGACCCGCGCGCAGAGACGCTCGGGAACGCTGGGCTCGGGCGCCTCCTGGCGG CGGCAGCACGCGGCACACGCTCGGTTCTCCGGCCCGAGGGGGCGCGTGGAGCGTACGCGGGATCCGCGCGCGG GCCTGGGCTGCTGGCCCACATTTCCCCGCTTGCTCGGATGGCGGCGCTGAGGCCTATTCGCCTCTTTATTAAT AACGATGCCTCGGGAGGGAAAAAATAGAGCCTTTAAAAATCAGAGTGCGAGAGAGGAGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTCTCGGGGCGTTGGTGAAAGCAATAAAACTCAGATCGCTTCCTTGGCGAGAT AGCGGCGGCTATAATGCGCCGGGGGGATCAGGGGTTTATTTGCAGATCCTGGATAAAAGATGATATATCGACA CGGTTTAGAGTGTCACTGCGCTTGGCCTCTCAGGGAGCCACAAGTACATATTTCCTGAAATACCGCCCAGCAC AGTATCTAATCCGCCCGCCACTTAACACCGGGAGGGGAACTTCAGCAGCGCACAAGCGCGCTCCCGGTTTCCT GGTTCTGGGTGGGGAGAGCCCAAATGAGAAGGATCTGGTATGCCTAGACGCCCCCTCCCCTGGCCTTTGTCTT CAGTCCAAGTAATCACTTAGCGATGGGCCTTAATAAATACGTCTGAGAACTGTCCTTATGCTCGGTAAATATT GGATTAGCTTTTCAATGACCAGGCTCTTGAAAAGGCTCGAGAAATACACACCAGGTCTCAACTAAGCCCAACA GTCAATAGGTAAGGAAATAAGTTATTTCCCCATCTGAGGTGGGGAATGTTGGGAAGGGGGACTTCCACTCTTA CCAAATTATCTGATTCTACTAAATATGACCGTTGTACTAAATAGGAAAGGGGGCGCATCCAAGTTTCCCATTA GTCGGAATTTCCACCAGCTCAGTTCTGCTCATTAAGGGCCGAGTGACTTTGTGGGGAACATATCTGGGTTCCA GTTTTTATTTCCACAGAGCTCAGCATAAACTATTTTTGTTTAGTACATATGGTTTATTTGGGGACTGCTTATG GGAGTTTTGACCTGGCAATTGCAGGGGAGAAGGCATGACCCAAATTATTTCCGACTGCCTCGCGCCAATTTGG ACCGCTTAGAGGAGGCAAAAAATGGGCAAATTCCTTGGAAGCCCTGCTGTGTCTCCCTGGTACTGAATTTTGT AAGCACGCGATACAGGAGACATTGAAAATTAAAGAGGAAGTATCTCCCTCCTCCAACATGGGGAGAGACGCTG TTGGAAGAAGTTTCTGAAGTGGTTTCCCATCGCACCAAGAGGCCAGTGGGATGGATCCCCGCGCATAATTCAA AGGAACGCGCGCGTCTTTAGCTCTTCGGGGTTGGTAACCAAGTGGTCCGGCCGGGCGCAAGTCGCCTTGGAAC CGGCTGCAGCCCAAGTCTAGCTGGGCCCGGGACTGAGCGGCACCCTTGGCCTCTCAGAACCTTTCTCGCGGTG AGTGGAAGGGCGGCTCCGCGCGCGGGCGCTTCGGGGCCGGTCGGTTGCGAAATCAGGGGGTGGATTTTCATCT ACCCAGGAGCCGCTAAGCCCGTAGGGGACCGAGCATCACCCAGGCCCTGGGTACCCTGAGTTGCCTCCTGAGC CCCAGGACGGTCCGATGGTGCAGAGCTCCCAGGCAGAAGTTAGTTTCCTGATACACACACAGCAGTGAGCAAA GTGCGCACAAGTGAGCCAAACCCTGAAGACGCAGGTTCGCGGACTCCCATCCCAGCGTTAGAGTCAAGGAGAC AGAAGAGAGGAAGGAGAGAAGTGAGGAAGGGAGAGAGATTATGAGAAAAAGAGATTATGAAAGTAGAGAAAGA GATTATGAGAGCGAGATTATGAGAAGAGAGAAAAAGAGAGATTTTGAGAGAGAGAGACAGAATGAGAGAGATC CAACTTTCAGTGTCACGGGGCCTAGGCGGGGCAAGCGCCCTCCGAAGCCATCAAAGACAGGGGTGGCTTTTTC TCCCCTCCTCCAGCCTCCTCCCCAATAGATATAGCACGAATTTTTAATGCGTCTTCCTTTCACAGACAACAAT ACAGGGTTTGAAAGCCGGACACAATTTAGGTTTTGTGCGGGTCCCTCCTCGCGCTCCCTCGGCCCAGCTGGCC ATATGGAATCCAGCATGGAGCCCGTGGATGACAAAGGGACCCAGTGACAGGCCCAACAAAACCCCAAGGAGAC TTCTGCCTGACTCCGGGATTCACTGCCGGCGATAAGCGCGCTGAATGGTGCGGGGTGGGGCGGGGGGTGGGGG GCGGGCCCCTTCTCCTTCTTCCCCTCTCTCTGTCCCCGCGATCCTTTCTCTGTCCCTTTTTAATATGCACGCC TCTAACATCTCCGGCTCCCAGCTTTCCCATTGTGCGGTTTTGTACCGCCCGCTGTAGATTGGGCGAAGATAGA CTGCTGAAGCGGACCCCGCGCCGGGTGCGCTCCCAGGGCGCTGGGGTTAGGGCCACACAGGGCTCCGCAGGCG CTTTTATTGACTCCATGGGGACCCGAGGACAGAGAGAGGCGGGCGCCGGGTCCACCTCCCGGGCTCCCGGCCG GCCACAGGAGCGCACACCCAGATTGCAGGCCCGCGGTCCTGGCCACAGCTCCAAATTTGTCCTCAATGAGCAA GTGGTGGAAGCCTGCCAGGGTGAGGACCTTCCACGCTTCCCCCTTCCTCTCTGGAAACCTGAGGGTCTCTTGT GATCATTCTCACCCTGGAAGCCCTGGGGCCTGGAAAAGTCAAAATGGCCTCAGGCCTTCTGACAGCTCCGCTC CAAGAGACTTGAAACCCTCACCTTTCCTCCCAAGAGGATTTTGGGATTAGGGGAAGTTGCAAGTGGATGTTGA GTGGTTAGTACCAGGGCAGGTTGGGCGTTCAATTATTGCACAACAAACTATTTGGGAGAAATTCGTTGGCCTT TAAAAACAGTAAGACATAAGCCCCCAAACATTGCCAAGCTAGTGTGGAGAACAAAGGGAGACCTTTTAGCATT TAGAAAAACTGCCCTTTCCCCGAGGATGAGCCCGGAGATGGGAAAGGACCTTTACTGGGGTATTAGAAAGACT TCCGAGCCCTCAATTATCCAGGGGCGGTGTGGAACGCGGGAATAAAGTGTCATCGCGTCCCTGGGCTGCTGCG CAGAGTGCTATCGACGCACAGATTTGGTCGCACGGATAATCATGTTTGCTTTAGATATTGAATTAAACCTGAT CATCAACTACAGGGAGCGAGAAAGTCAGCTGGGACCGCTCCTTTTGCCCGGCCTCCTCACTGCCACCCAACCC CCCAGCCTTGATGGTGCAGCTTCGGAGAGAACAGAGATACAATTTCCAAATGCGCCGACGTTCAGTCCCTCAG CGTCTGCAGCACCCGCTGGGCTCTGAGCTAGAGTCCCAAGTATTTTTAGAAACCCGCGAGATAGAGGAGAAAG GCTCATCCTCCAGTTGGCCAGGCTTCCTAAGACGCTCCCCCGCGTGGCCAAGTGTGCGCCAGCATCTGCCAAG GAGATCTTCCTCCAGCAACAAGGGTGGGACGGAATCCGTTCCCCGCCGGAAAGATGGATGCGCCCTTCCCGGG CGTGCCCGGGGCTGTGTGCCCACTTCCCATCCGGGGAGCTCACCCCACCCCCAAACCTCTACTTCCTAGCAAT CCACCCAGTTCCACGCTCAAGGGCTGACCTGGGGGGACCGCACACCCTGGTTCGGACCGCCGAACGCTGGAGG GAAGGAGGCCCGGGATCCAGTCCCCGGAGAGAGGCCTGGAAGCCCGGAAAGGATGGGAGCGTAAGGGAAGGGA GAGGCATGGTTTGCTGGGATTGCCAAAGATTCTCGCTCCCTGGCTTCCTGGGGCCAAAGATCCTAGGGAGGGC TGCAGTATCCCCTCCCTCCCCCGAGCCCAGAACCCCGCGTACTTCCCCCAAGCCCCCTAAGCCAAAGCCTCGC GCGCCCTGACCGTTCCCACCCCCAGCCTTAGCGGTCTCCTAGGTCAGCACCAGCCCGCAGATTTTGAAAAGGA GTGGGGAGTGGGGAGAAGGCAGCCAGTCTTAACCTCAGACCCCCACCCACCCACTTTCTTAGCGTGAGGTAAG TCAAATGTAACAAAGTGAAAGTCATCGAGTGTAGTGGCTTCAACAGCTTCTCAGGCTGAAGGAGCCACTCATA GATTTGGGCCAGCGAGGGGGGTTTGCTCTCCTCGCCTTTGCGGCTCCCGAAGTCACTTTTCCTCCCGTAGCCG GACGCTGCCGCCCGGGGTTCAGACAGCGCGCGAGACCAGGGGAGATGCGGGGGAGGGTGGGCGGCCCTGGGCT TCCGGCCGACCGCTCGCAGGCCGGAGGCCGAGCGTTCTCCTCCCCGCCCCAATCCTAGGCGCGGGGTGCAGCC TGTGGTCGGAGGGGCCTGCACCGGGAGCCCCGCCCGCCCCAGGGCCCCGGTACCCCCGGCCTCCCCGCCCGAG AGGAACCGCCTGTGGGAGCCCCGCGGGCGGCCGGGCCCGGCTCCCAGGCCCAGGCCTCCGGCCCGGCGCAGTA GGACAAACGGGAGGGCAGGGATTTTTTCTTTTTTTCTTTTTTAAACACAGGATTTTTATTAAAATTCTTATTT AAAAAATCGAAAGCTTTCTGCGCCCGGCGCTGTTGGGGAACCGCGCCGAATAGCTGAGCTCCAAGTTCGGGGC TGAAGGCCCGGAGGACAGGGCAGAGGGCTCCCTGCCTACAGGGTTTTCTTTTCCATATTTGAGAAATGTTTGC ACAATAAAATAAAAAGAGAAAGGAAGAAAGCAGGGGAAAACGCAAAAACAAAAACAAAACAAAAAACAAACCC AAACAAGCCACAAAGAAAGGAGTTGGACCCAGACGGGAAACAGGCCGGTCCTGAAGGTCATTTTGGCAACAAT CACCACCGATATTTACAACGAAAAGCGAAATCTGCCACCAGTTGTCAGAACGTTTACATGGCCATAAATATTT AGCATTTTCTTATTTTTTTTTAAAAAAAGGAAGAAATTCTCTGTATTTTTAAAGTGTTCTCCACTTGCTTTAG AAGACGGCTGACAATATCGCTACTCACACAAACATATTTTACAAAATGCACGAAAGCAGGGGTGGGGGGTCGG TCTTTTTCTCGTTTTCAAGTGACGACATTAACGCTGGGACGGTTTGGTCCCCCCGGGGAGAGGCAAAGAAGCG AAGCTGCGCAAACATTCTGTAAACACGGCGTAGAGTTCAGCCCTCTCCCAAGGTTCAGAAGGAGAGGCATGGG CAGAGCTGGGTGGGTGGAATCTGCCACTCCAAGGAGACGCAGGCAACCTCCCGGCGCCTCCCTAGTGGAGCCG AGAGTCAACTCGACTCCATAATAATAATTATAATAATAATAATAACCACCATAAGGACCGAGGCCTCCTCGCC GCCACCGCCGCCGGGGTGGGGCCTGGGCCTGGGGCCGCGAGTCTCGTTGGGGCGGCGCTCACCAAGTCCACTG CTGGGCCTGGACCAGGGGGTGTGCTGTCGGGTACTGGGGGGTGCTGGCCGAGCTGTACTGGGCGTTGTACTGC ATGTGCTGCAGCGACTGCGCGCTGTAGGCAGAAAAGGGAATGCCCGCCTGGAAGGTGGCGGCTGCCAGGTCCT GGGCTTTGAGCGCGTGACATGGTTTGCCGTCCCTGACCAAGACGGGCACGGCCACCCGGCGCGGCGAGGGCAG GGGCGTCACCTCCATACCTTTCTCGGCCCGGGCGCGCTTCATCTTGTAGCGGTGGTTCTGGAACCAGATCTTG ACCTGCGTGGGCGTGAGGCGGATGAGGCTGGCCAGGTGTTCGCGCTCGGGCGCCGACAGGTACCGCTGCTGCC GAAAGCGCCGCTCCAGCTCGTAGGTCTGCGCCTTGGAGAAAAGCACTCGCCGCTTTCGCTTCTTGCCGGCGTC CCCCCCGCCGCCCGGGGTCTCCTTGTCATTGTCCGGTGACTCGTCGGCCGAGGGCTCCGGGGACTTGGAGCTT GAGTCCTGAGGGGGCGCCCCGGCAGCCAGACCGTGCACTGGGGGGAGGGGGAGAGAGAAGCGCGTCAGGCGTC TGGAGGCCGCGCGCAGCCTGCACCAGACTCGGAGCACCCTGGATCCTCCGTGCGACCCTGGACCTCCGCGCCT GGCAGCCCAGCCCCGCTGCCTTTGCCATGACCCCTGCCTTCCTCTACGCCTGACGAAGACGTCGGGACCTCCC AGGGTAAAGAGGGAAATCCGTAGGAGTGGGGGCTAGGGGCTCGCCTTTCAAGGGGCTCACATAGTGTGGGTGA GAATTTGGGGGGGGAAGTGGCACTGAAGATCATCGCGGGTTAAGGGCTCCGGCGCCCTTAAGCGGTTTCCTCT CCGGCGAGACGTGGGCAGATTTTTAAAAGAAATACCCCACAATCCCAGCATTGATCGGCTCGGCCATTTAAGG CAGGTTTTTGGGGGCTTTCGTTTCTGCTTTCGGGCCTTCTAGACACCCCCTGCACTGCACAAAGCGTCCTCTA TGATCGCGCAGGGGGCAGGGTGAGCTATTTATACCCGGGCCACCCGAAGCCTCCCCACCCTCCACCCGTACCC GGACGAGGCTCGCTGGCTACCTCCAGGGCGCCAGGCCAGTCCCTCCCAGCGGCCGGAGTCCGGGGGCTGCGGC TGGAGCCATCGGTCCGGGTTGACATCATATACCAGCCCCTGGGAGGTATAGCCCTTCTCCCTCTTTCTCCTTA ACTTCTCGCATTGAAAAAAATTTTGGAGACCAAGTTCTTTCCCGGAACTAAGGAGGCTTGAAGAGGAGGGCAG AGGACATCCTATACAGGTGTTAAAAATCTTTCTACGGATCCGAGTGAGGGGGTCCGGGCTTACATGGCCCCTT CCCCTTTCACTCCCAGCGTCCAACCCGGGCTGCGGCTGCAGGAATGGAGGGGACCACGGCCTCGGCAGCCAAG TTTTGCTACTTACGGGAGTACTGAAGGCCCTCGGTGCTGGCCAGCCAGCGCGTGTACGGGTTGTCGCTGCTGT CGTAGAAGGGGTTCTTCAGGGGCAGGCTCTGCACCGCGTCCAGGGCGCCCTGCCCCAGCGGCCCGGCCCTCTT GGCTGGCTCGGGCCCCTCGTTCTCTTCCTCCGGACCTTCGGCCACAGAGCCCTCCTCATCGTTGGTGTCCGGC AGGTCTAAGATGTCCTTGACCGAAAACCCCGTCTTTGTGTTGGTCAGCGACATGGTTCGAGACCCCAAAATTT ATGTCGCAAAGTTGTAGCTTCACTTGGTCAATTCGTGGCGCTCCCCTGCCCCGGCGGGCGGGGGAGGGGGGAG TTGGGGGGAGGGACTGGGGGAGGGGAGGGGGGAATTGGCTTTAATTATTGGGATAATTATTATTTTTAAAAAG AGAAAGAAACTGGGGATGGGGAGGAAAAAAATGAAGCCCAACCCAGTGCCTCTCTCTGTCTTCTTTGAAAGCA CGCGGAAATGGACGCAGGAAGCCGGGCGGCCTGCGCGCCGAGCGCCGCGGGCCCCGGCCTTAGTTTCTAACTC CAGGAGGGGTGCCAAGGCGGCGTCAGCTCGGGCTCCGGCGGCCGCTCGGCGCGCGGTGGCGGCTGGTGGCGAG GAAAAAATGGGCCATTGCCCGAGCGATCAGTCCATATAAGGCTGGGCTCCACTCACGAACCTGGGGAGGCGGG GAGAGGGGGAGAAAGAGAGGGAGGGAGGGAAAGAAAGAGGGAGGGAGGGGGAGCGAGAGAGGGAGCGGGAGAA GGGTGGAAAAAAGGGGGAAGAGACATTAAAAACGCAAAGGTTGGCCACGTGTGGGCGGGTCTTGGGAGTCAAG TGGATGAAGACAGTATTTGCAGATGTGAAATTGTGGGTTTTGGGGAGCTCCGCGCTCCCAGCCAACGGCCCTC TAGAGCAAGATGAGAGGTGTAACGTGTCAATTAATTGCAAAGACGGGGCGAGCCTTTTTTTTTTTAAACCCAG TATTTACATACAAAGGGCCACCGCGTCGCTCGCGAGTCCACACACTTGAAAGGGCCGTTTTAACAAATTGCAT CTTAAAAAAGGTGGGGGTGGGGAGGAGGAGGGGAGAAAACAAAACAGAAACCAGGAGGAGGGAAAAAATCCTC TTTAACATTCACCGGTTCCTACCTCCCCGCCCCCGCGCGCCCACCCCCGGCAAGCCGGAAAATTGGCGATTTG TGGCGCCTTTGGAAAAGGGGGAGGGGGCGAAGGCCGAGCTGCGGAAATCTCTCCTTTCCATCGTTGGTGGTTG CCTAAACAAGATCCGGTTCAAATGGCAAGAGCCCAACTTCTGTAAGCCTCCTAGGTCAATATTTTGGTTGAGG CTTAAGGATGAGTGCTAGAAATGACAAGGCAAGTAATTGATTCCAGTTAACCGCGAGAGAGCCCAAAACCCAG GAGAGAGCTCCGCTCCGGGCCGGCCAGAGCCACCACCAAGCGACCCGCCCCCTTCCAGCCGCCCTTTATTTGC TAAAGACTCATTTATTTCCTTCACTCCGCCTCCCCCCACCTCCCACCCCCAACCCCCCGCCTCCACCTCTCTG CGGCCAAGGAGGACGCGCAGTTCACTTTCTGCTTTGCGGGCGGTCCCGGGGAGGGCGGGGTAAGAGTGAGGAG CTCCAACTTCGTCTGGGGTCGGACCCTGGCCCTGCTGCCTCTGGGCTCTGCGGGCCTCTTTCCCCGGGTGGAG GAAAGGGCAGACGGCCCTGCTCTTTCCTGCCCTCTATTATCCCTCCCTCTCCGGCCCCCTCCCTCTCCAGCCT CTGGCTAGAGGTGGAGCAGCGGGAAGGCGGCGGGGCGGGATTGCGGGGGTGGGGGTGGGGGTTGTGTCTCCAG CCTGGGTGAAGACCCAGAAAGCTGCGGGGGAGGGGGGTCGCTGGGTGGCCCGACGATGCCTCGTTTTCTCCCC AGTTTTCTTCTCCCACGCGAGTTCTTTAGTGTGGTCTCTTTTTGGACGCCTTGGGTGCGTTCGGAGTACGCGC TCCACGTTTCCAGGTTAAGTCAGGTTAGTGTGAAGTTTCCAGCCACTCTCGGCTCTGGGAACTGAACTTTCCC GGGACTTGCACTTCCTCCTCGGCGCTGGGGTTGGAAAAGACCACGCCGCATTTGCCACCCCTTCTTCTAGTTA AAACTTTTTTGGGGGGGGGGTGCAGGGGTGTAGATTGGCTACCTGATGCTCGTTCGCCCCAGAGGAGTGTCAG GAAGGAGCTTTGTCTGGGGGCGGGGAGGGGCACAGAAGGCCACCCCTGCGGGGTCCAGGTCTAGTCTTCCCAC AACCTGGGCTCCTCCGCGCGGGCCAAGCTGAGCGCGCGGGCACCGGGTCCTCCTCGCGCGCAGCTGCAGCGGA CGCCGCCGCGCCCCAGCTGCCCCCGGGTTGCCAGCGCTGGGTGAGGGCACCTCTCCCCGAGCCGCTCGGCGGC TTTCTGCAGCCCTAGCTGCCTCGCCCCCAGTATGTGACGTGGGTGACAATGGCCCAGGTTAGAGCAAGCCCCT CGTCGGCGCGTCCTGGGTGGTCGGACCCGGGCAAACACAAATACAAACCGATTGCTAAGCTGCGGACAATGAG CGAAATGTAGACAAATGTCCCGCTCCCGTTGGAAGCCTTTGTCCCGGCTCG CGI: 61 range = chr20: 23294035-23294650 CGCCACGGCGTGGCCACCGAGGTGGTGTACCGCTGCGACACCTGCGGCCAGACCTTCGCCAACCGCTGCAACC TGAAGAGCCACCAGCGCCACGTGCACAGCAGCGAGCGCCATTTCCCATGCGAGCTGTGCGGGAAGAAGTTCAA GCGCAAGAAGGACGTGAAGCGGCACGTGCTGCAGGTGCATGAGGGCGGCGGCGAGCGGCACCGCTGCGGCCAG TGCGGCAAGGGCCTGAGTTCCAAGACAGCGCTGCGGCTGCACGAGCGCACACACACGGGAGACCGGCCCTACG GCTGCACCGAGTGCGGCGCCAGGTTCTCGCAGCCGTCCGCGCTCAAGACGCACATGAGGTACGCGGGGAGCCG TCCGGAGGGGTCCCTGCGCACTGGAAGGGTGTGTCAAGCACTGAGGTCGTCCTGGGATTTGATGTCTCACTGC TTAATTTCTCCGCTCCAAACCTGGGGGCTTATTTCGAGACAGCGTTTAGTTCTCTGTCAAGGTACAGGGGCTG CGAGTGATGGCTCTGCTCCCTTGTTCTGAGACCCCTGGGGCGCCCCTGCTGGCCGGGACGTCCCTCTGGTGGG ACCGCGACAGCGGCCGCGGGCTCGCCCCACCG CGI: 118 range = chr20: 25011839-25013525 CGCGCTTTGAACCCAACCAGCCCTCATCGCTCGGAGCCCTGCGTCCCCCGCTTCCCAATCCCAGAACCCCGGA AGCAGATCTCCTCAGTCCCACTCCCTGAGGGTCCTACAGTCCGAGGTCCCGCAGCGAGGGAGGAGCAAACGCC TGAGCTCCGCGGGAACCCGGCGCGGCTGCCTGCGCGCACGCAGGGACCGGAGCCCGAGCCTGGGCCCTGCAAA GTGGGTCTCCCACTCGCTGCGCGTTCGAGTGGGGCCTCCGCTAAACATGCAGATTAAACAAGGGGCTTCCGAT AAGGATAATTACAGGAGGCTGCGCATTGACTTTCCGTTACTAAAGGAAGACCCAAATCTCCCCCTTGCAAGCT GTTCCCGGGATTACCAAAACAATCACTTTCTTTTGAGATCATTGTCTTTTGAACCACTCCAGCTCGGGGCAGA ACGCTTTAGACGCTGGCGTTGTTTTCCGCTCCGCGAGGAATTTTCCCCCAGATTTATCTCTGGGTTTAGGGAA GGCGTTGGGCATTCGGGACTGCGTAGTCGTTTGTAAATCCGAATTTGGGGTAGCAGTTAAGTGAGATACCTAC GCTTCCACACAGTTTGTAGCCCGAGACCAGTCAGGCAGGCAGGGTAGTCGATTCTAAGGTGGCCCGACCGGGG TCGCCCGCGAATGGAAAGCCTAAGGGGCGAGGGCGGACGCGGGCGCCGTGCCTGCAGCCCCGGGTGCCGACCA AGTGGCCTCACCTGGGACAGGTCTTGGGGTCTCCCTCCCCTAGGTCTCCCTGGAAGGTAGGCGATCACGGGAG TGACAGACCCCGAGTAGATAGCCAGTGATCCAAAGACACCAAAAGGCCAGGCGGTAGGAGCCCAGCCTCAGAC ACTCTCTATAGTGACCGCGGCGCCTCGGGAAGGATCGTCTTAAACTCATTTTGCAGGTGAGAGCAACTGGGAC TTATTAACCCAGTCACATCGGACACAGAGACGTGGCGAGGGCGACACAGAGCAGGAGACTCAATCAAGGAGCC CGTATTGGAGCTCTAAGGGGACTCAGAGATGCAGAAGGAACGAACTTCTAAGGGGTCTTGCAATTCCTGGACT GGGGCGTTCCTAATGCATCCCGGGACCCCAATGCCAGGGAGGGGCCTGCAGGACCCCAGCGGTGGGCGAGTTG TGTCCTGGGTCACCTTGTGTTTCGCAGCGTGGCGGTGGCAGGAGCCCAGCGCGGGAGGACATTTTCATAGCCT CCTACAGTGAGAAACGCCCCCCACCCGACGCTGCGCTCATCTGTGTCCCCGCTGTTGCCGGGGCTCTGGTATC CACTTGCGCGCCCTATGTGGTGGGGATCCACCCAGAGCCCAGCGTCAAGTTATACGGGCGCTTCACTCAGCGT CAGCCAAGACCAGGGAAGCGCTTCTTGCCGTTTAGGAGACGTCTGCAAGAGATAAAAAGCTAGCCCACGATCC ACCCACAATCCTCGTGTCCCCGGGGTGCCCTCGCAGTTGCCAAACCTACGGGCCGCGTTTAGGGGAAGCCTCC GCGTCCTGGCGGCCAAAAGAATGGGCTCCTTCCAGCTTCCCCCTACCGGATACCACCTGCAAATCTATTGCCA GAGGCGCAGCTCCCGCGAACGTTCCCGCCCCGGGCGGCCCCCAGGAGTCGTTTTGGGTCCCTAAATCCGTTGA GGGTTCCG CGI: 380 range = chr20: 36785545-36790786 CGGCCGTCGGAGCAGGGCCCCAGCGCACCGCGAGCCTCTGCTTCCTCCGCCTTGCAGCGCCGCGAGCCCTTCT TTCCTCCGCGCCTGGCCCCGTCTGCGCCCCTCTCGGCGTGGGCATTCGCAGACCCGCTAGGAGGCTGACGAGA GGTGTCCTCATAGAGTCCTGCCTTCTTCCAGACCCCCAAACGAAAAGAAAGAGAAAAGCCAACCTTTCGCCTC CATTCTGCACGCATTTGGAGAGCGGCTGGTGGCGAGCGATCCGCACAATCGCTTCCCTCGCGGCGTCCCTGGA CGGGCGGAGAGAACCCGGGTGACTGAGCCTGAGGCTGAGCTTCCTTGGGAGCGATCCATGCCAGCCACTTCTA CCTTCAAGGGGGACTCGCGGCCGGGTTTACGCGCGAAGGATGGGTGCCAGGGAAACTGACTTATAGACGACCC GCTCCGCGAGAGACTGACAACTCAGTCCTGCGGGCTTTCGGGGCGCCCAGACCAGTCCTTAGCCAGAGGATCT GGGGCTGCACAGCTCCCGGACCCTGGAGGGGGTGGTCCGGGGGTGGGAGACTGCGAGCATCAGCCCACGCCGG CCCCCTCCCACCCTGCGGCGGCGAGGTGGGAAGGGCCAGGATGCGAGCTTAGCACCTCCCCTAGAAATGCAGC ACTTCGCCCCCCCACCTCCCCTGCCCTCGGCGCTCCCTCTTTCACGCGCTCCCTCCCGCCTCCTTCCCAAGGG CGCCCTTCTTCTGCCCCCAGCTCACGTCTGAATCCCTCGGCGCCCCCTTTCTCTTCTCCTAGCCCCTTCCTCA CGTCCCCTGCCTCCGGGTATTTCCTCTCTCCAATCCCCCACCCCCGCACCGCCTGATTCCGAGGGGCGGGAGC GCATTGGGCTGCGCACGGGTGGGGGCGCCGCGCCAGCTTCGCGTAGCTGCTCTGACGCCGCTGCCGCCGCCGC CGCCGCCGCCGCCCTCCGCAGCCCAGCTCGCGCCCCGCGGCAGCTCCGCAGTGCACTAGCCACCACCGCCGCC GCCGCCGCTCCGCCAGACCTGCTGCCAGCTTGCCCGGTCCAGCCCTGAGAGAGCCTCGAACGCCAGCTGCGAG GGTCATGAGCCAGAGAGCCCCGGGGCGCCGCGCGGAGAGCAAGCGGAGATAGCGACTTTGCGCCCCCCAGCCC TCGCCTTCTTGCATCGCGTTCCCCGCATCCTCGGGTCCTTCTGTCCTTTCCGCTGTCCCCACCGCCGCCATGG CCACCTTGCTCCGCAGCAAGCTGTCCAACGTGGCCACGTCCGTGTCCAACAAGTCCCAGGCCAAGATGAGCGG CATGTTCGCCAGGATGGGTTTTCAGGCGGCCACGGATGAGGAGGCGGTGGGCTTCGCGCATTGCGACGACCTC GACTTTGAGCACCGCCAGGGCCTGCAGATGGACATCCTGAAAGCCGAGGGAGAGCCCTGCGGGGACGAGGGCG CTGAAGCGCCCGTCGAGGGAGACATCCATTATCAGCGAGGCAGCGGAGCTCCTCTGCCGCCCTCCGGCTCCAA GGACCAGGTGGGAGGTGGTGGCGAATTCGGGGGCCACGACAAGCCCAAAATCACGGCGTGGGAGGCAGGCTGG AACGTGACCAACGCCATCCAGGTAAGCGCGGGATTCCCAGTTCTGCCTGTCCTCCCCCCTCCCAGCTCAGCGT GCCGGGCTCTGCCCCCGACAGTCGCCCGGTGATCTCGGCCTGGAGACCCCCTCCTGTACCCAGGAATCTCCCT TTCTCCATCCCTCCCAGCCCTGCGCGGGGACCTACGCCCCCAGGCGGTGTTTTCCGCCCTAACCCACGCTCCC TCCCAACGGCACCAGCTGCAAGACCGCTAGGCTGAAGTTCGGTCTGAGACACCTGTCCGGAGACACTGCAAAA GTGAAGGAAATGGGGGGAGGGAGCAGGAAGCGATGAGAAAGAAAGAAAATCAGGATTGGAGGGCACGGTTTGG TCTTGGACTCTGGAACGGATTCACAGCTGCATTTTTGGGAGGAAAGAAGAAGGGGAAATCGCTGAGGTCGGAG TCTCCTCCCCCCGCACACACGCATAGACACGCACACGTATATAGGCAGGCACACCACATGCCCACAGCCCCCC TTCCCACGAACAAAGGCGCAGGCACAGGCGCACACGACATGTATCTATATATAGACCACAGTACTATCCCCAA ATGCACCTGCGTACACCCCTACAGCTCCACAAACAAAAGCATATACCTGCACATACCAAACACACGAATATTC GTTTGAACATATGCACACACACATGCACAGATGCATGCAGACAGGAACCAGCCTGCTCCCTTGGGTGCGGCCC TGTTGGAGACATACAGGTATACACACACGAAAGCACACACATGCTCCCACACAAACACATTTAGTCCGCAATA ATCCAGCATTACCTGTGCACAGACTCGCCCCTCTCGCCCGAAATCCCGGCTGCACCGCAAAGAGGCGGCCAGC TCCTCCCCGTGTGACCCTGGCGAAGCCCTCTCCAGAGGCTAAGAATGGCCCCTGCTCTCTAGGCCCTCTCCCC TTATTCCTAACCCCCCACTCCCCACCAGGCGGCGCAGGACTCCTACATAGGGAGCAGGTTTGGAGTCTTGGCA ACGACCTCCGAGCTAGCAGGGGCTGGCAGGCCGCAGCTTTCTGGGCCGAAGGAGACTTCAGCTCTAGGCAACC CCGGTCCCTTACAGCTTGGCCCCGCGGCGTCCCTGGAGCGCACTATCACTGGGGCCACGGAAGGCAGGTTTTC TGGGAGCAGAGGCCTCCCAGGGGTTGTTCCATGTATCGGGGTAAGCAGGACTCCACCGGGCCCCGAACACCAG ATGGCCCGACCCAAGGCGCTTTCCGCTCCGGGGCCCGGCGAGACGGCCTTGCTGGATCACGGACCCGGGGCTG CTCCCGCCTTCGCTGTGCCCCGCGACTTCCCGGGGCGTCTTTCAAGGCTCCGTTTGATAGGCCCCAAGGGAGG CCAGGGCAGGAGGCTGGAGGCTCGTAGGCCTCCGGGACCCTGGATTTCGTTAGCTCTTAGTCCCCGTGTGGAT TCTAAACCCTACAGCCCTGTCCGCCTGACCCTGAAGCTTCTGGTTCTAGACTCTTGCTCGGTTCGGCTTTCTG GCCTCCCTGGCGCCTTCCCGCCAAGCTCCTCCTCCTGCTTGCCTCCCCAGCCTCCACTTAGTCCCCTTCCTTA GGTCTCGCCCTCGCCTCACTCTAACTCCAGCCTTGTCCTAAGACTCTCAATTTCCAGCCCTGCTTCCTCCTCC CCGCGCGCTGCTCCCCAAGCGTCTTCACATTGTCTCTGTTCTTGCCTCCCAGGGGCTTTGCCCCACCTTCAGC CCCTCTCCCTCTCTACCCTATTTCCTTTTCGCCTCACAACTGCAGCCTTTAACGTTTCCTCCTCTGGTCTGAG CCTGAGACGCCCGAGTTTTCCTCTTTAGCTCCCGTGCCCCATTCCAGCCCCACCACAAATCCCGTGCCCACTC TTTCCACTGGCCCAGGCCCAGCTCACTACCTTTCTTAGAGCCCCTTTCCGACTACGCTCCCTTCTGTCCCTTC TCATCTCCTCCCCCAACTCCTCATTCTGTTCCTGTCCCCAGAAACCATCCCGAAGTATCTCCCTTCCCTCCTG TGGCTTCTCCCTATTCTCAGCCCTCTCCCACCCTAGCCCTCTCGCTATCACCAGCCATTAGCGCACCTTTCCT TCTCAGATCCGTCCATACATCCCTCCCTCTCCATCTCTGGCTCGACACCCGGGCTCACTATTAGTTCCCCTAC ATCCACCCCGCAGCCTGCTCTTAACCTCTCCTCCCCGGCGGCTCAGACCCAATTCTCAGTGTCCTTAGCGCCC CCTTCGGGCCACAGCGTTAAGCCACGCCCCCCGGGCCCCTCATCCGTTGCCAAGTTCGCTGAGCGTCCGCGTC TGGTTGCCTCTCCGCCCCACAGGGCATGTTCGTGCTGGGCCTACCCTACGCCATCCTGCACGGCGGCTACCTG GGGTTGTTTCTCATCATCTTCGCCGCCGTTGTGTGCTGCTACACCGGCAAGATCCTCATCGCGTGCCTGTACG AGGAGAATGAAGACGGCGAGGTGGTGCGCGTGCGGGACTCGTACGTGGCCATAGCCAACGCCTGCTGCGCCCC GCGCTTCCCAACGCTGGGCGGCCGAGTGGTGAACGTAGCGCAGATCATCGAGCTGGTGATGACGTGCATCCTG TACGTGGTGGTGAGTGGCAACCTCATGTACAACAGCTTCCCGGGGCTGCCCGTGTCGCAGAAGTCCTGGTCCA TTATCGCCACGGCCGTGCTGCTGCCTTGCGCCTTCCTTAAGAACCTCAAGGCCGTGTCCAAGTTCAGTCTGCT GTGCACTCTGGCCCACTTCGTCATCAATATCCTGGTCATAGCCTACTGTCTATCGCGGGCGCGCGACTGGGCC TGGGAGAAGGTCAAGTTCTACATCGACGTCAAGAAGTTCCCCATCTCCATTGGCATCATCGTGTTCAGCTACA CGTCTCAGATCTTCCTGCCTTCGCTGGAGGGCAATATGCAGCAGCCCAGCGAGTTCCACTGCATGATGAACTG GACGCACATCGCAGCCTGCGTGCTCAAGGGCCTCTTCGCGCTCGTCGCCTACCTCACCTGGGCCGACGAGACC AAGGAGGTCATCACGGATAACCTGCCCGGCTCCATCCGCGCCGTGGTCAACATCTTTCTGGTGGCCAAGGCGC TGTTGTCCTATCCTCTGCCATTCTTTGCCGCTGTCGAGGTGCTGGAGAAGTCGCTCTTCCAGGAAGGCAGCCG CGCCTTTTTCCCGGCCTGCTACAGCGGCGACGGGCGCCTGAAGTCCTGGGGGCTGACGCTGCGCTGCGCGCTC GTCGTCTTCACGCTGCTCATGGCCATTTATGTGCCGCACTTCGCGCTGCTCATGGGCCTCACCGGCAGCCTCA CGGGCGCCGGCCTCTGTTTCTTGCTGCCCAGCCTCTTTCACCTGCGCCTGCTCTGGCGCAAGCTGCTGTGGCA CCAAGTCTTCTTCGACGTCGCCATCTTCGTCATCGGCGGCATCTGCAGCGTGTCCGGCTTCGTGCACTCCCTC GAGGGCCTCATCGAAGCCTACCGAACCAACGCGGAGGACTAGGGCGCAAGGGCGAGCCCCCGCCGCGCTTCTG CGCTCTCTCCCTTCTCCCCTCACCCCGCCCCCACCAGCCCAGTGCGCCCTGCCGCCGCG CGI: 315 range = chr20: 38749965-38753401 CGCTGGTGGAGCCCGCCTCCCTGAAGCCGGAGTTGGCGAGTTTCTCGCACTTGACCTTGTAGGCGTCTCTCTC GCGGGCCAGCCGGGACACCTCCTGCTTAAGCTGCTCCACCTGCTGAATGAGCTGCGTCTTCTCATTCTCCAGG TGGTGCTTCTGCTGGACGCGTTTATACCTGCAAGACTGGGCGTAGCCCCGGTTCTTCAGGGTCCGCCGCTTCT GCTTCAGGCGGATCACCTCGTCCTTGGTGAAGCCCCGCAGGTGGCGGTTCAGCTCGCGCACGGACATGGACAC GAGCTGGTCGTCGGAGAAGCGGTCCTCCACGCTGCCGTTGCCGCCCGCCGCCGTCGCCGAGGCCGTCGCGTGC GGCCCGGGCCCGGGGTGGCTAGTGGGCAGCTGTTGCGCCGGGCTAGCGGCGCTGGACGGCGGCGGCGACGCTT GGTGATGATGGTGATGGTGCGGGTGAGCGTGCGGGCCCAGCTCGTCGTGGGCCACGCCGGCGCCCGGGTACGC GTGGTGCGGGTGAGGGTGGTGGTGATGGTGGTGGTGGTGAGCGCCGCGAAAGCTGTCGAAGCTTTGCAGCGGC TGTGGCACTGGGTGCGAGCCGATGAGCGCTTCCACCGCGTCCTCGGGCGTCAGGTTGAGCGCCTCGGGGTTCA TCTGCTGGTAGTTGCTCGCCATCCAGTACAGATCCTCGAGGTGTGTCTTCTGTTCGGTCGGGCTGAAGCTGGG CGACGAGGGCACGGAGCTACACGGAGTGCTGAGCGGTGTGGAGGACACCGAGCCGGCTGGCTGCAGGCGTGTG CAGGGCCTGCCCGGACGCTCCGCGCGCCCCAGTGGCTCCTTCTTCACGTCGAACTTGAGCAGGTCGAAGTCGT TGACATACTCCATGGCCAGCGGGCTGGTGGGCAGCTCTGGCCCCATGCTCAGCTCCGCGGCCATCGCTGAAGC GAGGCGCAGCCGCCGCTGCCGCCCGGGAAACTTTGCGGCCGGCCGGAGCGCGCCGAGCCAAGCGCGGGGGGGA AGAGCGGAGAAGAGCTGGGGAGGCGGGGAGCGAGGGCGCAGCGGGCCGGGGCCGCCGGCCAAGCCTTTGTCTG GGGACGCGGCGGCGCGCCGGAGAGTCCCGAGGCTGCCTGCACCGCCCCAGAGCTCTGGGCTGTGCCCGCGCAG GGACCGGGCCGGGTAGAGTCGGGCGGGGTGGAGAGGCAAGCGGAGCGCGCGGTGGGGCTGAGGGGAGGCGTGG GGCGAGTGCCCGTTGCTCGCTCTCTAGCTCTCTTGCTCTTACGCTCTCTCGCTCGCAGCCGCTCGCAGCTCGG CGGTGCAGCTGTGCTGGATCCGGCGGCGCCGCAGCCTTTTATCGCCTCCTGATGTCACTGGGGTGCGGGGGCC CGGGCGGCCCGGTGCGCGGGCCAATAGCTGCACGGCCTCCGCGGCCCAGCGGCGCAGGGCGGGGCGCGCCTGA CAGCTCCCCCGCCCCCCGCGTCAGCTGACTGGCGGCCCGAGCGGCCCCGGAGCGGCGGAGGCCTGGCGGAGCG CTGGAGCGGAGTGGGACGGCCAGCCTGGGCCCACCCCCGTACCCTGCAGGTCCCGGCCCACGCACGCTCGCCT GGAGTGCGCGCCCCACCTCTAGGCCAAATCACCGCTTTCCCCTCCTCGCGCACTCTCCTCCCTCAGTTCCCTT TGCACCCCACCCCCATCCCGTGTCACCCCCAAGGAGGCTCAGAATGAGCGCCGGGACAACGCCTCCTGGGCCC TTTGTTCCCAAGCGGCCCCCGCCCAGTGGGCGACGCTCTGTGTGTCCTCGCGGCTTCTGGCCGTGTGTGTCGT GCGTTCCTGTTTCTGGAGATCTGCGCGTATTTGTATGTTGGGGAGGGCGGGCTCGAGGCTCCGAGAGTTGTGT TCAGACCCAACTCTTAACCTCAGGGGACCTTTCTCAGGCCAAGCGAGGGCCCCTCCTGGCGGGTGCAGTCGCA GAGCCCTGAGGTTCGACTCCACTGGCCCCGCCGCTCCCCGCGTTCACCCCACCGCACAATGTTCACAGTGAAG GCGACGGGAAAAGCAGCAGCCCAAAGGCTCTGAATTCCTCTTCCCCGCCACACGCACGGAATCCTGAGCCCCC GGAGCCTCGGGGCCGAGGCCGGCCCGGGACGGTGCTCCGAGTAGCTCTCCACTGCTGGGGAGCCGGCCCTGTT TTTGTTTGAACGTTTTGTAACGATTAAGCAGATCCCGGCGTCAGCCCGCCGCGGAGAGGCTCAAACAGGCATA AAGTGCGACCCCAAGTGGCCACTGTGCGCAAAGGCGCCGCGACCGCCCGGCCCACGGCCGGAAGGCTTGGACG GCGCCTCGTACCCAGCCAGGTCTCCCCTACCTGGCCCAACCCAAGCCAGCCCAGAACGCATACTATGTGTGCA CCAGAGCCCAGGACAGGTTCCCCTCGAGCGATGTACAGGTCCTCGGGTCCCGTCTTCGTACTCAGCCGCGAGC CTCGAGCCGCGAGCTCCGCTCTGGTCGCCCCGTTGAAATTCCGTGCCCCAGCGTTCGGGGGTGCCCGTCGGCT GCTCCCTGGGCCGGAAGGTCCTGGGCGGAGGAAGGCCGGTAGCCAAAAGTGGAAGCGCCACAGTGAAGCGGCC CAGGGCCACCGGGTGAGAAACCTCCCCGGAGGGCAGACGGGGAGACCGAAGCACACCGCACTAGGCATCCAGA CTGGGCTTGGGAGCCGCGCACCCTCCCTACCCAGATCCAGGATGGCTAGAATTAACGGGTTCTTTCTGAGACC TCGGCTCAGGCGCCGAAACCGGATAGATCGCGAATTCGCTGGACCCGGAGACCCGACCCGCCTCCCGCGTCAC CTTCTTCTTTCTAGCTTTGGGCGCGCGCAGCGAAAGGCAGGAGAGGCGCGCACTGGGTGAGTGAGTCCCGGCC GCTGTCTGCGCTGGACCAGCCCGACTGACCTCGCGCGTAGGGGTCGCGTGAGCCACACCGGTGCAGACGCGCC TAGATTATTTTTAAATGTTAGAAGGTAAAATATTTGCCTCCAATTAATCTGAAAACTCTCTATTCTCTTGCGC CCTCGGAGAGGCTGGGGTACGGCGTGGTATTGGGCCGCCTATTTTTAATAAAATGAGTGTATTTTAACTAAAA CTTAACTCAATCTTGTGGGGTGGCAAATTAAATGCTGGAAGAGCGCGTCTACAACCCTCTTCGAGAAGCGTGC TCTCCGCAGAAATGAGTCGGCCGCCTGGAGAGAGAGCCTGGGCGGTGCCGCTGCGCAGCCCCTGCCAGTAGCT GGGGGTTGGGGACTCGCACCTTGTAAATGTCCTCGTCTTGTTTGAACGCAGTGAGAGCACACTCGTTTCCAGA TCACTCGGGACCGGGTGTCTCGGATCTGTGCAGACTATGTATGGCTCCGGCCTCAGGCGGCCAGGGCGGGACA AGCACG CGI: 43 range = chr20: 49542203-49542863 CGCTGGCACCACCGAGCCCCGCCGCACCCCGCCGCTATTCTCAGGACGACCTGGGCAGCCCCCCAGCTTCTAG AAAAGACACAGAGGAGACTGCGCAATCAACAGGCAGGAGTGTGCGTGAGTGCGGCATGACATGGGCACGCCAC CCCAGAGAAGTGGGCGCCTGCTGCGCTAAACGTCATCCGTCATCCTTTCGCTGAAAAGTTGGAAAACAAACAA CAAAAACCCCGCCCAGCCTCATTTAATGCGAACCAAACACAAAAGCCACAGGGGAAAGCTTTTCCTCTCTGTG CTTCCCTTTTCCGGCCGAGGAACACCACCAGCCAAGATAAGGGGACTGTGCGGGGCCCTCTGCGCGGCTTCAA AGGGCTGGCACCCGCCCGGGCCCGCTCCCACTCCCACTGGCTAATGGGCTCCCCGCTCCAGCCCTTGGGGAGC AGGAGGCGGCCGGGGCTCCATGCCAGGCGACTTGGAAGAGGTTTAAGGCTCACGCCACACAAGGGAGGAAGCT CGGCCTGTCAAGAGGCGTGATAAAGCAGCCCCTTATCGCAGTTTTCCTTTCAACTGCCTCCAAGTGAGCGCCG GCCGGGGCTGGGCCTGTCAAGGCCAAGCGTGTTCCTTTCATGTCGCCCTGGGTTCCTCGGTCAGCGACGTATC CACG CGI: 20 range = chr20: 54411932-54412178 CGCGGGTTTAAGTGGACGCCAGGTGCACCGGACACAGGCTGTGTTTAACCACACCGAGGACTATGTGTTGCTG CCCGACGAGAGGACGATCAGTCTTTGCTGCTGGGACTCGAGGACAGCCGAGCGGAGAAACCTGCTGTCGTTGG GGCACAACAATATTGTACGCTGCATAGTGCACTCCCCCACCAACCCCGGGTTCATGACGTGCAGCGATGACTT CAGAGCGCGGTTTTGGTACCGGAGATCG CGI: 30 range = chr20: 55680656-55681057 CGCACGCGCACGTGTGTGCCTGCATGCACTCACATGTGTGTTTCCAACCGGCCGACAGTGACGCACGTATGCC CTCGCCACTCGGCAAGCACCTCGTGCTCCTTGGTAACCAGCAGATGTTTCTCTCAATTACTGATTTTCAAGAG CCTGGTGTTTCCTGACATGAGCCAGGATGGCGGGCGGCGCCCAGGGGAGGGGAAGTGAACCGGGGCTCCGTTT CCAAGGCTCTTGGACAAAAAGCGAAGCCCTGGATCAGGAAGCACAATGCGGCTGGTATTTAGCCGCTTCTCAA TAGTGCCTCATTCAATCCCCGGGGCCTCATTGATGCCCGCCGCGTGCTGGAGAGCCTCTGAGGGTCAGTCGGC GACGGGCACCGTCTGGAGGGGTCTCGCCGCTAACCCG CGI: 26 range = chr20: 56860125-56860442 CGCAGCATGGTAGCGGGAGCGCAGCTGCGCGGGCAACCGCCGGGTTTGTGGCCGGTTGGCGGGCTCAGTGCCG CCTCAGTGGGCTCTAGCAGTAGAAAAGTAAAGCGACTACCCTAAGATACCCAGAGCGAGAGGAGAGGGGCTAG AAGGGTGCTGGAGGCAGGCTGTAGTGGGGCTAAAGGAGCTGACTGACCAGCGCTGCGGCCGGTGCCCGAAGCA GCGAGCAGCGCACCTCAGCTCCGGTTGCCGCGCGGCATGGTATTTATCTGTGGGTTCAGTGCGCACAGCGTTG TCCAGTCTCGAAACCACCCTAAACCG CGI: 18 range = chr20: 62371744-62371958 CGTGAGTGAGGGCGTGCACGGTGTGGGGTCCTGTGAGTGCGGGTGTGCACGGTGTGGGGTCGTAAGTTCAGGC GTGCACGGTATGGGGTTGTGTGAGTGCATGGCGTGGGGTCTTGTGAGTGCGGGCGTGCACGGTGTGGGGTCTT GAGTTCAGGCGTGCACGGTATGGGGTCGTGTGAGTGCATGGTGTGGGGTCGTCAGTGCGGGCATGCACG CGI: 22 range = chr21: 45511336-45511549 CGCAGGGCCCACGCTCCCGGCCTCTGGGACGCTCACGGCAGCCCCACGAGAATGATCACACGAGGGCCCACGC TCCCGGCCTCGGGGACGCTCACGGCAGCCCCACAAGAACGATCACACGAGGGCCCATGCTCCCAGCCTTGGGG ACGCTCATGGCAGCCCCACGAGAATGATCACACGAGGGCCCACGCTCCCGGCCTCGGGGACGCTCACG CGI: 24 range = chr21: 46892946-46893236 CGCGGCCTAGAGCGGTGAGTGGGGTCTCGAGCGCATCCCGGGTGTTTGTGCCGAGGCTGGTGACGTCCGAGGT GGCCTCTGAGTGTGCTGACTTGTGACCCTGAGCTGTTGGGGGCTCACCGGTGACTCCATGGTCTTGTTGAGCA CCCTGCACGTGGGGCTCAGGGTCGGTAAAATAGCAGTGCGTGGAGACCGCGTGCTAGAGGCCGTGGCGCCCGC GTACAATGAGTCGCAGACAGCACAGACGGGAGTAGGGCAGAATAGACAATATCCCGTGAATTGCGTGGGGCG CGI: 38 range = chr22: 18453364-18453931 CGCCAGCGCACAGCGCGGCAGGACGCGCCCGGGTCTCAGCGGACTTGTGCATGTTAGCTGTGTAGATTTATGT GAGGGCTTGTAAAACTCTGGTCTTGTAAACTAGTCTTAAGCGCTTTTAATATGGAGACAGATGAGAGCCCCTC TCCGCTCCCGTGTGGGCCCGCAGGAGAAGCGGTGATGGAGAGCCGAGCTCGCCCCTTCCAAGCGCTGCCCCGT GAGCAGTCTCCACCACCTCCCCTGCAAACGTCCAGTGGTGCAGAGGTAATGGACGTTGGCTCTGGTGGTGATG GACAGTCCGAACTCCCTGCTGAGGACCCCTTCAACTTCTACGGAGCTTCTCTTCTCTCCAAAGGATCCTTCTC TAAGGGCCGCCTCCTCATAGACCCGAACTGTAGTGGCCACAGCCCGCGCACCGCCCGGCACGCACCTGCGGTC CGGAAGTTCTCCCCTGACCTTAAGTTGCTTAAGGATGTAAAGATTAGCGTGAGCTTTACCGAGAGCTGCAGGA GTAAGGACAGGAAGGTGCTGTACACAGGAGCAGAGCGCGACGTGCGGGCGGAGTGCG

TABLE 8 PcG target genes methylated in all bladder tumors or specific subgroups. All NMI-wt only NMI-mt only MI only NMI-mt and NMI-wt MI and NMI-wt MI and NMI-mt DLX5 ADCYAP1 BARHL2 TBX3 CNTNAP1 EVX1 HOXA5 DLX6 ATOH1 BCL11B EBF2 GATA2 FOXD2 BHLHB5 FOXA1 HOXB5 GAD1 C20orf103 FOXD3 MSC HLX1 CACNA2D4 HHEX NKX2-8 HOXA7 CBLN1 HOXC4 SIM2 HOXA9 CBLN4 HOXD3 VAX2 IRX3 CDKN2A MAFB MAB21L1 COL12A1 ONECUT2 MEIS1 COL27A1 OSR1 MSX1 CYP26B1 PCDH17 MSX2 DMRT3 PCDH7 NR2F2 DPP10 PITX2 NXPH1 ELAVL2 SIM1 OTX1 EMX1 SIX1 PAX9 EN1 SOX7 PITX1 FBN2 UNG2 PRKCZ FEZF1 ZIC1 SHH FLJ46347 ZNF503 SIX3 FOXA2 SOX21 FOXB1 TFAP2A FOXF1 FOXG1B GATA4 GNAS GRID1 GZF1 HAND2 HEY2 HMX2 HOXA11 IRX1 IRX5 ISL2 ISLR2 KCNK9 LBX1 LBXCOR1 LHX4 LHX9 LMX1A LRAT MAP1D NFIX NKX2-2 NKX2-3 NKX6-1 NPAS3 NR2E1 NR3C2 NR4A3 NRN1 OLIG2 ONECUT1 OTX2 PAX5 PAX6 PCDH1 PCDH10 PHLDB1 PTGER3 SEMA6A SFMBT2 SIX2 SIX6 SLC32A1 SNRPF SORCS3 SOX17 SOX9 T TBX15 TBX20 TBX5 TFAP2B TRIM2 TRIM36 TWIST1 VIPR2 VSX1 ZIC4

TABLE 9 CpG islands (CGIs) methylated in blood but not in bladder cancer. Provided for each are: ID no.; Coordinates of selected regions containing relevant CpG islands based on Homo sapiens full genome as provided by UCSC (hg18, March 2006); GeneName; Location of the probe used; the Fold Change; and the sequence of the CGIs. No CGI Gene Name CGI probe location FC 1 chr19: 53930240-53930625 RASIP1 chr19: 053930330-053930374 2.66 2 chr7: 72883371-72883981 CLDN4 chr7: 072883457-072883501 2.64 3 chr22: 26522794-26528592 MN1 chr22: 026525238-026525282 2.21 4 chr7: 5614184-5614510 FSCN1 chr7: 005614143-005614190 2.15 5 chr16: 66239477-66241425 RLTPR chr16: 066241103-066241147 1.93 6 chr5: 551112-551430 SLC9A3 chr5: 000551380-000551424 1.86 7 chr19: 6426223-6426998 DENND1C chr19: 006427051-006427102 1.82 8 chr3: 32836146-32836433 TRIM71 chr3: 032836466-032836511 1.78 9 chrX: 129301145-129301626 SLC25A14 chrX: 129301313-129301357 1.76 10 chr9: 124027565-124030907 LHX6 chr9: 124029663-124029718 1.74 11 chr10: 129424401-129427356 FLJ46831 chr10: 129426989-129427033 1.71 12 chr1: 3147370-3148160 PRDM16 chr1: 003147944-003147988 1.65 13 chrX: 128941527-128945710 BCORL1 chrX: 128944842-128944886 1.64 14 chr17: 7584523-7585036 DNAH2 chr17: 007584859-007584908 1.63 15 chr1: 27548507-27550603 SYTL1 chr1: 027550188-027550232 1.6 16 chr19: 10304689-10307022 ICAM3 chr19: 010306004-010306051 1.56 17 chrX: 129132628-129134108 AIFM1- chrX: 129133196-129133244 1.55 RAB33A 18 chr21: 45648960-45650662 COL18A1 chr21: 045663489-045663539 1.53 19 chr10: 134864694-134865392 KNDC1 chr10: 134865054-134865098 1.48 20 chr9: 129556229-129557670 SH2D3C chr9: 129556146-129556190 1.48 21 chrX: 47305347-47306043 ARAF chrX: 047305953-047305997 1.45 Sequence of the CGIs of 1 chr19: 53930240-53930625 CGTGCGGGGCTGGGGCGGCGGTTACCTGGGCGTCCTGGTAGCCCTGGAGCAGCAGGAAGTAGGGGCGGTTGCTG GGGGCCTGGATGAGGCACTGAGTCAACTGATCGAAGTCCCCGGGGTCTGCAGTTCCGATTTGGGCGTCGGCTGCC CCTGGGGCCATGCTAAGTGCCTGCTGTCTCCGCTCCTGCTGCCGCCGCCGCCGCCCCTGAAGGCTAAGCTCCGAC ACGCTGCGCCGCAAAGACAAGTTTTCTGAGCGCTCCTTGCCTCCAGACCCAGCTGGGGCCCCTGATCCGGTCCCC GGGCCAGGACTGGCCAGCGCTGCCCCACCCGACGCCGCCCGGGAGCGGTTCTTCTGTGGCCGCCACGAAGGGGC GCCGGTGCCTGCG 2 chr7: 72883371-72883981 CGAACGTTAAGTCCGTCCCCAGCGCTTGGAATCCTACGGCCCCCACAGCCGGATCCCCTCAGCCTTCCAGGTCCT CAACTCCCGTGGACGCTGAACAATGGCCTCCATGGGGCTACAGGTAATGGGCATCGCGCTGGCCGTCCTGGGCTG GCTGGCCGTCATGCTGTGCTGCGCGCTGCCCATGTGGCGCGTGACGGCCTTCATCGGCAGCAACATTGTCACCTC GCAGACCATCTGGGAGGGCCTATGGATGAACTGCGTGGTGCAGAGCACCGGCCAGATGCAGTGCAAGGTGTACG ACTCGCTGCTGGCACTGCCGCAGGACCTGCAGGCGGCCCGCGCCCTCGTCATCATCAGCATCATCGTGGCTGCTC TGGGCGTGCTGCTGTCCGTGGTGGGGGGCAAGTGTACCAACTGCCTGGAGGATGAAAGCGCCAAGGCCAAGACC ATGATCGTGGCGGGCGTGGTGTTCCTGTTGGCCGGCCTTATGGTGATAGTGCCGGTGTCCTGGACGGCCCACAAC ATCATCCAAGACTTCTACAATCCGCTGGTGGCCTCCGGGCAGAAGCGGGAGATGGGTGCCTCGCTCTACGTCGGC TGGGCCGCCTCCG 3 chr22: 26522794-26528592 CGCCAACGTCTTGTCGTCGTCCGCGCTGTCCACCAGGGCCTTGTCAGCGGGCATGTACCAGGCAGCGCTGTGCTC TGCCATCAGCGAGTCCAGGTCAATGGTGCTCATGGCGCTCTTGACCGCCTCGGAGCAGCAGCTGCCCAGCTCGCT GTCGCCATTCTGCGCCCCTGAGGCCCCGACGGCGCACTCACCCTTCTTGCCACCCTTCAGCCCCAGAGGCTGGTC CTCGGAGATGCTGAACTGCTGCCTCTGTAGCTGGATCTGCGCCTGAAGGATCTCCAGGGGGTGGATCTCGTCGGG TGGCGGGGCGCCGCTGCTGCTCGTCGGGGTGCGGACCTGCTCCAGGCCCGGAGTGCCCGGATGGCCCGGGCCCC CACCGCCGCCGTAGCTGTCAGGGGTCGAGGTAGAGTTAGACATGATGCCCAGGCCGAGGGCGGGCGGGGGCGCC TTCGGTCCGTGTTCCCCGGCGCCTACCCCACGGGGAGGGAGTTTGGGCGAGCCGGTCACCAGGGGACTCCTGCTC GCTTTAACTAGTGCCTGGGGGTTGTCAGAGCTGGACGACACCTCGTCCTCATTGGCGTAGCTCGTGCTCACCTCG TCCGAGGCGAACTCACCCACGTTTGGCGAACTACTGTCCGACTTGGCCCCGCCGTCCAGGGACCCAATGAGGTCC GGCTGATCCCCCAGGAGCAACTCAGCCCCCTTCCCCCAGGATGGCGACGTGAGCGCCTTTTCGTGGGGCGTCGGT GCCCCGCGCGTCTCGCCTGCGGAGCTTCCCCCGACGGCTGCGCCTGACGCTTGCTGCTGCCCTGGGCTCACCCCA GGTGCGCCCCCGCTGTCCGGAGCCGCCGAGTACTTGTCAAAGAAGGTGCCAGGGCTCACGTGACCACTGTCCCTT TTTCTGCGACCCCGTCCCCGGCCGCCGCCCCCGGAGACCGGCTTGCCGTCATTCCCCGACGTGGATTCCAGGGTG TAGTTGGGGGAGAGGCTGGTGCCGTCCCCCTGGGCTGGAGGGTTGGGCGGCCCCGAGGCTTTGGAGCCGCTGCT ACTGGTCCCGGACGGGCCTCCGGGTCCTGGGGCCCCAGGAGCAGTCCCTCCTGGGAAGTAATCCGAGCCCGGGT TGCCGGCCACTGCCGCGCCGTCGGTCTCGTTCTGGCTCAGTTTCCTCTTGCCCTCTGGCGGGTTCTTCTTGTTGAA GGTCACGTTGAGGTTGGGGGCCCCGAGGCTGGCGATCATGTTCTGGCAAGCGGTGGAGAGCGCAGCCAGGCAGC TCTGGCCGAACAGGTTGTCCTTGGAGCTGGGCTTGTTGAAGGAGCCCAGCGAGAGCGCGCCCAATTTACTGGCCG AGGTGCGCTGGCTGGGCTGGAAATCAGGCTGCGGCGGGTAGGCACCCCCGCCACCGCCGCCACCAGAGCTGCCA CCGCCCCCTCCCGCGCTGGGGGGCGAGTTCACGCCTGGACCGCTGTGCGGCGTGGACTGCCGGCCGGCTGCACC AAACGGAAAGCCCGGCTGGCCCCCGAGCGCAGACGTAGCAAAGTCCGGCGGCGGGGGCCGGCGCTCCGAAGCAG CGCTGGGGAGCCCCACGCCCGCCCCGGGCGACTGCAGCTGACCCAGGCCTCCCAGACTGCCCCCGAACTGCAGG CCCGGTGAAGGCAGCGCGGGCACGTGGCCCTCTCCGGGCATCCTCATCGGCTCCTGCAGAGGGCCCCGGAACAG CACCCCCGAGCCACCAGGCGGAGGAGGGGGCGCCAGGCTGGGGTCGTGCGGGCCACAGTCAGCGGGCAGACCC GAGCCGCCCATCCTACGGGGCAGCAGGTCTCCGGGCGGCGGATGCGGACCTGAGAACCACGCGCTCTCTTGCGC CAAGTGCGGCGCCTGCTGCTCGAAGGTGCCCAGACGCCCGGCGCCCGTGCTGCCGCCTTCGCGCTCAAAGTTCGG CTGGGCCAAGCCGCCCACCGGGCCGCCATGCACCAGGCCGCCCTGGCCCACGTCCCCGGGGTGGCCTAGCTGAG CCAGGTTGGGCTGGCGCAGCCGCTGCTGCTGATTCCGCGACGCCATCTGCTTAATCATGAGGGCCGCGTTTTGGC GCTGCTGCTGCTGCTGCTGTTGCTGTTGCTGTTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTG CTGCTGTTGCAGGGACTGGTGGTCCGGGGCCGGATGCTGCAGGGGCGGCCCCGAAGGGAAGCTGTCGGGCACAG GCGGTGTGAACTCGCCGGGTAGGCCTGGGTAGGCGGAAGGGGAGAGGTGATTATCCAGAGCGCCGTTGTGCATG CTGCCGTTCCACGAAGCGCAGCGGTCCACTCCCGCGCTGCCCGGAAAGTCGAAGCGCGGCCTCTTGGCCACGTTC ATGTAGGGGGGCGCGTCGAAATGCTGCAGCCGCTGGTTGGGCGCCTGCTGCGGAGGAGGATGCTGCATGCTGAA AACAGGCTCGGAATAAGGGTGCATGCTCCGGTTCTCCAGCCGGTGGATGGGATACTCGAATTGCGCGTGCTGGCT GGGCAGCATGGGGCCTCCGTCCTGCAGGCCGCCGCTGGGCGTGCCCGCCTCGCCCTGCTGGGGCCGAGGGAGCG CAGGCGGGCACGAATTTTGTCGGACTAGAAGCCCGGGTGGCGGCGGCGGCTGCTGCTGTGGCGGCTGCTGCGGG GGCTGCTGCTGAGGGGGTGGCGGGGCCTGCTGGGGAGGCTGCATTAACGGGTGCCTGGAGCCCACTGAGGGCTC CAGACCCACAGGCATCTTTCTGGCCCCACTGAACCTCTCAAAGAACACACCATGCTGCTGCTGCTGCTGCTGGGG CTGCTGCTGCTGCTGGGGCTGCTGCTGCGGTGGCTGGGCGTGCATTTTGGACAAGCCCACCATGCCCGCAGCTCT GGGCATGGCCGAGGCGCCCGGGAAAGCGCCCCCAGGAACCTGGCGACCCGCTGCATAATGAGGCAGCTGCCCTT CGGAGTCAGAGGGCGAAAACATGTCAAAATGTCCCGAGGGCGCCTCGCCCGGGTAATTGTATTCCAGCGAGTCGA CGGCTCCTTGGTTCGTCACCCTCCGTGGCTCCAGACTGTGGGAATCGGAGCCGCTGGAGGACGGCAGGCCGTGG AAGGAGGCGGCTCGGTTAGGGCTCTGGTCCAGCGGCAGGCATGGGGCCGGCACGGCGTGGCTGGAGGCACCTGA ACTGTGGAAGTCCGGGAGGTTCCCCGGTCGCTGCGGGCCGAAGCTCTCAGGCCCCTGGCTCTCCGCCATGTGCTC ATAGCCCTCGGCGAAGGGCGGCTGGCTGCCCAGGCCTCCGGCTGCGCCGCCGTAGCCGAGCAGGCGACCCCCGT GCAGGCACGAGGCCCCGGGGTCCGGGCCACCGAAGTTGCCCCCAAAGTGGGGGTGATGCTGGTGGGGATGATGA CTTCCCGGGTGGCCGTGGTGAGGCTGCTGGCCGCCAAAGAAGCCGTGCACAGGCTGCGCTTGCAGCCCCCCTGC GTGCAACTCCGAGTGGCCGCGCGCGTGGAAGCCGTAGGGCTCCATGTTCATGCCCAAGATCGGGGGTTCGCCCA GCGCGCTCATAGCAGGATCCACAGGGCCAGGGGGCCCCCCAGTGTGGAAAGCCGGGGCCTTAAAGTGGGTGTTC ATGCTCAGTCCGGTCTCGTTAAAGTTCCTCTCGCCCTGGCCAGCGTTCCTGCTGTTGACCTGGGGCTCGAATTGGT CCAGCCCAAACATACTTGGCGGGGGGCAGAGGGGGATCAATAGGGCATGACAGCCGGCTCTCCGCGGCGCGCCT CCGGCCAGCTACTCGTTCCAGCCCAGGATTGGGCGCTCCGGGACGCTCAGCACCGCGGGGGCTCAGCGCGCACC TCCACCCCGCCTGATGTGAGGGACGGGGGGCGGGGTATTAGCTCCTCTCCTGAAGCTCCGATTCTGCCCGGGGAG GGCCTCTCACATCTTGCGAGGCCGCGGGGCCTCTAGGAGCCGTGTTGGGGGGCCCATGCCCCGGGCGGTTGTCA CAGCCGCGGGTGGGTCTGCGGGGAGGGGACGAAGCCGCGGATGAACGGAGACAAAAAGTTAAGTGGGGGGAAT GGGGAGGGAAGGGGGTTGGGAGAGCAGAGCGATCACCTTCTCAAGTCCGATTGGGTCTGCTGGGGAGCCCTCAG GACGCCGCCCGCAGCCTCCCGGAGTCCGTGGCAGAGCTGCTAAGGGCAGGGGAGGGAGACCCTTCAAAGCCGCG GCTGGCGCCGGGCACCGACAGAGCGGTCCCTCCCCCCGCCCCCCGGAGTCCCCGCGCCCCGCAGCCCGAGCCTC CACCGAGCACGATCCGCTCGCACAATCCCCGTAGGCTCCGGGCGAGCGGCTGCTGCTTCTTCAGCGGGTCGGAGG ACTGGAGGCTCCGCTCGGCATCGCCGGTGCCGGCCCCCGAGCCGAGGACGCAGAGGGGCTGCGAGGCGGCAGGC GCCGGGGGCTGGAGCCGAGGGTCGGGGAAAGGCGCGGCTCCTCTGCTCGGCAGCGGGTGCGCTGCGTTCGGCGC GCAGCTTCGCGGCCACGTCCGCCGCCTGCCGCTTCTGTTCTCCGCCGTTGGGTGTCTGAGTTCGCCGGAGTCTCC GCGCACCGTTGCAGGCGCGGGAGGGCAGCGAGACGAGGGGTTGGGTCGCTCCAAGGCTCCGGTTCCCTGCCTCC GCGCTGAGGTGCTTCGCGAGTCCCTCTCGGACCTGAGGGAGGGGGGCGTACGCGGGTCGGGGGGCCACGCCGGG CGAGCAGGCTAAGGCGTTCCCGCTGCGCTCTCAGAGCCCGGAATGGGGGGAGGGGGGCGCGGGGGCAGCTCTGG GGGGTCTGCGCACCCCTCTCCCGACTAGCGGGGGGGCTCTGCGTGGGGCGTTCCGAGGGTCTCGGCTCCCCTCTC TGTGTCTGCCTCTCGCCCAGCGCCGGGAGAAGCAGCAACAAGTTTTGCATTTCAGCAATCAATTTCAGCCATTACA TTTGCACCAATCAGCGCCGCCCAAGTTCCGGGCTCGGGGCGGGGCTCGCTCTTAAGGTGGTCCGGGGTCCTGGCT GCCGAAGCCCCCGCCACGAACCCGCACTACCCCAGCTCTGGGGTCCCCTGCGCCCGCCTCTCCTCGGGGTCCGGC GTCAGTGCGCTGGGGGCGCGCCCCGGCCTCCGGGCGCATCGAGCTGGAGAGGGTGCAGGCGGAGGAGAATGGC GGGAGCTTGGCTTTGTTCACCCCCTTCCCATTCACACTGTTCCCAACTCCCCACCCCCAACTGGAGCGAGACCCAC CGGGTGGGCAGGGGGCGGGGAGGTGGGCGGTGAGCGGTACGGGGCGCTCAGACAATGAGGTCGCCAGGCAAAG ACCCTAGACTCGCCACGGAAAGTCGCTAAGTGTCTACTGCACTTCGGCTCCGGGGTGAACACTCCGTTCTCCGCT AGCGGCGCCCAAGTTAGCCGGCCCTGGGATTTTCTTGGAGGGTAAAGCAGACGGGGAACCTCGAAGTTAGGGTTC TCCTCGAGAGACCTGGGCGCTTGCTCACTCCTCCGTCACTAGGGCGTTCACAATTGTTCCCCTTCCCCACTGCCTG GGGTTCCCGGTTCTCACCGGCCGGCGTGGGCTCCAAGGAGTCACAGTCACTCAGCCACTTTATGGGGGAGCACAT CGGTTGAGCCCAGTAACCGGAGCGACTTGCGAGGCGGCTGGGAACCCCGAGAAGACACGCACGAAGAGGGCGCA CCCGCCGGGCCGCACACCTTGCCCTGGGCCACCCGGTCCAAGACCCAGACCCTCTGCGGGTGCG 4 chr7: 5614184-5614510 CGCCTACCACGTGGCCGAGATTCCCGAGGCTGCAGCCAATGAGCAGCATAGTCCGATGGGGGAGGCTGGAAGGG CCGTTCACGAGATCTCTCGGGAGGAATCGGTAGGAGCTGCCCAACTGAAAGGGACGGGGGAATAACCCGGGGCG AGGGACCTGCCCAGGCCCTGCCCTCTGGGGGGAAGCCAGGCCAGGGGCCGGGGGCATCTCTGGGGTCCCAGGTG AGATGCGGGTCGAGGGAGCCAGGCCACGGTTCTCCAGACTCGCGTGGAGGCCACGAGCGTCTTCTGGAGGAGCG GGCACTGCGCGGACCGGCAGACTCTGGGGCG 5 chr16: 66239477-66241425 CGTCCTAACGTACTGTCGTTCCTGAATCTCGCAGGCACCGACACTGCCCTGGACACTGTGAGGGGGTGCTCCGTG GGGGGATGGATGACCGGCAGGGCGGACTGGAGGGCGGGACGGGGAGGGCTCGGTCCCCCCGCGGGTGTAGCCA ACAGCCTCCCCCCGCAGCTCTTCGCAGCGGTATCCCGAGGCTGCTGCACCAGCCTTACCCACCTCGACGCTTCGA GGAACGTCTTCTCCCGCACGTAAGGGGGACCTGTCGGGGCCGGGGGAGGCTGCTGGAAGCCGCCTCCTTGCGGC CCCAGGCCCACCTTCCCACTTCCCCCAGGAAGTCCCGCGCCGCGCCGGCCGCGCTGCAGCTCTTCCTCAGCCGCG CGCGGACGCTGCGGCACCTGGGCCTGGCGGGCTGCAAGCTGCCGCCCGACGCGCTCAGGTCAGTGTCGGACCCC GGCCACGCCCCCGCGGGCGCTCCCACCCTGCCCTGGCCTTCGCCCCTCCCCGCTCCTGCTTCTGTCGCTCCCACA ACCTCCCCCAGATCCTGGCCCTGCCTCCTTCGTTCGCACCCTGGAGCCCCCTGTCCCAGCTCCCGCCACCCCGTGT AACGTCCTCTCCCAGAGCCCTTTTGGATGGCCTCGCGCTCAACACGCACCTCCGCGACCTGCACCTGGACCTCAG CGCTTGCGAGGTGAGCGCCGGCCCCCAGAAGAGACCACACATTGGGAGAGGCGCTGGGAGGCGGAAGGGCAGG GCCGTGGGCCGCCTGCCCCTCCCCACTCGCGGCCTAAGTGGGTCCCACTTCCCACCTCCCACCTCCCACATACAG CTGCGCTCGGCCGGCGCCCAGGTGATACAAGACTTAGTGTGCGACGCAGGCGCTGTGAGCTCCCTGGATCTGGCG GATAACGGTGAGGCTGCAGGAGAGCCCATCCTCGCATCATCCACTCGATTCCCAATCCCCACCCTACCCTTGCAAC TTCGCCTCGTGCGTGACCCGAGTCACCCCCAGGCTTCGGCTCAGACATGGTGACTCTGGTGCTGGCCATCGGGAG AAGCCGGTCCCTGAGACATGTGGCGCTTGGAAGGAACTTCAACGTCCGGTGCAAGTGAGCCCCCACCCTACTCCT GGGCCTCCCAGACAACACCCCACCACCCCTGTCCCCCACAACTGCGGCCCCTGCCCACAGGGAGACCCTGGACGA CGTCCTGCACCGGATTGTCCAGCTCATGCAGGACGACGATTGTGTGAGTTCACGGGACCTTGCAGGGCCTCGGGC AATTAGACCACTTTGGTCCTCCTTTCTCTTGTTCCCTCAGACCCTGTGACCTGCCCTCACTGACCCCTGACTCCAG CCATCAATGGCTTTCTCTTAACCCCAGCCTCTTCAGTCTCTGTCGGTGGCTGAGTCTCGGCTGAAGCTGGGTGCCA GCGTCCTACTCCGGGCCCTAGCCACCAATCCTAACCTGACCGCGCTGGATATCAGCGGCAACGCCATGGGGGACG CGGGCGCCAAGTTGCTGGCCAAGGCGCTGCGGGTCAACTCGAGGCTCCGGTGGGCGGGGTCAGAGGGGTGGGAC CAGCGGGCAGGGGGCGCGGTGGAGAGGAGGGCACCGGGCTAAGGGGAGGGACTGAATGAGGCGGAGCAAATGG AGCAGGCTGACGAGGCGAATGGACTAGGCCGAGGGTTGGGTGGGGCGTTGGGAAGCTCCGTCCCCGACTGAAGC CAGGCCCGGCCCAGGTCTGTGGTCTGGGACCGGAACCACACATCTGCTTTGGGTCTGCTGGACGTGGCGCAGGC GCTGGAGCAGAACCACAGCCTGAAGGCCATGCCTCTGCCACTGAACGACGTGGCCCAGGCGCAGCGCAGCCGCC CGGAACTGACAGCACGTGCAGTCCATCAGGTGGGCGTCCCCCTCTTCCCTTGCCCTTCTCTGCACGGTAACTCCGT CCCTCG 6 chr5: 551112-551430 CGGATGCCGGCCTCCTGCCTCGGCCACCGCCCTCCTCTTCAAGGATGCTGTTTTGCCTCTGGTCGCTCTATCTTAT CTTTTTTCTCCGCACTCCTGGACGTCTCTCGGACCTTTCGCTCTGACAGTGGCTTGAGCCTCGGCCGCCACTTCCG CCCCTGCTACTTCGGGGCCACGTCTCGGTCCGACGCTGAGGGGTGCTGCCAACCGTGTCTTCTCTGTGAACGTCC TCACGATGAACGCCCCCGTTCCACTTCCCACCCTGGAGCTGCTGCTTCCGTGACTCACATTCCGGCCATTTCCGTG GTGTGAGGTACGGGCG 7 chr19: 6426223-6426998 CGTTACATTGCGATTCATTCAGGAACCCACGAGACCTCTCCCGCAGCGTCCCCGCTGCTCACCGGGCTGCAGACG AGTGCGTCGCGGTACCCCCCGAAGAGCAGGGCCTGGGCTTTGAGGAAGAGACGGGACACCCCTTCCCCGGGGGC CAGGGCGACCTTCCTGAGCCGGAGCCTCAGCAGGGACACCTGAAGCACAAGGGAGTGGCCCTGAGTGGGCAGGT GTGGGCCCCTCGCCTCCCGGGGCAGGAAGGTGGGAGGGGCGACACTGACCACGTCTGGAGGCAGCGCCTGCACG TCGTTAAAGGTCGTCTCCAAGGTATTGGCGTCCACGTTCAGCACCACGACGTCCTCCAGGGCTTTTTCTCGTACTC TCTGCGGAAAAGCGGGGTCGGCCGCTCAGAGCCCGGGAGTCCTTGGCAGAGGAGGGCATCTGGGGATGTAGAGG AAGGGGGAACCCTCACGTCCCCGTCGTCTGGGTAGATCCACGCTCACCTCGGCGAGACTGGCGTGCACTCCAATG AGGTAGGGCATGGGCGCGCTGCGGACCGAGGGGACGGGGTCATGCAGGCACCGCCCCCAGGGCCTGCCCACAGG CCCTGCCCCTCCCAGCTGCCCTCGCTCACCAGCAGTAGTCCAGCAGGTGTGGGGGCAGCGTGGGGATCAGCACGT GCTCCCAGCGCATGGGGTACAGGAGCGCGCAGGACGCGTGGACGCACGAGGTCAGCTGGGGAGCGATGGCGGG GCGTGGAGTCAGGGCCTGGACCCTCTAGCGCG 8 chr3: 32836146-32836433 CGTGAAATCGCCGTTCGTGGGCCCACGGCTGCACCCCGAGATAGAAGCGGAATAAAGGGACGACGTTACCTTCAC CAGCCTGAGTCTCTTGGGCCGCGCCCGCCTGCCCCGACTCCAAGCCCTACAGGAACCGGTTTCCCTGGTTAGGAG GTATCCACCCGGCTCAACCAGGGTCTCGACTTCCTTGGAAAAGACCAAGGCAGCCGTACGCTGCTGGAACGCCGG AGTGCAAAGGCTTTTAGGGCTACATTGCAACCCTCGGGCTCGATTTCGCCCTTTGGGCTGTCG 9 chrX: 129301145-129301626 CGTTGCCGCCTTTTTCGTACTGAGCGCGCAGGGCACTACGCCCACCACTCCCCTTGACCCACTCCTCAAGCCCTGA TACCGGGGCGAGGCCCCTTCCTTTTCTAGTCCTTCTACGCGCCAGGTGGGTGGGTTTCGCGGTGACGAGGCGACA CCTCTTTCCCCTCTGGCGAGCACGTTAACTGGGGAAGCTACCAAATTCTCACGCCTTAGCTGCCCTGCCTCCACCT CCCGCAAGTCCGGTTGCCCCTCTAGGCTTCTGCGCCTGCAGTGGTTCCGACCCTCGCCTTTAGAACTCTGCCGCTT CCGCCTCTTATTTCGCGCCTTTGTTTTTAGTTTTGGAAGGGGCGGAGTTGAAATGGCTGCGCCGCGGTTGCCGAA GCAACGCTTTGGTTACTTCCGTTGGTTTCAATGCTTCCGGGTTGGCGCTGCAGTGGCGTTTCCGACTGTGGGAGC CTCAGCTTCCCAGTCGTCCGATGAGCCCG 10 chr9: 124027565-124030907 CGAGGCCCAGGCGAGTGGCCAAGACGCGGCAGGACAGGAGGATGCGCCTGGCTGCTCTCGGCTGCTGGACGCGG CCTGCAGTAGGGAGAGCGCAGCCCGGGGTAATCCCACTCAGGGCTCCGGGTGCCCAGTTCTCCCACTTCCCATCC TGGCGGCCTAAAGGCAAGGCCTAGACCCTGGAGAGGCCAAAGTCGGGCCAAAACAACAGCGAAGCTGGGACTGG AACAGGCGCTGGGGGCCTGCGCATGACCCCAGGCTCAGAATGCGACACTCCAGTGACGCCGGGGAATGAGTTGA GATGGAGCCGGAGACAGAGGTTGGGGTTCAGGACGAGGCGCTTGGGTATGGGATCGGATCTGAGACGGTTGCGG CGCTGGTGCTTTGGGCTGGACCAGACTCGAACCCAGAGCGGAGCGAGGGTCAGAGCCAGGGCAAGAGTCCGAAG CCCAGCTCAGCGTCCAGCCCGCGAGAGACCCCACCATGAATGACGTCCGAGTAGGGTTGGAACTCGAAGCCCGAA CGCACTGGAAATGCAGCCGGACGACGGCTGGGATCCGAGTGGGTCCGGGCCAGAAATGGGGACCTCAGAGCTCC ACCGAGGCGCTCGAGGTCAGAACTGAAGCCTGAGACTTAGGCAGGACCCGAGACAGAGCCAGAGACGATACCGA AACCCAATGGACCGCGAGGACCGAAGGCAGATCCGGGGCGCAAACCTGTGCAGGCACTGGCGCGCTGCCTGGAG CTCTGGGTTCGCGCCGCTGAGCGCCGGCAGGTTGGACCAGCGCTGCGCGCCGGAAGTGCACTCGGGACGCCGGG GTTCTGGAGGAGAGACCACACGCCGCAAAAGTGGCCTCCGAATGCGCCCGGGGCCTGCCCTCGGCGACACTGCT GGCTCGGCGGCCGCAGCCTACCTGAAGTAGTCCATCTTGCAGAAGATCTCCTTGTTCTTGATGTAGCAGCTGTTCT GCTGCCTCAGCGACGTGCGACACACGGAGCACTCGAGGCACCGCACGTGCCAGATGAGGTTGTTGACCTGGGGA CGGGGCGGGGACGGAGGTCGGCTCAGCGCGGGCCTCTTTCACTCCGGGCCCCAGCCTTCCCGGTCTCATTTACAG TCAGAGGCGCTGAAGCTCAGAAGGTGCATGCGATTCCCCTATTTTTCTCCCGTAATACTGAGACTCAGGGAAATG GAAATAAACTCTTCTTATTTTTCAGACGGAACCCGGGGGCTCAGGCAGACCCTAAGTCTTGCCCAAAGCTTCGCAG TCGGGCAGCAGTGGAGCCAGGATTTGGAAGTAAGAGGACCTGCGGTGCTTCCCTGCAGTCTCCTGCGCTGCGTCC CACGCCCCGACAACACGCACGCAACACCTACCCCTGTCTCACCTTGAGCAGATATCGGTCCAGGATCTCGAGGCC GCAGCTGGAGCAGATGTTCTTGCCTGCAGACGGCACGGAGGAGGCGGCAGAGGGCGGTGAGCAGACAGATGGCG TGCTGGGCGTACATGGGGAGGCCTGACCCTCGTCCTTGTCCAGAGCTCCTGCCAGGGCCTCGGCGTCAGACTGAG CCTGCGGCGGGGGAGAGAAGGAGAGGAGCGCTGATCCGGGCACCCAGAGTTGGGGCTGCCTTGGAGACAAATCT GGGGCCCCCGAGCACCAATTGACAACGAAATCTCCCCAGGACAATGCGCCGTAGACTGAAGGACAGGGATGGAA GGGCCTATTGGAGAGGAAGGGACGGCCCCAACTTTTAACACGCGCATTCTGGGTGCTGGGAGCGGTTAAAGCCAA CATTCCCTGCCGGAAAACCGAGGCTCAGAGAGGGGCGGCGCCCGCCGGGAGTCCCCCAGAGCGTGAGCAGCAGT TCGTGGCCGGAAAACCTGGCCAGGTCCCCAGGGCCGGGCCGCTGGAGGACTGGGCACCGCAGGCAGGGCCAAAC GGACTCACCATGGCGGGCGGCGCGGTCCCTTCAAGACAGCGGGTGGTCGCTTTGCAGCCGGACCCTGGCTGGGC CATCACCTGGGGGAGGGGGGGAGGGAACGCAGGCGGCGGCGGCTGCTGAACTGGCTCCGCACAGCCTGAGCCCA GCGCCTCCCCGCGCCTGTTATATAAACCGGCGCCGAACAATGAGTCCTAACTTTGTAGTGGGCATTTAAAGCCCTT CCCCACAAAAGCGGTGTCTCTCTAATGAAGCAATTTGAATTTGGATTGGATTTTTTCCCTCTCTCTCCCCCTCTCCC TGCACTTAACCCGTGGCTCTTGAAGTAATCGCTTAGTTCCCTTGCAATCCAAGCCTCTGAGGGGGGAAGAAAAACA CGCGCACACACACACAAACTACCTGCAATTAGAAATTGTCGTGAATGCCCAAGATAAGAGGTAGCCAGAGTGTCA ATTCCAACTGTCAATCAGTGAGATCCATCAGGCCGCCCAAAGAATTGCAAATTTGATTTTTTAATGGTAGTAATTA AAAATCGAATTTTTTCTCTCTCCACCCGCCCCCCCACCCCACTCCCCTTCCTCGCTCCCTTCTCCTCTCGGCACAAA ATGCAAAAAGGAGAAAAGAGAGAAAGAAAGAAAATAAAAAAGAGATGGGTGAGGGGCGGAGGGTGGTTGAAGAA AAGAAAACCCCGAGCGCGGTGAGCACCCGCCCGCCCGCCCGCCTGACACGCGCGGCGAAATTGAAGCAGCTATA TTGACACGGATTCAGGCGCCTTTCGAGGGCCAGTCGGAGGGAAACCCGGAGCAAAAAGAGAGCGAGATCGGGGC GAAACGGGACCAAAAAGAGAAAAGAGAGGCGCTCAAGGGGAGGAAAAAGCACCCTCCAGCCCCTCGGCGCGCCG GGTACCGGCCCCGCGTCGGGATTCTCAGCGCTGCGCCGGCACAACCCCCGGCGCATCGGCGCTATCAGCGCCTAT TCAGACGGACAATACCGGCCTCGCCTCCTCTTGATTCGCCTGTGTCTTTACTAAATCGCTTTTTGAGAAATTCCTC CAACATTTGCATAATGTGTTCCCGCTTTCCGCGACCCCCCCCCCCCGCTCGCGCGCGCGCTCCCACACTCACAAGC ACACACTCACAGGCGCACCCTCGTACCCCTCCTTCCTGCAACCGCCCGCCACCCTGCTCGGCCCGGCTGGGTCCC GGACCCTGCCCGACCCCGGCCCGGGCCGCTCACCCAGTCGTTCGCCGGCTCACCTGGTCGGTGGCGGGGCCGCC CTCGGCCGGCAGCCGGCAGCCCTCGGGCAACGCCGGGGCGGCGTTCTCATGCTTCCAGTACATGGGCCGGGGAA CCTCGGGCTCAGCGGGCGCGCAGCGCGGAGAGCTGCGCCGAGGGGGACCACAGCCG 11 chr10: 129424401-129427356 CGCCTCTTTCGCACAGGTGCCCGACTCGGAGTCCGGGAGGCGGGCCCTCTTTCCAGGTACCCAGCCCAGCGTCAG CCTGGGTCCATCCTCCGCCACCCCACAGCGCGGGGAGCAGGGGAGGCCGAAAGCCGGGCAGCTTGGGGGGCCGG GATAACCCGGGCTGCAGCAACCCCGGGCGGCAGCAGGACTGGAGAGCTGGTGTCGGACGCACTGCAGAGACGTC CCTGTTTTCGGCGCGTCCTCCGACACCCAGCAGAGAGCTTGGCGCTCTCCGCTCTGCGCGCCCGAGGTCACAGCG CGGAGAAACCTGGCGGGGCCCCGGACTCCCCGGCTTGGGAAAAGCGATGACTGCCCTGAACTGCTGGGGCGTTC GAAATTTCCAGGGTCCCGACCCTCCGTGGGGTACGCGCGACTTCGGCGCAGATGTCAGTCCGCTGCCTTCCGGGT TGAGGGAGCGAGGACTCCAGACGACCCCAGGGCCGCTGTCCAGGCCCAGCCCCGCGTTCTCCACCTCGCCACCTC GCTCTGCGGCTCCAGCCTGGAGATCTACGGACTTCATTGCGATCTCTTGCGCAGTGTAGTCGCCCTCTATCCCTAG CCCCGAGTCCCGGGTAACCCAGGGGCCCCGGCGAGGCGAGTTTCTTTGGGGCGAGATGTCCCGAGCCGAGCAAA GGGGCCGCGCATTGGACGGGGCTCCCAAGCCACAGCCCTGGGGGCCTTGAGGAGTCGTGGTACGGTCCAGGGCA GTCGGGGCTGCGGGGCCCGTGAAGCCAGACGAGGCTACGGACTTAGGGTCCCTGCAACCAAGACCGCGAGCGAC TGTGGACTCGGGACGGATCGCACAAAGGAGGAAGGGGGAATCAGAGGGGCGTCCGGTCCAGGACGTGTCAGGCC TGGGCGGGGCGGAAAACTGACACCAGGGCGAGGACAAGGATTTCGCTCCTCCAGGGCTGCCAGGGGAGGGGCTC GCCACCGTCACTCTCCATGGGCTCTGGCCCCGACGGTGTTTAAAGGGCGGAGGGCTGGGCCGGGCTGGTCGCAC CCGGGCGCTGCTGGCGGCCAAGCTGGATGGGTCGCCAGTGAGTTTCGGTGCGGCACCGCTGGCCCAGGCCCGGG CGCGGCTGGACATGGCCACCTACTGCGACGACCTGGGCCCCTCCTCGGCCCCGCCCGGCCAGGCCCAGGCCACC GCGCACCCCCCGGGCTATGAGCCAGGGGATCTGGGCGCGGTGGGCGGGGGCCCCCTCCTGTGGGTGAACGCGCC AGCGCTCAGCCCCAAGTCCTACGCTTCGGGTCCCGGGCCTGCGCCGCCCTACGCGGCCCCGAGCTACGGGGCTCC CGGCCCGCTCCTCGGCGCCCCGGGCGGCCTGGCGGGCGCCGACCTCGCCTGGCTGAGCCTCTCCGGCCAGCAGG AGCTGCTGAGGCTGGTGCGGCCGCCCTACTCCTACTCGGCGCTCATCGCCATGGCCATCCAGAGCGCGCCGCTGC GGAAGCTGACGCTCAGCCAGATCTACCAGTACGTGGCTGGTAACTTCCCTTTCTACAAGCGCAGCAAGGCGGGCT GGCAGAACTCCATCCGCCACAACCTGTCGCTCAACGACTGCTTCAAGAAGGTGCCCCGCGACGAGGACGACCCAG GTAACAGCGGCGCGCCGGCTCGCTCCGTCCAGGACTCCCCATCTTCCCGCCGGGCCGCGGGCACTCCGGGGGTG GGAGCACCTTAGACAACCTAATTTCTCCCTGCGCGGTTGGGGATACCCGGGGAGGAGGGAGAAGGGGAAGAAGT GCTTGGGCATGGACAGGTTCTCAGACAGCGGCTGAGCCCACCACAGGCCCGCGTTTACAGTGCGGCGGTCCCGG GGCTCTCAATCTCTGTGCGCTCCTTCGGAGGAAGAAGCGGGAGAGCCAGCAAGCTGGGTGACCTTGGGAGTGACT CAACTTCCCTGGGCCTCAGTGCCCTACCTGGTAAAATGGGGAAGACAGCGCCTACCCCAAGGATGGGCAAAACAA ATAGGATGCCCGTTTGGAAAGCTCTGGAGCCTACCTGGGGGCCTGGCGTGGTCTGCGCTGTCCTTGGCAGAGCGG CTGGCGGAGTCCCACCATTAGCATCTCGCAGGCCTTCCTTCACCTTAACGGGGCTCGGCCTTTCCCAGGGCTCCCT TCCTCCTCCTTTCTGGATTGTCACTTTCTTCCCAGTCCTGCTGTGGAGGCCCATCGGGTACAGAGTGCCCGTCAAG GGTGGAATGGGGGCGAGGACTCAGACCCTCTGTAAGGGCCAGCAGGGGATCTTTCTGAAGCTGACCTCCTCGCTG GCTCACACCACGGCCCGTCAAAGCTCGAACCTTCTGAACTGGGCTGTTTCTTCTTCTGCAGGTAAAGGCAATTACT GGACCCTGGACCCCAACTGCGAGAAGATGTTTGACAACGGGAACTTCCGAAGGAAGAGGAAGAGGAGAGCTGAA GCCAGCGCGGCCGTGCGCTCGGGAGCCAGGAGCGTGGGAGGGGCCGAGGCGCCAGCGCTGGAGCCCCCGAGCG CGGCTTGCCTGGACCTGCAGGCCTCGCCCTCTCCATCCGCACCCGAGGCCGCCACCTGCTTCTCCGGTTTCGCTT CTGCTATGAGCGCTCTGGCTGGCGGCCTTGGCACCTTCCCCGGGGGCCTGGCGGGCGACTTTTCTTTCGGGAGGC GGCCACCGACAGTCGCCACCCACGCTCCCCAGACCCTTAACCCCTCCCCTGGCTTCGCCCCTGGCCACCAGACCG CGGCCGCCGGCTTCCGCCTCAGTCACCTCCTCTACAGCCGGGAAGGGACCGAAGTTTGAAGGGAGGCTGGAGGC TAGCCGGGTGCGGGTCCAGAGGTGCTGAGCTCAGGCCTCCGGTTTCCCCTGGTGACAGCCCCACGTGTTGGCGTT GAAGGCCTTGGTGCCCTGGGAGGAAGCGCAGAGCCGGGGGCGGCTCG 12 chr1: 3147370-3148160 CGGGGTGCGGGGAGGTTGAGAGCGCGGCGGCCGCTGCCAGCAATCGAGGAGCCAGCGGCGCGTGTGCTGAGGG CCCAGCTAGCAAAATAAAGAGGGTTTTCAGCGGAGCGGCGGCTCAGGCGAGGCTGGGGGAGCCGGGGAGCGCGT CCCGCCATTTTTCCAGCCGAGGTCAGCAGCGGGTGAAGGGGCGGAGTCCGTGGTGTTCCCAACTGCCCAGGCGG GCGGTGAGATGGGGCAGGCGGTTCCGCAACGCGGCTCAGGCCCCAGCGCCCTGCCTGCAGGAGGCCGCTTCTTT CTCTGTTGCCATCGGGCGCCGGTTTCCTCTTCCGGGGATGCAGGGCAGCTGGGGGGGCTCTGCCTCTGTGCGGCT CTTCCGTGGTTCCACGCTGGGCTCCGGGGTGACCACAGTCCTCAGCAGCCCACACCCTCAGCCCGAAGGGGGCCC AGGCCCCGTGCCCAGAGGATCCAGAGAGACAGCCGGGAGCCCAGCAGCTGTGGCAGCTGCCCCCACCACCACCC CGGGGCTGGCCAGGTCCCACCTCCTGACGCCACACGGTATGACTGGGCCCTCCTGGTCAGTGCGTCGCATGTAAC GCCTTCAACTATTGGGGCCGGTGTTGGAGCATCCGTCTCTGCGTCCCCACCTGATGACAAGCTCCGGGGAGCAGG AGTGCTGGCCAAGCCCACGCACGGACCAAGCCCACGTCAGACTCCGCCAGAAAGGCAAGAAGGGCCTCCGCATG GCGTGACGGATGGGTTTATGGGGGCATTCCATCCCACCCGGACGCTCG 13 chrX: 128941527-128945710 CGGAGCTTGAGCGCCAGAACCACGCACTGAGGTCGCCCAGGGTGGGGAAGTGGGGGGCCGGGGGAGGGGCGGG GCATCCGGCGGGGAGGTCTCCCCCACCGCATGCAAGACCCTTTGCCCCCCCACAACATACACTGAGGCTAAAACG GGGATGAGAGTCACACAGAGCAGGAGCGAAATCTTTCGCTCTCCGACCCGAACGGCGCGTTGCTCGACCCCCCCC TTCCTGGAGCCAGGGGCTGGCCGAGGAAGGTGGCTCCGTTCTTCCCCCGTGGCCAGTGCGGGGTCTGCGGCTGC CCGGCGAGGTTCCGGCTTCCCCGGGACTGGCAGGGGGAGCCCCGAGAACTGCAGGCCCGCCCCCCCTTCCTCCT CCTCCTTCCCCTCCTCCCCCACGTGTCCTCCCTGAGCCCAGCAGCCTGATCCCAGCACCCCCCGCCACCTCCCTCC TCCCGCTTCGCCCGCTTCCCCGGCGGCGTGGAGAAGAGCAAAGTTGCGACAGCGGCCGGGGGCTCTGCCCAGGT AAAGGGGGCGCCGTGAGGCGGGGGTGGTGGGGGAACGGTGCGGCCCTGCGGCGGGGGCGGGGGGAGGATAAAG AAACTTGCTTCCCGCGGCCCCCACCCCGCGTGGGTTCCGATCTTGCGTGGAACGAGCCCGCGTGGCGAGTCGCGG CAACACTGCCGGGACCGAGGCCGGCACCTGGACCCGGACCCGGACCGCGCGCTTGGGCCGGCTCGGCGGGCGCA GGCAGCGGGCCAGGCCAGCACCCAGGCAAGGGCGGGGTGGGTGGCCGTACACCGGACCGAATCGGGGACTCCG GTGGCGTGGGCGCGGGCCGAACCCCGACCGGGCCGAGTTGGGTGGCGAAGTAGGACGTGGATTCGGGGGCGGG GCGCGGCGGGAGGGGGAAACCAGGCCTGGCCAGACTGGCCTGGGCGTGGGGGCGGGGGGCGAGTTCGGGGCAC TTGCTGGGCTCTGGACCGAGCGGTAGGGCGGGGCGGCGCTAGGGGCTGGGCCGGACCCGCAGGGAGAGGGCGA GGGGAGGGAGAGCCGGGGGTGGAGTAGGGGCGTGGAGTTGTGAGCGGGGTCTGGCCTCGGCCGGGGGCGAAGG TAGATCGGCGGGGCCGCGAGCGGAGGGAGGGAGGCCCGCGGCGGCGCGGCGGCAGCGAAGGCCAGCTTCCGCG GAGTTTGTGCCCGGGCTTCCCGGGCTCTGGCCGCCTCACGCGCACAAATGGGGCTAGGGGACTGAGTGGTAAGC AACTCCGAGTGTTAGACGGTGATCGGGCGGCGATTCCGGGAAAAGCGAGGAAAGACACAGTCTGCGATTGTGCC GCACCCCCCACCCACCTCTTAGCATCTGGATTCTGCTCTCGTAGTGGGGGCCGCGGACCCTCCCCGCCACAGTCC TTTTACTCTCCAGCACTCCCACCGCCTTCCCCCTTCTTCAGCCATCTGACTCTCCTAGGGGTATGTGTTTTTGGGG GTGGACGGCGACGGGGGTGGGGGATACTTTCCTTCCCGTGGCGGCAACCTAGTTCGTATCTTATTCCTACAAGGT AGCGTCGCTTCGAGTCGCATGGACATTGGGGTTTAGATAATTTACCCCCCACCCAAGCGATTTAATGGCTTTTAAG CAAAAGGCGAATACCTGGATTTCCATGGGAGGGATGAGGTTTGAAGATTGGGATTCACCCCTAGCTCACTTCCAC TACCAACCCCTCTTTCTTGTGAGCCACTTCCACGGGTATTCAAATCTGGGGGGGAGGGGGGACGGGAGTATTAAT ATGCTTCTCTATTTCTACACAGGGTCGGCGTGGCGAAGGACGGCTAGCCTTGGAGGGAAAGTAGCCACCAGTCCA ACTCGGGTCGCCCCCACCATTATTTCGGTGAGGGGGCAACGCTAAGAAGGGGATACTGGTGGGTAGGGGCCCAG TATAAGGGAGGGGGCTGGGTAGTCGTCCCCAGAAGGACTCCGTGTCTTGGCGGGGAGAGAGAGAGGCGAGCCCC GGCTTCAGGGGAGGGGTTCCGGGGAGGGAGATGGGGGGGTGGCGACGACGGTGGGGGGGGGAGCGGGAAGAAG GGGGAGTCACGCCCTGCCTGCAAGGGGAGCCTCCCTCAGGCCCCTGGGAGAAGGGGACTGAATGCGTCTGTTCT CCGCTGCCCGGCAGAGGAGATCTGGGGTCTCGAGATTTGCACACTGGATCGGCACCAGTGGCCTGAGAAAGTCAG GTCGGGGCATAAGGTGGAGAACGTTGGAAGAAAGAGAGAGAACCCTTTGGCCGCGGCTCACTGACCCTCTCCCTT CCTCAACCTCCCCCTTCGAGGGGCGTCGAGGTGGGGGGGGACGTGGGGCTCCTGCAGCCCCGCAGATTGAGCGC CTCCGCCTCTCCCAGGAGTCTAGCTTTTTGCCCGGCTTGCTGCAGCCACTGCTGCCTCCCTCTCCGGAATCCGCTC GGTCCTCTCAGCGATCCCCTCCTCCTCTCCTCCCCTCCCAGTGTCACCGGGGCTGCTTGGCTCTGCCCCCTTCGCC GCCGCTTGCTCCCTGCTTTCGTCCCTCCCTCTCTTGCTCGCTCCCTCCCTTCGCCTCCTCCTCCCCATTCCCCCCCA CCCGCGTAGGCCGCATTCTGGGAGTTGTAGTCCGGTGGAGCGGGGGTTGGCGCCGCCCGCGGACCCAGCCGGAC TCCACTTCCCGTCGAGCCCTGCGACCGGCACCCACTCCACCAGGCTTCGCTCGCACACAGACACACACACACACC GCTCTCCCCCTCACTCTTTCGCTCGCCGCGGCTGCTGCCAGTGTGTGGCTCTGTCTCTCCTCCGCTTTGCTGAGCC CTCCCTTCTTCCTCTCAGTTCCTAGAGTCCGACCGCCGCCGCCGCCGAGAGAGAGGAGAAGGAGGTCGGTGGCGA TAAGGGGCGGAGGGGGGCATCAGATCGGGGCAGTATTAGGCGGGTGGCGGTTAAGAGGGAGTAAGAGGGAGCC CGGGTGGCGGCCTGAGCCTCCCCGCGGAGCCGACCCGGGAACAGGTGCGTCTTTTTTCTCTCTCCCCCAATCCCT CCACCCCTTTTGACTCCCCGGCTTTTTCGTATCCCCCCACCCGCTTCTTTCTATCTTAAGCCTTTCTCCAACCCTGT TCCTTCTTTTCCCTGCGGCCGCTCGGCTTGCCCCCCGGGGGCGCCGTCCTCTTCGTGTCCCCGGACGTAGCGCTC CCTGGAGCTGGGTATGTCTTCGCCCCTCCCTTCGGGACAGCTCCCTTCCACTTCCCACCTTCGTACCCCATCCCCT GACTTGCCCTACCCCCTTCTCGACCCCCTTCTCTCTTAGCCAGGTGAGACTCGTTCGCCACGATCCAAGAGAGTCT TCTTCCCGGCTGGGCGGGGGTCTCCATGGAAACGGGGGTCGGTTGATCCTGGGGGGGAAACCATAGGAATTACC CCACTCCTCGGAAAGGGAGGTGGAGGCTATGGTCTTGTTAACTACCTGACTCCAACCCCCGATCCAAGGATCCGA CGATCCGAAGGGAGGCTGGCTAGCAGGGCAGGGCGAGAAAAGGCTTTTTTTTGGGGGGGGGGGGTGTCCGTGAT GAAGTGTTGAAGAGACCGGGAGAAAATGCCCTCCAACCTCAGAGGGGAGGTGCGACGGGTGCTCTTCAGGGCTG CTTTCTTCCCGGCGCTGGGGTGCGGGAATCGTAGGGTAAGGGGTACCCCTAGGTGGCGGCGGGGCCTGGGTTCG GGAGTGGGAGTGCTGTGATGGGGGCAGGGGCAATTATCCGAGTCCCTGGAAAAAAGGCGGGGGATGACTTCGGA GCGCCCTGGCTCCGCTGCCCTCGCTCTAGGGGCGGGGGCCGCCGGGCCGGGCGCGGCGGGGAGGGGGCTTAAAT TGAAGGAAGATGAGATCGGGGGCAATTCATACTAGCACCGGCAAGCCAGAGGGGAGATCCGGCGTGCAAGCCCT CCACCCGCTTCGCGCCAGGCCTGGAGGCAAGGGGTCGGCGAGCGAAGCCGAGGGCTGGAAGGAGGGAGGCTCC GGTTACGGGGCCGGGTTTCGGGATCAGGGGCAATCCCCCGGCCCTTGGAGAAGGAGGGAGAGGGATGGCCGCGA ACCCCAGGGCTCCCCCACCCCGGGTCCTAAGGGGCGTGAGGGACGGACAGCAGGCCCAGCGGAGCTGGATTCGA GCGGATCGCGGCCG 14 chr17: 7584523-7585036 CGAGTTGGTGCGGGACGTGCCGCACGGCGTGCTTCTGCTGGACACCTTCCACAGGCTTGCCTCCCGCGAGGTGCG GCTGCCCCGCGGCTTCCTCGGCTTCCCGTCCCGCGTGCTTTCCTGGAGTCCCTCCTTCCGGAGGCCCTCCTGCCTC CACGTGTGCCCTTCTCCATGTCCAGCATTCGGGCGCCTCTTGTCTTTCTTCTGTTCCCTGGCTTCGGCGTCCCCGG GAGTGTGACTCCCGCAGCGGGGTGCAGCTTTCCTCTGGGATGAGTGACCGGAGGGAACCCGCCTTCCCGGGCAC GTCGCCAGCCTCTTCCTCTTCTTCCCTAGGCTATCAAGCGGACTTATGACAAGAAGGCGGTGGATCTCTACATGCT GTTCAATAGCGAGCTGGCCCTGGTGAACCGTGAACGGAACAAGAAATGGCCAGACCTGGAGCCCTACGTGGCCCA GTATTCCGGAAAGGCGCGCTGGGTGCACATCCTCCGGCGTCGCATCGACAGAGTCATGACCG 15 chr1: 27548507-27550603 CGAGGAGGCTGACCCGGAGCTGGAGCCCGCGTCGGGGGGAGAGCAGGAGCCGCGGCCCCAGCAAGCCCAGGTA GGCGGGAGTGGCCCGTGGCTGCTCTCAACATCCGGAGCGGACTCCGGGCGGGGAGCGCTCCTGCCCAGGGCTGC GAGCCGCCCGCGACCCAGGGCGCTCGGGGCAGGGGTGGGGAAAGAAGGGGCGCCCCGTCACTTGCCCCCTCTGC AGACCAAGGCCGCGTCCCAGATCCTGGAGAATGGGGAGGAGGCCCCGGGGCCCGACCCCTCTCTCGACCGCATG CTCAGCAGCAGCTCCTCGGTGTCCAGCCTTAACTCCTCCACGGTGAGGCGGGAGGGAGGGGACCCGGGCGGCCG GGGGGTGGACCCGTTCCGATGCGTAGCCCCTGCCTGCCCCTCCCTCGCCGCGGGACCCACCGCTGCAGCCCCCCA GCCTGCCACCTATGACCCGGGTCTGAAGCCTCCGCGCTGCCCGCGGCCCCGACGTGAGCCCTGCGAGCGGCCCT GACTCCCACCCACTCCCGTCCGCAGCTGAGCGGCAGCCAGATGAGCCTGTCAGGCGACGCGGAGGCGGTGCAGG TCCGCGGCTCCGTGCACTTCGCGCTGCACTACGAGCCGGGCGCCGCCGAGCTGCGCGTGCACGTGATCCAGTGCC AGGGCCTGGCCGCCGCCCGGCGCCGCCGCTCGGACCCGTGAGTGCCCCGCCGGCCAAGCGGGGCGCGGCTGTCA CAGCCCAGCCCACCATTCACAGGGTCTCGGCCTCCTCGTCCTCATCTTCAAAATGGGAACAACAGCGTTATTGGGA GGCGTGCGATTAAGCGAGACAATCCCTGTAAAGCGCTTAGCACGAGGCCTGGCACGTGTTCGGGATGGTGGCTGG GGGAGCCCACAGGCAGGGGAGAAGGCTCTGGGAGGGCCCCTCCTCACCTCGGGTTCTCACCTCCCCAGCTACGTC AAAAGCTACCTCCTCCCGGATAAGCAGAGCAAGCGCAAGACGGCGGTGAAGAAACGGAATCTGAATCCGGTTTTC AACGAGACTCTCCGGGTGAGGCTGTGACCACGATGCGGTTCCCCGTTAATGAACTGGACGCCCCCTTCCTGCGGG GCTAGGTGGCAAGGGCAGCCAGTAACGTCATTGCCCGGAGGATCGGCGGAGGGGGCCCATTAACTCGTTATCCA GTGTTGTCAGCCTCGTGGTGGGCGTGGTGATAGTGCAGGTCCCCATTAATGCCCTTAGGGGCTCCCCAGAATTCC ATCATGGTAGGAACGCGGTAGGACCTGCCTCAGCCAACTCGCGCAGCATCTACGCGGGCCACCAGCAGTGCTCCA CTAAAGCTCACCTCCTGTCCTCAGTACTCCGTCCCGCAGGCCGAGCTTCAGGGCCGCGTGCTGAGCCTGTCTGTG TGGCACCGCGAAAGCCTGGGTCGCAACATCTTTCTGGGCGAAGTTGAAGTGCCCCTGGACACGTGGGACTGGGGC TCTGAGCCCACCTGGCTCCCCCTGCAGCCCCGGGTGAGGCAGCCAGGCCGCGTGGGGAGACCTGCGGCCCGGGT CTCCTGCATTTACCCCACCAGGCTCTCCCGCAGCCCCCTCACACCCCGCCTTCGACAGAACCTCCCCTCAACCTCT TAACCTCATGGCCCCAGGCGAAGCCCGGCCGGCCACGGCCCCTTCCCCGAGGGCGCTAGGACCCCTAGGTTCTGC CCCTGCAGGCCCCGCCGTCTCTTCTAGCCGCACCCCATCCGGGTCTGCAGACCCCACCCTCCTGAGGCCCCTTTC CATTAGCCCCTGCTCCACGATAAGCCCGCCTCTCGCAGGTCCCACCCTCTCCCGACGACCTTCCGAGCCGCGGGT TACTCGCCCTGTCCCTCAAGTACGTCCCCGCCGGCTCCGAGGGTGAGTGACAGCCGGAGAGGCCAAGCTGGACAC GCCCTGAAAAGCGGGAGACTCCAGTCCCCGGGTTTGGGGGCGGTGGACTCCATCCGTGTGCGGGCCTGAGCCGA GCCTCTCCGCAGGCGCAGGACTGCCCCCGAGCGGGGAGCTGCACTTCTGGGTGAAGGAGGCTCGGGACCTCCTG CCGCTGCG 16 chr19: 10304689-10307022 CGCCCCCTTCCATTCCCCGCCCGCTTCCATCACTTGGTGTCGCCCAAGCCTGTGGTCGCCCCTAGCAACGCCCTCC CTCACTTCGCAGTCGGTTTCCCCTTTCATCATCGCCCCCCCACGTCCCGCTCTTGGTCTCTCCCGATCCCGCGTGG ATCCGGTGCTTGGGCGCCCCCGCCAACGACCCCCGCGCACCTCAGCGTTGGTGTCGCCCGGTTCCCCCCGCGCAC GCGCACCGTGGTATTTCCCGCCACGCTCCTACACCGCCCCCCCCAATACCTGGTTGGTCACGTCCCCCGGGAGGC CCCGGATCAGTATCTTGCGGCGGTTACGGAACTGGCGCTCGGTGTGTTCCAGGCGTTTCCGGATCTCTTCTGGAT CTAGAGGCGGCAGCTCTTCTTCCGGCGCCCGGCGCTCCGCGGCATCGCCGGCTTCGACTTCGGCCCCAGACTTAG GGCTCAGCGGGGGCCGGTGAGTAACGGACACGTCCGCCGCCATCTTGGGAAACCCGGCGCCTTCTGGGACCAGC GAGCCGGGGCGGAGCGGCATAGAGCGGCAACGAGGGCGCGCCCGTCGATTGGCTGGGAGAAACCCCACCTCCTT CCCGCCCCCCTTGCCCCGTTGGCTAAGCCCCAGCCCACCTCTCAAGAGTTCAAGCTGCGTCTGCGCGCCACAGGC CCCGCCCCCTTCCGTCGCAGCGACGCTACTCAGTGGATGTGCACCTGGGTGGGAGAGACTTGCAGCGCGGGTGG AATCAAACCACAGATTAGGGAGTTTGAAGGCTTTATTGGTGCGGAATCTGAGGGCACAGCCAAGCCCCCGCCAAC TTTGATCCCGGATCCCAGCGTCACTCAGCTCTGGACGGTTCTTCCCCCATTGCTTCTGTCGGCTGCATAGACGTGA GGGGCAGATAGGTGCTCTCCTCCCTAACATGGTAACTGCCGCTCCGTTGGTGCTCCCTGAAGACGTACATTAAGG CCAGTACGATAGTCACCACGCCCAGGGTCAGTAACACCGCCACGAAGACGGGGACAAAGTGGGAGCTCCCAGCT GTGCAGAGAAAGCGCTAAGTCAATATGCGTCCCTTCTGTCTCCAACCCCCCCGCCCCCCGGCTTACCGGTCCAGA CCCGCAGCCCCGTGTTAGCTCACCCTCAATGTCCATCACCACGACCAGGGTGTATTTGCCTCGTGAGCTGGACGC TTGGCACTGATAAGTACCATTATGTGTTACGTTGACGAAGAACGGGATCCCCACCGGCACCTCCCGGCTGGAGCC TTCCTTCAAACACCGCAGCTCGGGGTACGGGTTGCCCCTGGCTTGGCACTGCAGGACGTGTCTCGTTTTATCTTTC CATTTCAAGTGCTGGGGGCATGTGGCTCGGTCAATTTTGGGACCATCTGTGGAACCACCATGTGTGATCAGACAC CCAACACACCCGAGGCACAGTGGTGCAGAGGAGCGTCTAATCTTTCCAGGGCAGGGGTGGAGGGATTAAAGGTC AGGGTGACCGACTCACACAGGACTCGCAGCTGGACGCTACTGTTCCTGTGCAAGAACTCGCCGTCCACCTCGAGA GTGGCACTGCAGAAGAAGCTGCGTCCGTCGTCACTCTCGGTAGCATTTAGCTGAAGTTGAGCTGGCTGCCCCGGG GCCGCGGCCGGAACTCCGTCCAGCGTGACCTGGACTCGAGCCCCAGCCATGCAACTCACGGTCACTGTGGACCCC TCATGGGCGGTGGGCTCGCTGAGGTTCACAATGGGTCCTAGGAAGCCTAAAGGCGGGGCATTGCCCAGGAGCTTA ATGAACAGGACCTTCCTGTGGGTCAAGCCGCTCCCTCCGCCCTCCCCTTTCCTCTCGGGATATCCGGGCCACGCTT TCGGCCGTTCAAGCCTCGCCCTCTTTCCGCGCTGTGTCCAGCTTCGGGCACTCAGGCCCAACCCACGTTGCAACT GCTATTGGGGCAAGCCAGGCCCCACCTTTTCGGCTAGTCTCCGCCCCCTCTGCCACGCCCCCAGACTGCTGAGGC CGCGCCCCCTTCCCACGCCTCCTCTTACTAAAGACCGTCAAGTTCTCCCGGGCCTCCCGTCTCTCGCCCCCTAGGG TCACGTTGCAGACGATCTCCCGGGCACCCTCCTGATCCGCGCGCGCCGTGGCTGTGGCTGTGGCCGTTAGCGTGT CCCCGTGGTTCATGACTGTCGCATTCAGCATCTGGTCCCCCAGCGCCAGGTAGACCTGGGCCTCTGAGGCTGGAA AAAGCCCGTCTAGGGTGCAGTCCACCGGCCACGACGTTTCCACCTCCAAGAACCGGGGGGCCACGAGGCGCGGG GGGGTCACG 17 chrX: 129132628-129134108 CGCGGCGGGCCTTCCCCATTGGCCAGCCAAACACAACCGACTGCGGCAGCCAATAGGAGCCGCTCTCCTGAACAT TCAGAGGATGGGTGCGCGTGGTGTGATAAGGGGATGTTGGCGCCTGGTACGCGCCCCCCTACATCTGGCAAGTCT GTAACAGAAACAGTTACACCCCCTACACACGCACACGCGTGCCCGCTGGCTCCCTCCTCTCAGCTGTACAGGCCC CGGACAACCCACTGCGTGTCTTGGCAGCGGCCTCCCAGGCTGCCTGGGGCCCGCGAGTGCACCTGCTCACTCATT AAGACAGAGCATCCCTTTATCCCAAGGCGCGGGTCGGGTAGAGGGTGGGGGTAGAGGGGACGGGGTAGCGGGGA CCGGGAAGGCGCGGCTCAGCTGCCCGCTGCTCCCGAGGTGAAAGAGGTGCCTCCGCCCCCACCCCATCCCCGCA GAGTTGCGTTGCTCCAGGGAGGCCGAAGTGATCCAGTGATGTCTTAAGGTGCAGCTCTTTGTCCTCCCCAGCTGT GCTCCCTGCCCGCTGACCCCGTGCGCTCGAGCCAGTGGGGGTGGGGAGCCCGAAACCTATAACATAAACGGGGG CAAGGAGAAAGAAGTCTATCCCGGGGTGGCGTGTGCCGCTGTCCCCACCCCGTCTCTTTCCTCCTGAGGCTTCTT CCCTCGGGTCCGTCCCGGGAATGCAGGCAGGGGAGGGTGTGGGCCGAGGCGCGGCGGCGGCTGGAGCAGCGCG GTAGGGTCCTTCGCCAGAGCATCCGGTCCGAGGGCGCACACAGGCAGAAGGCTCGCGGCTCGTCCACTCTCCTCC CTCTCTCCTCCTCTCCCTGGCTTTTGTGTTGGTGCCTCCGAGCTGCAAGGAGGGTGCGCTGGAGGAGGAGGAGGG GGGCCCGGAGTGAGAGGCACCCCCTTCACGCGCGCGCGCGCACACGGTGCCGGCGCACGCACACACGGGCGGAC ACACACACACGCGCGCACACACACACGCACAGAGCTCGCTCGCCTCGAGCGCACGAACGTGGACGTTCTCTTTGT GTGGAGCCCTCAAGGGGGGTTGGGGCCCCGGTTCGGTCCGGGGGAGATGGCGCAGCCCATCCTGGGCCATGGGA GCCTGCAGCCCGCCTCGGCCGCTGGCCTGGCGTCCCTGGAGCTCGACTCGTCGCTGGACCAGTACGTGCAGATTC GCATCTTCAAAATAATCGTGATTGGGGACTCCAACGTGGGCAAGACCTGCCTGACCTTCCGCTTCTGCGGGGGTA CCTTCCCAGACAAGACTGAAGCCACCATCGGCGTGGACTTCAGGGAGAAGACCGTGGAAATCGAGGGCGAGAAG ATCAAGGTGATCCAGGGGGTCAGGTCCAGGAAGGGTGGGACCCGGGAGGGGACCTCGCCCGAGGCATAGCTCTA GCGGTTGTCGTCGTCCAGCGTCCAGCGCGTGGCGGTTTCGCCTCTTGCTGAGCCGAGGACCCTCG 18 chr21: 45648960-45650662 CGCACGCCCCTCCTGTCTCGCGTCCGTCCCTCCGTGCAGCCGGGGCAGGACCCTGCAGGGGCCTTGCGGGCCGG AGGTGCCGGCTTCCTCCTCCGTCCCGTCCCCCCCGCGGTGACTCTATTCAAATCTCCCCCCTTCCCGCTGCCCCAC CGGACTCAGGGGCTGGGGTCGTAGCCCGGCGGGCAGCGGTGTTCACCTTCCGCATAAACCTGGGCTTCCTCGCG GGGCAGCCCCCGGGCCCTGTGCTGGGTCGCAGCCTCGGGCGGTTCCCTCGGGGCGGGACGTGTCCCCGTCCGTC CTCGCCCGTCCCCGCCGCCCCCGGGTCCCGGCCCGCCCCGTCCTCGCAGCCGCAGGTCCGCTGCGGCGCCCGCC CCCCTCTCCCCTCCCCGGGCCTTGCCCTGCTCGTCGCTCCGCCCCCTGCCCGGCCCCTGCCCGGCCCCGCCCCGC GCCCGCCCCCTGCCCGCGCCCGCCCCGCCCCCTGCCCGGCCCCTGCCCGGCCCCTGCCCGCCCCCTGCCCGGCCT CCCAGCGGCGGCGGCTGCAGCGCGGCGGTCCGAGCGGGTGCACCGCGGCGGAGGAGGCAGCATCCCGCGGCGC TGACGGTCCTGGGGAGAGCATGGCGCCGAGGTGAGGCCGGGGCTGCGGGCAGGGGTTGGGGGACGCCAAGATG CGGCTGCGGGGGTCGCGGGGGTCGCGGGGCTCGGCCGGGTCCTGCGGGGGTCGCGGGGGTCCTGCGGGGTCTG ACCCGTGCCTGTCCCGCGCAGGTGCCCCTGGCCATGGCCGCGGCGGCGGCGCCTCCTGGACGTGCTCGCGCCCC TGGTCCTGCTGCTCGGGGTCCGCGCGGCCTCCGCGGAGCCAGGTAAGACCCGGGCGGGACGGGAAGGTTCGCGC CGGTGCCCGCCGGCCTCGCCGCCCTGGCTGGGGTCCCCGCCCGGCTCCCTCACCCCCGCCCCGGCCGCTCTGGG TTCAGCCCCGGCCCTGCCCACGCGCGCAGGAGGCGCCGGAGCCGGACGGAGCGGGGCGGGGTGGCCGGAGTCC CGCCCATTCATTCTCCCCGCGGGGTCCGGGCCGGGAGGGGTGCGCGGTGCGAGCGGCCGGAGTCCCCGCGCGGG GACCGAACCTCCGCGGCCGGCGGGGTCGTCGGTGCCGGGAGGGCTCGGGGCGGGGCCGCGGGGTCTCGGGAGA CGCGGCCTCTGTCGCCGTCACGGCCTCGTCCCCGCAGCGCCGGGTCCCGGGACTGACCGCGGGCGGAAGGCGGC GGAGCGCGGGGCGTCGTCTCCGCGTTTCCAACCTGTTGAGGCTCCTCGCCGCGGGCCGGGCCTTGTGCGCCTCTG TCCCCGCCGCCCTCAGGCCTCTGTCCCCGCGCCCGCCGTGGTGTCGGGTTGCGCGGTCCCCTTTGATGCCAACCG AGCGCCGCGCGGTCCGAGAACAATGCCCAGAAGCCGCTGCCCCGCCGGCCTCGCCGCTTCCCGTGCGCGGCAAA CGGTGCGCGGGGCCCGTGGGGACCTTCCTGCCTCCAACCCCGGGACCCAGTTCCCCACCACCTGCTAACCGGGGC CTCCTGCCTCCAGCCAGCCCAGCAGAGGCCCGGGGGAGGCGGCGGGGACGCGGACCCCAGGGGAGCCCCGCCCA AAGGGCCTGGGTGCCTTGTCGCGGGTGGAATCCCACCCGGGGGTCCACGCAGCCAGCGCCTGCCTCCGACTCG 19 chr10: 134864694-134865392 CGAGGACAGGGCCCGGCCCCACCCCGGGGCGAGTACGAGTTTGGAAGCAGTGAGGGCGCAGAGTGGGGCTCCAT CTGGGGAGAGGCCTCTCTCTGTCACCCGGCCCCGTGCGGCAGTTCAGGGTCCCAGCATCTCCCCTGCACTGGGAG GCGGCAGCCGTGCCCGGGGGGCGCCCGTGGTGGGCGGGTGCAAGAGAGAAGGGCGTCGGGTGTGCAAGCACCA CCGGCCTCCCATTAACAGCCTGCCCGGGCTCCGCCCACAGGAGCCACTGTCCACGTAACCTGCGTCTCTTTCTTTC AAGGAAAAGAGAAGCCAGCCATGGCCAGGACCAGCAGCAGGGCCCCCTGCTCACCCACCTCGGTGTCGGATGTG GACTCGGACGCACTGTCACGGGGAAACTTCGAGGTGGGGTTTCGGCCTCAGAGGTCCGTAAAAGCCGAGAGAGC GCAGCAGCCTGAGGCTGGCGAGGACAGACGGCCAGCTGGCGGGGCCTCAGACGTGGAGGCAGTGACCCGACTGG CCAGGTCCAAAGGGGTCGGCCCAGCCTTGTCCCCCGGCCCAGCCGGATTCCAGAGCTGCAGCCCCGGCTGGTGC AGCGCCTTCTACGAGGCCGACTGCTTCGGGGCCGACGTCCACAACTACGTGAAGGACCTGGGGCGGCAGCAGGC GGACGGGGCCCTGCCCGACGCCCAGAGCCCG 20 chr9: 129556229-129557670 CGAATGCAGCATCCCTGCGCTCGGCGCCCTGCTATTGGCCAGAGATGATCTCACCGCCTCCCGGCCTGCGCGCGC CTGATTGGCCGGTGCGGGGATGCTGCGCTCCGCCGCCGGCGGGGCAGTCCTTCAGGCGGGCTCCGCGAGCGTGT GTGAGCCTGGGGGAGCGAAGAGCCGACGCGCCTGGCATCTCCCAGGGGGCTCAGGGGGCAGGAGCGCGGAGAC CCCCGGACAGGGTCTTAACCCCTTCCCGCCAGCCCGAGCCCAGCATCCCCTCCAGCTCCCCTCGGCGTCCCAACC CCAAGCAAAGCCATCCCCAAAGGATGCTCCGCAGAGAGGCGGGGTCCGGGTCCTCCCCTCCACCCCCTTCCGTTT AACCCTCTCACCGCCGCGGCGCCGTCCTGCACTGCCCGGCCAGCTGGGCTGGGAGAGACCCGCGCCCCAGGCAT GTCCAAGCCCACCTAGAGGGCGGGAGGGTGGCGGGCGCTCTGGCCCCAACCCTGGCATCCGAAGCATCCCCCGC GTTTCCTGCTCCTCACTCAGTCTTCAGATCCCAGTCCGGCGCCCCCGGTACAATGGGGAGCCAGGGTGCCCAGGT CAGCCGCAAGGGCCAGCGTACCAGGCGGAGGACCGGCAGGACGCCGGAGACCCCATCTCCCAGTCCCCCCTGCC CCAGCTCTCTCCCTCCTGCGGAGGAGGCAGAAACGGACCGGCATCTACCGCAGCCCAGAGTCCCAGGAGTGGCC GCCGAACCCTCACCCCGCGGAGCGCCTGGGCGCCCAGAGGTGAGGCTGGGGTGACCCCGCCCCCTCCCCGGGTC GGCCGGGCCCAGCCCAGCCCGACCCTGCCGGGCGCCGCTGAGCTGCAGCTCCCCGGCTGGCTCTAGGGCCCCGG GCGGAGCGGCCGGGGGTCCCAGCCCGGCGCGCGTGGCGGGGGCCGAGCCGCCCCCTCACCTGCACCTGCACGAA GGAGCCGCGGTAGAAGCAGCAGGCGGCGGCCGACAGGGCACTCCACAGGCTGCACCGCTCGGTCATGGTGGGGC CAGGCTGCCGGGGCCGGGACGGTGTGGGGGGGCGGTGGCCGGCGGGGCAGGGGCGCAGGGACCAACCGGCTAG GCACCGGCTGCGCGTGCCTCTCAGCGGCGCGATTACCTCATCGCCTTGTCGGGGGAGGAGCGGGGAGGCGGGGC GGGGAGACCCCACCCTCCAGCCGGCCAGGGGAGGGGAGGGGGCCATTGTTCCTCCCTCCGCCCGCCCCCCGCTC CCAGCCCCTCGCCCCCCGCCCTCCAGTTCCGCGCGCTCGGGCTGCCTGGAGCTGCGGGCGCGGAGCGGAGGACC TGCCAAGGAGGGTATTACCGGGGGCAGCGGGATCGGGTGGGGACCCATGGGCCAGCGAGGGGAGGTTCTGCCTC CCCCACTCGCCGCACCTCTAACAGACCGGGAGCG 21 chrX: 47305347-47306043 CGCCTGCGCGAGTCAGGACGAGCGCTTGCCCCAGATCTTGACGTTTCAGGCGGCCCCTCCTAATCCGGAACACGA CTCACATTCCGTTGGTCTTGCCTTGACAGACGTGACCCTGACCCAATAAGGGTGGAAGGCTGAGTCCCGCAGAGC CAATAACGAGAGTCCGAGAGGCGACGGAGGCGGACTCTGTGAGGAAACAAGAAGAGAGGCCCAAGATGGAGACG GCGGCGGCTGTAGCGGCGTGACAGGTGAGGGCGGGCCCGGGAGGGCTCGGTTTCTGGAGCGGCTGCCGGGCAC GGGCAGGGAGCCCGGACCGAAAGCTCAGCTCCAGGATGGCTGCGCTTGGGCCCCGGCGTTCCCTGCCCGGAACC GGAGGAGTGGTTTGACCCGGGGCGAGACCATCGTCGACAGCGGGGGTGGGGTGGGTAACAGGAATAGGCGGGCA AGGCTGCGGGTGATGGTTTCGCCCGCTGCTAGTGGTGGTGCGCCTGCGCAGAGCCGGAAGCCCTTTGGTAGGCG GGACCCGACCGAGTGGTGCCGGGATTCCGTCTTAACCCCCGCTAAGGTGTCCAATGACCTTTCCTTACCAACTGC GGGGAGTGTGTGGAAACGCGGTTCACTCCCCGGTTTCCTTATTCTGGATCAGTGTCTGACCGCCCCCGCCGGGAG AATGTCAGGATTCTCGCCTCT

TABLE 10 Hypermethylated genes and CGIs in bladder cancer. Fold Symbol CGI Change MEIS1 chr2: 66525936-66527140 4.76 NR2F2 chr15: 94688798-94689034 2.93 SOX21 chr13: 94152191-94153185 2.8 MAB21L1 chr13: 34950554-34951119 2.68 OTX1 chr2: 63134539-63134851 2.67 MGC2752 chr19: 63784504-63785085 2.64 IRX3 chr16: 52873104-52882105 2.63 PAX9 chr14: 36205265-36206099 2.62 FOXC1 chr6: 1549606-1560865 2.5 DLX5 chr7: 96488158-96489487, chr7: 2.45 96489900-96490182 NR4A2 chr2: 156892636-156892878, chr2: 2.45 156893804-156894601 CNTNAP1 chr17: 38089258-38089793 2.35 FOXF2 chr6: 1338049-1339169 2.35 HHEX chr10: 94441310-94441717 2.33 PRKCZ chr1: 2072175-2072389, chr1: 2106293-2106661 2.31 HOXA7 chr7: 27164708-27165039 2.27 MSX2 chr5: 174091287-174092335 2.26 SLC45A4 chr8: 142288380-142288627 2.22 FLJ44006- chr2: 111591678-111597436 2.21 BCL2L11 MAP2K2 chr19: 4059920-4060207 2.2 SHH chr7: 155288454-155292175 2.19 chr13: chr13: 49605587-49606020 2.19 MAD1L1 chr7: 2082894-2083307 2.18 hsa-mir- chr17: 44074360-44075233 2.17 196a-1 NXPH1 chr7: 8449658-8450236 2.17 chr18: chr18: 5186244-5187389 2.12 C10ORF114 chr10: 21828640-21829594 2.1 SIX3 chr2: 45014932-45016562, chr2: 2.08 45013398-45013616 TFAP2A chr6: 10530308-10530634, chr6: 2.08 10498025-10498551 ISL2 chr15: 74414579-74414893, chr15: 2.05 74419318-74422570 VAX2 chr2: 70984709-70985764 2.04 AMZ1 chr7: 2724531-2724783 2.01 CYB561 chr17: 58865386-58865618 1.99 HOXD3 chr2: 176737660-176738187 1.97 SIM1 chr6: 101003802-101004342, chr6: 1.95 101002495-101002783 EFNB2 chr13: 105943410-105943788 1.91 GAD1 chr2: 171384799-171385226 1.91 MSX1 chr4: 4915358-4915735, chr4: 4910534-4911092 1.9 FOXA1 chr14: 37137198-37138958 1.88 HDGFL1 chr6: 22677564-22678684 1.85 chr13: chr13: 49595986-49600287 1.84 chr16: chr16: 87372445-87372706 1.84 EVX1 chr7: 27251165-27252762 1.83 UNG2 chr5: 54554812-54555385 1.83 (CCNO) ONECUT2 chr18: 53254153-53259851 1.81 HSF2BP chr21: 43902100-43904249 1.8 chr1: chr1: 119350668-119352843 1.8 FOXD3 chr1: 63554983-63563059 1.79 FOXA2 chr20: 22514822-22515055, chr20: 1.77 22510737-22514104, chr20: 22505518-22507240 GRIK2 chr6: 101953488-101953856 1.77 chr2: chr2: 45249374-45251690 1.77 SIX1 chr14: 60178708-60179539 1.76 HOXA9 chr7: 27170441-27172987 1.75 FOXD2 chr1: 47671713-47671985, chr1: 1.73 47682300-47683607, chr1: 47672249-47672972 NKX2-8 chr14: 36122886-36123441 1.72 ZNF274 chr19: 63420090-63420541 1.72 TAF4 chr20: 60061693-60062033 1.71 SIX2 chr2: 45085286-45086054 1.7 chr8: chr8: 145909302-145910517 1.7 PCDH7 chr4: 30330303-30333940 1.69 PITX2 chr4: 111774415-111774953 1.68 TCF7L1 chr2: 85213468-85216104 1.68 chr6: chr6: 10492952-10493478 1.68 SOX7 chr8: 10624024-10624296 1.66 HOXC4 chr12: 52726910-52727810 1.65 PITX1 chr5: 134390992-134393045 1.65 PCDHGA12 chr5: 140790679-140792801 1.64 chr6: chr6: 170422815-170423038 1.64 EPN1 chr19: 60907042-60907388 1.63 DLX6 chr7: 96469320-96469736 1.62 hsa-mir-10b chr2: 176723195-176723460, chr2: 1.62 176720618-176720921 SIM2 chr21: 36990064-36995761 1.61 CACNA2D4 chr12: 1844001-1845219 1.6 HOXA5 chr7: 27149139-27152087 1.6 NCK2 chr2: 105864220-105865009 1.6 OSR1 chr2: 19424445-19425131 1.58 C17orf27 chr17: 75936057-75936582 1.57 (RNF213) chr6: chr6: 169051743-169052507 1.56 EVX2 chr2: 176652334-176656692 1.53 ZNF503 chr10: 76825135-76839606 1.52 chr5: chr5: 92931996-92934631 1.52 KIAA1303 chr17: 76404186-76404427, chr17: 1.48 76390187-76390410

TABLE 11 Genomic distribution of methylated probes in bladder cancer. Probe location % on array % in bladder cancer divergent promoter 2.5 2.4 downstream 3.9 4.0 inside 52.4 52.3 promoter 26.0 25.9 intergenic 15.3 15.3

TABLE 12A Overview of the CGIs differentientially methylated between tumor and control urine. Fold Symbol CGI Change HOXA9 chr7: 27170441-27172987 16.53 PENK chr8: 57520681-57521969 14.69 PCDH7 chr4: 30330303-30333940 12.00 KCNA1 chr12: 4888847-4891432 11.89 HLX1 chr1: 219134071-219134808 10.46 POU4F2 chr4: 147778656-147781351, 10.17 chr4: 147777682-147778033 LHX4 chr1: 178464743-178471598 9.79 FOXD2 chr1: 47682300-47683607, 9.67 chr1: 47672249-47672972 LBX1 chr10: 102986025-102986636 9.44 chr11: 115956893-115956940 chr11: 115955870-115957122 9.03 LMX1A chr1: 163590111-163590435 8.86 BHLHB5 chr8: 65662303-65662699, 8.61 chr8: 65661156-65661382 OTX1 chr2: 63134539-63134851 8.22 GAD2 chr10: 26544390-26547440 8.02 EVX2 chr2: 176652334-176656692 8.02 FLJ44006-BCL2L11 chr2: 111591678-111597436 7.89 ONECUT2 chr18: 53254153-53259851 7.75 ZIC1 chr3: 148619591-148620015 7.33 FOXA1 chr14: 37137198-37138958 7.24 DSC3 chr18: 26875488-26877115 7.19 SIM2 chr21: 36990064-36995761 6.78 MEIS1 chr2: 66525936-66527140 6.74 FEZF1 chr7: 121727243-121727884 6.62 ZNF503 chr10: 76825135-76839606 6.57 SLC35F3 chr1: 232106922-232108080 6.34 FEZF2 chr3: 62331811-62332352 6.26 NR4A2 chr2: 156893804-156894601 6.20 EN1 chr2: 119329502-119332035 5.59 PCDH10 chr4: 134291113-134293078 5.53 OSR1 chr2: 19424445-19425131 5.23 ZIC4 chr3: 148591199-148594390 5.00 CBLN1 chr16: 47868915-47869809 4.92 HMX2 chr10: 124891898-124892607 4.89 FOXB1 chr15: 58083428-58085812, 4.76 chr15: 58079172-58079459 chr19: 057648585-057648629 chr19: 57648469-57649057 4.58 DPP10 chr2: 115635208-115637235 4.55 chr7: 032768257-032768301 chr7: 32768010-32768497 4.48 C10orf114 chr10: 21828640-21829594 4.44 FOXD3 chr1: 63554983-63563059 4.39 chr5: 092933638-092933682 chr5: 92931996-92934631 4.25 TCF7L1 chr2: 85213468-85216104 4.21 VAX2 chr2: 70984709-70985764 3.99 CBLN2 chr18: 68359955-68362770 3.97 PCDHGA12 chr5: 140790679-140792801 3.94 chr21: 037857850-037857894 chr21: 37857725-37858416 3.89 HOXA7 chr7: 27164708-27165039 3.79 GRIK2 chr6: 101953488-101953856 3.77 NKX2-8 chr14: 36122886-36123441 3.65 SOX9 chr17: 67627870-67631593 3.64 chr18: 005186349-005186393 chr18: 5186244-5187389 3.50 SOX21 chr13: 94152191-94153185 3.43 SNRPF chr12: 94776152-94776377 3.39 MSC chr8: 72916429-72917309 3.18 PITX1 chr5: 134390992-134393045 3.05 SOX7 chr8: 10624024-10624296 2.99 chr2: 042182832-042182879 chr2: 42182944-42183157 2.97 TBX15 chr1: 119333515-119333719 2.96 SIM1 chr6: 101003802-101004342 2.91 PFKFB1-APEX2 chrX: 55043085-55043710 2.89 GATA2 chr3: 129688183-129694961 2.86 chr5: 122462228-122462286 chr5: 122461778-122463450 2.82 GPR103 chr4: 122521018-122521740 2.81 SIX2 chr2: 45085286-45086054 2.80 SFMBT2 chr10: 7489383-7495345 2.79 NXPH1 chr7: 8449658-8450236 2.73 CA10 chr17: 47590175-47591465 2.71 CNTNAP5 chr2: 124498723-124499725 2.66 ZNF274 chr19: 63420090-63420541 2.62 HOXD3 chr2: 176737660-176738187 2.61 PITX2 chr4: 111774415-111774953 2.55 OLIG2 chr21: 33316999-33322115 2.54 FOXA2 chr20: 22505518-22507240, 2.53 chr20: 22510737-22514104 DBC1 chr9: 121170908-121172035 2.49 PAX2 chr10: 102497473-102499636 2.45 MAB21L1 chr13: 34950554-34951119 2.35 CYP26B1 chr2: 72224630-72228512 2.31 CBLN4 chr20: 54012011-54014085 2.26 GAD1 chr2: 171384799-171385226 2.25 HHEX chr10: 94441310-94441717 2.22 chr9: 013268499-013268548 chr9: 13268313-13269805 2.20 FOXF2 chr6: 1338049-1339169 2.17 DLX5 chr7: 96489900-96490182 2.08 TBX3 chr12: 113589232-113589931 2.04 MEIS2 chr15: 35174679-35174906 2.04 PTGER3 chr1: 71284813-71286392 2.04

TABLE 12B Overview of CGIs associated with progression of NMI-BC. Symbol CGI FC GPR103 chr4: 122520930-122520974 1.81 chr2: 042182832-042182879 chr2: 042182832-042182879 1.96 KCNA1 chr12: 004890074-004890118 2.01 HLX1 chr1: 219134113-219134157 2.14 DBC1 chr9: 121171898-121171944 2.59 GPR103 chr4: 122521031-122521075 4.17 TBX3 chr12: 113609259-113609303 2.76 GATA2 chr3: 129693434-129693486 2.20 TBX2 chr17: 056833879-056833928 2.15 TBX2 chr17: 056835246-056835290 2.10 ZNF577 chr19: 057082979-057083023 2.08 MSC chr8: 072916695-072916739 1.82

EXAMPLES Example 1

The CpG island hypermethylations as indicated in the Tables 1-5 are the result of comparative studies using well characterized patient samples. Both tumor samples and controls were analyzed. The DNA was extracted directly from the tumor and control tissue. DNA samples were analyzed using a CpG island microarray comprising 200.000 CpG islands (Agilent Technologies Inc.). The results obtained are indicated in the various Tables 1-5 as listed herein.

Example 2 Materials & Methods

Patient samples, ethics statement and DNA isolation Samples from 44 fresh frozen bladder cancer tissues were collected, representing 29 non-muscle invasive tumors (19 with FGFR3 mutation (NMI-mt) and 10 without (NMI-wt)) and 15 muscle-invasive tumors (MI). Tumor tissue of patients was obtained from the Department of Urology of the Erasmus MC, Rotterdam. The medical-ethical committee of the Erasmus MC Rotterdam approved the project. All patients gave written informed consent. For validation, 90 formalin-fixed, paraffin-embedded (FFPE) bladder cancer samples (27 Ta NMI-mt, 13 Ta NMI-wt, 10 T1-mt, 14 T1-wt, 26 MI) were collected from the Department of Pathology. Usage of these samples was performed according to standards presented in “The Code for Proper Secondary Use of Human Tissues in The Netherlands” (http://www.federa.org). Tumor samples were included only if at least 80% of the sample consisted of cancer cells, as verified by H&E staining. DNA from tumor tissue was isolated with the DNeasy Tissue kit (Qiagen, Hilden, Germany), according to the instructions of the manufacturer. Commercially available normal human genomic blood DNA (Promega, Madison, Wis., USA) was used as a reference in the genome wide analysis and the GGMA. DNA isolated from cells present in normal urine of four healthy persons of more than 50 years old was used as reference DNA in the GGMA validation assay.

Differential Methylation Hybridization (DMH) and Data Analysis

DNA amplicons were prepared for hybridization according to the DMH (differential methylation hybridization) protocol described by Yan et al [Yan et al. 2002.) Methods Mol Biot 200: 87-100]. Briefly, 0.5 μg of genomic DNA was digested with the four base (T̂TAA) restriction enzyme MseI, which restricted genomic DNA into fragments less than 250 bp in length, while leaving the GC-rich CGIs relatively intact. Subsequently, the sticky ends of the fragments were ligated to linker primers. Samples were then digested with the methylation-sensitive restriction enzymes HpaII and BstUI to increase the genome coverage and to ensure complete digestion. Reference samples were treated in the same way to generate amplicons. PCR reactions (20 cycles) were performed using the purified, digested, linker ligated DNA as template to generate final target amplicons, followed by coupling to fluorescent dyes (Cy3 in case of human genomic reference DNA and Cy5 in case of tumor samples) before hybridizing to the Agilent 244K CpG island microarray. The pooled amplicons were co-hybridized on the array. Using this approach, genomic DNA fragments containing unmethylated CpG sites in one sample (e.g. the human genomic reference DNA) were degraded by restriction digestion and not amplified. However, corresponding DNA fragments in the other sample (the bladder tumor) that contain methylated restriction sites were protected from digestion and subsequently amplified by PCR. Differentially methylated sequences were identified by comparing hybridization signals between fluorescently labeled tumor (Cy5) and reference (Cy3) amplicons.

All microarray data generated are compliant with current MIAME standards according to Brazma et al [Brazma 2009. Scientific World J 9:420; Brazma et al. 2001. Nat Genet 29:365]. Normalization, preprocessing of raw data and statistical analysis were done using Bioconductor packages in an R programming environment (http://www.r-project.org/). Raw hybridization signals were normalized by applying the within-array global “lowess” normalization method [Yang et al. 2002. Nucleic Acids Res 30: e15], which assumes that the bulk of the probes on the array are not differentially expressed. The normalization also includes a pre-processing step, as a result of which the normalized intensities were log 2-transformed. The log2-transformed intensities were then subjected to further statistical testing to determine which loci were differentially methylated. The linear model “limma” was applied [Smyth 2004. Stat Appl Genet Mol Biol 3: Article3]. We performed the following comparisons: All tumors vs. Blood, NMI-mt vs. NMI-wt, NMI-mt vs. MI, and NMI-wt vs. MI, to find genes that have different methylation profiles across the groups compared. These comparisons are analogous to a classical two sample t-test analysis.

The p-value threshold was calculated using the Benjamini and Hochberg method [Benjamini et al. 2001. Behav Brain Res 125: 279]. The loci corresponding to p-values less than 0.05 and a log fold change of either greater than 0.5 or less than −0.5 with more than 2 probes representing the same CGI were classified as differentially methylated. We left chromosome Y probes out of the subsequent analyses.

Illumina Custom Golden Gate Methylation Assay and Statistical Analysis

We designed a custom Golden Gate Methylation assay interrogating 384 CpG containing probes representing 238 CGIs, 184 genes, and 46 intergenic regions. The selection of the probes was based on the differentially methylated loci in the genome-wide analysis. Probes were included to detect methylation in all bladder subgroups, but also probes that appeared to be specific for a certain subgroup compared to others, and some probes specific for progression or death of disease. The methylation assay is an adaptation from the Illumina high-throughput SNP genotyping assay described by Fan et al. [Fan et al. 2003. Cold Spring Harb Symp Quant Biol 68: 69]. In short, non-methylated cytosines (C) were converted to uracil (U) by treatment with bisulfite. Sodium bisulfite modification of genomic DNA was carried out using the EZ DNA Methylation Gold Kit (Zymo Research Corp, Orange, Calif., USA) according to the manufacturer's protocol, using 0.8 μg of FFPE DNA. The conversion efficiency was monitored by PCR with universal BS specific primers provided with the kit. Arrays were run at Service XS, Leiden, the Netherlands according to the manufacturer's protocol and as described by Bibikova et al. [Bibikova et al. 2006. Genome Res 16: 383].

Data were analyzed with Illumina's BeadStudio Methylation module software. All array data points were represented by fluorescent signals from both methylated (M) and unmethylated (U) alleles. The average methylation value β was derived from approximately 30 replicate methylation measurements for each locus. The methylation level was given by β=(max(M, 0))/(|U|+|M|+100). The β-value (0≦β≦1) reflects the methylation level of each CpG site where 1 represents fully methylated and 0 represents unmethylated. At each locus for each sample, the detection p-value was defined as 1−p-value computed from the background model characterizing the chance that the signal was distinguishable from negative controls. Using this as a metric for quality control for sample performance, 6 FFPE samples (6%) were dropped from the analysis, because they either had very low overall signal intensities or >25% of loci failed. The significant differences were assessed by comparing the average β value per locus per group. Significant loci were selected on the basis of an average β value ratio larger than 1.4 and a difference between the average β value (Δβ) larger than 0.3.

Validation of Methylation of Individual CGIs

We used the MS-SNAPSHOT method described in [Gonzalgo and Liang 2007. Nat Protoc 2: 1931; Lurkin et al. 2010. PLoS One 5: e8802] to investigate methylation in urine DNA quantitatively. The method involves the bisulfite conversion of genomic DNA and the subsequent amplification of interested genomic region. This is followed by the methylation specific single nucleotide primer extension with CpG specific probes and finally the fragments are visualized on a ABI sequencer. To test the method, methylation of MEIS1 gene was investigated using normal, patient urine samples along with bladder cancer cell lines. In vitro methylated DNA was used as a positive control. A list of primers and probes used is given in Table 6.

Results

A genome wide methylation profile for bladder cancer

To investigate global DNA methylation in bladder cancers, we analyzed 44 bladder tumors on Agilent 244K human CpG island microarrays using differential methylation hybridization. We found that 729 different probes were significantly more methylated in bladder tumors compared to blood with a log fold change greater than 0.5 and a p value of <0.05. To select the most hypermethylated CGIs, we used as an additional criterion that 3 or more CpG dinucleotides should be highly methylated in a specific CGI. This selection generated a list of 82 CGIs representing 71 genes and 11 CGIs not directly associated with a gene according to the Agilent information file. These are shown in Table 10. The gene showing the highest degree of methylation was MEIS1 with a log fold change of 4.8 for the most highly methylated probe and an average log fold change of 2.2 across the 10 probes that were present on the array for this CGI (FIG. 1). We observed that for most of the significantly methylated CGIs, the adjacent CpG dinucleotides within a CGI were co-methylated. In contrast, CGIs neighboring a methylated island were usually not methylated.

Methylation of Intronic CGIs is Associated with Reduced Gene Expression

The 244k array contains probes for CGIs as displayed in the UCSC genome browser (http://genome.ucsc.edu/cgi-bin/, build 19). Of the CGIs represented on the array, 26% is located in promoter regions. Many studies have shown that aberrant methylation of CGIs in promoter regions represents one of the most frequent epigenetic events associated with gene silencing in cancer. In our analysis we observed that there was no specific preference for methylation of promoter regions. Instead, methylation was distributed proportionally over CGIs in promoter regions, within genes and in intergenic regions (Table 11). Examples are shown for CGIs in two of the selected genes, MEIS1 and NR4A2 (FIG. 1). To investigate whether methylation outside promoter regions also repressed gene expression, we next compared genes with methylated CGIs with available genome-wide expression profiles of bladder cancer using the Oncomine database [Blayeri et al. 2005. Clin Cancer Res 11: 4044; Dyrskjot et al. 2004. Cancer Res 64: 4040; Dyrskjot et al. 2003. Nat Genet 33: 90; Lindgren et al. 2006. Oncogene 25: 2685; Modlich et al. 2004. Clin Cancer Res 10: 3410; Sanchez-Carbayo et al. 2006. J Clin Oncol 24: 778]. This information could be obtained for 54 genes. Out of these 54 genes, 22 showed promoter CGI methylation and a positive correlation with low expression was observed in 17 genes (77.3%). The remaining 32 genes showed methylation of CGIs within introns. Interestingly, 23 of these genes also showed low expression (71.9%) in bladder cancers. These data suggest that not only promoter CGI methylation but also methylation of intronic CGIs leads to reduced gene expression. The expression profile box plots of MEIS1, NR4A2 and HOXA9 are shown in FIG. 1.

Analysis of Individual Subgroups Shows NMI-wt Tumors to have a Highly Methylated Profile

To explore whether global DNA methylation can identify subgroups of bladder cancer, we performed an unsupervised analysis by means of a principal component analysis (PCA) using all probes on the array (244K) (FIG. 2A). The first three components of the PCA explained 42.4% of the variability between the samples suggesting that there is a reasonable discrimination between the subgroups. This unsupervised analysis indicates the presence of two clusters of bladder cancer patients. The NMI-wt tumors (in green) clustered closely together and separate from the NMI-mt (in blue) and MI tumors (in red). Furthermore, we looked at the individual subgroups of bladder tumors. NMI-wt tumors showed a 2.7 to 4.6 times higher number of hypermethylated probes compared to the NMI-mt and MI groups (FIG. 2B). A list of genes differentially methylated between subgroups is given in Table 12.

We next clustered the different subgroups of bladder tumors based on all probes that were differentially methylated between two groups with a p value of <0.05, regardless of the log fold change. For clustering of probes differing between NMI-mt and MI tumors, we had to use a p-value<0.5 because not many differences exist between these two groups. We employed a hierarchical clustering algorithm choosing Euclidian distance and complete linkage to organize the three different comparisons (FIG. 3). We then performed principal component analysis on the same data. The probes along with gene names and p-values are listed in Table 12. These semi-supervised analyses showed clearly that the different bladder cancer subgroups can be identified based on their methylation pattern.

Genes Hypermethylated in Bladder Cancer Often are PcG Target Genes

Polycomb group (PcG) proteins function as transcriptional repressors of genes that have been implicated in stem cell self renewal and differentiation. These PcG target genes have been shown to be particularly prone to DNA methylation in cancers [Ohm et al. 2007. Nat Genet 39: 237; Widschwendter Met al. 2007. Nat Genet 39: 157; Schlesinger et al. 2007. Nat Genet 39: 232]. We investigated whether DNA hypermethylation in bladder cancer was more present in PcG target genes by matching our list of 71 genes from Table 10 with recent studies showing that 8-14% of all genes in the genome to be PcG regulated [Bracken et al. 2006. Genes Dev 20: 1123; Lee et al. 2006. Cell 125: 301]. Notably, we found that 63.3% of the hypermethylated genes in bladder cancer were PcG target genes, with a representation factor of more than 3 (http://elegans.uky.edu/MA/progs/representation.stats.html) (FIG. 4A). This was approximately the same for all different tumor subsets. Twenty-two PcG regulated genes were methylated in all three subtypes, while a striking 81 genes were specific to NMI-wt tumors (FIG. 4B). A list of the PcG target genes methylated in bladder cancer is given in Table 8.

Genes Methylated in Blood Compared to Bladder Cancer

We also observed 21 CGIs that were methylated in blood but not in bladder tumors. These are listed in Table 9. We compared our results with a study based on methylated DNA immunoprecipitation (MeDIP), in which the genome-wide methylation pattern in blood was investigated [Rakyan et al. 2008. Genome Res 18: 1518]. We found a 90% correlation with their study.

Validation of Hypermethylation and Markers for Diagnosis and Progression

Next we set out to validate the selected significant CGIs on a custom Illumina platform based on bisulfite conversion of tumor DNA. The following CGIs were included in the custom array:

1) Differential methylation between tumors and blood (Tables 9 and 10);

2) Probes that could be of use as biomarkers to distinguish the subgroups. There were 7 CGIs representing 6 genes found to differentiate between NMI-mt and NMI-wt tumors. In the MI versus NMI-wt comparison, we found 17 CGIs representing 13 genes to be significant. No significant probes were found between the MI versus NMI-mt subgroups at a p-value<0.05. Therefore we decided to include probes from 6 CGIs representing 6 genes with a p-value<0.5;

3) CGIs that were associated with progression and survival. In all cases the CGI to be validated had at least 3 CpGs that were highly methylated.

We employed a hierarchical clustering algorithm on the average beta values per subgroup with all 384 probes on the array choosing Euclidian distance and complete linkage. The analysis clearly separated the bladder tumors from normal urine and blood (FIG. 5A). We were able to validate more than 70% of the probes hypermethylated in all bladder tumors. For example, in the custom 384-plex GGMA, there were 205 probes which were methylated in bladder cancer but not in blood based on our Agilent array data. Of these, 147 probes were also methylated in bladder cancer but not in blood in the GGMA. These probes are shown in the heat map (FIG. 5B). We also included DNA isolated from cells present in urine of healthy individuals, which most likely are derived from normal urothelial cells. Eighty % of the probes validated against blood were also not methylated in urine. For the different subgroups of bladder tumors, the number of probes validated varied between 65-75% of probes compared to blood and 76-83% compared to urine.

CGIs that are differentially methylated between tumors and urine from non-bladder cancer controls represent potential biomarkers for urine tests (Table 12). We validated several of these using a bisulfite specific PCR followed by a Snapshot assay for the CpG. The results of these analyses are shown in FIG. 5C. We were able to detect methylation in urine DNA quantitatively using this method. We investigated MEIS1 gene methylation at two CpG sites using different probes (MEIS1 A and B). The black peak (Cytosine) represents methylation and red peak (Thymine) represents no methylation. In vitro-methylated DNA (IM), BC patient urine sample (PU) and bladder cancer cell lines (RT112, T24, J82) showed a strong methylation signal while normal urine (NU) and blood DNA (NB) were not methylated.

Next we analyzed the CGIs that were included on the GGMA as potential markers for progression. To this end the 6 best CGIs that were methylated in non-progressors vs progressors and similarly, 6 CGIs that were methylated in progressors vs. non-progressors were analyzed separately and in several combinations (Table 12B). The Kaplan-Meier curves depicted in FIG. 5D show that a combination of CGIs in the GPR103, DBC1 and GATA2 genes can significantly predict progression (p=0.001). Interestingly, methylation of the GPR103 and DBC1 CGIs was inversely correlated with progression and methylation of GATA2 was strongly indicative for progression. The DBC1 associated CGI overlaps with the promoter of this gene, whereas the GATA2 and GPR103 CGIs are located in introns.

Discussion

We report an investigation of bladder cancer-associated aberrant DNA methylation. To our knowledge this is the first study that addresses genome-wide methylation in bladder cancer. The major goal of this work was the identification and validation of methylated CGIs that could serve as biomarkers for the early detection of primary and recurrent tumors as well as markers that are predictive of disease course. The genome-wide screen resulted in the selection of 177 CGIs that significantly differed in methylation in tumors when compared to blood. About 70% of these CGIs could be validated in a custom GGMA assay. This analysis also showed that most of these CGIs were not methylated in urine-derived DNA from age matched non-bladder cancer controls. This group of CGIs represents markers for urine based assays. Methylation of some of these markers was confirmed on urine samples. Another important finding is that a combination of CGIs from the GRP103, DBC1 and GATA2 genes is able to predict progression to muscle-invasive disease. Loss of heterozygosity or homozygous deletions of DBC1 (also called DBCCR1) gene (deleted in bladder cancer 1) have been observed in many bladder tumors, as well as methylation of the promoter. Methylation has so far not been correlated to disease course. In our study methylation of the promoter CGI of the DBC1 gene was associated with a decreased risk of progression. The role of the GATA 2 transcription factor in cancer is contradictory. Decreased expression was found to be correlated with proliferation in monocyte progenitors, whereas high expression seems to poise prostate cancers for a more aggressive phenotype and gain-of-function point mutations have been found in chronic myeloid leukemia. In bladder tumors a lower expression of this protein has been observed in MI vs. NMI-BC, which correlates with methylation and the positive association with progression. The GPR103 (QRFPR) gene encodes a G protein-coupled receptor and hence the protein is involved in signal transduction, however, but no further data about the gene or its product can be found in the literature.

Most genes discovered in the present study have never been shown to be methylated in bladder cancer or in other types of cancer. Some of the previously described methylated CGIs in bladder cancer that are associated with the SOX9, CDKN2A, TERT, DAPK1, EDNRB, and LAMB3 genes were also found to be methylated in our study, although only SOX9 and CDKN2A made it to the list of our 177 highly methylated CGIs.

To our surprise we observed that NMI-BCs with a wild-type FGFR3 gene have more methylated CGIs and the intensity of methylation is more profound than in the FGFR3 mutant NMI-BC and MI-BC groups. The difference in methylation presents additional evidence that the two subgroups of NMI-BC develop along different pathogenesis pathways. WT NMI-BCs also have more wide spread chromosomal aberrations than FGFR3 MT NMI-BCs. The extensive methylation in WT NMI-BC is reminiscent of the CpG island methylator phenotype (CIMP) that characterizes a subset of colorectal cancers (CRC). CIMP in CRC also identifies a subset of CRCs as it is associated with BRAF mutations, microsatellite instability and occurs more often in elderly females. No large-scale genome-wide study on DNA methylation has been performed for CRC, however, CIMP has been studied using a 1536-plex GGMA array.

When comparing the genes methylated in this study with those found by us, there was hardly any overlap. This confirms that CGI methylation is tissue and tumor type specific.

In line with previous reports in solid tumors, a high proportion of the genes we find de novo methylated in bladder cancer are repressed by polycomb complexes (PcG) in embryonic stem cells. PcG target genes are as much as 12 times as likely to be silenced by DNA methylation in cancer as non-PcG target genes. The association between DNA methylation and PcG has further been substantiated by the finding of interactions between DNMT1, DNMT3A, DNMT3B and several PcG complex subunits like EZH2 and BMI1. Another recent study showed that 49% of the genes methylated in colon cancer are polycomb targets in embryonic stem cells, agreeing with other reports showing that genes prone to tumor specific hypermethylation in colon cancer were more likely to be marked by H3K27 methylation in normal tissues than genes lacking H3K27 methylation. Another study reported that many genes hypermethylated in a prostate cancer cell line were bound by PcG in normal cells but lost PcG binding upon acquiring DNA methylation in cancer. In this perspective we found that 60% of the hypermethylated genes in bladder cancer are PcG targets in embryonic stem cells. These epigenetic alterations occurring in early development specifically in stem or progenitor cells might be bladder cancer specific and this strengthens the further understanding of bladder cancer tumorigenesis. Besides finding 92 commonly PcG regulated genes in bladder cancer subgroups, a group of 336 genes regulated by PcG complexes are found to be specific to NMI-wt tumors. Besides a possible CIMP phenotype being the cause for the extensive methylation in this group, another possible explanation for this finding could be that the cell from which the WT NMI-BCs originate is more closely related to the embryonic or bladder stem cell than the founder cells of the MT NMI and MI-BCs. In general it is thought that lineage-specific genes are activated during subsequent differentiation steps and during this process the PcG complexes will be replaced by cell fate specific transcription factors. Hence, fewer possible methylation targets will remain after every differentiation step.

Our data clearly shows that adjacent loci within a certain CGI are co-methylated, while neighbouring CGIs of a certain gene can have a very different methylation level. Significant association among the methylation states of adjacent CpG sites and a high frequency of short-range co-methylation was reported previously. Another interesting finding in this study is that our data shows no preference for methylation of CGIs in promoter regions compared to gene bodies, since the location of the significant CGIs is distributed over the genome in accordance to the distribution of CGIs on the array. The effects of promoter methylation on chromatin organization and gene expression have been well documented in various types of cancer. In our study, besides promoter methylation, we found more than 50% of all significant probes to be located in CGIs located within gene bodies. The influence of this on gene expression in not fully known. Previous reports in Arabidopsis have shown that gene body methylation was low in genes transcribed at low levels, higher in highly transcribed genes, and absent in genes that were not transcribed. By comparing our methylation results with gene expression studies, we show that for 70% of our genes there is an inverse correlation with gene expression, suggesting that intragenic methylation also contributes to gene silencing.

In summary we have identified hypermethylated CGIs in bladder cancer. The aberrant DNA methylation in bladder cancer seems to be very selective and could be the first step in tumor initiation, especially for the WT NMI-BCs. The study also illustrates an interesting biological finding: besides the promoter methylation intragenic methylation observed to the same extent in bladder cancer and it also appear to influence the gene expression. Many discovered methylated CGIs represent putative biomarkers for early detection in urine-based assays. The combination of CGIs from the GRP103, DBC1 and GATA2 genes predicts progression to muscle-invasive disease. Thus, the CGIs identified in this study will be of considerable interest for further investigation of their clinical and functional relevance and will provide advance insights into the pathogenesis of bladder cancer. 

1. A method for diagnosing non muscle-invasive bladder cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated, and wherein said CpG island is selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12, wherein said method comprises detection of recurrent forms of cancer in DNA isolated from patient urine. 2-3. (canceled)
 4. A method for diagnosing non muscle-invasive bladder cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with bladder cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated, wherein said method comprises detection of primary forms of cancer in DNA isolated from patient urine and wherein said at least one CpG islands methylation associated with cancer selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12, wherein said DNA is obtained from a urine sample of said subject. 5-6. (canceled)
 7. A method for the prediction of the recurrence, progression or prognosis of cancer, in particular bladder cancer, comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated, and wherein said CpG island is selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12, preferably from Table 5, Table 10 and Table 12B.
 8. The method according to claim 7, whereby the CpG island is selected from the group consisting of the CpG islands in GPR103, DBCl and/or GATA2.
 9. The method according to claim 1, wherein said method comprises methylation-specific PCR (MSP).
 10. The method according to claim 1, wherein said method comprises multiplex ligation-dependent probe amplification (MLPA).
 11. Method of treating bladder cancer or reducing the chance of relapse of a cancer in a subject comprising at least one CpG island in the DNA of said subject which is hypermethylated in the cancer cells of said subject relative to a control subject, and wherein said hypermethylation is associated with said cancer, comprising administering to a subject in need of such treatment a therapeutically effective amount of a demethylating agent capable of selectively demethylating said at least one CpG island associated with cancer.
 12. The method according to claim 11, wherein said cancer is bladder cancer, preferably muscle invasive (MI) bladder cancer.
 13. The method of claim 11, wherein the at least one hypermethylated CpG island is selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table
 12. 14. The method of claim 11, wherein said treatment is part of a priming therapy for chemotherapeutic regimes.
 15. A pharmaceutical composition for treating aggressive bladder cancers, comprising at least one demethylating agent capable of selectively demethylating said at least one CpG island selected from the group consisting of the CpG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table 12, and a pharmaceutically-acceptable carrier.
 16. A diagnostic composition for use in a method according to claim 1, 4, 7, or 11 comprising a nucleic acid capable of selectively hybridizing under stringent conditions to a hypermethylated CpG islands selected from the group consisting of the CPG islands listed in Table 1, Table 2, Table 3, Table 4, Table 5, Table 7, Table 9, Table 10 and Table
 12. 